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Contact Name
Dharma Lindarto
Contact Email
jetromi@usu.ac.id
Phone
+6282168842564
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jetromi@usu.ac.id
Editorial Address
Jalan Dr T Mansur No 9 Padang Bulan, Kecamatan Medan Baru, Kota Medan, Sumatera Utara, Indonesia
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INDONESIA
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Published by TALENTA PUBLISHER
ISSN : 26860872     EISSN : 26860856     DOI : 10.32734
Core Subject : Health, Science,
Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI) is an international peer-reviewed journal (February, May, August and November) published by TALENTA Publisher, Universitas Sumatera Utara and managed by Faculty of Medicine, Universitas Sumatera Utara. It is dedicated to interchange for the articles of high quality research in the field of Medical Science. The journal publishes state-of-art papers in fundamental theory, case report, experiments and simulation, as well as applications, with a systematic proposed method, sufficient review on previous works, expanded discussion and concise conclusion. As our commitment to the advancement of science and technology, the JETROMI follows the open access policy that allows the published articles freely available online without any subscription. Each publication contains 6 (six) research articles which will be published online.
Articles 151 Documents
Prevalence of Cockroach Density, Gastrointestinal Disorders, and Identification of Parasites in Cockroaches in Helvetia Deli Serdang Village Irawan, M Ari; Panggabean, Yoan Carolina; Dalimunthe, Dina Arwina; Siahaan, Lambok
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 1 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i1.14224

Abstract

Background. Cockroaches are known to be vectors of various pathogens that can infect humans, one of which is intestinal parasites. Parasitic infectious diseases can cause symptoms of gastrointestinal disorders in sufferers, which can interfere with the sufferer's quality of life. This research aims to determine cockroach density, and gastrointestinal disorders in the community, and identify parasites in cockroaches.                                                             Method. The research method used in this research is observational analytics. The population and sample for this study were the houses of the Helvetia Deli Serdang Village community which met the slum criteria of 100 houses. The caught cockroaches are then examined in the laboratory. Results. The results obtained were that 96 houses (96%) were not infested with cockroaches, 4 houses (4%) had no cockroaches, and no houses were infested with cockroaches. The number of respondents who had experienced gastrointestinal disorders was 41 respondents (41%) and 59 respondents (59%) had never experienced them. Based on laboratory examination, 22 rhabditiform hookworm larvae (21.78%), 5 hookworm eggs (4.95%), and 1 Oxyruris vermicularis egg (0.99%) were found. Toxocara sp. as many as 1 piece (0.99%), and cysts Entamoeba histolytica as much as 1 piece (0.99%). Conclusion. Based on these results, there was no high density of cockroaches found at the research location, the majority of respondents had never experienced gastrointestinal disorders in the past year, and parasites were found in cockroaches.
A Correlational Study Elevated Risk of Cardiometabolic Illness and the Prevalence of Obstructive Sleep Apnea Among the Population of Tebing Tinggi, North Sumatra, Indonesia Raynaldo, Abdul Halim; Pase, Muhammad Aron; Ketaren, Andre Pasha
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 3 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i3.14330

Abstract

Background: Obstructive Sleep Apnea (OSA) is a prevalent sleep-related breathing issue, marked by repeated full or partial blockages of the upper airways. It's a primary respiratory condition that heightens the chances of cardiometabolic diseases. In our research, we explored the link between the increased risk of cardiometabolic ailments and the potential for OSA. Method: We studied 75 participants during community service activities and investigated the association between the high risk of cardiometabolic disease and the risk of OSA in the Society of Tebing Tinggi. We measured variables such as gender, age, weight, height, Body Mass Index (BMI), blood pressure, heart rate, random blood glucose, waist and neck circumference, and total cholesterol. Subsequently, we categorized the data and performed chi-square tests to analyze the associations between various factors and the risk of OSA. Variables with p<0.05 are considered eligible for multivariate analysis using binary logistic regression. Results: We identified 42 patients had a high risk of OSA (59.2%), while 33 patients had a low risk (40.8%). The study identified significant links between OSA risk and gender, age, blood pressure, and neck circumference (p-values <0.001, <0.001, and 0.01 respectively). In contrast, BMI, heart rate, glucose levels, waist size, and cholesterol did not show a significant connection to OSA risk. This indicates that while certain factors like gender, certain age groups, hypertension, and neck size are important in assessing OSA risk. However, BMI, heart rate, random blood glucose, waist circumference, and total cholesterol are not significant factors in determining the risk of OSA (p=0.2, p=0.4, p=0.2, p=0.1, p=0.9). Conclusions: Higher risk of cardiometabolic diseases (older age, gender, hypertension, neck size) was positively associated with the risk of OSA.
Prevalence of Congenital Heart Disease and Pediatric Rhythm Disorder or Arrhythmia in Children in Rantau-Prapat City, North Sumatra, Indonesia Lubis, Anggia Chairuddin; Nasution, Ali Nafiah; Lubis, Hilfan Ade Putra
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14332

Abstract

Background: Cardiovascular diseases (CVD) are responsible for the leading cause of a 30%  global mortality rate and are a major contributor to reducing the quality of life. Approximately 25% of the cardiovascular mortality rate is caused by sudden cardiac deaths and cardiac arrhythmias are one of the causes of sudden cardiac deaths. Besides that, Congenital Heart Disease (CHD) also contributes mortality rate in children. Long-term experience has provided evidence that systematic screening, with 12-lead ECG, after history and physical examination, is effective in identifying individuals with potentially lethal cardiovascular disease for early intervention. However, in Indonesia screening for heart abnormalities and rhythm disorder in children has not yet been systematically established. Method: This study was a descriptive study conducted through a cross-sectional study design. The primary objective was to assess the congenital heart disease (CHD) and Arryhtmia prevalence in children in Rantau City. Data was collected from interviews and on-the-spot examination with validated measurement tools. Data was analyzed using SPSS version 26. Categorical variables were presented using frequency (n) and percentage (%), and numerical variables with normally distributed data were presented with mean and standard deviation (SD). In non-normally distributed data, numerical variables were presented using the median and interquartile range. Results: There were 157 children included in this study. Most subjects were female (n=94, 59.9%) in the age range of 12 to 16 years old. Most subjects (n=129, 82.2%) had normal sinus rhythm. The only rhythm disorder that was found in this study was sinus tachycardia (n=28, 17,8%). One subject (0,9%) had congenital heart disease, which was a secundum atrial septal defect. Conclusion: In the children population in Rantau-Prapat city, the most common arrhythmia found in children was sinus tachycardia. The atrial septal defect was the only congenital heart disease found.
Prevalence of Valvular Heart Disease and Pulmonary Hypertension in Children in Rantau-Prapat City, North Sumatra, Indonesia Haykal, Teuku Bob; Sitepu, Andika; Ilyas, Kamal Kharrazi
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14333

Abstract

Background: Valvular heart disease and pulmonary hypertension (PH) are two distinct but often interconnected cardiac conditions that can affect children and encompass abnormalities of the heart's valves such as the aortic, mitral, tricuspid, and pulmonary valves, and can present with symptoms such as chest pain, fatigue, and dyspnea. In contrast, PH refers to elevated blood pressure in the pulmonary arteries. Routine screening for these conditions is needed for prompt diagnosis and management. This study was conducted to obtain data on children with valvular heart disease or PH who participated in the Community Service Program of the Department of Cardiology and Vascular Disease, Universitas Sumatera Utara. Method: This study was a descriptive study conducted through a cross-sectional study design. Data was collected from interviews and on-the-spot examination with validated measurement tools. Data was analyzed using SPSS version 26. Categorical variables were presented using frequency (n) and percentage (%), and numerical variables with normally distributed data were presented with mean and standard deviation (SD). In non-normally distributed data, numerical variables were presented using the median and interquartile range. Results: There were 157 children included in this study. Most subjects were female (n=94, 59.9%) in the age range 12 to 16 years old. Most subjects (n=152, 96.8%) had normal mitral valves, three subjects had anterior mitral valve prolapse (1.9%), one subject (0.6%) had anterior mitral valve thickening and one subject (0.6%) had mild mitral regurgitation. 10 subjects (5.7%) had pulmonary regurgitation. Two subjects had tricuspid regurgitation (1.2%). No subjects had any aortic abnormalities. No subjects had a PH. Conclusion: In the children population in Rantau-Prapat City, most subjects with valve abnormalities had mitral and pulmonary valve abnormalities. No subjects had aortic valve abnormalities or PH.
Type 1 Diabetes and Cytomegalovirus Infection: Cytokine and T Lymphocytes Profile in Pointe Noire, Congo Atandi Batchy, Aladin; Charley Elenga-Bongo; Luc Magloire Anicet Boumba; Fredy Kibouilou; Freddy Saturnin Pouki; Ben Dorel Kyabaambu; Christ Nkaya Kimpolo; Exaucé Massengo; Ghislain Loubano Voumbi; Donatien Moukassa
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14352

Abstract

Background: Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of beta cells in the pancreatic islets of Langerhans. This study aimed to investigate the T lymphocyte pathway involved in cytomegalovirus (CMV) infection in T1D patients in the context of. in Pointe Noire Method: We conducted an analytical case-control study over 6 months between June and November 2022. A total of 234 subjects were enrolled, including 68 (T1D +CMV+) cases, 62 (T1D +CMV-) cases, and 104 healthy subjects as the control group (healthy controls). The plasma concentrations of CD4, CD8, CD28, IL2, IL4, and IL10 were measured using ELISA. Linear regression analysis was performed to explore the correlation between T lymphocyte types (CD4, CD8, and CD28) and interleukins. Results: In the case group, the average age was 20.85±0.63 years for (T1D+CMV+) cases, 21.88±4.07 years for (DT1+CMV-) and 31.95±2.13 years for healthy controls. Men were the majority in the study, representing 55.38%, with a male-to-female ratio of 1:2. Plasma concentrations of different types of lymphocytes were higher in the case group compared to the controls CD4 (7,21±0,23 vs 5,71±3,27 vs 2,07±0,14; p<0,0001); CD8 (13,73±0,91 vs 10,01±1,88 vs 1,27±0,14 p <0,0001); CD28 (45.95±2.18 vs 14.39±1.99 vs 7.97±1.96; p<0,0001); IL2 (1048.0±43.47 vs 252.0±10.91 vs 52.91±23.95; p<0,0001); IL4 (474.3±18.45 vs 279.3±169.2 vs 194.9±136.2); IL10 (275.0±134.0 vs 206.0±84.77 vs 44.62±7.22; p <0,0001), and (CD4, CD8, CD28, IL2, IL4, and IL10) showed significant elevation in the case group compared to the controls. The study also revealed a direct correlation between CD4 and CD28. Conclusion: These findings suggest that CMV infection worsens T1D by promoting the increase in CD4, CD8, and CD28 lymphocytes as well as plasma concentrations of interleukins (IL2, IL4, and IL10), and no correlation was observed with CD8.
Factors Associated with the Severity of COVID-19 at H. Adam Malik Hospital, Medan, Indonesia Destylya, Dyana; Bintang Yinke Magdalena Sinaga; Siagian, Parluhutan; Eyanoer, Putri Chairani
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14389

Abstract

Background: Several studies have shown an association among laboratory values, comorbidities, and the severity of COVID-19. This study aimed to find the factors associated with the severity of COVID-19 patients in Adam Malik Hospital. Method: This is a descriptive study with a cross-sectional design. The subjects were COVID-19 patients from December 2020 to April 2021 whose data were in the form of secondary data obtained from their medical records. The inclusion criteria were patients diagnosed with COVID-19 based on RT-PCR while the exclusion criteria were incomplete medical record data. Statistical analysis was conducted via the following tests Kruskal Wallis Test, Kolmogorov Test, and Chi-Square based on the data category. Results: A total of 110 subjects were enrolled in this study. Most subjects were male (55.45%) with age >40 years old (66.36%). The laboratory values of lymphocyte count, NLR, D-dimer, procalcitonin, ferritin, fibrinogen, and CRP were significantly associated with the severity of COVID-19. Also, there were several comorbidities statistically associated with the severity of COVID-19, including hypertension, diabetes mellitus, coronary artery disease, renal disease, and HIV (p <0.05). Conclusion: Lymphocyte count, NLR, CRP, procalcitonin, D-dimer, fibrinogen, ferritin, and comorbidities including diabetes mellitus, hypertension, HIV, coronary disease, and renal disease, were associated with the severity of COVID-19.
Correlation between Apolipoprotein B Levels with Coronary Lesion Area Based on the Gensini Scores in Coronary Heart Disease Patients Siallagan, Delpiana; Siregar, Jelita; Hasan, Refli
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 3 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i3.14396

Abstract

Background: Coronary heart disease (CHD) is caused by atherosclerosis. apolipoprotein B (Apo B) is a large glycoprotein, that plays a role in lipoprotein metabolism and human lipid transport, reflecting atherogenic cholesterol transport. The Gensini scoring system has the highest correlation with the severity of coronary artery stenosis as assessed by angiography. This study aims to determine the correlation between apolipoprotein B levels with the area of ​​coronary lesions based on the Gensini score in patients with CHD Methods: This research is an observational study with cross cross-sectional data collection method of 76 coronary heart disease patients who were treated at H. Adam Malik General Hospital Medan (December 2021 – April 2022). Examination of the Apo B value was carried out by the immunoturbidimetry method (Architect). Coronary lesion area calculated from coronary angiography with Gensini score. The research was conducted after obtaining ethical approval and informed consent. Result: There were 57 male subjects (75 %). The mean age of the subjects was 56.17 years with the youngest age being 24 years and the oldest being 77 years. Most of the subjects who experienced STEMI amounted to 38 people (50 %). The mean Apo B level was 89.18 mg/dL. The mean Gensini score was 62.84. By using the Pearson correlation test, it was found that a significant correlation was found between Apo B and Gensini score, r = 0,288 (p = 0.012) Conclusions: There was a significant correlation between the levels of Apo B and coronary artery lesions based on the Gensini score. Apo B examination and Gensini score can be used as a risk assessment of severity in CHD patients. Further research is needed to involve a larger number of coronary heart disease patients.
Relationship between Vascular Cell Adhesion Molecule-1 (Vcam-1) Level with Severity Degree of COVID-19 Patients at General Hospital H. Adam Malik Medan Elvira; Siregar, Jelita; Lubis, Inke Nadia Diniyanti; Herman Hariman
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14410

Abstract

Background: The mechanism and pathogenesis of COVID-19 that distinguishes asymptomatic, mild, moderate, severe to critical symptoms is not yet known with certainty. Endothelial dysfunction and immune thrombosis serve as a profound pathogenic mechanism in COVID-19. Vascular Cell Adhesion Molecule-1 (VCAM-1) is a major regulator of leukocyte adhesion that contributes to the formation of thrombosis. The purpose of the study determine the relationship between VCAM-1 level with the severity degree in COVID-19 patients. Methods: An analytical study with a cross-sectional design was conducted from September – March 2022. This study was followed by 50 patients aged over 18 years with moderate, severe, and critical degrees of COVID-19 admitted to Haji Adam Malik General Hospital Medan by excluding malignancy and pregnancy patients. Serum VCAM-1 levels were measured using Chemwell Analyzer.  Results: Among 50 patients, 33 patients (66%) were male and 17 patients (34%) were female. The mean age was 57 years with the youngest 19 years old and the oldest 81 years old. The median level of VCAM-1 was 23,02 ng/mL (10.96 ng/mL - 50.63 ng/mL). The median concentration of VCAM-1 was 37.85 ng/mL (15,59 – 50.63), 36.68 ng/mL (19.58 – 49.71), and 18.83 ng/mL (10.96 – 46.32) for critical, severe, and moderate degree respectively (p = 0.001). The cut-off value of VCAM-1 levels to predict the severity of COVID-19 is 32.01 ng/mL. Conclusions: There is a significant relationship between VCAM-1 levels and the severity of COVID-19.
Relationship between LDH Levels with COVID-19 Degree of Severity Tambunan, Adrian Nurrachman; Ganie, Ratna Akbari; Tarigan, Amira Permatasari
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14414

Abstract

Background: LDH has proved to be a significant predictor for prognosis and follow-up in COVID-19 patients. Several studies report elevated LDH in hospitalized COVID-19 patients to be associated with a higher risk of death. Increased LDH levels can result from any tissue damage due to SARS-CoV-2 infection. The study aims to describe the relationship between LDH levels with COVID-19 19 degree of severity. Methods: This study is a cross-sectional study of 55 patients who confirmed positive by RT-PCR SARS-CoV-2 at H. Adam Malik General Hospital Medan (November 2021 – Maret 2022). Examination of the LDH level was carried out by the Chemiluminescent Immunoassays method (Abbott Architect). COVID-19 degree of severity was assessed based on the diagnostic criteria for COVID-19 cases in Indonesia. Results: Among the 55 COVID-19 patients in this study, the average age found was 45.73, with men 54.5%. Moderate, severe, and critical patients were found in 63.6%; 29.1%; and 7.3% respectively. The mean LDH level at admission was 278 U/L, higher in the severe (333.19 U/L) and critical (465.75 U/L) groups compared to the moderate (231.31 U/L) groups. Increased LDH ≥ 256 U/L proved to be related to COVID-19 degree of severity upon hospital admission (CI 95%; p = 0.001). Conclusions: LDH levels that increased ≥ 256 U/L were significantly related to COVID-19 degree of severity during hospital admission.
Effect of Nonsteroidal Anti-inflammatory Drug (NSAID) in Disease Relapse, Progression, and Development of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis: NSAID and IBD Darmadi; Imelda Rey
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 4 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v4i4.14473

Abstract

This systematic review and meta-analysis investigated the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and inflammatory bowel disease (IBD). Pooled analysis showed no significant association in disease relapse (OR 0.97; 95% CI 0.70–1.35; p = 0.86) and disease worsening (OR 2.06; 95% CI 0.92–4.57; p = 0.08) of existing IBD in patients receiving NSAID. In patients without prior IBD diagnosis, NSAID medication was significantly associated with risk of new-onset IBD (OR 1.51; 95% CI 1.19–1.92; p = 0.0008). Given the varied effects of NSAIDs on IBD, careful management and consideration of dosage and frequency are essential in IBD patients. Despite these insights, the heterogeneity of study designs and small sample sizes in some cases call for further large-scale research to validate these findings.

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