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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 17 Documents
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Search results for , issue "2023: Webinar Nasional " : 17 Documents clear
METODE ALGORITMA PENENTUAN KEPUTUSAN TERKAIT PEMBELIAN OBAT Tangkas, Hansel Hens; Yuwindry, Iwan; Abdi, Muhammad Mahendra; Melviani, Melviani; Gumarus, Ellora Griselda; Syahran, Dayna Maharani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1637

Abstract

Medication is one of the important or primary needs in health services used by the community. Cases of acute renal failure totaled 326 cases with 204 children dying as of July 19, 2023. A study explains that the safety of a product is significantly related to purchasing decisions. Decision methods related to drug purchases have never been found until now. Feelings of indecision or anxiety due to the rampant cases of acute renal failure can be eliminated by the existence of a method or fixed scale. This study generally aims to help the community in determining drug purchase decisions through a method. The design in this study is to use a descriptive observational design with a survey research design. Data were obtained by interview and analyzed by making verbatim tables. Then, the algorithm was tested for validity and reliability on 30 samples. The results explained that the interviewees prioritized quality, price, and opinions from others in deciding to buy drugs. Researchers created an algorithm based on indicators of drug purchase decisions, including drug needs, drug usage history, drug information, and drug needs. The algorithm has been said to be valid as evidenced by the value of r count> r table and reliable as an instrument that helps people determine as evidenced by the value of Cronbach's Alpha> 0.6. Indicators of drug purchase decisions are influenced by drug usage history, drug needs, drug information, and drug needs. The algorithm created has been tested valid and reliable.
STUDI STABILITAS FORMULASI SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) EKSTRAK DAUN SERUNAI SEBAGAI ANTI DIABETES DENGAN VARIASI KONSENTRASI ASAM OLEAT Norliani, Rahma; Noval, Noval; Melviani, Melviani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1646

Abstract

Management of diabetes mellitus can use chemical drugs and traditional medicine. One of the medicinal plants used by the community is chrysanthemum leaves (C.Odorata). The use of traditional medicine still has drawbacks, one of which is that its pharmacological effects are relatively weak and slow, affecting bioavailability and the therapeutic effect is not optimal. The aim of the study was to determine the stability of the formulation of the SNEDDS of chrysanthemum leaf extract as an anti-diabetic agent and to determine the effect of variations in the concentration of oleic acid in the formulation of the SNEDDS on evaluation and stability testing. This research method uses the Quasy Experimental Design method. The simplicia was made into an extract and then made into a nanoemulsion preparation with varying concentrations of oleic acid. The results of this study in the centrifugation test were stable at F3. Unstable hot-cold and freeze-thaw cycle tests. Stable resistance to dilution test at F2 250 ml. Week 0 and 4 accelerated storage tests were stable on F3 and F1. The evaluation results showed that variations in the concentration of oleic acid had no effect on particle size and PDI values ​​but had an effect on the transmittance value (%) as shown in the One Way Anova statistical analysis (p<0.05). The evaluation results showed that F2 with 10% oleic acid concentration was a stable formula because it had the smallest particle size and PDI (Polydispers Index) value.
PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN Mayna, Mayna; Noval, Noval; Khairunnisa, Aisya Fitri; Octaviani, Olivia; Wilujeng, Wilujeng
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1647

Abstract

Hypertension in pregnancy including chronic hypertension with or without pre-eclampsia, gestational hypertension increases maternal and infant mortality significantly. The treatment for hypertension in pregnancy is the administration of methyldopa. Methyldopa transdermal patch is made by mixing the polymer first and then adding the active substance, namely methyldopa drug. It is intended that the polymer becomes an outer layer that controls the release of the drug. The resulting transdermal patch formulation was then evaluated, including organoleptic test, pH test, weight uniformity test, patch thickness test, folding resistance test, moisture test and penetration test using Franz diffusion cell. SPSS statistical data analysis. The penetration rate results showed F1 with 832.16 µg/cm2, F4 with 767.95 µg/cm2, F2 with 2819 µg/cm2 and F3 with 275.38 µg/cm2 all formulas have met the requirements. Based on the results of physical characteristics evaluation research, all formulas have met the requirements. The results of the in vitro evaluation of the methyldopa patch transdermal penetration test found that the difference in concentration in each formula had no significant effect on the penetration test. Based on physical evaluation parameters and in vitro penetration tests, the most optimal formula is F4 with the ratio of HPMC and ethyl cellulose (300:100) seen by fulfilling all physical characteristic evaluation tests and having a constant percent of cumulative amount to rise.
EFEKTIVITAS EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia Steen.) SEBAGAI ANTIDIABETES PADA MENCIT (Mus muculus. L) Stevani, Anggita Nadia; Rissa, Mexsi Mutia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1649

Abstract

Diabetes Mellitus is a disease with lifelong treatment, while antidiabetic drugs consumed can cause side effects in the long term, so it requires alternative therapies with traditional medicinal plants such as the binahong plant (Anredera cordifolia (Ten) Steen.) which contains flavonoids and saponins. These compounds have the ability to lower blood sugar levels. This study aims to determine the antidiabetic effect of the ethanol extract of binahong leaves on alloxan-induced swiss male males. This type of research was experimental with the method of pre and post test with controlled group design, using 15 male swiss strains which were divided into 3 groups. Negative control (CMC Na 0.5%), positive control (Glibenclamide dose 0.65 mg/KgBB), and the treatment group ethanol extract of binahong leaves dose 17.5 mg/KgBB. Data on blood sugar levels obtained were analyzed using SPSS 23 with a 95% confidence level. The results of this study showed that the ethanol extract of binahong leaves at a dose of 17.5 mg/kg could reduce blood sugar levels in alloxan-induced swiss male mice. Data on decreasing blood sugar levels obtained were analyzed by One Way ANOVA, followed by LSD. The test results showed that the decrease in blood sugar levels in mice given the ethanol extract of binahong leaves at a dose of 17.5 mg/KgBW was not significantly different from that given by glibenclamide at a dose of 0.65 mg/KgBW (sig > 0.05).
ANALISIS EFEKTIVITAS BIAYA (Cost Effectiveness Analysis) PENGGUNAAN ANTIPSIKOTIK MONOTERAPI ATIPIKAL DENGAN KOMBINASI ATIPIKAL DAN TIPIKAL PADA PASIEN RAWAT INAP SKIZOFRENIA DI RUMAH SAKIT JIWA GRHASIA YOGYAKARTA Novi Afitriyani; Afitriyani, Novi Afitriyani; Dwinta, Eliza; Radne Rimba Putri, Imram; Susila Astuti, Witri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1656

Abstract

Schizophrenia is a serious mental disorder characterized by impaired thinking, hallucinations and social behavior. Yogyakarta Special Region (DIY) ranks 2nd with a prevalence of schizophrenia reaching 10.4 per 1,000 population. The high number of people suffering from mental disorders can lead to increasingly expensive costs. To reduce the problem of health financing, a cost-effectiveness analysis is needed by calculating the cost of antipsychotic drugs and calculating the Average Cost Effectiveness Ratio value. The aim of this study was to determine the cost-effectiveness of using atypical antipsychotic monotherapy with atypical and typical combinations in schizophrenia patients at RSJ Grhasia Yogyakarta. The research method was carried out descriptively and retrospectively using medical record data for the period January-December 2022, with a proportional sampling technique. Results: research shows that atypical monotherapy antipsychotics are more cost-effective with an Average Cost Effectiveness Ratio value of IDR 204.4/week of therapeutic treatment compared to atypical-typical combination antipsychotics with a greater value of IDR 343.2/week of therapeutic treatment. Conclusion: The antipsychotics used by inpatient schizophrenia patients at RSJ Grhasia Yogyakarta had the highest effectiveness, namely in the atypical monotherapy therapy group, amounting to (93.02%).
ANALISIS BIAYA MEDIS LANGSUNG DAN TARIF INA-CBG’s PASIEN DIABETES MELITUS TIDAK TERGANTUNG INSULIN DI RSUD ANUTAPURA PALU Rinaldhi Tandah, Muhamad; Rhaudatul Janna, Rischa; Mallisa, Twulyenna; Khusnul Diana
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1667

Abstract

Diabetes mellitus is a long-term disease with an increasing prevalence. Diabetes mellitus is one of the main causes of human morbidity and death and has a significant impact on health financing. Indonesia itself has implemented a national health insurance program that prioritizes effectiveness and cost efficiency. This study aims to determine the average direct medical costs, INA-CBG's rates, the suitability of direct medical costs and INA-CBG's as well as the influence of treatment class, severity, number of secondary diagnoses, and length of stay on the direct medical costs of diabetes mellitus patients at Anutapura Hospital Palu. This research is a descriptive observational study with retrospective data collection from medical records and files detailing patient care costs at Anutapura Hospital Palu in 2020 from the hospital's perspective. The sample used was BPJS inpatients with a primary diagnosis of type 2 diabetes or non-insulin dependent diabetes mellitus (DMTTI) who met the inclusion and exclusion criteria, totaling 132 patients. Data were analyzed descriptively and to see the influence of variables on total costs, the Independent sample t-test and Mann-Whitney test were used. The research results show that the average direct medical costs are IDR 2,751,449, the average INA-CBG's rate is IDR 4,505,508, so there is a mismatch between direct medical costs and INA CBG's. There is a significant influence partially or simultaneously and in a positive direction from the variables treatment class, severity, number of secondary diagnoses, and length of stay on direct medical costs.
ISOLASI ALFA SELULOSA DAN PEMBUATAN SERTA KARAKTERISASI MIKROKRISTALIN SELULOSA DARI KULIT BUAH LIMPASU (Baccaurea lanceolata Muell) Yuspa, Yuspa; Hafifah, Rahmalisa; Mursyidah, Siti; aldeina, Soraya; Muhammad, Muhammad; Indah Lestari, Yulianita Pratiwi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1676

Abstract

Indonesia is rich in biological natural resources and has diversity spread throughout Indonesia. One of the typical Indonesian plants, especially in Kalimantan, is Limpasu. Limpasu is a typical Kalimantan plant, where this plant has many nutritious contents such as antioxidants and has high potential to be used as a raw material for making microcrystalline cellulose. Microcrystalline Cellulose (MCC) is cellulose that is partially purified, then processed with ɑ-cellulose preparations. The aim of this research is to obtain microcrystalline cellulose from Limpasu fruit peel waste. The research method used in this research is chemical delignification, followed by hydrolysis using dilute acid to produce MCC, then characterized with Avicel PH 102 as a commercial comparison. Based on the research results, the yield of α-cellulose was 14.14% for simplicia powder, the MCC yield was 11.48% for α-cellulose and the characterization of MCCKBL powder showed similar characteristics to Avicel® PH 102 as a comparison.
KETEPATAN REKOMENDASI PADA KASUS VIGNETTE SWAMEDIKASI SAKIT KEPALA OLEH APOTEKER DI APOTEK Amalia, Nurul; Wibowo, Yosi Irawati; Halim, Steven Victoria; Setiawan, Eko; Irawati, Sylvi; Presley, Bobby; Setiadi, Adji Prayitno; Brata, Cecilia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1677

Abstract

Headache is a symptom which people often self-medicate and community pharmacies are often places where self-medicating patients with headache obtain the medicines. Therefore, community pharmacists played an important role in providing appropriate advice for these patients. A cross-sectional study design was used. A questionnaire consisting of (1) pharmacy and pharmacists characteristics, and (2) two vignette cases of headache (tension headache and migraine due to an oral contraceptive) was developed. Data was collected using a structured interview with community pharmacists in an East Javan district. Data was analysed using content analysis. Appropriate recommendation was determined based on the literature and expert panel opinion. The total population was 81 community pharmacists. Of these, 47 agreed to participate. Of 47 participating pharmacists, 36 (77%) and 23 (49%) pharmacists provided appropriate advice in the case of tension headache and migraine due to the use of an oral contraceptive respectively. Appropriate recommendation provided by pharmacists varied according to the cases. Optimization of pharmacists’ recommendation in a case of headache requiring medical referral is needed.
UJI STABILITAS FISIK LOTION ANTI NYAMUK KOMBINASI MINYAK LAVENDER (Lavandula angustifolia) DAN MINYAK ROSEMARY (Rormarinus officinalis) Sari, Devi Amelia; Ambari, Yani; Ningsih, Arista Wahyu; Rahmawati, Dewi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1680

Abstract

Lavender essential oil 15% can be used as an anti-mosquito protection power on average 56% at 6 hours. Rosemary has a more fragrant aroma and can make mosquitoes uncomfortable and avoid it. This study aims to determine physical stability of mosquito repellent lotion. Lavender oil mosquito repellent lotion (Lavandula angustifolia) and rosemary oil (Rosmarinus officinalis) made in 3 formulas, namely F1 containing lavender oil (10%), F2 (15%), and F3 (20%), and F1 containing rosemary oil (30%), F2 (25%), and F3 (20%). Mosquito repellent lotion was tested for its physical stability using the cycling test method which included organoleptic, homogeneity, pH, adhesion, and spreadability. In this research, citronella and lavender oils can be formulated into anti-mosquito lotions. The results of physical stability (organoleptic, pH, homogeneity, spreadability and adhesion) using the cycling test method show that the anti-mosquito lotion did not change during storage and the results were in accordance with the expected specifications. It can be concluded that the difference in the concentration of lavender and rosemary essential oils does not affect the stability test of the anti-mosquito lotion preparation.
ANTIHIPERURESEMIA FLAVONOID DARI EKSTRAK ETANOL PELEPAH DAUN NIPAH (Nypa fruticans.Wurmb) Raharjo, Danang; Dwi S, Anita; Ardiyantoro, Bagas
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1681

Abstract

Hyperuresimia or gout in advanced stages causes joint damage (gout), kidney stones and kidney damage. Flavonoids as antioxidants can inhibit the activity of the enzyme xanthine oxidase which causes uric acid not to form. Nypa fruticans or known as nipah is traditionally used in the treatment of asthma, leprosy, tuberculosis, sore throat, liver disease, snake bites, as a pain reliever, as a sedative and carminative. The content of flavonoid compounds in nipah plants includes chlorogenic acid, protocatechuic acid, kaempferol, gallic acid, hydroxybenzoic acid, rutin, quercetin, cinnamic acid, and anthocyanins. The purpose of this study was to isolate flavonoid compounds that have potential as antihyperuresemia from nipah fronds. The research process began with the extraction of nipah leaves using 96% ethanol by maceration, fractionation using liquid-liquid partition method, isolation using centrifugal chromatography (chromatotron) method and structure elucidation using 1HNMR, 13CNMR, FTIR and GC-MS. Antihyperuresemia testing was carried out in-vitro by inhibiting xanthine oxidase enzyme activity. From the results of the study, two flavonoid compounds were successfully isolated including (-) epicatechin, and chamferol. The results of measuring the inhibitory activity of xanthine oxidase enzyme obtained IC50 values of (-) epicatechin and chamferol of 3.543 ppm and 10.383 ppm, respectively.

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