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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

JIIS
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Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

ISSN : 2502647X EISSN : 25031902 DOI : https://doi.org/10.36387/jiis

Core Subject : Health,

Medicine & Pharmacology

Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 429 Documents

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ANALISA SENYAWA METABOLIT SEKUNDER DAN PENGARUH PEMBERIAN SERBUK SEMUT JEPANG TERHADAP KADAR KOLESTEROL PADA TIKUS PUTIH JANTAN Evi Ekayanti Ginting; Cindy Fatika Sari; Leny Leny; Parhan Parhan; Pricella Ginting
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

This study aimed to examine the anticholesterol activity of Japanese ant powder on male white rats of the Wistar strain. This research was conducted experimentally with the method of pre-test and post-test with control group design. The negatif control was given Na-CMC 1%, the positive control was simvastatin 10 mg/kgBW, and the Japanese ant powder treatment group was given a dose of 100 mg/kgBW, 200 mg/kgBW and 300 mg/kgBW. The treatment of rats was given orally. Total cholesterol levels were measured in rat blood serum by the enzymatic CHODPAP method. Measurement of total cholesterol levels was carried out on the 15th and 22nd days using a microlab 300 photometer. The results showed that Japanese ant powder had anticholesterol activity. The percentage of cholesterol reduction in positive control was 59.75%, Japanese ant powder dose of 100 mg/kgBW was 41.79%, dose of Japanese ant powder 200 mg/kgBW was 48.72% and 300 mg/kgBW was 53.83%. The results of the ANOVA test showed a significant difference with a p value <0.05. The conclusion of this study is that Japanese ant powder has activity in reducing cholesterol levels in male white rats and the effective dose is 300 mg/kgBW.

PENINGKATAN FOTOSTABILITAS PIGMEN BETA KAROTEN DENGAN PEMBUATAN MIKROEMULSI Ika Agustina; Mega Efrilia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Sepanjang tahun 2018 BPOM menemukan berbagai macam kosmetik illegal yang mengandung bahan dilarang/bahan berbahaya. Salah satu bahan berbahaya yang ditemukan adalah pewarna tekstil Merah K3 pada lipstick. Solusi yang diperlukan adalah dengan membuat pewarna alami yang memiliki kestabilan yang baik terhadap cahaya. Tujuan penelitian ini adalah untuk meningkatkan kestabilan pigmen beta karotenoid terhadap cahaya dengan membuat sediaan mikroemulsi. Sumber senyawa beta karoten berasal dari Daucus carota L. Teknik ekstraksi menggunakan maserasi dengan pelarut etanol:heksana (4:3). Untuk mendapatkan formulasi mikroemulsi terbaik dibuat variasi konsentrasi PEG 40 HCO:gliserol:ekstrak. Formulasi mikroemulsi terbaik adalah kode FW3 dengan komposisi 2:2:1 (PEG 40 HCO:gliserol:ekstrak). Kemudian ekstrak Daucus carota L dan mikroemulsi FW3 diuji fotostabilitas. Hasil pengujian fotostabilitas menunjukkan penurunan kadar ekstrak Daucus carota L. sebesar 2.84%, sedangkan mikroemulsi Daucus carota L mengalami penurunan kadar sebanyak 1.33%. Kedua sediaan tetap dikategorikan sebagai substansi yang fotosensitif.

PEMENUHAN OBAT COVID-19 DI INSTALASI FARMASI PROVINSI KALIMANTAN SELATAN Laeliyatun Ikrimah; Abdul Rahem; Anita Purnamayanti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Covid-19 pandemic has not ended and reach its peak in July 2021. The handling of this pandemic is carried out with logistical support for treatment as therapy. Antivirus and antibiotic widely used are Oseltamivir75mg, Favipiravir 200mg and Azithromycin500 mg. The purpose of this study was to determine the need and fulfillment of these medicines in 13 cities and health facilities in South Kalimantan. This study uses observational methode with a total sample of the need and fulfillment of these drugs in July 2021 at IFP South Kalimantan which includes IFK in 13 cities and health facilities that serve the handling of COVID-19. The method of analysis used is descriptive analysis with the most usage and the average percentage fulfillment of needs.The result showed that IFP South Kalimantan could meet about 51,35% of the need for Oseltamivir 75mg, 65,71% for Favipiravir 200mg and 38,68% Azithromycin 500mg from the total needs of 13 cities in South Kalimantan. The most commonly used oseltamivir 75mg and azithromycin 500mg were IFK Banjarmasin, Tanah Bumbu and Kotabaru. This indicates that Covid-19 severity was mild in that cities. The most use of favipiravir is Ulin Hospital, Idaman Hospital and Ansari Shaleh Hospital as 3 referral hospitals in the cities of Banjarmasin and Banjarbaru. It is indicate of moderate to severe COVID-19 that requiring hospital treatment. Conclusion of this study are the fullfill of Favipiravir 200mg and Oseltamivir 75mg are more than 50% of IFK need in 13 cities.

EVALUASI POLA PERESEPAN PADA PASIEN LANJUT USIA MENGGUNAKAN WHO PRESCRIBING INDICATORS Mia N. A. Fatin; ED. Y.M. Pasha; Khairunnisa Fadhilah; Vera L. Fitriani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Older patients are very susceptible to drug use problems. Drug use problems are related to physiological conditions that affect the pharmacokinetics and pharmacodynamics of the drug. This study aimed to evaluate drug prescribing pattern in older patients at Pasundan Health Center Bandung. Data were retrospectively collected from prescriptions from March to June 2021. The pattern of prescribing drugs was evaluate using the WHO prescribing indicator with five indicators: the number of drugs per prescription, antibiotic use, generic drugs, the percentage of injection preparations, essential drug use. A total of 638 prescriptions met the inclusion criteria. The average number of drugs per prescription is 2.8. The prescription drugs from a total of 1.777 drugs in the form of generic drugs amounted to 83.29%, and essential drugs amounted to 74.28%. The antibiotics and injection use percentage were 11.82% and 0%, respectively. The most frequently prescribed antibiotics were amoxicillin, clindamycin, ciprofloxacin, betamethasone, and miconazole. The most frequently prescribed drugs were amlodipine, paracetamol, diclofenac sodium, chlorpheniramine maleate, and multivitamins. The use of essential and generic drugs was below WHO standard, while the average number of drugs per prescription was above WHO standard.

VALIDASI METODE ANALISIS DAN PENGUJIAN FORCE DEGRADATION STUDY PADA MEREK DAGANG YANG MENGANDUNG PARACETAMOL Chresiani Destianita Yoedistira; Gytha Novella Ongkowijoyo
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Paracetamol is the drug most consumed by the public,so itÃ¢â‚¬â„¢s necessary to carry out strict quality assurance. Therefore, a forced degradation study was carried out using a UV-Vis spectrophotometer with various degradation conditions recommended by ICH. The research was conducted on five brands of paracetamol tablets that were treated with hydrolysis, oxidation, photolytic, and thermal treatment, which were detected by UV-Vis spectrophotometer at a wavelength of 243nm. The developed method is validated with linearity, selectivity, accuracy, precision, detection limit, and quantification parameters. The results obtained are selective, linear with a regression of 0.99; accurate with %Recovery between 99.4 - 100.9% and %CV <2%; and precision with %RSD <2%; LOD 24.35706967 mg/L; LOQ 79.95750448 mg/L. The five brands of drugs tested were subjected to hydrolysis, oxidation, photolysis, and thermal degradation. Under alkaline and oxidizing conditions, it was found that the degradation was beyond the limit of levels, according to the Indonesian Pharmacopoeia 90% - 110%.

POTENSI TABIR SURYA EKSTRAK ETANOL DAUN MATOA (POMETIA PINNATA) DENGAN VARIASI KONSENTRASI PELARUT Erwan Kurnianto; Ika Ristia Rahman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Secondary metabolite compounds that have potential as sunscreens are flavonoids with chromophore groups. Flavonoid compounds are found in the matoa plant (Pometia pinnata). This study aimed to determine the possibility of matoa extract sunscreen with various solvent concentrations. Variations in the concentration of ethanol used were 50%, 70% and 96% ethanol. Matoa leaf simplicia was macerated with each solvent for 3Ãƒâ€”24 hours. Then the macerate was concentrated using a rotary evaporator. The viscous extract was tested for flavonoid qualitative using the staining method and tested for sunscreen potency using UV-Vis spectrophotometry with absorbance readings at a 290-320 nm wavelength. The potential for sunscreen in the form of an spf value is calculated using the Mansur equation. The results showed that the ethanolic extract of matoa leaves contained flavonoid. Matoa leaf extract has sunscreen potential. The highest SPF value in the extract with 70% ethanol solvent provides ultra protection value.

DAMPAK KADMIUM DAN MERKURI TERHADAP METABOLISME KARBOHIDRAT: KAJIAN IN SILICO PADA ENZIM GLIKOGEN SINTASE DAN FOSFOFRUKTOKINASE Azka Lahdimawan; Siti Arika Bulan; Eko Suhartono; Bambang Setiawan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Cadmium (Cd) and Mercury (Hg) is a heavy metal with high cytotoxicity, implicated as causes of chronic inflammation, oxidative stress, obesity, hyperglycemia, and even diabetes. The long-term exposure of Cd and Hg can affect enzymes involved in carbohydrate metabolism, on the process of glycolysis and glycogenesis. by changing the structure and enzymatic activity of proteins which can cause toxic effects on enzymes involved therein including glycogen synthase (GS), which can cause glycogen content depletion and has potential to limit the glycolysis process in liver and muscles by decreasing the phosphofructokinase (PFK) enzyme activity. There are not many studies that explain the interactions between Cd and Hg on GS and PFK enzymes. For this reason, this research was carried out using in silico. The structure of the enzymes was obtained from the RCSB Protein Data Bank (http://www.rcsb.org) with the following code, GS (PDB ID: 1RZV) and PFK (PDB ID: 4WLO). The interactions between Cd and Hg with these enzymes were used by MIB: Metal Ion-Binding site prediction and docking server (http://bioinfo.cmu.edu.tw/MIB/). The interactions between Cd and amino acids of targeted protein were visualized on UCSF Chimera 1.14. The results showed that Hg interacted with amino acid residues at the active site of the glycogen synthase enzyme at the end of the C-terminal domain, namely at 3 cysteine ??residues Cys 295, cys 366, and cys 390. Meanwhile, Cd and Hg did not interact with amino acid residues. on the active site of the phosphofructokinase enzyme, but interacts with the protein structure of the enzyme.

PROFIL PENGGUNAAN OBAT ANTIVIRUS COVID-19 DI RSUD dr. MURJANI-SAMPIT Etik Suryanti; Abdul Rahem; Anita Purnamayanti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Coronavirus Disease 2019 (Covid-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2). The World Health Organization (WHO) until now still defines Covid-19 as a global pandemic where this pandemic is the cause of the biggest public health crisis in this century. RSUD dr. Murjani-Sampit uses several antivirals, including Oseltamivir 75 mg, Favipiravir 200 mg, Remdesivir 200 mg. The purpose of this study was to determine the antiviral profile given to covid-19 patients at dr. Murjani-Sampit. This study used a total sample of hospitalized patients who were given COVID-19 antiviral therapy in the period August 2021. This research method used an observational research design with retrospective sampling. Data collection techniques based on observation of patient prescription data recorded in the pharmacy installation management information system of RSUD dr. Murjani-Sampit. The analytical method used is descriptive analysis with the most data on the use of antiviral drugs and the average percentage for the period August 2021 at dr. Murjani-Sampit which opened 275 patients. The results showed that the most widely administered antivirals were favipiravir 200 mg in 249 patients (90.54%), remdesivir 200 mg in 17 patients (6.18%) and oseltamivir as adjuvant or additional therapy due to influenza in 9 patients (3.27%). The conclusion of this study is that the antivirals used include oseltamivir 75 mg 3.27%, favipiravir 200 mg 90.54%, and remdesivir 200 mg 6.18%.

PROFIL SPEKTRA INFRA MERAH SERBUK Gelidium Zollingeri DENGAN ANALISIS PCA Farizah Izazi; Yuyun Nailufa
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Gellidium zolingeri is a red alga of the Rhodophyta. Content of Gellidium zolingeri is Mycosporine-like amino acids (MAAs), proteins (amino acids), pigments (phycobiliproteins and carotenoids), phenolic compounds, fucoidan etc. Gellidium zolingeri has several benefits. From the drug content, Gellidium zolingeri can be used as a natural product. Different content in a plant is influenced by several factors, one of which is the climate and harvest time. It is known that in this study using three different harvest times, different harvest times will affect the percentage or content of the plant. Therefore, to ensure its quality, this research is carried out. Result analysis using Infrared Spectrophotometry, five functional groups were obtained, OH carboxylic acid, N-H (cyclic alkene), C=C (aromatic), C-O (ether) and =C-H (alkene) with their respective wave numbers. Result from spectra that these compounds are MAAs. Next step analyzed by PCA (Principal Component Analysis) minitab19, the data obtained are Score plots, Loading plots and Biplots. The results of the three samples with different collection times have three different spectra results. Harvest time of November the dry season and harvest time of December and January the rainy season is grouped separately. November is also a transitional climate where results of these spectra are in between the rainy season spectra (December and January).

KARAKTERISTIK FISIK MIKROPARTIKEL KUERSETIN DENGAN KOMBINASI KITOSAN-NATRIUM TRIPOLIFOSFAT MENGGUNAKAN METODE ORIFICE IONIC GELATION Aditya Trias Pradana; Roisah Nawatila; Muhammad Rifani Rachman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Antioxidants are compounds to resist free radicals. The natural antioxidant group that is currently being developed is the flavonoid group, one of which is quercetin. Quercetin has a low solubility, so it can be increased by reducing the particle size. This study aims to determine the differences that are influenced by the combination of chitosan polymer and sodium tripolyphosphate as matrix forming quercetin microparticles on the physical characteristics of the results made using the orifice ionic gelation method. The resulting preparation showed a particle size of 1326.33 nm; 3497.33 nm; and 6000 nm at various concentrations of 0.2% chitosan and 0.1%; 0.2%; and 0.3% sodium tripolyphosphate, respectively. The Fourier Transform Infrared (FTIR) results showed that there was no change in the marker group on quercetin and an ionic bond was formed between chitosan and sodium tripolyphosphate. The X-ray Diffractometer (XRD) results showed that the crystalline structure of quercetin changed to become more amorphous. Although the Scanning Electron Microscope (SEM) results, it is seen that the quercetin microparticles produced are needle-shaped, especially when the concentration of sodium tripolyphosphate is increased. Based on the results of these physical characteristics, it can be proven that the microparticle was formed at various concentrations of the polymer concentration combination with the best characteristics are on 0.2% chitosan and 0.1% sodium tripolyphosphate concentration.

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Editorial Address Jl. Flamboyan III/7c Kayu Tangi 70123 Banjarmasin Kalimantan Selatan

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Siska Musiam

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Jl. Flamboyan III/7c Kayu Tangi 70123 Banjarmasin Kalimantan Selatan

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