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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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SWAMEDIKASI PADA PENDERITA COVID-19 MENJALANKAN ISOLASI MANDIRI DI WILAYAH JAKARTA PADA TAHUN 2021 Wardiyah Wardiyah; Adin Hakim Kurniawan; Dinda Unique Valentine
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.45 KB) | DOI: 10.36387/jiis.v7i1.846

Abstract

COVID-19 or Coronavirus disease 2019 is a pandemic in the end of 2019. Currently, several studies for the therapy of COVID-19 have been carried out, but specific drugs that have been proven effective and safe to treat it do not available yet. Self medication is expected to reduce the severity of sufferers and also spreading of COVID-19 in Indonesia. Patient without symptoms or mild symptons can self isolated and do self medication. Patients with self medication can use drugs to treat symptoms, immune boosting drugs, such as multivitamin or herbal medicines. The purpose of this study is to find out the illustration of Jakarta's self medication pattern for COVID-19 patients who are self-isolating in 2021. This study aims to describe the pattern of self-medication in self-isolated COVID-19 patients in the Jakarta area in 2021. This research uses quantitative descriptive. The technique uses purposive sampling and gets 100 respondens. The data collection is collected by making questioners and analysed by univariat. From the results of data processing, it is known that the tests carried out by PCR Swab were 49 people (69%). The symptoms felt were fever as much as 22.3%. The drug consumed is paracetamol by 45.1%. The supplements consumed were vitamin C by 38.7%. Sources of information are friends/family by 61.4%. The place to get medicines/supplements/traditional medicines is pharmacies by 40% (38 people).
UJI FITOKIMIA DAN AKTIVITAS ASAM SUNTI (Averrhoa bilimbi L.) SEBAGAI ANTIMIKROBA Misrahanum Misrahanum; Nia Ayuningrum; Hira Helwati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.221 KB) | DOI: 10.36387/jiis.v7i1.854

Abstract

Many plants that have potential as antimicrobial agents are found in Indonesia. One of them is bilimbi (Averrhoa bilimbi L.) which comes from the Oxalidaceae family. People in Aceh usually process the fruit into asam sunti. This research was conducted to determine the phytochemical, characterization simplicia, extract, and antimicrobial activity of the asam sunti methanol extract. Phytochemical tests were done using two methods that are the addition of reagents and thin-layer chromatography (TLC). Phytochemical results in each test showed that the asam sunti methanol extract contained alkaloids, flavonoids, tannins, saponins, steroids, and triterpenoids. The water content, water-soluble extract content, ethanol-soluble extract content and total ash obtained was 4,6; 46,6; 54,16 and 39,6% for simplicia and extract respectively, with a value of 22; 42.6; 47.6, and 10.3%. Antimicrobial activity testing used a diffusion well at various concentrations 10; 20; 30; 40 and 50%. The smallest inhibition zone results were obtained at a concentration of 10% with a range of the inhibition zone is 7.43-7.86mm. The biggest antimicrobial activity was found at a concentration of 50% with an inhibition zone of 17.76; 10.63 and 8.7 mm for bacteria and fungi, respectively. in conclusion, the results showed that asam sunti methanol extract was more active in inhibiting the growth of Staphylococcus aureus bacteria than Escherichia coli bacteria and Candida albicans fungi.
PENETAPAN KADAR FLAVONOID DAN AKTIVITAS ANTIOKSIDAN PADA EKSTRAK BATANG BROTOWALI (Tinospora crispa L.) DENGAN METODE CUPRAC Asep Roni; Dewi Kurnia; Nurani Hafsyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (143.168 KB) | DOI: 10.36387/jiis.v7i1.856

Abstract

Oxidative stress is damage caused by reactive oxygen species Compounds that can prevent oxidative stress are antioxidants. The brotowali plant (Tinospora crispa) has been used for the treatment of diabetes and hypertension. The brotowali plant contains secondary metabolites such as flavonoids. Flavonoids are known to be a class of compounds that have antioxidant activity. so it can be kind of solvent which is the most excellent in the test plant extract brotowali. Extraction was conducted by reflux-rise that use nhexane, ethyl acetate and ethanol 96%. Determination of antioxidant activity using them CUPRAC method. Determination of total flavonoid content using colorimetric aluminum chloride method with quercetin as standard. The results showed that the ethyl acetate extract sample had strong antioxidant activity compared to the extract sample with 96% ethanol and n-hexane. The EC50 value of the ethyl acetate extract was 53.637 g/mL. Extract with n-hexane solvent had the highest flavonoid content, namely 9,937 ± 0.009 gQE/100 g extract.
IDENTIFIKASI DAN UJI ANTI KANKER TABLET EKSTRAK DAUN PALIASA (KLEINHOVIA HOSPITA LINN) SECARA MTT ASSAY Yetri Elisya; Junaedi Junaedi; Maratu Saleha
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.519 KB) | DOI: 10.36387/jiis.v7i1.859

Abstract

Indonesia has several plants that can be developed into cancer drugs. This study aims to make tablet preparations containing Paliasa leaf extract to produce pharmaceutical preparations for anticancer use. Paliasa leaves were extracted by maceration using 70% alcohol; then, the tablets were made using the wet granulation method. The extract obtained from 2,207 kg of dried simplicia paliasa leaves was 542 grams, with a yield of 24.56%. The flavonoid content in the extract was 1.79%, and the tablet was 0.75%. There are active compounds, namely 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl, a powerful antioxidant blend, hexadecanoic acid, or palmitic acid functions as an antibacterial and antioxidant, and kaempferol is one of the compounds, which has potential as an anticancer. The identification of extracts and tablets of paliasa leaf (Kleinhovia hospital Linn) resulted in IC50 above > 30 ppm in the inactive category, so the bioactivity of paliasa leaf extract was studied further fractionation.
PENGARUH PEMBERIAN MINYAK BIJI JINTEN HITAM TERHADAP KADAR INTERLEUKIN-6 PADA PEROKOK AKTIF SEHAT Arif Santoso; Akrom Akrom; Laela Hayu Nuraini; Titiek Hidayati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.385 KB) | DOI: 10.36387/jiis.v7i1.861

Abstract

Exposure to cigarette smoke causes cellular oxidative stress and is the key to the inflammatory process in the lungs. Black cumin seed oil (MBJH) is one of the traditional medicines that is proven to contain the active substances timoquinone, nigelon and negelin which have antioxidant and immunomodulatory effects. Interleukin-6 (IL-6) is a proinflammatory cytokine and a multifunctional cytokine that is very important for determining the immune response, cell survival, apoptosis and proliferation and is a protumorogenic agent in many cancers. The purpose of this study was to determine the levels of IL-6 in healthy active smokers after being given MBJH at a dose of 0.5 ml/capsule. The research design used was a single blind Randomized Controlled Trial (RCT). A total of 39 healthy healthy active smokers were divided into 4 groups: Group 1 was given a placebo 3x1 capsules/day, group 2 was given MBJH 3x1 capsules/day, group 3 was given MBJH 3x2 capsules/day and group 4 was given MBJH 3x3 capsules/day. The placebo and MBJH interventions were administered for 30 days. Statistical analysis obtained showed that there was no significant difference in the mean levels of IL-6 between the treatment group and the placebo group with p>0.05. The results showed that the use of MBJH for 30 days can reduce the average level of Interleukin-6 but not significantly in healthy active smokers.
UJI AKTIVITAS ANTI-AGING KRIM TABIR SURYA KOMBINASI EKSTRAK TONGKOL JAGUNG (Zea mays L.) DAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora Pierre Ex. A. Froehner) Harpolia Cartika; Yetri Elisya; Fatwa Hasbi; Khairun Nida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (501.535 KB) | DOI: 10.36387/jiis.v7i1.863

Abstract

Skin aging which is characterized by wrinkles and reduced skin moisture due to sun exposure can be prevented by using sunscreen preparations. The sunscreen cream combination of corn cob extract and robusta coffee bean extract has strong antioxidant activity and extra protection, so it has the potential as anti-aging. This study aims to determine the anti-aging activity of the test cream. Research using experimental methods. The sunscreen cream contains 10% corn cob extract and 15% robusta coffee bean extract. Physical testing and cream stability using the cycling test method. The anti-aging activity of the cream was tested in vivo using female Sprague-Dawley rats, the observations were continued by SEM, the parameter was wrinkles. The results of the evaluation of physical stability meet the requirements of the cream. Details of the average score of wrinkles on the skin of the feet of rats given a cream base of 2.5, a test cream of 1.5 and a comparison cream of 1. This indicates the test cream has the potential as an anti-aging.
UJI TOKSISITAS AKUT DAN TERTUNDA FRAKSI BUTANOL DAUN AKAR KAIK-KAIK (Uncaria cordata (Lour) Merr.) PADA MENCIT PUTIH (Mus musculus L.) Meiriza Djohari; Tania Tiara Efendi; Noveri Rahmawati; Husnawati Husnawati; Fina Aryani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.132 KB) | DOI: 10.36387/jiis.v7i1.874

Abstract

Uncaria cordata is a plant that is used to treat diabetes and has antioxidant properties. Research has been carried out on Acute and Delayed Toxicity Tests of Butanol Fraction of Leaves of Kaik-Kaik Root Plant (Uncaria cordata (Lour) Merr.) on Male White Mice (Mus musculus L. This study aims to determine the effect of acute toxicity of the butanol fraction of the leaves of kaik-kaik root by determining the LD50 value. Observations made in this test were the number of dead animals, toxic symptoms, and observations of the organs of the test animals. Observations were made for 24 hours to determine the LD50 value to 14 days after administration of the test preparation. In the observation of toxic symptoms, there were no tremors, seizures, salivation, diarrhea, lethargy, weakness, sleep, and coma in each experimental animal. In the relative weight parameters of organs consisting of the heart, liver and kidneys, there was no effect of this fraction, and there was no change when compared to the control group. The results showed LD50 values > 5000 mg/kgBB are considered relatively harmless and potentially as standardized herbal medicine
POTENSI DAUN TEH HIJAU (Camellia sinensis) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) COVID-19: SEBUAH STUDI MOLECULAR DOCKING Haidar Ali Hamzah; Junoretta Haviva Ernanto; Putri Mahirah Afladhanti; Theodorus Theodorus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.789

Abstract

Green tea is an herbal plant that has active compounds including anti-inflammatory, antioxidant, anti-allergic, and antiviral compounds. A previous study, flavonoid compound in tea leaves has been proven as antiviral. The development of effective antiviral drugs against COVID-19 remains a challenge for researchers across the world. A previous study investigated the role of the main protease enzyme (Mpro) which is useful in the viral life cycle as a promising drug target. This study aims to know the potential compounds of green tea leaves as a COVID-19 Mpro inhibitor using molecular docking. 12 compounds and lopinavir were used. Lipinski analysis was carried out to assess potential compounds as a drug. Docking was carried out by Autodock Tools 1.5.6 and Autodock Vina. The visualization was carried out by Discovery Studio v16. The results showed that all compounds compiled the criteria as a drug based on Lipinski rules. Catechin and epicatechin have the same energy bond as lopinavir with a binding energy of -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest energy bond with a binding energy of -9.0 and -8.2 kcal/mol. All compounds bind in the active site of the COVID-19 Mpro so they are competitive inhibitor. Catechin gallate is the strongest inhibitors.
PENGARUH GUGUS FUNGSI CINCIN PIRIDIN, BENZEN, DAN ATOM NITROGEN PADA CINCIN PIRIDIN TERHADAP PENURUNAN KADAR PLASMA PIRIDOKSIN TIKUS WISTAR Hafrizal Riza; Jordi Buannata
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.873

Abstract

In this study, researchers will conduct further studies to determine the map of functional groups that have an affinity for neuropathy-causing enzymes in the pyridine ring functional group after previous research on pyridine ring substituents. Through this study, it will be known whether there is an effect of the N atom on the pyridine ring, and the structure of the benzene ring. Therefore, the three structures, namely benzohydrazide, butyrohydrazide, formohydrazide, and isoniazid control, will be tested for their effect on the inhibition of the pyridoxal phosphokinase enzyme in experimental rats to see the effect of changing functional groups on decreasing affinity for the pyridoxal phosphokinase enzyme receptor which can be indicated by a decrease in active pyridoxine levels in the blood. mouse. The three compound structures were then examined for their interactions with the pyridoxal phosphokinase enzyme through their effect on increasing levels of pyridoxal 5 phosphate which is the active form of pyridoxine, using the Ultraviolet-Visible Spectroscopy method which showed an accumulation of enzyme analog substrates from the three compound structures with substrates from the body. The results of the ultraviolet-visible spectroscopy test showed that the active pyridoxine levels of rats in the isoniazid, benzohydrazid, and formohydrazid groups and the negative control group were 160,259, 120,548, 107,086 and 104,490, respectively. Based on the results, it was concluded that benzohydrazide and formohydrazide did not have a pharmacophore group against the pyridoxine phosphokinase enzyme.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETIL ASETAT DAUN RAMBUSA DAN DAUN KARAMUNTING TERHADAP Streptococcus mutans Muhammad Priyadi; Nurul Chusna; Guntur Satrio Pratomo
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.875

Abstract

Empirically, many natural ingredients have been used in preventive care for the treatment of dental and oral disorders. Chronic conditions on the teeth with the appearance of plaque and tooth decay are referred to as dental caries which are characterized by toothache and also digestive disorders. Streptococcus mutans is known as the bacteria that most often causes dental caries. Karamunting and rambusa plants have enough potential as antibacterials because there have been many studies that have shown their potential as antibacterial activities. The purpose of this study was to determine the antibacterial activity of ethyl acetate extract of karamunting leaves and rambusa leaves against Streptococcus mutans. Antibacterial activity test using well diffusion method by measuring the diameter of the inhibition zone. The results showed that the ethyl acetate extract of karamunting leaves 1%, 5%, 10%, 15%, 20% had inhibition zone diameters of 4.6 mm, 4.1 mm, 0 mm, 0 mm, 0 mm, respectively while rambusa leaves 1%, 5%, 10%, 15%, 20% had inhibition zone diameters of 4.4 mm, 8.7mm, 9.4 mm, 5.3mm and 8.8mm respectively. The ethyl acetate extract of karamunting and rambusa leaves is known to have weak antibacterial activity in the resistant category.

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