Pharmaceutical Sciences and Research (PSR)
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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<![CDATA[Pengembangan Sediaan Dengan Pelepasan Dimodifikasi Mengandung Furosemid Sebagai Model Zat Aktif Menggunakan Sistem Mukoadhesif ]]>
<![CDATA[Sutriyo, Sutriyo]]>;
<![CDATA[Rachmat, Hasan]]>;
<![CDATA[Rosalina, Mita]]>
<![CDATA[ Majalah Ilmu Kefarmasian Vol. 5, No. 1 ]]>
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<![CDATA[Drug bioavailability is one of the parameter which is used to evaluate the effectiveness of pharmaceutical dosage form. Rate of dissolution and drug residence time in gas-trointestinal tract is a factor which can influence the bioavailability. Solid dispersion and mucoadhesive drug delivery system is one of the method which can be used to solve the problem concerning the rate of dissolution and residence time in gastrointes-tinal tract. In this research mucoadhesive microgranule had been made with furo-semide as a drug model and Carbopol 934P® as a mucoadhesive polimer. The mucoadhesive microgranules resulted from this investigation has a particle size range of 425-850 µm, and was evaluated by type 1, 100 rpm speed and phosphate buffer pH 5.8 dissolution test and by wash off test. Furosemide was made in solid dispersion with polyvinylpyrrolidone (PVP K30®) with weight ratio of 1:7 using solubility method. The results showed increasing the dissolution rate of furosemide in solid dispersion compared to pure furosemide. Increasing the concentration of Carbopol 934P® in microgranule will cause inhibition of drug release and increasing the amount of microgranule sticked to gastric and intestinal mucous.]]>
<![CDATA[Validasi Metode Analisis Cilostazol Dalam Plasma In Vitro Secara Kromatografi Cair Kinerja Tinggi ]]>
<![CDATA[Harahap, Yahdiana]]>;
<![CDATA[Mansur, Umar]]>;
<![CDATA[Estherina, Christine]]>
<![CDATA[ Majalah Ilmu Kefarmasian Vol. 5, No. 1 ]]>
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<![CDATA[Cilostazol is an antiplatelet agent with the mechanism of action by inhibiting phos-phodiesterase III (PDE III). Referred to Food and Drug Administration(FDA),cilostazol is a drug recommended to be bioequivalence (BE) studied. A high-perfor-mance liquid chromatographic (HPLC) method with ultraviolet detector for in vitro determination of cilostazol in human plasma had been developed and validated. Cilostazol and pioglitazone as internal standard were extracted from human plasma by protein precipitation method using methanol. The mobile phase consisting of ac-etonitrile-potassium di-hydrogen phosphate buffer 50 mM (40:60) was used at the flow rate of 1.5 mL/min on reversed phase C18 column (SunfireTM, 5 µm, 250x4.6 mm), and was detected at wavelength of 257 nm. Linearity was established within concentration range of 20-2000 ng/mL with coefficient correlation (r) was 0,9999. Accuracy (% diff) of this method was -14.67% up to 8.84% with precision (CV) being 0.98% to 4.93%, and absolute recovery was established to be 82.26% to 119.85%. Cilostazol in plasma was stable for 30 days in -200C storage.]]>
<![CDATA[Evaluasi Penggunaan Sediaan Farmasi Intravena Untuk Penyakit Infeksi Pada Salah Satu Rumah Sakit Swasta Di Kota Bandung ]]>
<![CDATA[Surahman, Emma]]>;
<![CDATA[Mandalas, Esther]]>;
<![CDATA[Kardinah, Endah Ismu]]>
<![CDATA[ Majalah Ilmu Kefarmasian Vol. 5, No. 1 ]]>
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<![CDATA[An usage evaluation of intravenous pharmaceutical dosage form for infectious dis-eases at one of the private hospitals in Bandung by retrospective method on October to December 2005 had been done based on the rationality of drug used according to the certain criteria. The result of the evaluation from 1170 prescriptions found that the combination of two or more drugs was 7.78%, no drug dose improper, no duplication of drug used, nor interaction with another drugs were found. The preparation of intravenous pharmaceutical dosage form had been well done, but the aseptic tech-nique still less of attention.]]>
<![CDATA[Uji Aktivitas Antimikroba dan Uji Sitotoksik Ekstrak Etanol Akar Tanaman Akar Kucing (Acalypha indica Linn), Daging Buah Mahkota Dewa (Phaleria macrocarpa (Sheff) Boerl) dan Sari Buah Merah (Pandanus conoideus Lam) ]]>
<![CDATA[Radji, Maksum]]>;
<![CDATA[Sari, Ratna Chandra]]>;
<![CDATA[Sumiati, Atiek]]>
<![CDATA[ Majalah Ilmu Kefarmasian Vol. 5, No. 1 ]]>
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<![CDATA[The antimicrobial activity and cytotoxic effect of ethanol extract of Acalypha indica Linn, Phaleria macrocarpa (Sheff) Boerl and Pandanus conoideus Lam, had been carried out. The results of the research showed that those ethanol extracts had antimi-crobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosae ATCC 27853 and Candida albicans. The determi-nation of cytotoxic effects of those ethanol extracts by brine shrimp lethality test (BSLT) using Artemia salina Leach showed that LC50 of Acalypha indica Linn, Phaleria macrocarpa (Sheff) Boerl and Pandanus conoideus Lam were 1,279 ug/ml, 0.123 ug/ml and 0.054 ug/ml respectively.]]>
<![CDATA[Pembuatan Teh Herbal Campuran Kelopak Bunga Rosella (Hibiscus sabdariffa) dan Herba Seledri (Apium graveolens) ]]>
<![CDATA[Munim, Abdul]]>;
<![CDATA[Hanani, Endang]]>;
<![CDATA[Mandasari, Andita]]>
<![CDATA[ Majalah Ilmu Kefarmasian Vol. 5, No. 1 ]]>
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<![CDATA[Rosella calyx (Hibiscus sabdariffa) has been reported exhibited on decreasing high blood pressure activity. Celery herb (Apium graveolens) has been acknowledged as an antihypertension herb with vasodilator and diuretic effect. Combination of the extracts was expected to provide synergism effect on decreasing high blood pressure. This study was intended to prepare the combination of herbal tea from standardized extracts of rosella calyx and celery herb. Standardization of rosella calyx and celery herb included determination of several specific and non-specific parameters. Three different formulas of herbal tea were prepared that would be hedonically tested to obtain the most favorable herbal tea formula from the 30 panelists. The most favorable formula was formula C which contained rosella calyx (2 gram) and celery herb (0.5 gram).]]>
<![CDATA[Peran Tenaga Kefarmasian dalam Penanggulangan Bencana Role of Pharmacist in Disaster Management ]]>
<![CDATA[Faradilla, Meutia]]>
<![CDATA[ Pharmaceutical Sciences and Research Vol. 5, No. 1 ]]>
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<![CDATA[Indonesia is a country that has high potency to be affected by disaster, either by natural or man-made disaster. After the 2004 tsunami, Indonesian government has improved its disaster prevention policy and program. In disaster management study, health management in disaster setting is aimed to assure the implementation of health service toward victims accordingly. As integrated part of the healthcare team in disaster management, pharmacists have to understand the importance of pharmaceutical care in pre-disaster, disaster, and post-disaster phase. This article aims to provide an overview on pharmacists’ role in disaster management from preparing and distributing medicine and medical devices to its role in therapy management, counselling, and patient education. This article also proposes to stakeholders in pharmacist professional organization to arrange plan and policy to increase and improve pharmacists’ involvement in disaster management.]]>
<![CDATA[Evaluation of Propolis and Milk Administration on Caffein-Induced Mus musculus Fetus Skeletal ]]>
<![CDATA[Dillasamola, Dwisari]]>;
<![CDATA[A, Almahdy]]>;
<![CDATA[Sari, Novita Purnama]]>;
<![CDATA[Putri, Biomechy Oktomalio]]>;
<![CDATA[Noverial, Noverial]]>;
<![CDATA[Diliarosta, Skunda]]>
<![CDATA[ Pharmaceutical Sciences and Research Vol. 5, No. 1 ]]>
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<![CDATA[Caffeine consumption by pregnant women at doses above 300 mg/day was suggested to cause skeletal damage. Propolis with high flavonoids concentration could increase the number of osteoblasts. This research aims to evaluate the effect of propolis and milk administration on fetal skeletal of caffeine-induced female mice (Mus musculus). Mice were divided into six groups: negative group, positive group of caffeine (a dose of 75 mg/kg BW), positive group of propolis (a dose of 1400 mg/kg BW), positive group of milk (200 ml), group D1 (caffeine 75 mg/kg BW and propolis 1400 mg/kg BW) and group D2 (caffeine 75 mg/kg BW and milk 200 ml). Data were processed using one-way ANOVA. The results showed that administration of propolis and milk on caffeine-induced mice during pregnancy does not affect the mice body weight, the number of fetuses and fetal weight significantly (P> 0.05). No skeletal defects detected in group D1 and D2 (observation with Alizarin solution) compared to the negative group. In conclusion, the admnistration of propolis at the dose of 1400 mg/kg BW and 200 ml of milk can repair skeletal damage caused by caffeine induction.]]>
<![CDATA[Potency of (Poly) Acrylic/Carboxymethyl Starch-Chitosan Biohydrogel for Curcumin Oral Delivery Matrix ]]>
<![CDATA[Ruriani, Eka]]>;
<![CDATA[Mangunwidjaja, Djumali]]>;
<![CDATA[Richana, Nur]]>;
<![CDATA[Sunarti, Titi Candra]]>
<![CDATA[ Pharmaceutical Sciences and Research Vol. 5, No. 1 ]]>
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<![CDATA[Biohydrogel has gathered great interest in the pharmaceuticals field. This natural polymers were biodegradable, non-toxic, biocompatible, and its specific ability to response environment change can be considered for the controlled released matric of bioactive compound. In this study, the biohydrogel was synthesized by graft-copolymerization of acrylic acid onto carboxymethyl starch (CMS) and chitosan. The objective of this research was to determine the effect of CMS-chitosan ratio on the biohydrogel characteristic. The acrylic acid was grafted on to the backbone (3:1) using cerric ammonium nitrate as the inisiator.A standarded curcumin was applied to test the binding potency of matrix. A higher CMS ratio in the polymer mixture (4:1) revealed the highest swelling power (16.9 w/w) and percentage of curcumin absorption (17.34%). All samples have pH-responsive swelling properties, with the swelling trend was observed in the order of distilled water >HCl solution > phosphate buffer solution. FTIR spectra and SEM micrographs has confirmed the graft-copolymerization of PAA/CMSCs biohydrogel by describing the appearance of peak around 1600 cm-1and the morphology of granular structure, respectively. The graft-copolymerization of acrylic acid onto the two anionic natural polymer by cerric ammonium nitrate as the initiator has resulted a pH-dependent swelling biohydrogel, and it has the ability to deliver curcumin in stomach-targeted system.]]>
<![CDATA[Optimasi Aktivitas Bakteriosin yang Dihasilkan oleh Bakteri Lactobacillus plantarum dari Minuman Ce Hun Tiau ]]>
<![CDATA[Sari, Rafika]]>;
<![CDATA[Apridamayanti, Pratiwi]]>;
<![CDATA[Octaviani, Melly]]>
<![CDATA[ Pharmaceutical Sciences and Research Vol. 5, No. 1 ]]>
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<![CDATA[Bacteriocin is a protein compound with a small molecular weight that has an antibacterial activity. Bacteriocin has been widely applied as a natural food preservative, as it effectively prevents the growth of pathogenic bacteria in foods and beverages. The aim of this research was to know the activity of bacteriocin produced by lactic acid bacteria Lactobacillus plantarum from Ce hun tiau beverages against Escherichia coli and Staphylococcus aureuswith different pH and temperature treatments. In this study, Lactobacillus plantarum bacteria isolated from Ce hun tiau beverages were characterized by Gram staining test. Bacteriocin was extracted from Lactobacillus plantarum bacteria which had been incubated in deMan Rogose Sharpe Broth media. Confirmation test using proteolytic enzyme and bacteriocin activity test with different pH (2, 4, 6, 8, and 10) and temperature (40°, 60°, 80°, 100°, and 121°C) treatments were conducted. The results showed that bacteriocin hadantibacterial activity against Escherichia coli but had no activity against Staphyloccus aureus. The inhibition zone was formed at pH 2 to 6 and at temperature range of 40°C to 121°C.]]>
<![CDATA[Aktivitas Mukolitik Kombinasi Ekstrak Etanol Daun Kemangi dan Ekstrak Etanol Daun Sirih Merah ]]>
<![CDATA[Kurniati, Neng Fisheri]]>;
<![CDATA[Suwandi, Deden Winda]]>;
<![CDATA[Yuniati, Safira]]>
<![CDATA[ Pharmaceutical Sciences and Research Vol. 5, No. 1 ]]>
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<![CDATA[A cough is a protective physiological mechanism that is useful for removing and clearing the respiratory tract from sputum and foreign particles that can cause infection. Treatments for cough disorders using medicinal plants were conducted because medicinal plants were widely known to have less side effects than synthetic drugs. Basil leaves (Ocimum sanctum L.) and red betel leaves (Piper crocatum Ruiz and Pav) have been used traditionally to treat a cough. The purpose of this study was to determine the mucolytic activity, and the effective concentration of the combination of basil and red betel leaves ethanol extract. The mucolytic activity was performed by measuring the decrease of viscosity of mucous from the cow intestinal mucosa. Mucolytic activity was evaluated upon treatment by each extract (concentration 0.1%, 0.5%, and 1%) and the combination of both. Results showed that ethanol extract of basil leaves or ethanol extract of red betel leaves could reduce viscosity of artificial sputum at the dose of 0.5% each. Moreover, the combination of these extracts synergistically decreases the viscosity. Combination of ethanol extract of basil leaves and red betel can be an alternative medicine for cough treatment.]]>
