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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
Core Subject :
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 16 Documents
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Search results for , issue "Vol. 7, No. 1" : 16 Documents clear
Assessment of Depression Among Older Adults Staying in Old Home Care in Klang, Malaysia Qamar, Muhammad; Zahirah, Nurul; Ahmad, Sohail
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Mental disorders such as depression are widespread, often underdiagnosed, and usually inappropriately treated. The early recognition of factors that may promote depression with the help of depression screening aid can help to plan better care for the patient. Therefore, this study aimed to determine the depression prevalence among the older adults staying in old home care, to explore any association and differences of depression across various socio-demographic variables, and to study the predictors of depression among study subjects. A cross-sectional study was conducted with a convenience sample of 141 elderly by using the validated tool. The study instrument was divided into two sections: Section I (Socio-demographic data); Section II (M-Geriatric Depression Scale-14). The results showed 44.7% were in the age group of 65-75 years, the majority were Chinese (42.6%), and male (57.4%). Among the subjects, 43.3% had hypertension, followed by 39% of diabetes, and 8.5% were with heart disease, while more than 90% reported not known history of depression. The study revealed that more than 50% of the respondents had depression. Statistically, a significant difference was observed between the depression prevalence with marital status (p=0.021) and a history of heart disease (p= 0.002). On multivariate analysis, heart disease was found to be statistically significant. Depression was prevailing among the older community those who were staying in old home care. Daily evaluation should be done for the older population staying in old home care to attenuate the prevalence of depression. Family and social support were vital to highlight the issue of depression among older adults.
Evaluation of Potential Drug Interaction of Analgesic in Cancer Patient Receiving Palliative Care in Dharmais Cancer Hospital Sitepu, Eme Stepani; Puspitasari, Atika Wahyu; Azmi, Nuriza Ulul; Sari, Lila Nilam
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Analgesics are mostly used in cancer patients receiving palliative care to improve the quality of life of patients. Besides analgesics, cancer patients receiving palliative care were also given other drugs in combination to overcome other symptoms of cancer, and this combination could potentially cause drug interactions. This study was aimed to analyze the potential of drug interactions with analgesics in cancer patients. The study design was cross-sectional with a retrospective method and descriptive study. The sample of this study was cancer palliative care patient’s prescription at Dharmais Cancer Hospital in the period of January – December 2017. The sample analyzed in this study consisted of 273 prescriptions. This study found that there were 191 prescriptions (69.9%) of analgesics which potential- ly interacted with 316 interaction cases. Fentanyl and morphine with 61 cases (19.3%), morphine and gabapentin with 60 cases (18.9%) and morphine and amitriptyline with 33 cases (10.4%) were observed as the three most analgesics-other drugs interaction. Based on severity levels, there were 73.5% of major interaction, 26.3% of moderate interaction, and 0.2% of minor interaction. This study concluded that high occurrence of drug interactions was observed in analgesic drugs, therefore close monitoring is needed in cancer patient receiving palliative care.
Formulasi Gel Ekstrak Daun Kelor (Moringa oleifera Lamk) Sebagai Sediaan Antiinflamasi Sugihartini, Nining; Jannah, Syauqul; Yuwono, Tedjo
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

The development of anti-inflammatory gel of Moringa oleifera leaf extract has been performed. This study aimed to determine the physical properties, irritation index and anti-inflammatory activity of gel with various concentration of Moringa oleifera leaf extract. The extract was obtained by maceration method using ethanol 70%. The extracts were formulated in a gel with a concentration of 3%, 6%, 9% by using Carbopol 940 as gelling agent. The gel was evaluated for its physical properties (viscosity, pH, spreadability, adhesivity), irritation index with rabbit test animals and anti-inflammatory activity with mice test animals based on epidermal thickness parameters. The test results showed that the increasing of extract concentration changed the viscosity, pH, adhesivity, epidermal thickness and spreadability of the gel. Based on the results of this study it can be concluded that the optimum concentration of Moringa oleifera leaf extract in gel as anti-inflammatory was 3%.
Profil Terapi Antihipertensi dan Antihiperlipidemia Terhadap Fungsi Ginjal Pasien Diabetes Melitus Tipe 2 dengan Komplikasi Penyakit Ginjal Kronis di RSUP Dr. Hasan Sadikin Rachmaini, Fitri; Amalia, Lia; Rahayu, Cherry
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Chronic Kidney Disease (CKD) complication increases the risk of morbidity and mortality in type 2 diabetes mellitus (DMT2) patients. The presence of hypertension and dyslipidemia as comorbidity increases the risk of macrovascular and microvascular complications and further adding to the list of drugs used. Management of this comorbidity is essential to prevent cardiovascular events and minimize kidney damage. This study aimed to evaluate therapeutic profile of antihypertensive and antihyperlipidemia drugs towards kidney function in DMT2 patients with CKD complication at Dr. Hasan Sadikin Hospital. Study was done by using a prospective single cohort design with consecutive sampling technique and obtained 37 patients. Serum creatinine, ureum and eGFR values were collected from December 2017 to February 2018 and became the basis of analysis in this study. The result of this study showed that there was a significant decrease in creatinine serum (p < 0.05), ureum (p < 0.05) and a significant increase in eGFR value (p < 0.05) after three months therapy. Based on the result it can be concluded that therapeutic profile of antihypertensive and antihyperlipidemia can control kidney function in DMT2 patients with CKD complication after three months study based on serum creatinine, ureum and eGFR values.
Development of Ethanolic Extract of Pinang Masak Jambi (Areca Catechu L.) as A Modulator of Doxorubicin Cytotoxic Effect in Breast Cancer Therapy Fitrianingsih, Fitrianingsih; Maharini, Indri; Utami, Diah Tri
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Doxorubicin is one of the chemotherapy agents that is often used in breast cancer therapy. Phenomenon of breast cancer cell resistance to chemotherapy agents has been traced to the molecular level. The development of compounds that can overcome drug resistance chemotherapy needs to be continuously developed, especially agents with specific molecular targets, namely P-glycoprotein (Pgp), NFkB, cyclin, and cyclin-dependent kinase (CDK). Another alternative is the combination of chemotherapy agents with chemopreventive agents (co-chemotherapy) to reduce side effects and increase sensitivity of cancer cells. Doxorubicin is often used in breast cancer therapy. This study was performed to determine the effect of ethanolic extract of Pinang Masak Jambi (Areca catechu L.) (EEPMJ) and doxorubicin combination on MCF-7 breast cancer cells. Cytotoxic assay of EEPMJ and doxorubicin, alone, or in combination, was done using MTT test method to determine the IC50 and CI (Combination Index) values. The results indicated that EEPMJ and doxorubicin had IC50 values of 75.1 µg/ml and 22 µg/ml, respectively. Based on CI values, all combination concentration showed varying CI values. The concentration of 1/8 IC50 of EEPMJ with 1/2, 1/4, and 1/8 IC50 of doxorubicin showed a strong synergistic effect (CI 0.1 - 0.3), with the inhibition of cell viability up to 67.39%. This synergistic effect occurs because EEPMJ potentially could increases the cytotoxicity of doxorubicin.
Encapsulation of Temulawak Extract by Using Nanocrystalline Cassava and Sago Starches and Maltodextrin Sunarti, Titi Candra; Pasaribu, Fatimah J; Winarti, Christina
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

This study was conducted to evaluate the performance of Curcuma zanthorrhiza crude extract after encapsulated in nanocrystalline starch, and to investigate the effect of the ratio of nanocrystalline starches and maltodextrin; and the effect of concentration of temulawak extract on nanocapsule characteristics, as well as encapsulation effect on the stability of antioxidant activity. Preparation of nanocrystalline starch was conducted by using lintnerization and ethanol precipitation of cassava and sago starches. Nanocrystalline starch and maltodextrin were used as matrices with the ratio varied from 25:75, 50:50, and 75:25. The mixture of temulawak extract and matrices were homogenized and spray dried. Nanocapsules characteristics included the efficiency of encapsulation and drug loading, and antioxidant activity test were investigated. Nanocrystalline cassava and sago starches were potentially modified starch that can be used as the matrix for its low solubility and digestibility. It showed that the ratio of nanocrystalline starch, maltodextrin, and concentration of temulawak extract significantly influenced the nanocapsule characteristics. The best encapsulation condition obtained for nanocrystalline matrix from cassava starch with the ratio of nanocrystalline starch: maltodextrin 25:75 (%w/w) and 10% concentration of the temulawak extract, while for sago are 75:25 (%w/w) and 10% concentration of temulawak extract. Nanocrystalline matrix from cassava starch revealed higher encapsulation efficiency and antioxidant activity. The use of high temperatures during spray drying affected by the slight decline of antioxidant activity of encapsulated temulawak extract. Encapsulation of temulawak extract by using nanocrystalline starch and maltodextrin could retain and protect its antioxidant activity.

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