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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 355 Documents
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Analisis Kandungan Ion Fluorida pada Sampel Air Tanah dan Air PAM Secara Spektrofotometri Astriningrum, Yodifta; Suryadi, Herman
Majalah Ilmu Kefarmasian Vol. 8, No. 2
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Abstract

Fluoride ion is one of the compounds that are known to have benefits in the prevention of dental caries when used in certain concentrations, but also hasnegative effects that may cause the occurrence of dental and bone fluorosis when the intake was in excessive concentration. One of the fluoride intakes comes fromwater that is consumed. The aim of this research was to identify and measurefluoride ion levels in groundwater and piped water that used as drinking water consumption in the community. Measurement of fluoride ion concentration isdone by using visible spectrophotometry at the maximum wavelength of 586 nm using the sodium 2-parasulfophenylazo 1,8-dihydroxy-naphthalene-3,6disulfonate (SPADNS)-zirconil acid reagent. This method was optimized by thesearch of range of absorption which stable for 10 minutes after reagent addition.The limit of detection, limit of quantitation, and coefficient of variation forfluoride ion were 0.0452 mg/L, 0.1506 mg/L, and 0,63%, respectively. While therecovery of fluoride ion in sample were in the range of 90,50-102,04%. The measurement results of the samples showed levels of fluoride ions in groundwaterand piped water varied between 0.05 to 0.78 mg/L. This range was still within allowed levels according the rules of Indonesian health ministers No.492/MENKES/PER/IV/2010 where the maximum allowable fluoride concentration is 1.5mg/L.
Formulasi Sediaan Granul Mukoadhesif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta indica A. Juss) dan Kunyit (Curcuma domestica val.) Sutriyo, Sutriyo; Khairunnisya, Khairunnisya; Mun’im, Abdul
Majalah Ilmu Kefarmasian Vol. 8, No. 2
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Abstract

Neem bark (Azadirachta indica A.Juss) and turmeric (Curcuma domestica Val.) extracts have been found posses gastroprotective effect so that they are used in the treatment of gastric ulcer. Administration of combination of both extracts can give synergistic effect so that the administration dose can be reduced. In this research, combination of neem bark and turmeric extracts were formulated as mucoadhesive granules to improve their effectivenesses by increasing the residence time of dosage form in the stomach. Mucoadhesive granules were prepared by wet granulation method in six formulas using HPMC, Carbopol, and combination of HPMC and Carbopol as mucoadhesive polymers. Granules were evaluated for particle size distribution, swelling, mucoadhesive strength with bioadhesive in vitro test and wash off test, and dissolution. Bioadhesive in vitro test showed that all formulas have goodmucoadhesive strength.Wash off test showed that combination of HPMC and Carbopol can improve mucoadhesive strength of formulas. Mucoadhesive strength increased with the increasing of HPMC. The result of this research indicated that formula with combination ofHPMCand Carbopol (2:1) showed best mucoadhesive strength with percentage of mucoadhesion 98.67%in bioadhesive in vitro test and 38.00% in wash off test.
Efek Antidiabetes dan Identifikasi Senyawa Dominan Fraksi Kloroform Herba Ciplukan (Physalis angulata L.) Sediarso, Sediarso; Sunaryo, Hadi; Amalia, Nurul
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Abstract

Antidiabetic activity of ciplukan (Physalis angulataL.) herb has a lot to do, as an extracts and infusions, proven to reduce blood sugar levels in rats or mice induced by alloxan. The research objective was to evaluate the antidiabetic effect and identify the content of the chloroform fraction ciplukan herb eluated with methanol-ammonia. Antidiabetic effects testing conducted using 30 male white mice (Mus musculus) ddY strain were divided into 6 groups, each consisting of 5 mice. K-1 is a negative control induced by alloxan, K-2, K-3 and K-4 induced by alloxan and treated with the test substance dose of 50 mg/kg bw/ day, 100 mg/ kg bw/day, 200 mg/kg bw/day, K-5 is a positive control, induced by alloxan and treated with metformin dose of 65 mg/kg bw, K-6 as normal controls. Each mouse blood samples taken on day 7 and day 14, to test their blood sugar levels . Data were ana- lyzed using one-way anova and multiple differences test. Identification of the content of the chloroform fraction eluated with methanol-ammonia , carried out by gas chromatography mass spectrometry (GC-MS). The results showed that all three doses showed a decrease in blood sugar levels significantly at day 7 , but the decline has not reach normal levels. Blood sugar levels drop significantly and the decline has reached normal occurred on day 14 . Dominant content of the chloroform fraction eluated with methanol-ammonia is a class of unsaturated fatty acid chain length is Hexanoic acid, C16H12O2, hexadecanoic acid methyl ester, C17H34O2, 9-octadecenoic acid methyl ester, C19H36O2, Oleic acid butyl ester, C22H42O2, 9-octadecenoic acid, C19H36O2, Octadecanoic acid, C18H36O2, 1,2-Benzendicarboxylic acid, C8H6O4, and Aplysterylacetate, C31H52O2. Another result is that Nordextromethorphan alkaloid compound, C17H23NO. The conclusion is chloro- form fraction of ciplukan herbhas antidiabetic effects and has a class of compounds content of unsaturated fatty acids, Aplysterylacetate and alkaloid Nordextromethorphan.
Analisis Adduct DNA Setelah Pemberian Natrium Nitrit dan Dimetilamin Secara Berulang Pada Tikus Meilianti, Sherly; Harahap, Yahdiana; Hayun, Hayun
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Abstract

Nitrosodimethylamine is a carcinogenic compound which can be formed from the reaction of nitrite and dimethylamine that is found in food. Nitrosodimethylamineis activated in liver and alkylates the DNA base and producing a DNA adductssuch as O6-methylguanine and N7-methylguanine that have a role incarcinogenesis. In this research, DNA was isolated from rat’s blood which waspreviously given nitrosodimethylamine’s precursor, sodium nitrite anddimethylamine. DNA adducts can be obtained from hydrolysis in hydrochloricacid 0.1 N for 30 minutes at 7000C. Then the adducts were analyzed using High Performance Liquid Chromatography (HPLC), with a strong cation exchangecolumn (Supelcosil LC-SCX, 5 μm, 250 x 4.6 mm), mobile phase consisting ofammonium phosphate with a final concentration of 40 mM, pH 3.00, flow rate 1.5mL/minute, column temperature 30oC and detected at exitation wavelength 286 nm and emission wavelength 366 nm. This method gave an acceptable validation result according to accuracy and precicion test results that fulfill the requirementand linear calibration curve with a quantitation limit of 22,5403 ng/mL. Rats were divided into six groups that two groups were given nitrosodimethylamine aspositive control, three groups were given prekursor, and the other was normalcontrol. Blood samples were collected in 1,2 and 4 hour after last induced. Aftergiving sodium nitrite 110 mg/kg bw and dimethylamine (1:5) orally for a week,N7-methylguanine and O6-methylguanine had not been detected in rat’s blood.
Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks Sagita, Erny; Anwar, Effionora; Surini, Silvia
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Abstract

Floating tablet is one of the drug delivery system retained in the stomach which aims to prolong the lag time of the drug in the stomach. This principle can be used to improve the efficacy of famotidine in treating diseases in the stomach The purpose of this research is to develop dosage form afloat by using Chitosan Pectin Electrolytes (PEC) as matrix then used as the matrix in tablet dosage form with famotidine as a drug model. PEC also combined with hydroxypropylmethylcellulose (HPMC) with different. PEC was also combined with hydroxypropilmethylcellulose (HPMC) in different concentrations. The results of the dissolution study showed that PEC could retard the release of famotidin for 10 hours. PEC in combination with HPMC could retard the release of famotidin for 20 hours. Tablet that only contains PEC as matrix could remain buoyant for 12 hours while tablet with combination of PEC and HPMC could remain buoyant for 24 hours.
Pengembangan Sistem Penghantaran Obat Solid Self-Emulsifying Mikropartikel Gliklazid untuk Meningkatkan Disolusi Suryani, Mega; Sutriyo, Sutriyo
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Abstract

Gliclazide is a Hypoglycemicdrug, second-generation sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Gliclazide exhibit poor aqueous solubility, so that their low bioavailability. Objectivesthis study is to develop solid self-emulsifying (SE) microparticles of poorly soluble gliclazide to dissolution enchancement. These microparticles were prepared by spray drying method, using three surfactant (acripol, tween 80 and sodium lauryl sulphate) with various concentration. SE microparticles characterized in terms of morphology (SEM), particle size distribution (PSA), x-ray diffraction (XRD), thermal analysis (DSC), functional group analysis (FTIR), solubility test, and dissolution test. The all gliclazide SE microparticlesexhibited particle size smaller than pure gliclazide. The dissolution rate of gliclazide SE microparticles at one hour was increased about 2 to 3 times than gliclazide.
Pengaruh Pemberian Infusa Herba Sambiloto (Andrographis paniculata Nees) Terhadap Glibenklamid Dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes Sari, Santi Purna; Azizahwati, Azizahwati; Ratimanjari, Diandra Andina
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Abstract

Many diabetics perform self-medication with antidiabetic herbs and synthetic drugs with the aim to obtain a synergistic or additive effects without informing their primary physician, such as the use of creat and glibenclamide. This research was carried out to know the impact of creat herb infusion on glibenclamide in bwering blood glucose levels on diabetic male albino rats. This study used 24 male Sparague-Lawley rats, which are divided into 6 groups, normal control and diabetic control were given 0,5% CMC solution I ml/200 g bw of rat, glibenclamide control were given glibenclamide suspension 0,9 mg/200 g bw of rat, creat control were given creat herb infusion 50 mg/200 g bw of rat, and 2 interaction groups were given creat herb infusion in 2 variant doses (50 and 100 mg/ 200 g bw of rat) and glibenclamide suspension 0,9 mg/200 g bw of rat, each of them were administrated orally. All of groups were induced with alloxan 32 mg/ 200 g bw of rat except normal control. Blood glucose was measured by 0-toluidine method at 2 hours and 4 hours after administration. The result showed that the creat herb infusion at 100 mg/200 g bw gave significant impact on glibenclamide in lowering blood glucose levels week after administration.
Uji Penghambatan Aktivitas alfa-glukosidase Ekstrak dan Fraksi Daun Antidesma neurocarpum Miq. Widihasputri, Rieka; Elya, Berna; Azizahwati, Azizahwati
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Abstract

Diabetes mellitus is a metabolic dysfunction disease showed by hyperglicemia and abnormality of carbohydrates, fats, and proteins metabolism. It is known can be cured with a-glucosidase inhibitor. Previous experiment reported that methanol extract from leaves of Antidesma neurocarpum Miq. has a strong inhibitory activity of a-glucosidase (IC50 = 2,18 mikrogram/mL). The aim of this experiment was to know about the most active extract and fraction of inhibitory activity of a-glycosidase and also the chemical compounds from those most active extract and fraction. Extraction is done by using multilevel maceration (n-hexane, ethyl acetate and methanol). Inhibitory activity of a-glucosidase tested with microplate reader at 405 nm wavelength. As standard, we used carbose (IC50=38.37 gg/mL). Methanol extract has the strongest inhibitory activity of a-glucosidase as shown the highest inhibitor percentage (89.53%). It is identified the chemical compounds and fracinationed by flash column chromatography. Fractination produced 15 combined fractions. Combined fractions which more than 200 mg tested to know their inhibitory activity of a-glucosidase. Result showed that the most active fraction is the 8th (IC50=40.77 gg/mL) with a competitive inhibitor mechanism to a-glycosidase. Chemical compounds that is found in the methanol extract and 8th fraction of Antidesma neurocarpum Miq. leaves are flavonoids, tannins, glycosides, fenol and alkaloids.
Efek Antidiabetes dan Identifikasi Senyawa Dominan Fraksi Kloroform Herba Ciplukan (Physalis angulata L.) Sediarso, Sediarso; Sunaryo, Hadi; Amalia, Nurul
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Abstract

Antidiabetic activity of ciplukan (Physalis angulata L.) herb has been widely observed, as an extracts and infusions, proven to reduce blood sugar levels in rats or mice induced by alloxan. The research objective was to evaluate the antidiabetic effect and identify the content of the chloroform fraction ciplukan herb eluated with methanol-ammonia. Antidiabetic effects testing conducted using 30 male white mice (Mus musculus) ddY strain were divided into 6 groups, each consisting of 5 mice. K-1 is a negative control induced by alloxan, K-2, K-3 and K-4 induced by alloxan and treated with the test substance dose of 50 mg/kg bw/day, 100 mg/ kg bw/day, 200 mg/kg bw/day, K-5 is a positive control, induced by alloxan and treated with metformin dose of 65 mg/kg bw, K-6 as normal controls . Each mouse blood samples taken on day 7 and day 14, to test their blood sugar levels. Data were analyzed using one-way anova and multiple differences test. Identification of the content of the chloroform fraction eluated with methanol-ammonia, carried out by gas chromatography mass spectrometry (GC-MS). The results showed that all three doses showed a decrease in blood sugar levels significantly at day 7 , but the decline has not reach normal levels. Blood sugar levels drop significantly and the decline has reached normal occurred on day 14. Dominant content of the chloroform fraction eluated with methanol-ammonia is a class of unsaturated fatty acid chain length is Hexanoic acid, C16H1202, hexadecanoic acid methyl ester, C17H3402, 9-octadecenoic acid methyl ester, C19H3602, Oleic acid butyl ester, C22H4202, 9-octadecenoic acid, C19H3602, Octadecanoic acid, C18H3602, 1,2-Benzendicarboxylic acid, C8H604, and Aplysterylacetate, C31H5202. Another result is that Nordextromethorphan alkaloid compound, Cl 7H23NO. The conclusion is chloroform fraction of ciplukan herb has antidiabetic effects and has a class of compounds content of unsaturated fatty acids, Aplysterylacetate and alkaloid Nordextromethorphan.
Skrining Fitokimia dan Uji Penghambatan Aktivitas alfa-glukosidase pada Ekstrak Etanol dari Beberapa Tanaman yang Digunakan sebagai Obat Antidiabetes Munim, Abdul; Azizahwati, Azizahwati; Andriani, Ayu
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Abstract

Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglicemia and associated with abnormalities in carbohydrate, fat, and protein metabolisms. Patients with DM in the world continue to increase along with population growths. Starting from this condition, searching for sources of DM treatment is always performed. One therapy of DM is a-glucosidase inhibitor. a-Glucosidase is an enzyme that can break down a complex carbohydrate into simple sugar. lhe inhibiton of this enzyme can retard the rate of carbohydrate digestion resulting in a delay in glucose absorption. The purpose of this studywas to identify the content of chemical compound and to test the a-glucosidase inhibitory activity in ethanolic extracts of some plants used as antidiabetic. a-Glucosidase inhibitory activity test carried out by spectrophotometric method. The simplisia powder was extracted by reflux using 80% ethanol. Based on a-glucosidase inhibitory activity test, all the plant extracts were active in inhibiting a-glucosidase. lhe three most active extracts were Ceiba pentandra (L.) Gaetern bark extract, Saccharum offcinarum root extract, and Persea americana Mill. bark extract with IC50 of 5.16, 10.35 and 10.83 ppm, respectively. They contain glycoside, tannin, and saponin. The test results of the kinetics enzyme inhibition showed that Randu bark extract had competitive inhibitory activity.

Page 13 of 36 | Total Record : 355

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