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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
Core Subject :
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 355 Documents
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Evaluasi Aktivitas Antioksidan Senyawa 4-[(E)-2-(4-okso-3-fenilkuinazolin-2-il)etenil]-benzensulfonamida dan Analognya Jatmika, Catur; Maggadani, Baitha Palanggatan; Hayun, Hayun
Pharmaceutical Sciences and Research Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Quinazolinone derivative compounds exhibit a broad spectrum of biological activity, including antioxidant. Quinazolinone derivative compound 4-[(E)-2-(4-oxo-3-phenyl quinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs (2a-f) have been synthesized and demonstrated its activity as a selective inhibitor of cyclooxygenase-2. The aim of this research was to evaluate the antioxidant activity of compound 4-[(E) -2-(4-oxo-3-fenilkuinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs with DPPH radical scavenging method, ferric reducing activity potential (FRAP), and phosphomolybdenum method. The experiment revealed that the % inhibition and antioxidant capacity of compound 2c, 2e and 2f were higher compared to compound 2a, 2b and 2d. The DPPH radical scavenging analysis found that the % inhibition of compound 2c, 2e and 2f at high concentration of compound solution (1000 µg/mL) were 4.8 %, 3.46 %, and 3.68 %, respectively. While the total antioxidant capacity of compound 2c, 2e and 2f were recorded 37.93, 33.4, and 46.3 µg ascorbic acid equivalence/mg of compound, respectively. However the antioxidant activity of all synthesized compounds (2a-f) were lower than the standard ascorbic acid.
Sintesis dan Karakterisasi Hidrogel Superabsorben Kitosan Poli(N-Vinilkaprolaktam) (Pnvcl) Dengan Metode Full Ipn (Interpenetrating Polymer Network) Wivanius, Nadhrah; Budianto, Emil
Pharmaceutical Sciences and Research Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Polymer material used for hydrogel should have capability to swell and to keep water molecules in its structure without solubilised in water. Natural polymers has functional groups which can perform as active sites in modification to produce polymer with better characteristic. Chitosan is a natural polymer which has good swelling ability but lack of structural strength. Synthesis of chitosan hydrogel by interpenetrating polymer network (IPN) will increase its strength through crosslinking. In this research, the first step of modification was the synthesis of chitosan polymer network crosslinked by acetaldehyde. The next step was the synthesis of PNVCL polymer network crosslinked by N,N-methylbisacrylamide (MBA) through free radical polymerization of NVCL monomer with ammonium persulfat (APS) as the initiatior. Optimum reaction time, chitosan/PNVCL ratio (w/w %), concentration of crosslinker agent, and concentration of initiator had been observed. The optimum conditions were obtained as followed: 2 hours reaction, the ratio chitosan/PNVCL of 90:10 (w/w %), %-w MBA concentration of 0,5%, and APS concentration of 3%. The swelling ratio of the hydrogel was 380,66% while the crosslinking degree was 60,85%. Fourier transfor infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TGA), Scanning Electron Microscope (SEM), and X-Ray diffraction (XRD) were used for the characterization of the hydrogel.
Skrining Fitokimia dan Aktivitas Antioksidan Fraksi Etanol Alga Merah Eucheuma spinosum Sari, Bina Lohita; Susanti, Nurulia; Sutanto, Sutanto
Pharmaceutical Sciences and Research Vol. 2, No. 2
Publisher : UI Scholars Hub

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The red alga, Eucheuma spinosum from South Bangka Waters was shown to contain antioxidant activity. Natural antioxidants from algae are known to play an important role against various diseases and aging processes. The study objective was to investigate phytochemical screenings and antioxidant activity of ethanol fractions Euchema spinosum from south Bangka waters. Antioxidant activities of fresh algae (FA), dry algae (DA), and algae product (AP) were determined with DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. Extraction was conducted using 70% ethanol in acidic environment for 24 hours. Then, the extract was evaporated using rotary evaporator. Dry extract was fractionated with ethanol - n - hexane ( 2 : 3 ) and the ethanol fraction was dried. The phytochemical screenings showed that all fractions had flavonoid, alkaloid and triterpenoid compounds. The most potent antioxidant activity was found in the ethanol fraction of AP with IC50 value 333.66 μg/mL, FA 418.32 μg/mL and DA 472.14 μg/mL. Based on the results, it can be concluded that the ethanol fraction of algae product can be used as a antioxidant source.
Enzim Papain: Aspek Green Chemistry pada Reaksi Knoevenagel Haryanto, Laurentius; Cahyana, Antonius Herry
Pharmaceutical Sciences and Research Vol. 2, No. 2
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Abstract

Green chemistry aspect is the chemical approach that has been studied in the past two decade. One of the principles is the development of green synthesis process that is friendly for the environment. This research showed that papain can be used as catalyst for Knoevenagel reaction with 3 kinds of substituted-benzaldehyde and malononitrile as substrates in aqueous medium. The best reaction condition with 80% yield was reached by utilizing of 25 mg papain/mmol substrate. Reaction was conducted at ambient temperature and pressure for 30 min. Products were as yellowish to yellow needle crystals and successfully characterized by melting point, UV-Vis, IR, mass spectra, and 13C & 1H-NMR, named as 2-(4-hydroxybenzylidene)-malononitrile); 2-(3-hydroxybenzylidene)-malononitrile); and 2-(4-hydroxy-3-methoxybenzylidene)-malononitrile).
Daun Jambu Biji (Psidium guajava L.) sebagai Antikanker Payudara Dwitiyanti, Dwitiyanti
Pharmaceutical Sciences and Research Vol. 2, No. 2
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Abstract

Guava leaves are used as a cytotoxic. Previous research has demonstrated that guava leaves contained 61.71% of quersetin and has potential as an cytotoxic. The aim of this study was to determine the cytotoxic activity of 70% ethanol extract of guava leaves against cancer cells T47D. The method used direct counting (viable cell count) to obtained LC50 value. This study used a test solution with six concentrations that were 130.62; 67.98; 35.98; 18.43; 9.56 and 5 µg/ml. The LC50 value from the 70% ethanol extract of guava leaves was 27.54 µg/ml. The results suggested the extract of guava leaves has cytotoxic activity against T47D cells
Perbandingan Metode CBIA dan FGD dalam Peningkatan Pengetahuan dan Ketepatan Caregiver dalam Upaya Swamedikasi Demam pada Anak Lathifah, Marianti Avi; Susanti, Susanti; Ilham, Much; Wibowo, Aji
Pharmaceutical Sciences and Research Vol. 2, No. 2
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Abstract

Self medications which are ofted applied to children are including coughs, colds, flu, and nasal congestion (17.2%), fever (15%), headache (14%), diarrhea and abdominal pain (9%). The results from previous studies showed only 0.4% caregiver of 4-6 years old children in Banyumas Regency did correctly in children’s fever self medication. Aim of this study is to determine the influence of Community Based Interactive Approach (CBIA) and Focus Group Discussion (FGD) methods for improving knowledge and correctness of caregivers in children’s fever self medication with type of research of quasi experimental design with a control group of non random pretest posttest. Results of Wilcoxon test showed that there were significant differences of knowledge statistically before and after treatment using the FGD and CBIA methods with significancy values in FGD group of 0.000 (p < 0.05) and in CBIA group of 0.002 (p < 0.05), while for correctness before and after treatment with FGD and CBIA methods, there were no statistically significant difference in significancy values of correctness for FGD group of 1,000 (p> 0.05) and for the CBIA group of 1,000 (p> 0.05). Results of Mann-Whitney test showed that the obtained significancy value was 0.012 (p <0.05), it can be concluded that there were significant differences between FGD with CBIA groups. The difference of Mean scores in FGD group (2.45) were greater than the CBIA group (0.96), so that the FGD method was better in improving the knowledge compared with CBIA method even though they both gave some improvements.. Fisher’s Exact test results showed that the ​obtained significancy value was 1,000. According to these statistical analysis results, it can be concluded that based on statistical calculatios, there is no significant difference between FGD and CBIA methods in improving the correctness of children’s fever self medication.
Uji Toksisitas Akut dan Efek Antiinflamasi Ekstrak Metanol dan Ekstrak n-Heksana Daun Pepaya (Carica papaya L) Santi, Tahara Dilla
Pharmaceutical Sciences and Research Vol. 2, No. 2
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Abstract

The acute toxicity test and antiinflammatory effect of methanolic and n-hexane extracts Carica papaya L leaf have been studied. The results of phytochemical screening show that papaya leaf contains alkaloid, steroid, and flavonoid compound. Flavonoid and alkaloid extracted from methanolic extract of papaya leaf and steroid extracted from n-hexane extract of papaya leaf. The acute toxicity test of methanolic and n-hexane extracts Carica papaya L leaf have been studied on rat with giving a single dose of samples. The aim of this work was to investigate the behavioral responses (pharmacological profile), the development of body weight and mortality for 14 days. The results of acute toxicity test after giving dose of 250 mg/kgbw, 500 mg/kgbw and 1000 mg/kgbw of methanolic and n-hexane extracts of leaves of Carica papaya L to males rat showed no animal died and significant toxic effect. In the study antiinflammatory effects in white rat with carragenan induced 1%, and to determine an effective dose of extract papaya to decrease the edema volume of rat foot. The test was done using rat hind paw edema or esthablished an artificial inflammation in left foot of white male rats.The treatments were carried out on six groups, the positive control group was administered with Indomethacin 10 mg/kgbw per oral, the negative control group was administered with CMC 1%, and the extract groups were administered with 200 mg/kgbw and 400 mg/kgbw of methanolic and n-hexane extracts Carica papaya L leaf. Edema volume were measured every half hour for 5 hours using a pletismometer digital. Obtained data were analyzed by Kruskal-Wallis test followed Mann-Whitney test with confident level was 95%. The result of this study indicate that papaya leaf extract can reduce edema volume of rat foot.
Penetapan Kadar Fenolik dan Flavonoid Total Ekstrak Metanol Buah dan Daun Patikala (Etlingera elatior (Jack) R.M.SM) Ahmad, Aktsar Roskiana; Juwita, Juwita; Ratulangi, Siti Afrianty Daniya
Pharmaceutical Sciences and Research Vol. 2, No. 1
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Abstract

Fruit and leaves of patikala (Etlingera elatior (Jack) R.M.Sm), is a traditional medicinal plants used by people to treat various diseases. The purpose of this study was to determine the total phenolic and flavonoid compounds of E. elatior fruits and leaves extracts. We extracted dried fruits and leaves samples by maceration method using methanol. Qualitative analysis of chemical compounds with certain eluent was done using Thin Layer Chromatography (TLC) to determine the group of active compounds in the extract. The amount of phenolic compounds in the sample was determined by the colorimetric method at a maximum wavelength of 744.8 nm and flavonoid at 431 nm. The results showed that the methanol extract rendemen was 1.93% for fruit and 5.17% for leaf with a total phenolic content of the fruit was 2.29 mgGAE/g b/b extract and leaf was 6.29 mgGAE/g b/b extract. And total flavonoid content of the fruit was 1.7761 % mg Quercetin/g b/b extract and leaf was 5.45 mgQE/g b/b extract.
Losio Antioksidan Buah Naga Merah (Hylocereus polyrhizusBritton and Rose) Sinaga, Amanda Angelina; Luliana, Sri; Fahrurroji, Andhi
Pharmaceutical Sciences and Research Vol. 2, No. 1
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Abstract

Hylocereus polyrhizus Britton and Rose (Red dragon fruit) has been shown to have antioxidant activity which contains vitamin C, polyphenol, and flavonoid. This research was aimed to investigate antioxidant activity from H. polyrhizus in form of lotion. Lotion were made with 5 concentration from H. polyrhizus methanol extract were 0.04, 0.08, 0.16, 0.32 and 0.64%. Lotion antioxidant activity was measured using DPPH method. The result showed that H. polyrhizus methanol extract had antioxidant activity with inhibition concentration were 19.99±0.33; 25.01±0.08; 39.14±0.04; 66.69±0.12 and 83.37±0.05. The result showed significant differences on antioxidant activity. The physical stability observation of five formula with cycling test method showed unstability because of discolouration (oxidation). As well as the methods of mechanical test showed unstability of lotion because saponification process.
Aktivitas Antioksidan Ekstrak, Fraksi dan Golongan SenyawaKimia Daun Premna oblongata Miq Katrin, Katrin; Bendra, Atika
Pharmaceutical Sciences and Research Vol. 2, No. 1
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Abstract

Indonesia has many kinds of plants which can be used as natural antioxidant sources. This study was focused on antioxidant activity of Cincau Perdu leaves extract (Premna oblongata Miq.) using 1-Diphenyl-2-picrylhydrazyl (DPPH) methods. P. oblongata leaves was extracted using n-hexane, ethylacetate and methanol. It was found that methanol extract has the highest activity with IC50 value 20.01 μg/mL. The extract with highest antioxidant activity were fractionated with accelerated column chromatography and were earned 6 combination fractions. The antioxidant activity of each combination fractions were tested by DPPH methods. Fraction-5 showed the highest activity as antioxidant with IC50 23.51 μg/mL. The compounds of the active fractions were flavonoid, glikon, saponin and tannin.

Page 26 of 36 | Total Record : 355

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