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Prof. Diah Ayu Maharani, DDS, PhD
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Makara Journal of Health Research
Published by Universitas Indonesia
ISSN : 23563664     EISSN : 23563656     DOI : https://doi.org/10.7454/msk
Core Subject :
Makara Journal of Health Research (MJHR) is a peer-reviewed and scientific journal published by Universitas Indonesia. Starting from 2019 onwards, MJHR is redirecting its scope, focusing on publishing research articles relevant to non-communicable diseases (NCDs) addressing issues of surveillance, disease management and health policy in the Asia Pacific and Mediterranean countries. Relevant academic articles regarding NCDs analyzed from an integrated perspective including individual and population level, experimental and clinical approaches, epidemiology, public health, disease prevention and health promotion, diagnosis, treatment, prognosis and palliative care are welcome.
Arjuna Subject : -
Articles 270 Documents
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A Cross-Sectional Study of the Candidal Species Isolated in the Oral Cavities of Type II Diabetic Patients Samnieng, Patcharaphol; Sonthayasathapon, Sita; Siriwat, Masjutha; Jeamanukulkit, Supanee
Makara Journal of Health Research Vol. 21, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: The objectives of this study were to determine the prevalence and colonisation of Candida species and to study the factors related to candidal colonisation in the oral cavity among type II diabetic patients. Methods: The data of 102 diabetic patients was collected from the Outpatient Diabetic Clinic at the Naresuan University Hospital. Data was collected via a questionnaire and oral examination. The subjects were measured for their fasting blood sugar levels and salivary pH. Candida colonisation was assessed using saliva sampling, and was cultured on CHROMagar Candida plates. Species and colony forming unit/mL were recorded. Results: The results showed that the prevalence of oral Candida species in diabetic patients was 73.5%. The most frequent candidal species in diabetics were Candida albicans (68.6%), followed by C. glabrata (28.4%), C. tropicalis (10.8%), and C. krusei (2.0%) respectively. There was no statistical significance between the fasting plasma glucose levels and oral Candida species colonisation. Logistic regression showed that a decrease of the salivary pH was related to the colonisation of candidal species. Results showed that the use of a dental prosthesis was a related factor to the colonisation of candidal species (p < 0.05). Conclusions: A high prevalence of candidal species were found in type II diabetic patients. Salivary pH and use of a dental prosthesis are factors that promote candidal infections in type II diabetic patients
Impacts of Impaired Vision and Eye Diseases on Vision-Related Quality of Life in Indonesia Asroruddin, Muhammad; Artini, Widya; Gondhowiarjo, Tjahjono D; Rahayu, Tri; Lestari, Yeni D
Makara Journal of Health Research Vol. 21, No. 3
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Background: To determine the impacts of visual impairment and eye diseases on vision-related quality of life (QoL) in populations with severe visual impairment (SVI) and blindness in Indonesia. Methods: A cross-sectional study was conducted on 134 respondents from, 5 different provinces, simultaneously with a validation study using data from the 2013 National Basic Health Survey. Participants aged ≥ 18 years with visual acuity of < 6/60 underwent an ocular examination and guided interview. The impact of vision impairment related to their QoL was assessed using the NEI-VFQ 25 questionnaire. The scores were then compared between participants with blindness (< 3/60) and participants with SVI (> 3/60 to < 5/60), and the causes of visual impairment. Results: Severe visual impairment and blindness were mostly found in productive aged females with lower education and income levels, and cataracts were the leading cause. Vision-related quality of life was lower in the blind group compared to the SVI group (p = 0.001). The impacts of visual impairment related mostly to distance activities (p = 0.007), social functions, and near activities (p = 0.002). NEI-VFQ 25 scores were lower in glaucoma respondents than cataract respondents. Conclusions: Results suggest that subjects with blindness had a lower total QoL score than those with SVI, in addition to the subscale scores. Furthermore, glaucoma disease had the lowest QoL score.
The Antidiabetic Activity of Curry Leaves “Murraya Koenigii” on the Glucose Levels, Kidneys, and Islets of Langerhans of Rats with Streptozotocin Induced Diabetes Al-Ani, Imad M; Santosa, Rahajoe I; Yankuzo, Muhammad H; Saxena, Anil K; Alazzawi, Khalid S
Makara Journal of Health Research Vol. 21, No. 2
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Background: The aims of this study were to explore the antihyperglycemic effect of curry leaves, Murraya koenigii "MK" aqueous extract, and to examine its possible protective effects on the islets of Langerhans and kidneys of streptozotocin (STZ) diabetic rats. Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with "MK" control, diabetic control (non-treated with "MK"), diabetic treated with 200 mg/kg MK aqueous leaf extract and diabetic treated with 400 mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored gravimetrically. The animals were sacrificed on the 30th day; the kidney and pancreatic tissues were processed for histological studies. Results: The diabetic group showed considerable loss of body weight and increase in blood glucose levels and degeneration of the glomeruli and renal convoluted tubules and atrophied islets with disintegration of β-cells. Treatment of diabetic rats with MK extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The MK extract also caused an improvement in tissue injury induced by STZ injection in the kidney and islets of Langerhans. Conclusions: These findings highlighted the beneficial effects of MK aqueous extract against cellular oxidative damage in STZ-induced diabetic rats.
Psychological Distress and Sources of Stressors amongst Medical and Science Undergraduate Students in Malaysia Radeef, Ali S; Faisal, Ghasak G
Makara Journal of Health Research Vol. 21, No. 2
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Background: This study aims to compare the prevalence of psychological distress between medical and science undergraduate students and to assess the sources of stressors that are attributing to it. Methods: A sample of 697 undergraduate students participated in this study, in which 501 were medical students and the remaining 196 were Science students. Psychological distress was assessed using the 12-item General Health Questionnaire. The students were given a list of possible sources of stress which were chosen depending on previous studies. Results: The overall prevalence of psychological distress was 32.6%. Science students showed a significantly higher rate and mean score of psychological distress than medical students, and the mean score was significantly higher during the clinical phase rather than the pre-clinical phase in medical students. Overall, female students had a significantly higher mean score than males, however although the mean score was higher in females it was only significant in the pre-clinical phase. In addition to academic and psychological stressors, factors such as reduced holidays, lack of time for relaxation, and limitation of leisure/entertainment time were among the top ten stressors reported by the students. Conclusions: Psychological distress is common among university students, and it is higher among science students than medical students. Academic and psychological factors can be considered as sources of stressors which may precipitate psychological distress among college students.
Caregiver burden from caring for dependent elderly in Yangon, The Republic of the Union of Myanmar Naing, May Zun; May, Sein Yaw; Aung, Min Htike
Makara Journal of Health Research Vol. 24, No. 1
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Background: Elderly population and well-being of those are emerging as major challenges for families and communities. This study aimed to identify caregiving burden among caregivers who care for dependent elderly. Methods: A cross sectional descriptive study was conducted in Tharkayta Township, Yangon, Myanmar. Total 200 caregivers were selected applying multi-stage sampling method and structured questionnaires were used to collect data. Dependent score of elderly was assessed by using Barthel Index of activities of daily living (ADL) and assessment of caregiver burden through Zarit Burden Interview. Results: The results showed that over one fifth of caregivers 21.5% had experienced severe burden, 39.5% had experienced moderate burden, 32.5% had experienced mild burden and only 6.5% had experienced no/little burden. Among elderly population, 11.5% were fully dependent, 40.0% were highly dependent, 46.0% were semi dependent, and only 2.5% were almost independent. Burden of caregivers and dependent score of elderly were negatively correlated (ß = ̶ 0.247, p = 0.000) and statistically significant association between age group and burden level (X2 = 17.335, p = 0.008). Conclusion: This study highlighted that community health nurses should emphasize on health education activities regarding caregivers training and home visit program for elderly and their caregivers.
The Association Between Sanitation, Hygiene, and Stunting in Children Under Two-Years (An Analysis of Indonesia’s Basic Health Research, 2013) Badriyah, Lulu'ul; Syafiq, Ahmad
Makara Journal of Health Research Vol. 21, No. 2
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Background: This study aims to identify the relationship between sanitation, hygiene, and stunting in children under two-years in Indonesia. Methods: This was a cross-sectional study that examined 9,688 children under the age of two. We obtained data from Indonesia's Basic Health Research paper that was released in 2013 and applied multiple logistic regression analysis. The prevalence of stunting amongst children under two-years in 2013 was 33.3%. Results: Our analysis showed that stunting is closely related to low birth weight, age, gender, exclusive breastfeeding, socioeconomic status, garbage removal, and waste management. Appropriate sanitation and hygiene had a significant impact on stunting amongst children under two-years in Indonesia, with waste management and low birth weight being the most important indicators. Conclusions: Nutrition, socioeconomic status, and a healthy environment are key to ensure children under two-years meet the recommended growth standards.
Bionanomedicine: A “Panacea” In Medicine? Anurogo, Dito; Parikesit, Arli A; Ikrar, Taruna
Makara Journal of Health Research Vol. 21, No. 2
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Recent advances in nanotechnology, biotechnology, bioinformatics, and materials science have prompted novel developments in the field of nanomedicine. Enhancements in the theranostics, computational information, and management of diseases/disorders are desperately required. It may now be conceivable to accomplish checked improvements in both of these areas utilising nanomedicine. This scientific and concise review concentrates on the fundamentals and potential of nanomedicine, particularly nanoparticles and their advantages, nanoparticles for siRNA conveyance, nanopores, nanodots, nanotheragnostics, nanodrugs and targeting mechanisms, and aptamer nanomedicine. The combination of various scientific fields is quickening these improvements, and these interdisciplinary endeavours to have significant progressively outstretching influences on different fields of research. The capacities of nanomedicine are immense, and nanotechnology could give medicine a completely new standpoint.
Hypertension as a Determining Factor in the Rupture of Intracranial Aneurysms, Diagnosed by 64-MDCT Angiography Fatmawati, Heni; Santoso, Antonius G
Makara Journal of Health Research Vol. 21, No. 2
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Background: To determine a correlation between risk factors and the rupture of intracranial aneurysms. Methods: A cross-sectional study of 29 patients with a saccular intracranial aneurysm was obtained using consecutive sampling and examination of 64-MDCT angiography. Bivariate statistical analysis using Fisher's exact test was arranged using cross-tabulation to determine the correlation between each risk factor of age, sex, hypertension, and smoking with the occurrence of ruptured intracranial aneurysms. Results: The highest incidence of ruptured intracranial aneurysms were in patients aged < 60 years (70%), male (75%), experienced hypertension (85%), and were smokers (85.7%). Only the risk factor of hypertension had a correlation with the occurrence of a ruptured intracranial aneurysm (p < 0.05). The prevalence ratio of age and sex were 1.0 and 0.9, whereas hypertension and smoking were 2.6 and 1.3. Conclusions: The risk factor of hypertension leading to a ruptured intracranial aneurysm was 2.6 times higher than non-hypertensive patients, and as such hypertension is a risk factor associated with the occurrence of ruptured intracranial aneurysms
Contraceptive Services Available to Unmarried Sexually Active Adolescents Budiharsana, Meiwita
Makara Journal of Health Research Vol. 21, No. 2
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Background: Low contraceptive use amongst unmarried sexually active young men and women presents an ethical dilemma in Indonesia, particularly in realising reproductive rights as a fundamental human right. This study aims to address the difficulties in extending access to family planning for unmarried sexually active youths. Methods: A review of the laws relating to the provision of family planning was combined with a secondary data analysis of the 2012 Indonesian Demographic Health Survey throughout 6 provinces on the island of Java. The sample population included 5,150 unmarried adolescents, aged 15 to 24 years. The 2012 Indonesian Demographic Health Survey was the first and only survey that included unmarried young women in Indonesia. The association between subjects who had 'ever had sex' and three groups of predictors (demographic characteristics, peer influences, and knowledge of contraceptive methods) were examined using multivariate logistic regressions. Results: Results of the study found that subjects who were unmarried but had engaged in sexual activity were more likely to be those aged 19 to 21 years (OR = 2.36) and 22 to 24 years (OR = 6.81), of low education status (OR = 2.1), with a boyfriend or girlfriend (OR = 2.38), and those who approved of pre-marital sex (OR = 8.5). Conclusions: Results from this research suggest that new interpretations of the Law 52/2009 regarding family planning and Law 36/2009 that prohibits health services to unmarried sexually active youths are required in order to address the issues faced by Indonesia's youth
The impact of dental caries on oral health related quality of life amongst adult population in Lahore, Pakistan Shahzad, Hazik Bin; Awais, Faiza; Shirazi, Um-e-Rubab; Majeed, Hanna Abdul; Rafique, Aqeela; Shahbaz, Maliha
Makara Journal of Health Research Vol. 24, No. 1
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Background: Dental caries in adults is a public health problem. A comprehensive assessment of the association between caries and Oral Health Related Quality of Life (OHRQoL) measures is essential for understanding how it impacts the daily life of people and for assessing their oral health needs. Methods: The survey was conducted at Rashid Latif Dental Hospital, from March-June 2019. A total of 373 adults aged 18-80 years were randomly enrolled in the study. Dental caries was the main exposure, measured clinically. The OHRQoL was measured through Oral Impacts on Daily performance (OIDP) questionnaire. Caries was dichotomized and the relationship to OHRQoL was determined. Results: The results showed that 87.6% of the people presenting to the hospital had one or more carious teeth. Difficulty eating, and relaxing/sleeping were among the top reported impacts. Adults with caries showed higher odds for reporting higher oral impacts compared to those without caries. For every added carious tooth, there is 1.38 times increase in OIDP score. Conclusion: Individuals with caries were more likely to report more frequent and severe oral impacts that manifested into their daily lives through difficulty eating or relaxing. OIDP score increased linearly with increased exposure to caries.

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