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Prof. Diah Ayu Maharani, DDS, PhD
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Makara Journal of Health Research
Published by Universitas Indonesia
ISSN : 23563664     EISSN : 23563656     DOI : https://doi.org/10.7454/msk
Core Subject :
Makara Journal of Health Research (MJHR) is a peer-reviewed and scientific journal published by Universitas Indonesia. Starting from 2019 onwards, MJHR is redirecting its scope, focusing on publishing research articles relevant to non-communicable diseases (NCDs) addressing issues of surveillance, disease management and health policy in the Asia Pacific and Mediterranean countries. Relevant academic articles regarding NCDs analyzed from an integrated perspective including individual and population level, experimental and clinical approaches, epidemiology, public health, disease prevention and health promotion, diagnosis, treatment, prognosis and palliative care are welcome.
Arjuna Subject : -
Articles 270 Documents
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A Clinical Profile of Hepatitis A Patients in Jakarta, Indonesia Adiwinata, Randy; Kristanto, Andi; Richard, Timoteus; Edbert, Daniel; Angelina, Frida; Eppy, Eppy; Mauleti, Ifael Y; Lardo, Soroy; Firmansyah, Iman; Bur, Rika; Ahimsa, Titos; Nelwan, Erni J
Makara Journal of Health Research Vol. 21, No. 1
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Background: To determine the incidence of hepatitis A infections and the clinical profiles of adult patients admitted to public hospitals in Jakarta, Indonesia. Methods: This was a cross-sectional study that utilised consecutive secondary data from internal medicine wards of seven public hospitals in Jakarta between 2011 and 2013. Eligibility criteria included patients over the age of 18 years and an ICD-10 diagnosis code of B15, acute hepatitis A. Case proportion was reported per 1000 people by dividing incidence per year to total in-ward patients. Clinical profiles were reported descriptively. Laboratory results were compared and categorised into groups of patients aged below and above 25 years old. Results: Data revealed that hospitalisations of patients with hepatitis A had decreased from 2011 to 2013. 289 patients were studied, the majority were young adults (18-25 years old) and their common chief complaints were nausea (36%), fever (24%), and jaundice (21%). Higher bilirubin levels were seen in older patients. There were 13 patients coinfected with hepatitis B, one patient coinfected with hepatitis C, and one patient coinfected with HIV. Conclusions: The proportion of hepatitis A infection amongst adults admitted to public hospitals in Jakarta was low and had decreased during the study period. Most of the patients reported classical clinical manifestations. This study found that the targeted age group may benefit from receiving routine hepatitis A vaccinations.
The Relationship between Spirituality and Depression Among the Elderly in Indonesia Mahwati, Yeni
Makara Journal of Health Research Vol. 21, No. 1
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Background: Studies have shown that there is an association between spirituality and better physical and mental health. Depression has one of the highest prevalence amongst the mental health illnesses in the elderly, and it can lead to poor physical health. This study aims to determine the relationship between spirituality and depression. Methods: Data was obtained from the 4th Indonesian Family Life Survey, that was conducted in 2007; the total study sample included 3,103 elderly Indonesians. Logistic regression was performed to determine the relationship between spirituality and depression. Results: This study found that the prevalence of depression was 7.2%, with the largest proportion of those being ≥ 70 years, female, less educated, unemployed, elderly with multimorbidities, unmarried, and less spiritual. Logistic regression analysis showed a strong relationship between spirituality and depression (odds ratio= 1.869; 95% confidence interval; 1.422 to 2.458) after it was controlled for all variables. Conclusions: This study found that spirituality has a significant relationship with rates of depression. The government needs to develop a program that strengthens spirituality to improve mental health in the elderly.
Factors Associated with Choking During Meals; a Risk Indicator for Repetitive Fevers in The Elderly Community Nishiyama, Takeshi; Nagata, Emi; Oho, Takahiko
Makara Journal of Health Research Vol. 21, No. 1
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Background: Choking during meals is a common symptom in the elderly, however the factors associated with it have not been fully clarified. In this study, we examined the factors associated with choking during meals. Methods: The oral health status and practices that promote oral health conditions was surveyed in 1305 community dwelling elderly using a self-administered questionnaire. Eight items including satisfaction with their oral condition, denture fit, chewing ability, tooth brushing frequency, dental visits, exercises to train muscles for chewing and swallowing, choking during meals, and repetitive fever were selected for analysis. Results: 25.1% of the subjects experienced choking during meals, which was significantly associated with repetitive fever occurrence. Differences in satisfaction levels with their oral condition, denture fit, chewing ability, and tooth brushing frequency were observed between groups with and without choking. Age, satisfaction level, and chewing ability were significantly associated with choking during meals. Conclusions: This study demonstrated that choking during meals is a risk indicator for repetitive fever in the elderly living in community settings. Poor chewing ability and dissatisfaction with their oral condition were risk factors associated with choking. These results suggest that training the elderly to eat efficiently and safely and improving oral conditions is necessary for those who suffer from choking during meals to prevent repetitive fever.
Individual and Regional Factors that Affect Fertility Rates in Five Provinces of Indonesia Lutfiah, Umi; Besral, Besral; Herdayati, Milla
Makara Journal of Health Research Vol. 21, No. 1
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Background: This research paper aims to investigate the individual and regional factors that affect fertility in Indonesia. Methods: This was a crossectional study that analysed data from the 2002-2003, 2007, and 2012 Indonesian Demographic and Health Surveys and the 2012 National Family Planning Coordinating Board Routine Report regarding contraceptive services. The selection criteria for the sample population were married women considered to be of child bearing age (between 15 and 49 years), who had delivered at least one child. Analysis was completed using multilevel logistic regression. Results: Results show that regional factors that affect fertility are influenced by the contraceptive prevalence ratio. The individual factors that affected fertility were the job status of the participant's husband, the level of education attained, the perceived ideal number of children, intervals between births, and previous experience of child mortality. Conclusions: Both central and local governments of provinces with high fertility rates appear to have a lower socio-economic status and require strategic plans that increase expectant mother's participation in education. It is recommended that the National Family Planning Coordinating Board address high fertility rates in Indonesia by way of education. Women of child bearing age who have a low socio-economic status and education level should be targeted to reduce the perceived ideal number of children to 2 and to achieve longer birth intervals (more than 36 months).
The Cholesterol Lowering Effects of Eurycoma longifolia Jack (Tongkat Ali) Root Extract in Male Rats Faisal, Ghasak G; Najmuldeen, Ghazi F; Abllah, Zurainie; Radeef, Ali S
Makara Journal of Health Research Vol. 21, No. 1
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Background: To investigate the effect of Eurycoma longifolia Jack root extract on serum lipids in rats. Methods: Twenty-six mature male albino Wistar rats were used in this study. A group of 18 rats were fed a high fat and high cholesterol diet for 4 weeks, after which their lipid profile was compared to the control group, who were kept on a normal diet. The rats were then further divided into three groups, the Cf group that continued to feed on a high fat and cholesterol diet only, and group A and group B who continued on a high fat diet with the addition of 5 mg/kg and 10 mg/kg of Eurycoma longifolia Jack root extract respectively for 4 weeks. After the 4 week period, the rat's lipid profiles were analysed again. Results: Group A and B showed significant total cholesterol reduction when compared to the Cf group, 140 ± 7.23, 139.63 ± 7.95, 192.14 ± 8.96 mg/dL respectively (p < 0.001). The total cholesterol/HDL ratio in group A was 5 however there was a sharp increase in group B to a high-risk level of 9.2 indicating a significant drop in HDL levels. The LDL level increased significantly in both group A and B compared to the Cf group. Conclusions: Eurycoma longifolia Jack root extract is effective in lowering total cholesterol, however the dose needs to be adjusted to prevent an excessive decrease in HDL levels.
The Prevalence of Antibiotic and Toothpaste Sensitivity found in Oral Streptococcal Isolates in Healthy Individuals in the Okada Community of Nigeria Okwu, Maureen U; Mitsan, Olley
Makara Journal of Health Research Vol. 21, No. 1
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Background: This study aimed to determine the prevalence, antibiotic, and toothpaste sensitivity of oral streptococcal isolates in healthy individuals in the Okada community of Nigeria. Methods: Oral samples were collected from 230 volunteers and were subjected to standard microbiological tests. Antibacterial sensitivity tests were carried out on the streptococcal isolates that were obtained using a disk diffusion technique, and eight kinds of toothpaste (A-H) were screened for their antibacterial effects on Streptococcus mutans (S. mutans). Results: The prevalence of oral streptococci found in this study was 26.1% and the predominant species was S. salivarius (13.9%). S. salivarius was highly resistant to cloxacillin (100%) and Augmentin (96.9%), whilst resistance to gentamicin and erythromycin was low at 21.9% and 3.1% respectively. S. mutans were completely sensitive to gentamicin whilst resistance to erythromycin was 33.3%. The entire Streptococcus species showed the lowest resistance to erythromycin (20.0%), followed by gentamicin (31.7%). At 100 mg/mL all toothpaste samples had antibacterial effects on S. mutans. At 50 mg/mL all samples except toothpastes G and H inhibited the bacterium. Toothpastes A and E had the lowest minimum inhibitory concentration of 25 mg/mL. Conclusions: Toothpastes A and E were the most effective toothpastes of the eight assessed in this study.
The Effect of Squid Extract (Loligo Sp) on TNF-α and TGF-β1 Serum Levels during Wound Healing in Streptozotocin-induced Diabetic Rats Dewi, Kadek NP; Kristianto, Heri; Indra, Mochamad R
Makara Journal of Health Research Vol. 20, No. 3
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Background: Diabetes Mellitus is a chronic disease characterised by elevated levels of blood glucose known as hyperglycaemia. Diabetes is due to impaired insulin action in the metabolism of glucose and can result in impaired wound healing. Excessive production of pro-inflammatory cytokines, an increased number of macrophages and neutrophils, and decreased levels of transforming growth factor - beta 1 (TGF-β1) serum can be characteristic of impaired wound healing. This study aims to determine the effects of squid extract on certain wound parameters such as levels of tumour necrosis factor - alpha (TNF-α), and TGF-β1 serum and the number of macrophages and neutrophils. Methods: This was a post-test only, randomized controlled group study that was conducted on male Wistar rats. Experimental animals were divided into 6 groups; (1) normal wound with standard diet, (2) diabetic wound with standard diet, (3) diabetic wound with chitosan supplement, (4) diabetic wound given squid extract orally once a day, (5) diabetic wound given squid extract orally twice a day, and (6) diabetic wound given squid extract orally once every two days. Levels of TNF-α and TGF-β1 serum were observed using Enzyme-Linked Immunosorbent Assay. Haematocylin and eosin staining was used to observed macrophage and neutrophil counts. All data was analysed statistically by one-way analysis of variance. Results: TNF-α serum levels showed a significant decrease (p < 0.05) in subjects that received squid extract orally once every two days. The mean levels of TGF-β1 showed no significant differences. The mean number of macrophage cells showed a significant decrease (p < 0.05) in all treatment groups. The mean number of neutrophil cells also showed significant decrease (p < 0.05) in all treatment groups. Conclusions: Squid extract is effective in lowering the TNF-α serum levels and the number of macrophages and neutrophils cells in Wistar rats. However, there were insignificant findings on increasing levels of TGF-β1 serum. This data suggests that squid extract is most effective during the inflammatory phase of wound healing which takes places about 2-4 days after wound creation.
Placental Morphology of Pregnant Iraqi Women with Rheumatic Heart Disease Al-Assa, Anwar IS; Al-Rubai, Ragwa HI; Al-Ani, Imad M; Al-Ubeidie, Salim R; Al-Kaisy, Kawkab SN; Faisal, Ghasak G
Makara Journal of Health Research Vol. 20, No. 3
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Background: Placental morphology and cellular arrangement can be altered in maternal diseases. Rheumatic heart disease (RHD) is a chronic heart condition that can lead to death in pregnant women. The aim of this study is to determine the histological changes of the placenta in pregnant women suffering from RHD. Methods: Placentae were collected from 10 healthy pregnant women, and 31 pregnant women with heart conditions (26 with RHD and 5 with NRHD) who had been admitted to the Baghdad Teaching Hospital. Placental tissues were fixed in 10% formal-saline and were processed for light microscopy. Measurements including the placental weight and diameter of the chorionic villi capillaries were recorded. Results: The results indicate that there are many histological changes in pregnant women with RHD such as hyalinisation, fibrosis of the chorionic villi, proliferation of trophoblastic cells, and thickening of its membrane. Additionally, expectant mothers with RHD experience a reduction in capillary diameter and thickening of the capillary walls, and decreased size and weight of their placenta when compared with the control. Conclusions: Heart diseases, especially RHD, are associated with developmental damage of the placenta in pregnant women by injuring the endothelial cells of the placentas capillaries.
Bone Density Status and Vitamin D and Calcium Concentrations in Pregnant and Non-Pregnant Women Setiarsih, Dini; Wirjatmadi, Bambang; Adriani, Merryana
Makara Journal of Health Research Vol. 20, No. 3
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Background: The aim of this study was to analyse differences in bone density and vitamin D and calcium concentrations between pregnant and non-pregnant women. Methods: This was an analytical, cross-sectional study of women aged 30 years or over, residing in the Puskesmas Bangkalan district. The sample population was chosen at random and included 10 pregnant women in their third trimester and 10 non-pregnant women. This observational study consisted of an interview, a blood test, and a 24-hour recall. The concentration of serum vitamin D (25(OH)D) was measured by Gas Chromatography and a Photometric Test measured the concentration of serum calcium. Participant's bone density was measured by bone ultra sonometer. The data was analysed using the Mann-Whitney test and assessed ultraviolet-B exposure, bone density values, and consumption of vitamin D, calcium, energy, and protein. The Student t-test was used to analyse serum vitamin D and calcium concentrations. Results: There were no differences between the groups' serum vitamin D concentrations (p = 0.946). However, there were significant differences between the groups' serum calcium concentrations (p = 0.047) and bone density values (p = 0.019). Conclusions: A high prevalence of vitamin D deficiency (25(OH)D < 50 nmol/L) and insufficiency (25(OH)D < 80 nmol/L) was observed in both groups. The mean serum calcium concentrations and bone density values were lower in pregnant subjects than non-pregnant subjects.
Challenges that Hinder Parturients to Deliver in Health Facilities: A Qualitative Analysis in Two Districts of Indonesia Nasir, Sudirman; Ahmed, Rukhsana; Kurniasari, Miladi; Limato, Ralalicia; Tulloch, Olivia; Syafruddin, Din; Koning, Korrie De
Makara Journal of Health Research Vol. 20, No. 3
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Background: There are many challenges women face to be able to give birth in health facilities in many parts of Indonesia. This study explores the roles and observations of close-to-community maternal health providers and other community members on potential barriers faced by women to deliver in health facilities in two districts within The Archipelago. Methods: Employing an explorative qualitative approach, 110 semi-structured interviews and 7 focus group discussions were conducted in 8 villages in Southwest Sumba, in the East Nusa Tenggara province, and in 8 villages in Cianjur, in the West Java province. The participants included village midwives, Posyandu volunteer (village health volunteers), traditional birth attendants (TBAs), mothers, men, village heads and district health officials. Results: The main findings were mostly similar in the two study areas. However, there were some key differences. Preference for TBA care, traditional beliefs, a lack of responsiveness of health providers to local traditions, distance, cost of travel and indirect costs of accompanying family members were all barriers to patients attending health facilities for the birth of their child. TBAs were the preferred health providers in most cases due to their close proximity at the time of childbirth and their adherence to traditional practices during pregnancy and delivery. Conclusions: Improving collaborations between midwives and TBAs, collaboration, and responsiveness to traditional practices within health facilities and effective health promotion campaigns about the benefits of giving birth in health facilities may increase the use of health facilities in both study areas.

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