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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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NON-ADHERENCE FACTORS TO TUBERCULOSIS TREATMENT IN PULMONARY TUBERCULOSIS PATIENTS IN SURAKARTA CENTRAL GENERAL HOSPITAL, INDONESIA Hidayah Karuniawati; Gayuh Ilham Rahmadi; Erindyah Retno Wikantyasning
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.9109

Abstract

Tuberculosis is an infectious disease that must be treated in the long term. One of the therapeutic efficacy factors in tuberculosis treatment is medication adherence by patients. Non-compliance to treatment leads to no achievement of treatment goals, increasing the risk of resistance, mortality, and morbidity. This study analyzed association factors that predicted the influence of the pulmonary tuberculosis patient’s non-adherence to anti-tuberculosis medicines in Surakarta Central General Hospital, Indonesia. The research was analytical research with a cross-sectional approach. The study samples were 80 respondents. The inclusion criteria were patients diagnosed with pulmonary tuberculosis in Surakarta Central General Hospital, aged >17 years old, and patients who received Anti-Tuberculosis Drugs for at least two months. This study used a questionnaire that has been validated. Data were analyzed by bivariate analysis (chi-square or Fisher) and continued by multivariate logistic analysis. Of 80 respondents, there were 30 respondents (37.5%) were non-adherence to taking Tuberculosis (TB) drugs. The predicted factors that influenced non-adherence in taking anti-tuberculosis drugs were beliefs about the medicine of the harm subscale (p = 0.001; OR = 8.167), suffering from drug side effects (p = 0.022; OR = 4.222), and beliefs about the medicine of overuse subscale (p = 0.038; OR = 3.504). The wrong beliefs of patients and side effects may influence patients’ adherence to TB medicines. Counseling and education are needed to improve patients’ beliefs and manage medicines’ side effects.
MOUTHWASH FORMULATION OF ONION (ALLIUM CEPA L.) METHANOL EXTRACT FOR INHIBITING THE GROWTH OF STREPTOCCUS MUTANS BACTERIA Supriyanto, Sugeng; Kiromah, Naelaz Zukhruf Wakhidatul; Purwanti, Ery; Rahayu, Titi Pudji
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.5492

Abstract

Dental and oral problems experienced a significant increase from 2007 to 2018. Based on the results of basic health research, dental and oral problems increased from 23.2% to 57.6%. Dental caries is ranked sixth with a prevalence of 60% to 80%. The main cause of dental caries is Streptococcus mutans. The use of mouthwash with synthetic active ingredients can cause side effects. In addition, only a few mouthwashes were able to inhibit the growth of Streptococcus mutans bacteria. The purpose of this study was to make a mouthwash formulation from onion methanol extract and to determine its ability to inhibit the growth of Streptococcus mutans bacteria. Three mouthwash formulas were made with 10%, 20% and 30% extract concentrations respectively, then physical evaluation was carried out for 14 days on days 0, 7 and 14. Physical evaluation included stability tests (odor, taste, turbidity and precipitate), pH and diameter of inhibition. The results of the formula stability evaluation on day 14 there was a change in formulas 2 and 3 color, but not in formula 1. This was due to differences in the concentration of extracts and the sappans color stability in the formulas. The pH test results for each formula are in the range of 6.0-6.3. A good mouthwash has a pH close to neutral like the pH of the mouth, which is 6-7. The results of the diameter inhibition test ranged from 6-8 mm. A significant difference was seen between the positive controls with formulas 1 and 3, but there was no significant difference between formulas 1 and 3. The conclusion of this study was that the mouthwash of onion methanol extract had the ability to inhibit the growth of Streptococcus mutans bacteria with moderate strength and the best formula was mouthwash with 10% extract concentration.
EVALUATION AND DESIGN OF MANAGEMENT INFORMATION SYSTEM DEVELOPMENT IN COMPLETENESS OF RECIPE SCREENING IN AR-RASYID ISLAMIC HOSPITAL PALEMBANG Azzahra, Nia; P, Jason Merari; Saptarini, Opstaria; Wahab, Sabda
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.6233

Abstract

Errors in prescribing and administering drugs are things that often occur in medicine, so in an effort to improve pharmaceutical performance, an evaluation and development of a SIM is carried out to support pharmaceutical services in hospitals. The aim of this research is to evaluate the Management Information System needs at RSI Ar-Rasyid Palembang and continue with the development of a design model. This research is descriptive research conducted through direct observation and documentation. The development of this research system uses a prototype method starting from needs analysis, system design and implementation of the EUCS (End User Computing Satisfaction) framework system, creating a system design using context diagrams, Data Flow Diagrams and Entity Relationship Data, the data analysis method used is qualitative analysis. The results of the research from direct observation on the completeness of the IFRS SIM show that the SIM at RSI Ar-Rasyid in pharmaceutical screening has been fulfilled, but in administrative screening and clinical screening it has not been fulfilled and the results of evaluation using a questionnaire distributed to pharmaceutical installation staff show an average the answer to each statement variable is satisfied. In making a draft design, there are suggestions that include clinical screening of prescriptions, it is hoped that this will help pharmacy installation staff in providing services to avoid medication errors. Based on system design, input design and output design, the patient prescription screening management information system design meets the criteria so it is ready to be implemented into the system.
STUDY OF INDONESIAN STINGLESS BEE PROPOLIS POTENTIAL AS ANTIOXIDANT: A REVIEW Yanti, Evita Novi; Kustiawan, Paula Mariana
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.7105

Abstract

Indonesia is known have rich biodiversity, one of that is propolis. Propolis was an abundance bee product, especially from stingless bee species. Propolis has been known to have various health benefits, such as antioxidant and can maintain the immune system. However, comprehensive information regarding this potential is not widely known. The purpose of this study was to determine the potential of propolis Trigona sp. as an antioxidant from Indonesia. This study uses a screening method in journals that have been found through the search systems of Google Scholar, PubMed, Scopus and Garuda. Classification of data was based on inclusion and exclusion by selecting research journals that do not meet the criteria. The results of the screening that have been carried out show that the flavonoid and phenolic compounds present in the propolis Trigona sp. has potential as an antioxidant. The flavonoid and phenolic compounds contained in the propolis Trigona sp. has an important role in absorbing free radicals and has the potential to be developed as a product.
STUDENT OF PHARMACY, NURSE, PUBLIC HEALTH, NUTRITIONIST AND PHYSICAL EDUCATION READINESS TOWARD INTERPROFESSIONAL EDUCATION (IPE) Utami, Vitis Vini Fera Ratna; Satibi, Satibi; Kristina, Susi Ari; Prabandari, Yayi Suryo
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.7234

Abstract

The implementation of interprofessional education (IPE) into higher education curricula is a significant method for creating professionals with the skills necessary for interprofessional collaboration (IPC), including those in the health sciences, nursing, pharmacy, and nutrition. Due to the changes in health services, which are becoming more integrated, it is vital to have the capacity for interprofessional collaboration. The readiness of the pupils for IPE must be assessed before to its implementation in order to identify the subjects that should be highlighted at that time. This research is a cross-sectional study using descriptive analysis method. The distribution of respondents was as all in 4th semester students, consist of department of Pharmacy (n=92), department of Nursing (n=88), department of Public Health (n=95), department of Nutrition (n=66) and department of Physical Education (n=42) in Faculty of Health Sciences. Questionnaire data collection was carried out online. The independent variable that is measured is the student's readiness for Interprofessional Education. The results findings there is a significant difference between the readiness of students in Nurse department and students of all department. The nurse department received the highest score (score = 68.47) and the Health Education received the lowest score (score = 65.59). But all department receive score > 80% of the total score. There is still room for improvement in the areas related to the value of learning together in practical situations
ANTIBACTERIAL ACTIVITY OF BASIL LEAVES EXTRACT TOWARDS BACTERIA STAPHYLOCOCCUS AUREUS AND STAPHYLOCOCCUS EPIDERMIDIS IN DEODORANT SPRAY Khairani, Tetty Noverita; Fitri, Khairani; Andry, Muhammad; Nasution, Muhammad Amin
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.7542

Abstract

Body odor is a significant problem and is often encountered in some individuals characterized by excessive odor. A deodorant spray made from basil leaf (Ocimum Basilicum L.) extract is a product used to treat body odor caused by Staphylococcus Aureus and Staphylococcus epidermidis bacteria. The purpose of this study is to assess the efficacy of deodorant spray and basil leaf extract on bacterial activity, as well as the optimal dose of deodorant spray for lowering the activity of these bacteria. Method the research was conducted experimentally, testing antibacterial activity using agar diffusion. The results of the deodorant spray preparation test showed that the preparation was homogeneous, organoleptically brown in color, had a distinctive smell, and had a liquid texture; the pH test results met the requirements for deodorant spray 4.5-6.5. The average diameter of the inhibition zones produced from each preparation were Staphylococcus epidermidis bacteria, positive control 7 mm, negative control 10.1 mm; formula 5% 12.3 mm; formula 10% 13.3 mm; formula 15% 12.7 mm maximum concentration in inhibiting bacteria is formula 10% by 13.3 mm, while the bacteria Staphylococcus Aureus positive control 13 mm, negative control 11.2 mm, 5% formula 13.1 mm; formula 10% 13.4 mm; 15% formula 13.9 mm maximum concentration in inhibiting bacteria is 15% formula 13.9 mm. Based on the inhibitory zone created by 10% basil leaf ethanol extract, Staphylococcus epidermidis bacteria had a 13.3 mm clean zone and Staphylococcus aureus bacteria had a 26.5 mm clean zone.
MOLECULAR DOCKING STUDIES OF FLAVONOIDS FROM SECANG WOOD (Caesalpinia sappan L.) AGAINST GLUCOKINASE ENZYME AS ANTIDIABETIC CANDIDATES Aurellia, Rizky Natasya; Fitriana, Adita Silvia; Febrina, Dina
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.8228

Abstract

Diabetes mellitus (DM) is a metabolic disease caused by a deficiency of insulin secretion, insulin resistance, and increased hepatic glucose production. Secang wood (Caesalpinia sappan L.) is known to have antihyperglycemic activity. However, these compounds are not yet known. In silico studies are needed to determine the compounds that act as antidiabetics. This study performed molecular docking of flavonoid compounds in sappan wood against the 1V4S glucokinase receptor. The results showed that all flavonoid compounds of sappan wood were predicted to have antidiabetic activity because they had a lower docking score than metformin, the first-line therapy of type 2 diabetes mellitus. Butein is expected to have the best activity. It has the lowest docking score (-94.4836). Visualization of the docking results shows that butein interacts with the identical amino acid residues as metformin, namely ARG 63 and THR 65, through the formation of hydrogen bonds and Van der Waals interactions. SWISS-ADME web tool predicted that butein has good oral absorption and excretion. The toxicity prediction tool showed a slight contradiction in the mutagenic effect. Based on this research, molecular docking may be able to design new drugs, especially from butein in sappan wood (Caesalpinia sappan L.), as antidiabetic candidates.
TRACING THE ANTIBACTERIAL, ANTIFUNGAL AND ANTI-BIOFILM ACTIVITIES OF ROOT EXTRACT BAJAKAH TAMPALA (SPATHOLOBUS LITTORALIS HASSK) Setyowati, Endang; Irzani, Elza Fadia; Mochtar Luthfi, Chaerul Fadly; Hamzah, Hasyrul
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.8804

Abstract

Biofilm is a common causative factor for urinary tract infections due to catheter usage with a percentage of infection around 70-80%. The Bajakah tampala (Spatholobus littoralis Hassk) is one of native plants of Kalimantan which contains phenolic compounds, flavonoids and tannins which are proven to accelerate wound healing, have antibacterial activity, and have very high and strong antioxidant activity. This study aims to determine the antibacterial and anti-biofilm activity of bajakah root extract (Spatholobus littoralis Hassk) on catheter colonies of Staphylococcus aureus, Escherichia coli and Candida albicans and to determine their mechanism of action in vitro. This research is carried out with an in vitro experimental study design using a microplate reader. Extraction was carried out by maceration method using 96% ethanol solvent. The results showed that the ethanol extract of Bajakah tampala (Spatholobus littoralis Hassk) had antibacterial activity against S. aureus with a concentration of 1% w/v of 88.33% ± 0.01 and anti-biofilm activity of 82.21% ± 0.01. E. Coli bacteria had an antibacterial activity of 84.83% and an anti-biofilm activity of 80.11 at a concentration of 1% w/v. C. albicans had an antifungal activity at a concentration of 1% w/v of 82.31% ± 0.01 and anti-biofilm activity of 77.00% ± 0.01. From these results it can be concluded that the ethanol extract of Bajakah tampala (Spatholobus littoralis Hassk) has antibacterial and antifungal activities and the potential as a new anti-biofilm agent against S.aureus, E. coli and C. albicans
EVALUATION OF KNOWLEDGE AND BEHAVIOR ON ANALGESIC SELF-MEDICATION IN HEALTH AND NON-HEALTH STUDENTS AT MUHAMMADIYAH UNIVERSITY, YOGYAKARTA Putri, Claryza Amelia; Rahajeng, Bangunawati
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.8828

Abstract

Pain is the most common cause that encourages someone to do self-medication. A person's level of knowledge is known to influence a person's behavior in self-medication. The study evaluates the level of knowledge and behavior toward self-medication using analgesics among health and non-health students at the University of Muhammadiyah Yogyakarta. This research uses a non-experimental observational research design with a cross-sectional approach. The sample used was 752 health and non-health students at the University of Muhammadiyah Yogyakarta. The level of knowledge of health students is good, with a percentage of 75.3% good; 21.0% is sufficient; and 3.7% is less, while the level of knowledge of non-health students is adequate, with a percentage of 33.5% good; 50.5% is sufficient; and 16.0% is less. The behavior of health students is good, with 86.7% good, 12.5% adequate, and 0.8% less, while the behavior of non-health students is good, with 80.9% good, 17.5% enough, and 1.6% less. The difference in the level of knowledge and behavior of analgesic self-medication between health and non-health students is quite significant, with the results of the Mann-Whitney test analysis showing a value of 0.000 on the level of knowledge and 0.001 on behavior. The relationship between the level of knowledge and behavior of health students and the Spearman Rank correlation test showed a result of 0.039 with an R-value of 0.107. In contrast, non-health students showed a result of 0.027 with an R-value of 0.114, indicating a significant and weak relationship between both.
PHYTOCHEMICAL SCREENING, FORMULATION AND EVALUATION OF FOOTSPRAY CONTAINING HONEY PINEAPPLE PEEL EXTRACT (ANANAS COMOSUS [L.] MERR) Kusumawati, Dwi Endah; Rahmadani, Azmi; Puspitasari, Rega Putri; Ghazi, Fahreza Maulana; Husna, Ahmad Nida'ul
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.8829

Abstract

Foot odor or bromhidrosis occurs due to the activity of bacteria that convert leucine in sweat into isovaleric acid which results in unpleasant odors. Honey pineapple skin (Ananas comosus [L.] Merr) is generally waste, whereas honey pineapple skin is known to contain antibacterial compounds. The aim of this study is to determine the potential of honey pineapple peel as an active ingredient in footspray based on the results of phytochemical screening and physical evaluation. Honey pineapple peel was extracted by maceration method using ethanol 70% then phytochemical test. Footspray preparations were made with various extract concentrations of 0%, 25%, 35% and 45% then tested for organoleptic, pH, specific gravity, viscosity, homogeneity, spreadability, and dry time during storage period of 0, 7, 14 and 21 days at room temperature. This study showed that honey pineapple peel extract contained flavonoids, tannins, phenols and alkaloids. The footspray has brown color with honey pineapple scent, pH of 5.71-6.37, specific gravity 1.05-1.09 g/mL, viscosity 7.2-13.2 cP, spreadability 6.67-7.60 cm, and the dry time is 4-5 minutes. Footspray containing honey pineapple peel extract with concentrations of 25%, 35% and 45% has a pH value that is safe for the skin, with good specific gravity, viscosity, homogeneity and spreadability, also stable during storage. Formula 1 (25% extract concentration) tends to be preferred because its texture is soft and not too sticky when applied to the skin when compared with formula 2 and 3.

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