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Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE)
Published by Pusat Riset dan Inovasi Nasional
ISSN : 2828934X     EISSN : 28289358     DOI : https://doi.org/10.55606/jurrike.v1i2
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Jurnal Riset Rumpun Ilmu Kedokteran adalah jurnal yang ditujukan untuk publikasi artikel ilmiah yang diterbitkan oleh Pusat riset dan Inovasi Nasional, Universitas Sains dan Teknologi Komputer. Jurnal ini adalah jurnal Riset Rumpun Ilmu Kedokteran yang bersifat peer-review dan terbuka. Bidang kajian dalam jurnal ini termasuk sub rumpun Ilmu Kedokteran Spesialis, Ilmu Kedokteran Akademik, Spesialis Kedokteran gigi dan mulut, Kedokteran Gigi Akademik. Jurnal Riset Rumpun Ilmu Kedokteran menerima artikel dalam bahasa Inggris dan bahasa Indonesia dan diterbitkan 2 kali setahun: April dan Oktober.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 258 Documents
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Efek Latihan Core Stability terhadap Peningkatan Keseimbangan pada Anak Down Syndrome: Narrative Review Siti Atiqah Nurrahmah; Rizky Wulandhari; Asyhara Naela Arifin
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.7647

Abstract

Down Syndrome (DS) is a genetic disorder characterized by trisomy of chromosome 21 and is inherently associated with clinical manifestations such as hypotonia, joint laxity, and neuromuscular deficits, all of which collectively contribute to impaired postural control and balance. These balance impairments significantly affect the attainment of motor milestones, performance of daily activities, and increase the risk of falls. This study aims to analyze the effectiveness of core stability training in improving balance among children with DS. A narrative review approach was employed by conducting a literature search across electronic databases including PubMed, Scopus, Google Scholar, and ResearchGate. Inclusion criteria consisted of primary studies (RCTs, quasi-experimental designs) published within the last ten years (2015–2025) that examined core stability interventions targeting balance or postural control in children with DS. A review of 10 relevant studies demonstrated that core stability training, either as a standalone intervention or combined with other modalities (e.g., treadmill training or balance training), resulted in significant improvements in both static and dynamic balance. These improvements are facilitated through the strengthening of deep trunk muscles (such as the multifidus, transversus abdominis, and rectus abdominis), which play a crucial role in proximal stabilization and force transfer to the extremities. In conclusion, core stability training is an effective and recommended intervention modality within physiotherapy rehabilitation programs to enhance the quality of life and motor independence of children with Down Syndrome.  
Hubungan Dukungan Keluarga dan Pemanfaatan Herbal Medicine sebagai Upaya Preventif dengan Kepatuhan Pengobatan TB paru di Puskesmas Rawat Inap Sidomulyo Arnila Melina; Octariany, Octariany; Dewi Murni Manihuruk; Fahmi Nofriandi
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.7794

Abstract

Pulmonary tuberculosis (TB) remains a major public health problem in Indonesia. Despite the implementation of national TB control programs through the Directly Observed Treatment Shortcourse (DOTS) strategy, treatment success continues to face significant challenges, particularly related to patient adherence to anti-tuberculosis drug (ATD) therapy. Non-adherence to TB treatment can lead to treatment failure, disease relapse, and the development of drug-resistant tuberculosis, thereby increasing the overall burden of the disease.Treatment adherence in TB patients is influenced not only by medical factors but also by social and behavioral determinants. Family support plays a crucial role in encouraging patients to comply with treatment regimens by providing motivation, reminding medication schedules, and offering emotional support throughout the long duration of therapy. Patients who receive adequate family support tend to demonstrate higher levels of treatment adherence compared to those with limited support.In addition, the use of herbal medicine as a preventive and supportive health measure is common among the Indonesian population. Herbal medicine is often utilized to enhance immune function, reduce medication side effects, and improve patient comfort during TB treatment. However, the use of herbal remedies without proper medical guidance may lead to misconceptions regarding standard TB therapy.Therefore, it is important to examine the relationship between family support and the use of herbal medicine as preventive measures with treatment adherence among pulmonary TB patients in primary healthcare settings. Such evidence is expected to support a comprehensive family medicine approach and strengthen TB control programs in primary care services.
Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Talas (Colocasia esculenta) Terhadap Mencit Putih Jantan (Mus musculus) Nur Dania, Sharifah; Rachmayanti, Aprilya Sri; Suhailah, Dhia
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.7881

Abstract

Inflammation is a physiological response to tissue injury, infection, or harmful stimuli, characterized by redness, swelling, heat, and pain. However, excessive or chronic inflammation may lead to tissue damage and degenerative diseases. Long-term use of non-steroidal anti-inflammatory drugs is associated with gastrointestinal and cardiovascular side effects, highlighting the need for safer natural alternatives. Taro leaves (Colocasia esculenta) are traditionally used to treat swelling and wounds and contain bioactive compounds such as flavonoids, alkaloids, tannins, saponins, and triterpenoids with potential anti-inflammatory effects. This study aimed to evaluate the anti-inflammatory activity of ethanol extract of taro leaves and determine the most effective dose. An experimental study was conducted using male white mice (Mus musculus) divided into five groups: negative control (Na-CMC), positive control (sodium diclofenac), and three treatment groups receiving extract doses of 25, 50, and 75 mg/kg BW. Inflammation was induced by 1% carrageenan injection. The extract significantly reduced inflammation, with the highest inhibition (84.13%) observed at 75 mg/kg BW, comparable to diclofenac.  
Gambaran Tingkat Pengetahuan dan Sikap terhadap Infeksi Menular Seksual pada Siswa-Siswi di Mas Darul Mursyid Adila Salwa Siregar; Riydah Ikhsan; Fitriyani Nasution; Indra Gunasti Munthe
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.7891

Abstract

Sexually transmitted infections (STIs) are a reproductive health problem that is still common among adolescents and can have serious impacts if not handled properly. Low levels of knowledge and unfavorable attitudes towards STIs have the potential to increase risky behavior among students. Objectives. This study aims to determine the level of knowledge and attitudes of students towards sexually transmitted infections at MAS Darul Mursyid. Methods. This study employed a cross-sectional methodology and a quantitative descriptive design. All MAS Darul Mursyid students were included in the study population, and a total sampling procedure was used to pick 149 respondents. A questionnaire with 20 statements about knowledge and 10 statements about attitudes around STIs was used to collect data. The SPSS software was used to analyze the data univariately, and the results were displayed as percentages and frequency distributions. Results and Discussion. According to the findings, 78 respondents (52.3%) had an adequate level of understanding, followed by 63 respondents (42.3%) in the poor category and 8 respondents (5.4%) in the good category. In the meanwhile, most students had a favorable opinion of STI prevention. Conclusion: Even though the majority of respondents expressed support for STI prevention initiatives, additional health education and instruction are still required to give students a more thorough grasp of STI prevention.
Chimney Thoracic Endovascular Aortic Repair (Tevar) in Stanford Type B Aortic Dissection Patient: First Time Procedure in Manado Paat Rigel; Tamburian Christha; Sukanto Wega; Tangkilisan Adrian; Satriadi Wayan
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.7946

Abstract

Aortic dissection is a cardiovascular emergency characterized by a tear in the aortic intima layer and the formation of a false lumen, posing risks of fatal complications such as rupture and organ malperfusion. Stanford type B dissections may be managed conservatively; however, complicated cases require intervention. Thoracic Endovascular Aortic Repair (TEVAR) has emerged as the preferred modality, offering lower perioperative morbidity and mortality compared to open surgery. To report the first TEVAR procedure performed in Manado on a patient with Stanford type B aortic dissection, highlighting the technical approach, operative challenges, and clinical outcomes. A 62-year-old male with a history of hypertension and chronic chest pain was referred following a CT angiography that revealed a Stanford type B aortic dissection with an entry site in the proximal descending aorta. TEVAR was performed with stent-graft placement in zone 2 and a chimney graft to preserve perfusion of the left subclavian artery (LSA). Intraoperative aortography confirmed false lumen exclusion without endoleak. The patient showed significant clinical improvement and recovered without postoperative complications. The procedure was technically and clinically successful, with no major complications. Postoperative evaluation confirmed stable stent position and maintained LSA perfusion. This case demonstrates that TEVAR can be safely implemented in non-tertiary regional hospitals with thorough preparation. The first TEVAR procedure in Manado illustrates that this technique can be an effective solution for complicated type B aortic dissections. This experience marks a milestone in the development of endovascular services in resource-limited settings and may serve as a reference for similar institutions in Indonesia.
Korelasi Pemeriksaan Antropometri Dasar dengan Tekanan Darah, Gangguan Metabolik, dan Fungsi Ginjal Olivia Charissa; Santoso, Alexander Halim; Wijaya, Bryan Anna
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.7976

Abstract

The increasing prevalence of metabolic syndrome and chronic kidney disease underscores the need for simple, low-cost, and community-applicable screening indicators. This study aimed to evaluate the association between basic anthropometric parameters and blood pressure, metabolic indicators, and renal function among adults in the Badui Luar community. A cross-sectional design was employed involving 41 participants who underwent anthropometric assessment, biochemical measurements, and blood pressure evaluation. Pearson correlation analysis was used to examine linear associations between variables. The results demonstrated that neck circumference exhibited significant correlations with dyslipidemia components, including LDL (r = 0.377), TC/HDL ratio (r = 0.516), and HDL (r = –0.433), indicating cervical adiposity as a strong marker of atherogenic risk. Calf circumference showed protective correlations with fasting glucose (r = –0.352) and eGFR (r = 0.322), suggesting the metabolic relevance of peripheral muscle mass in glycemic regulation and renal status. Body mass index showed a weak correlation with systolic blood pressure (r = 0.149), whereas waist and hip circumferences exhibited mild, clinically insignificant correlations with triglycerides and total cholesterol. Overall, these findings highlight that simple anthropometric measures—particularly neck and calf circumference—may serve as early indicators of cardiometabolic and renal risk in community-based screening. Further longitudinal studies with larger and more heterogeneous populations are required to validate these associations and determine the predictive power of anthropometric indicators.
Perbedaan Komposisi Tubuh Wanita di 3 Wilayah (Baduy Luar, Salatiga, dan Kota Bambu) Fadil Hidayat; Santoso, Alexander Halim; Wijaya, Bryan Anna
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.7977

Abstract

This study aimed to analyze differences in body composition among adult women across three regions with distinct sociocultural and environmental characteristics: Baduy Luar (rural–traditional), Salatiga (semi-urban), and Kota Bambu (urban). Using a cross-sectional design, the study involved 268 participants and assessed total body fat, visceral fat, subcutaneous fat, and skeletal muscle mass using the OMRON HBF-370 analyzer. Significant differences were observed across most body composition parameters (p < 0.001). Women living in the urban area exhibited the highest levels of total fat, visceral fat, and subcutaneous fat, reflecting the influence of urbanization and sedentary lifestyle on adiposity. Conversely, women in the rural–traditional community demonstrated the highest skeletal muscle mass across all body regions, consistent with their physically demanding daily activities and traditional dietary patterns. These findings highlight the substantial role of environmental context in shaping metabolic health and cardiometabolic risk. Targeted public-health interventions—such as structured physical-activity promotion and nutrition education in urban populations, and preservation of active lifestyles in rural communities—are recommended. Longitudinal studies are warranted to clarify causal pathways and further characterize metabolic determinants.
Korelasi Pola Makan dan Aktivitas Fisik dengan Derajat Dismenore Primer pada Remaja Putri Priska Meilinda Priardhana; Ardhiles Wahyu Kurniawan; Rif’atul Fani
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8027

Abstract

Adolescent girls represent a population that commonly experiences primary dysmenorrhea. Inadequate dietary habits may contribute to inflammatory responses, while low levels of physical activity can reduce the body’s natural pain regulation, both of which may intensify menstrual pain. This study aimed to analyze the association between dietary habits and physical activity with the severity of primary dysmenorrhea among adolescent girls. A quantitative correlational study with a cross-sectional design was conducted. Participants were selected using proportional random sampling, involving 71 eleventh-grade students at SMAN 6 Malang. Dietary intake was assessed using a FFQ, physical activity levels were measured through the PAL indicator, and dysmenorrhea severity was evaluated using the WaLIDD score. The results showed that nearly half of the respondents had adequate dietary habits (49.3%) and moderate physical activity levels (47.9%), while most participants experienced moderate primary dysmenorrhea (53.5%). Statistical analysis using Somers’ d and Gamma tests yielded p-values of 0.039 and <0.001, indicating significant associations between dietary habits, physical activity, and dysmenorrhea severity. Correlation analysis demonstrated a moderate inverse relationship between dietary habits and dysmenorrhea severity (r = −0.301) and a strong association between physical activity and dysmenorrhea severity (r = 0.690).
Spektrum Sindrom Stevens–Johnson dan Nekrolisis Epidermal Toksik: Tinjauan Patogenesis, Diagnosis, dan Tatalaksana Intan Wuri Handayani; Lusiana Lusiana; Hadi Firmansyah
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8082

Abstract

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening mucocutaneous reactions characterized by extensive epidermal necrolysis and mucosal involvement. The entities represent a clinical continuum distinguished by the extent of epidermal detachment (SJS <10% body surface area [BSA], SJS/TEN overlap 10–30%, TEN >30%). Most cases are drug-induced, making early culprit-drug withdrawal and structured supportive care the cornerstones of management. Immunopathogenesis is primarily mediated by drug-specific cytotoxic T cells and NK cells through granulysin, Fas–Fas ligand, and perforin/granzyme pathways, with emerging roles of necroptosis and candidate biomarkers such as RIP3 and galectin-7. Diagnosis relies on timely recognition of the characteristic painful erythematous/targetoid lesions, Nikolsky/Asboe–Hansen signs, multi-site mucositis, accurate BSA assessment, and early severity scoring (e.g., SCORTEN) to guide referral and monitoring. Systemic immunomodulators (corticosteroids, cyclosporine, IVIg, anti-TNF agents) have variable evidence; thus, individualized selection and early multidisciplinary care particularly ophthalmologic involvement are essential to reduce acute mortality and long-term sequelae.
Analisis Hubungan Gula Darah Puasa dengan Tekanan Darah pada Pasien Hipertensi dengan Komorbid Diabetes Mellitus Nurmaya Azzahra; Andi Kartini Eka Yanti; Hidajah Hidajah
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8148

Abstract

Hypertension and diabetes mellitus are two highly prevalent non-communicable diseases that often coexist as comorbidities, significantly increasing the risk of cardiovascular complications. The coexistence of these conditions accelerates the onset of atherosclerosis, diabetic nephropathy, and kidney failure, thereby requiring more comprehensive clinical management. One of the key parameters in diabetes management is fasting blood glucose (FBG), which reflects the balance of glucose metabolism after a fasting period. Chronic hyperglycemia is known to contribute to endothelial dysfunction, increased peripheral vascular resistance, and activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, ultimately leading to elevated blood pressure. This study employed a systematic literature review approach, analyzing articles published between 2021 and 2025. Narrative synthesis was conducted across various study designs, including cross-sectional, cohort, and meta-analysis studies. The findings indicate that most studies support a significant association between FBG levels and blood pressure, although some reported varying results. Cohort studies provide stronger evidence that elevated FBG increases the risk of new-onset hypertension. Age, treatment adherence, and lifestyle factors were also identified as confounding variables influencing outcomes. Overall, the evidence highlights that glycemic control through FBG monitoring is essential in managing hypertension among diabetic patients. Multidisciplinary strategies, patient education, and strengthening of primary healthcare services are required to reduce cardiovascular risks. Longitudinal studies are recommended to deepen the understanding of the relationship between FBG and blood pressure and to reinforce the scientific basis for evidence-based clinical interventions.

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