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Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE)
Published by Pusat Riset dan Inovasi Nasional
ISSN : 2828934X     EISSN : 28289358     DOI : https://doi.org/10.55606/jurrike.v1i2
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Jurnal Riset Rumpun Ilmu Kedokteran adalah jurnal yang ditujukan untuk publikasi artikel ilmiah yang diterbitkan oleh Pusat riset dan Inovasi Nasional, Universitas Sains dan Teknologi Komputer. Jurnal ini adalah jurnal Riset Rumpun Ilmu Kedokteran yang bersifat peer-review dan terbuka. Bidang kajian dalam jurnal ini termasuk sub rumpun Ilmu Kedokteran Spesialis, Ilmu Kedokteran Akademik, Spesialis Kedokteran gigi dan mulut, Kedokteran Gigi Akademik. Jurnal Riset Rumpun Ilmu Kedokteran menerima artikel dalam bahasa Inggris dan bahasa Indonesia dan diterbitkan 2 kali setahun: April dan Oktober.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 235 Documents
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Regulation of Fasting Blood Glucose, Insulin, and Homa-Ir in Relation to Malnutrition Among the Elderly: Mechanisms and Clinical Implications Kosasih, Robert; Sari, Triyana; Santoso, Alexander Halim; Jap, Ayleen Nathalie; Hartono, Vincent Aditya Budi; Syarifah, Andini Ghina
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5057

Abstract

Malnutrition significantly disrupts metabolic processes like fasting blood glucose (FBG) regulation, insulin secretion, and insulin resistance (HOMA-IR), especially among the elderly. Aging amplifies these effects through declining β-cell function, reduced insulin sensitivity, and chronic inflammation, increasing the risk of type 2 diabetes and cardiovascular diseases. Globally, malnutrition affects 22% of the elderly, with prevalence reaching 28% in Indonesia due to food insecurity, limited healthcare access, and poor nutrition education. Malnutrition exacerbates glucose-insulin imbalances by causing muscle loss, increasing FBG levels, and inducing insulin resistance through chronic inflammation. Despite its impact, critical knowledge gaps remain, particularly in low- and middle-income countries like Indonesia. This study investigates how malnutrition affects FBG, insulin levels, and HOMA-IR in elderly individuals, focusing on mechanisms like inflammation and muscle loss to inform targeted interventions and improve metabolic health in resource-limited settings. This cross-sectional study evaluated fasting blood glucose, insulin, and HOMA-IR among 31 elderly participants at Panti Werdha Santa Anna. The study found no significant differences in fasting blood glucose, fasting insulin, HOMA-IR, or HbA1c levels across Mini Nutritional Assessment categories (normal, at risk, malnourished; p > 0.05). These results suggest no strong association between nutritional status and metabolic parameters, highlighting the need for further research with larger samples. This study finds no significant association between nutritional status and glycemic control in the elderly, suggesting malnutrition's indirect impact via mechanisms like inflammation and muscle loss. Comprehensive nutritional assessments remain essential to understanding its effects on metabolic health.
Hubungan Perilaku Masyarakat dengan Penyakit Malaria di Puskesmas Koya Barat, Distrik Muara Tami, Kota Jayapura Konstantina Marthina Pariaribo
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5074

Abstract

Malaria is an infectious disease caused by Plasmodium sp which is transmitted by the Anopheles mosquito. The spread and endemicity of malaria is greatly influenced by the existence of breeding sites for Anopheles mosquitoes as a result of human behavior. Papua still has the highest malaria endemic status in Indonesia. West Koya Community Health Center, based on data from the Jayapura City Health Service, has the highest number of malaria cases with the highest API figure of the 13 Community Health Centers. The aim of the research was to determine the influence of community behavior on malaria at the Koya Barat Health Center. This type of analytical research uses a crosectional study. The population is 14,442 people who visited the Koya Barat Health Center in 2022, with a sample size of 100 people calculated based on the Slovin formula. Data were analyzed bivariately using the chi square test and risk factor analysis calculating prevalence ratio (RP) values ​​with confidence intervals (CI 95%). Based on the results of the chi square test, it was found that the knowledge variable had an influence with a ρ-value = 0.049 ≤ 0.05, meaning that there was an influence of the respondent's knowledge on the incidence of malaria. Risk analysis obtained RP = 1.441; 95% CI (0.783 – 1.854) which is interpreted to mean that respondents with poor knowledge have a 1.144 times chance of suffering from malaria compared to respondents with good knowledge but it is not significant because the lower and upper values ​​exceed 1. Meanwhile, the results obtained for the attitude and action variables have no effect on However, malaria is a risk factor because the RP value is > 1 but is not significant because the 95% CI exceeds 1. 
Gambaran Karakteristik Retinopati Diabetik pada Penderita Diabetes Melitus Tipe 2 Syu’a Al Madina; Muhammad Jabal Nur; Hikmah Hiromi Razak Datu
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5194

Abstract

Diabetic retinopathy is a microvascular complication that often occurs in people with type 2 diabetes mellitus and is a major cause of blindness in older adults and the elderly. This study aims to describe the characteristics of diabetic retinopathy in people with type 2 diabetes mellitus through a literature review of 10 journals published between 2022 and 2025. The results of the analysis show that the prevalence of diabetic retinopathy globally reaches 35%, with the main risk factors including long duration of diabetes (>5 years), high HbA1c levels (>7%), and poor glycemic control. The majority of cases of diabetic retinopathy are found in the non-proliferative stage (65%), which is characterized by microaneurysms and retinal hemorrhages, while the proliferative stage is less common but has a high risk of causing blindness. The study also revealed that patients with comorbidities such as hypertension and dyslipidemia tend to experience more severe diabetic retinopathy. Further stages of diabetic retinopathy if not managed properly can cause vision-threatening conditions. However, low patient compliance in metabolic control and eye examination is a major challenge. Management of diabetic retinopathy requires a holistic approach that includes patient education, regular screening, and comprehensive risk factor control to prevent progression of diabetic retinopathy and maintain the quality of life of patients with type 2 diabetes mellitus.
Formulasi Sediaan Gel Variasi Konsentrasi Ekstrak dan Limbah Bunga Mawar Merah (Rosa damascena Mill.) Diyan Sakti Purwanto; Dewi Weni Sari; Diana Tanafasa
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5197

Abstract

Red roses (Rosa damascena Mill.) are known to contain active compounds such as flavonoids, tannins, and vitamin C, which have potential antioxidant and anti-inflammatory properties. However, the utilization of rose flower waste after extraction remains limited. This study aims to formulate and evaluate gel preparations based on red rose extract and post-extraction rose flower waste as an innovation in natural-based topical formulations. This research is an experimental laboratory study using a post-test only design. Three concentration variations were formulated for both the extract (F1, F2, F3) and rose flower waste (F4, F5, F6) using HPMC as the gel base. Physical evaluations included organoleptic testing, homogeneity, pH, adhesion, spreadability, and viscosity. Data were analyzed descriptively and statistically using the Kruskal–Wallis test to determine the effect of concentration variation on physical parameters. All formulations showed good organoleptic and homogeneity results. The pH values were within the safe range for skin (4.75–5.92). Adhesion times met the criteria of >1 second, with a tendency to increase alongside higher concentrations of active ingredients. Spreadability fell within the acceptable range (3–5 cm), decreasing as viscosity increased. The viscosity values ranged from 20,150 to 20,182 cps. There was a significant effect of concentration variation on pH (p < 0.05), adhesion in extract-based gels (p = 0.021), and spreadability in waste-based gels (p = 0.024). In conclusion, gel preparations made from red rose extract and its waste can be successfully formulated with good physical stability and meet standard criteria for topical formulations. Rose flower waste has potential as an alternative active ingredient in the development of natural-based gel products.
Peran Antioksidan dan Agen Antiinflamasi dalam Proses Penyembuhan Luka Bakar Nining Nurnanengsih; Fendy Dwimartyono; Adliah Purnawaty Harifuddin
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5271

Abstract

Burns are tissue damage or loss that occurs due to direct exposure to heat sources such as fire, hot liquids or fats, hot steam, radiation, electricity, or chemicals. The process of healing burns is a complex and long-lasting process and involves a repair process that depends on the immune system, there are three stages, namely: inflammation, formation of granulation tissue (proliferation), and remodeling (which can result in scarring). Research objectives and methods to determine the role of antioxidants and anti-inflammatory agents in the burn wound healing process by searching both international and national literature using databases such as PubMed, Google Scholar, ScienceDirect and Elsevier. Based on the results of a literature study from several journals, 3 research journals were obtained that discussed several plants that contain substances that can act as antioxidants and anti-inflammatory agents in the process of healing burns. The following are the results of screening of the journals, including betel leaves (Piper betleLinn.), Aloe Vera (Aloe Vera), Binahong Leaves (Anredera Cordifolia Tenn) have phenolic compounds contained in them, namely flavonoids, alkaloids, tannins, essential oils, saponins, monoterpenes, polyphenols, and steroids that have the potential as antioxidants, antibacterials, anti-have very good effects in the advanced phase, proliferation phase and remodeling phase which play an important role in reducing, shortening, changing the size of the wound edge distance and accelerating wound healing. Based on the results of the review of these journals, it proves the role of antioxidants and anti-inflammatory agents in the process of healing burns.
Formulasi Mie Kering Bahan Dasar Ikan Kembung dan Bayam Hijau sebagai Pangan Balita Stunting Maria Magdalena Fetowin; Melanie Christine Kamo; Nurhayati Prinanda Putri Embisa; Sarah Petronela Demena; Nia Budhi Astuti
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5441

Abstract

Stunting remains one of the major nutritional problems in Indonesia. According to the 2024 Indonesian Health Survey (SKI), the prevalence of stunting in Papua Province reached 16.8%. A child’s nutritional status is strongly influenced by dietary intake, particularly protein, which plays a crucial role in growth. One potential source of animal protein is Indian mackerel (Rastrelliger kanagurta), a type of fish commonly found in Papua. Indian mackerel is rich in protein and omega-3 fatty acids but is highly perishable, limiting its shelf life. To address this issue, the fish is processed into flour. Additionally, green spinach is used as a source of fiber and minerals, although it is also prone to spoilage. The spinach is processed by extracting its juice, which is then incorporated into noodle products. Dried noodles were chosen as a medium for fortification because they are widely consumed across age groups and often used as a substitute for rice.This study aimed to determine the effect of adding Indian mackerel flour and green spinach extract on the chemical properties and sensory acceptance of dried noodles. The research methods included nutritional content analysis and organoleptic testing. The sensory evaluation was conducted by 25 semi-trained panelists who were nutrition science students
Uji Organoleptik Teh Herbal Kulit Buah Naga (Hylocereus Polyrhizus) Kombinasi Jahe (Zingiber Officinale) sebagai Minuman Alternatif Tinggi Antioksidan Meilan Cefinaayu Mayor; Yusvin Sampe; Jane Josina Antje Wambrauw; Riska Salenda Wandik; Endah Sri Rahayu; Ferry Wicaksono
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5443

Abstract

This study aimed to evaluate the organoleptic characteristics of herbal tea made from a combination of red dragon fruit peel (Hylocereus polyrhizus) with red ginger and white ginger. The herbal tea was formulated into six variants (F1a, F2a, F3a, F1b, F2b, F3b) based on different proportions of dragon fruit peel and tested using a hedonic method for three parameters: color, aroma, and taste. A total of 25 trained panelists assessed the level of preference using a 5-point hedonic scale. The results showed that Formula F3 (with the highest proportion of dragon fruit peel) received the highest acceptance scores. For color, F3 received an average of 19% in the “strongly like” category and 5% in the “like” category. For taste, F3 received 4% “strongly like” and 12% “like.” For aroma, F3 received 7% “strongly like” and 11% “like.” Thus, F3 was identified as the best organoleptic formula and is recommended for further development. This study suggests that additional research is needed to analyze the antioxidant activity of the product to better understand its functional health benefits.
Gel Kombinasi Ekstrak Daun Meniran (Phyllanthus niruri L.) dan Daun Kenikir (Cosmos caudatus Kunth) terhadap Penyembuhan Luka Sayatan Abidah, Anisa Nur; Kusuma, Eka Wisnu; Suyono , Alip Desi
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5628

Abstract

Daun meniran dan daun kenikir adalah tanaman herbal yang bermanfaat dalam menyembuhkan luka sayat. Manfaat tersebut didukung senyawa yang terkandung didalam daun meniran dan daun kenikir yaitu saponin, flavonoid, alkaloid, tannin, steroid, terpenoid. Penelitian bertujuan untuk melihat kecepatan proses penyembuhan luka sayatan dengan menggunakan gel kombinasi ekstrak daun meniran dan daun kenikir. Hewan percobaan yang digunakan berupa tikus putih jantan, berjumlah 25 ekor dengan masing-masing kelompok perlakuan berjumlah 5 ekor yaitu kelompok kontrol positif (Bioplacenton®), kontrol negatif (basis), dan kelompok perlakuan variasi kombinasi ekstrak daun meniran : daun kenikir (10%:15%,15% :10%,20%:5%). Pengamatan dilakukan selama 14 hari, kemudian data yang didapatkan diolah dengan One Way Anova dan post hock test tukey. Hasil yang didapatkan dalam penelitian menunjukkan formula yang mampu memberikan kesembuhan luka paling cepat adalah formula 1 dengan variasi konsentrasi ekstrak daun meniran : daun kenikir 10%:15%, yaitu pada hari ke 4.
Ekstraksi dan Identifikasi Metabolit Sekunder Tanaman Obat sebagai Antimalaria di Kabupaten Keerom Dehi, Rosita Irianti; Iriani, Fitriah Ardiawijianti; Damar, Alpha Christyananda
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5699

Abstract

Malaria remains a significant public health issue in Indonesia, particularly in endemic areas such as Keerom Regency, Papua. Efforts to control this disease face challenges due to Plasmodium resistance to synthetic drugs, highlighting the need for safer and more effective alternative treatments. This study aims to identify the secondary metabolite content of several local plants traditionally used as antimalarial remedies. An experimental laboratory study was conducted using phytochemical screening methods. The plants examined included turmeric rhizome (Curcuma longa), meniran leaves (Phyllanthus niruri), papaya leaves (Carica papaya), sambiloto (Andrographis paniculata), and brotowali (Tinospora crispa). Extraction was carried out using the maceration method with 96% ethanol as the solvent. The results showed that all samples contained secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which are known for their antiplasmodial activity. Extract yields ranged from 18% to 24%, with turmeric rhizome showing the highest yield. These findings suggest that local plants from Keerom Regency hold potential as raw materials for the development of herbal antimalarial drugs. This study serves as a preliminary step for further in vitro and in vivo bioactivity testing.
Tinjauan Literatur : Determinan Stunting Pada 1000 Hari Pertama Kehidupan Anak Yudhistirana; Mona Nulanda; Maya Susanti
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5723

Abstract

Stunting is a growth disorder in children characterized by height-for-age below the standard due to prolonged nutritional deficiency. This condition affects physical development, learning ability, and metabolic health, and it tends to be persistent. In Indonesia, the prevalence of stunting remains high. This study was conducted to identify the causes of stunting during the first 1,000 days of life. The method used was a literature review with a narrative review approach. The results show that risk factors for stunting include prenatal conditions such as low birth weight, maternal nutritional status during pregnancy, and maternal height. In addition, low maternal education, limited access to healthcare services, lack of exclusive breastfeeding, infections, and poor dietary patterns also contribute. Strategies proven effective according to the literature include early nutrition education, nutritional supplementation, and technology-based growth monitoring. The most consistently identified determinant is low birth weight (LBW).

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