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Program Studi Farmasi UNAJA Jl. Sersan Muslim RT.24 Kelurahan Thehok Kecamatan jambi Selatan 081334089241 (Septa Pratama) Kota Jambi, Jambi , Indonesia lppm@unaja.ac.id 081334089241 (Septa Pratama)
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PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Published by Universitas Adiwangsa Jambi
ISSN : -     EISSN : 28306090     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmanaja : Pharmaceutical Journal of Unaja merupakan jurnal elektronik yang dikelola Program Studi Farmasi Universitas Adiwangsa Jambi. jurnal ini merupakan media publikasi hasil penelitian dan review artikel pada semua aspek ilmu Farmasi yang bersifat inovatif, kreatif, Original, dan didasarkan pada scientific dalam bidang kajian farmasi klinis komunitas, farmasi bahan alam, kimia farmasi, teknologi farmasi, farmakologi, toksikologi, managemen farmasi, farmasi umum, mikrobiologi farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 44 Documents
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Uji Aktivitas Anti Helmentik Infusa Daun Papaya (Carica papaya L.) terhadap Cacing Ascaris suum (Studi Invitro) Dhanny Jovindho
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Penelitian ini bertujuan untuk mengevaluasi aktivitas antihelmintik infusa daun pepaya (Carica papaya L.) terhadap cacing Ascaris suum secara in vitro. Ascaris suum merupakan salah satu parasit nematoda gastrointestinal yang umum menginfeksi hewan ternak dan memiliki kemiripan fisiologis dengan Ascaris lumbricoides pada manusia. Penggunaan obat sintetik sebagai antihelmintik telah banyak dilaporkan menimbulkan resistensi serta efek samping, sehingga diperlukan alternatif dari bahan alam yang lebih aman dan efektif. Daun pepaya diketahui mengandung senyawa aktif seperti papain, flavonoid, tanin, dan alkaloid yang memiliki potensi sebagai agen antihelmintik. Metode yang digunakan dalam penelitian ini meliputi pembuatan infusa daun pepaya dalam berbagai konsentrasi (10%, 20%, 40%, dan 80%), kemudian dilakukan pengamatan terhadap mortalitas cacing A. suum pada waktu pengamatan 1, 3, 6, dan 12 jam. Hasil penelitian menunjukkan bahwa infusa daun pepaya memiliki aktivitas antihelmintik yang signifikan secara konsentrasi dan waktu paparan, dengan konsentrasi 80% menunjukkan efektivitas tertinggi yang setara dengan kontrol positif (piperazin sitrat). Uji statistik menunjukkan perbedaan bermakna (p<0,05) antara kelompok perlakuan dan kontrol negatif. Penelitian ini membuktikan bahwa daun pepaya berpotensi dikembangkan sebagai kandidat bahan alam untuk terapi antihelmintik.
Pengaruh Penggunaan BB Cream terhadap Kejadian Acne Vulgaris pada Mahasiswa Ari Denggan Syahputra
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Background: The use of cosmetics such as BB Cream has become increasingly common among university students, particularly females, due to its ability to provide even skin tone and a radiant appearance. However, the active ingredients and occlusive agents in BB Cream are suspected to trigger or exacerbate acne vulgaris, especially in individuals with oily or sensitive skin types. Objective: This study aimed to analyze the effect of BB Cream usage on the incidence of acne vulgaris among university students. Methods: This was an analytical observational study employing a cross-sectional design. The sample consisted of 120 female university students aged 18–24 years, selected using purposive sampling. Data were collected through structured questionnaires addressing frequency and duration of BB Cream usage, as well as dermatological clinical examinations to assess the severity of acne vulgaris. Data analysis was conducted using chi-square tests and logistic regression. Results: The findings revealed a significant association between frequent BB Cream usage (≥5 times per week) and an increased incidence of acne vulgaris (p < 0.05; OR: 2.34; 95% CI: 1.21–4.51). Moreover, usage duration longer than three months was positively correlated with acne severity. Conclusion: Frequent and prolonged use of BB Cream significantly contributes to the increased occurrence of acne vulgaris in university students. These findings highlight the need for education on appropriate cosmetic use tailored to individual skin types to prevent adverse skin health outcomes.
Pengaruh Ekstrak Daun Teh terhadap Morfologi Spermatozoa Mencit Jantan Galur Wistar yang diberi paparan asap rokok Ezra John Pieter Limbong
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Penelitian ini bertujuan untuk mengevaluasi pengaruh ekstrak daun teh (Camellia sinensis) terhadap morfologi spermatozoa mencit jantan (Mus musculus) galur Wistar yang terpapar asap rokok. Sebanyak 25 ekor mencit dibagi menjadi lima kelompok perlakuan: kontrol negatif (tanpa perlakuan), paparan asap rokok saja, serta tiga kelompok perlakuan kombinasi asap rokok dengan ekstrak daun teh masing-masing pada dosis 100, 200, dan 400 mg/kgBB. Paparan asap rokok dilakukan selama 30 menit setiap hari selama 30 hari, bersamaan dengan pemberian ekstrak secara oral. Parameter yang diamati meliputi abnormalitas morfologi spermatozoa, vitalitas spermatozoa, berat testis, dan struktur histologis testis. Hasil menunjukkan bahwa kelompok yang hanya terpapar asap rokok mengalami peningkatan signifikan pada abnormalitas morfologi spermatozoa (29,8%) dibandingkan kelompok kontrol (7,4%). Pemberian ekstrak daun teh secara signifikan menurunkan abnormalitas tersebut secara dosis-respons, dengan dosis 400 mg/kgBB menunjukkan perbaikan paling optimal pada semua parameter yang diamati. Penelitian ini menyimpulkan bahwa ekstrak daun teh memiliki potensi sebagai agen protektif terhadap kerusakan morfologi spermatozoa dan jaringan testis akibat paparan asap rokok. Temuan ini memberikan dasar ilmiah untuk pengembangan terapi berbasis antioksidan alami dalam menjaga kesehatan reproduksi pria.
EVALUASI PENGGUNAAN OBAT ANTIHISTAMIN PADA PASIEN PENYAKIT KULIT DI APOTEK GEJAYAN DEPOK SLEMAN Qarriy Aina Urfiyya; Danang Yulianto; Rita Nur Fitriana
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract Background: Skin disease was included in the top ten diseases at the Yogyakarta regional health center in 2014. Skin disease can be caused by infection or allergies. One of the drugs used to treat skin diseases is antihistamines. Objective: To evaluate the use of antihistamines in patients with skin diseases at the Gejayan Pharmacy, Depok, Sleman for the November-December 2021 period. Method: This study used an analytic observational method, with retrospective data collection. Sampling used a purposive technique on prescriptions and medical records of skin disease patients for the November-December 2021 period, a total of 286 samples. Data were analyzed descriptively quantitatively on patient characteristics, use of antihistamines, and evaluation of the use of antihistamines in terms of the right drug and the right dose. Results: The results of this study showed that there were 84.3% of skin disease patients aged 15-64 years, and 15.7% aged ≥ 65 years. Patients with female sex of 57.7% and male by 42.3%. The highest patient diagnoses were contact dermatitis at 24.5%, atopic dermatitis at 12.9% and urticaria at 10.1%. The most widely used type of antihistamine drug was CTM with 22.7%, followed by ryzicor with 17.1% and river with 9.1%. Conclusion: Evaluation of drug use based on the right drug is 96.8% and the right dose is 100%.
PERBANDINGAN KADAR KLOROFIL DAN KAROTENOID DAUN SIRIH MERAH (piper betle) DAN SIRIH HIJAU (Piper ornatum) MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-Vis Yulianto, Danang
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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ABSTRACT Background: One of the plants that is widely known by the public is betel. Betel is a plant that has been widely used as medicine in Southeast Asia. Betel in Indonesia there are several types, which are distinguished by the shape of the leaves, taste and aroma, namely green betel, banda betel, clove betel, black betel and red betel. Green betel leaf (Piper betle) and red betel leaf (Piper ornatum) contain important components, namely chlorophyll and carotenoids. Objectives : this study aims to compare the levels of chlorophyll and carotenoids in red betel and green betel. Metode: Penelitian ini dilakukan dengan menggunakan sirih merah dan daun sirih hijau, 80% aseton dan air suling serta membaca absorbansinya menggunakan Metode Spektrofotometri UV-Vis pada panjang gelombang 663; 645; 480nm. Hasil: Daun sirih merah memiliki kandungan klorofil sebesar 81,25 mg/L dan daun sirih hijau sebesar 0,350 mg/L. Kandungan karotenoid daun sirih merah sebesar 35,07 mg/L dan daun sirih hijau sebesar 1,956 mg/L. Kesimpulan: penelitian ini menunjukkan bahwa daun sirih merah (Piper ornatum) memiliki kandungan klorofil yang lebih tinggi yaitu 81,25 mg/L sedangkan kandungan klorofil daun sirih hijau (Piper betle) sebesar 0,350 mg/L. Kandungan karotenoid daun sirih merah (Piper ornatum) lebih tinggi 35,07 mg/L dibandingkan daun sirih hijau (Piper betle) yang sebesar 1,956 mg/L. Kata kunci: Green betel, red betel, chlorophyll, carotenoids
Mekanisme Kerja Obat Antihipertensi Yang Bekerja Pada GPCRs dan Tanaman Yang Berpotensi Sebagai Antihipertensi Khutami, Chindiana
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Hypertension is the medical term for patients with systolic blood pressure above 140 mmHg and diastolic above 100 mmHg. Hypertension is a complex multifactorial disease that contributes to the main causes of morbidity and mortality in industrialized countries: ischemic heart disease and hypertension, stroke, peripheral atherosclerosis and renal failure. Commonly used antihypertensives are usually associated with many side effects. In the last three decades, many concerted efforts have been made to research local plants with hypotensive and antihypertensive therapeutic value. The hypotensive and antihypertensive effects of some of these medicinal plants have been validated and others have not been proven. G-protein coupled-receptors or GPCRs are targets of drug action, whose signaling is mediated by G-proteins. GPCRs are receptors that reside on the cell surface and have seven transmembrane domains. For example, GPR35 is a target for furosemide and bumetanide. This is especially important in cardiovascular disease secondary to hypertension, where the degree of vessel constriction is partly due to increased levels of agonists such as catecholamines and angiotensin II.
GAMBARAN POLA PERESEPAN OBAT DIARE PADA PASIEN ANAK DI RSUD H. ABDUL MANAP JAMBI PERIODE JANUARI – MARET TAHUN 2022 Supriadi; Dahlan, Ahmad
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Diarrhea is the second leading cause of death in children under five years old. Globally, there are 1.7 billion cases of diarrhea every year and around 525,000 children die each year. Objective of this study is to describe the pattern of diarrhea drug prescribing in children based on the type of drug and other therapeutic drug classes. The type of research used is descriptive quantitative. The population and sample in this study were all prescription sheets of pediatric patients with a diagnosis of diarrhea, namely there were 26 patient prescriptions and the method used in this study was saturated sampling. The results of the study of 26 pediatric patients showed that the most commonly prescribed diarrhea drugs were zinc and L-Bio (36.5%). Based on other therapeutic drug groups, the highest percentage of drug use is Antiemitics (100.0%). In Conclusion, Diarrhea drug prescribing based on the type of diarrhea medication that was most often prescribed was Zinc and L-Bio, each amounting to (36.5%). Other Therapeutic Drugs that are widely used or combined with children's diarrhea
DESCRIPTION OF THE LEVEL OF COMMUNITY KNOWLEDGE ABOUT THE USE OF COUGH DRUGS IN THE HAMLET OF KRAGAN, GRABAG, MAGELANG FEBRUARY 2022 Hastuti, Dwi
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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ABSTRACT Background: The prevalence of cough is 15% in children and 20% in adults. The knowledge obtained shows that respondents who have a good level of knowledge about cough medicine self- medication are 45% while people with a low level of knowledge are 15%. Objective: This study aims to describe the level of public knowledge about the use of cough medicine in Kragan Hamlet, Grabag, Magelang. Method: This research method is descriptive observational with data collection using purposive sampling. The population in this study is the community in Kragan Hamlet, Grabag, Magelang, aged 17-55 years, the data used is primary data collected with a questionnaire instrument. The data were analyzed by calculating the percentage value of correct answers in the questionnaire section, then the level of knowledge was categorized into good, sufficient, poor categories. Results: The results showed that the level of public knowledge about the use of cough medicine in the good category was 26 respondents (32%), 31 respondents (38%) sufficient and 24 respondents (29%). Conclusion: The conclusion in this study was that the majority of the community's level of knowledge about the use of cough medicine in Kragan Hamlet, Grabag, Magelang was categorized as sufficient.
Analisis Bahan Kimia Obat Parasetamol pada Jamu Pegal Linu yang dijual di Kecamatan Pasar Jambi, Kota Jambi Siti Marwah Lestari; Widya Twiny Rizki; Rahmadevi; Nindi Sepdina Yanti
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Background: Chemical drugs that were often added to pegal linu herbal medicine was paracetamol. Paracetamol added as analgesic. Objective: This study aims to analyze qualitatively the content of Paracetamol in the pegal linu herbal medicine, which is sold in Pasar Jambi District, Jambi City. Method: This study was conducted qualitatively, samples were taken by purposive sampling, and 8 samples (SA, SB, SC, SD, SE, SF, SG, and SH) were selected from pegal linu medicine that met the inclusive criteria. Samples were tested organoleptically, microscopically, spot test, and TLC. Results: In the organoleptic test, all herbs were in powder form, SA had a brownish-yellow color with an aromatic odor, SB had a light brown color with an aromatic odor, SC had a greenish-brown color with an aromatic odor, SD had a light brown color with an aromatic odor, SE had a yellowish-brown color with an aromatic odor, SF has a yellowish-brown color with an aromatic odor, SG has a light brown color with an aromatic odor, SH has a greenish-brown color with an aromatic odor. In the spot test, no herbs were found that had the same color reaction as paracetamol. In the TLC test, there were several herbs that had the same Rf value as standard paracetamol. In the 1st, 2nd, and 3rd tests, the Rf value of paracetamol respectively were 0.36; 0.33; and 0.40. Meanwhile, in the sample, it was found that the Rf value was the same as that of paracetamol. In the first test, the samples coded SD and SG, in the second test there were none, in the third test, the herbal medicine samples coded SC and SD. Conclusion: Pegal linu herbal medicine didn’t contain paracetamol.
Uji Efektifitas ekstrak Daun Beluntas (Plucea indica L.) Untuk Kelancaran Pengeluaran ASI Pada Masa Menyusui Tikus Galur Wistar (Rattus Norvegicus) Betina Fransiskus Aryo Pratomo
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 3 No. 1 (2024): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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This study aimed to evaluate the effectiveness of Pluchea indica (beluntas) leaf extract in promoting breast milk secretion during the lactation period in female Wistar rats (Rattus norvegicus). The experimental research was conducted at Universitas Adiwangsa Jambi using 24 lactating rats, randomly assigned into four groups: a negative control group (distilled water), a positive control group (commercial lactation booster), and two treatment groups receiving Pluchea indica extract at doses of 200 mg/kg BW and 400 mg/kg BW, respectively. The treatment was administered for 14 consecutive days during the lactation period. Parameters observed included the body weight gain of the pups as an indirect indicator of milk production, along with maternal nursing behavior and physiological conditions.The results demonstrated that administration of Pluchea indica extract, particularly at 400 mg/kg BW, significantly increased (p<0.05) pup body weight compared to the negative control group and showed comparable effectiveness to the positive control group. No signs of toxicity or disruption in maternal behavior were observed throughout the study. In conclusion, Pluchea indica leaf extract shows potential as a natural galactagogue agent that effectively enhances milk production, and it may serve as a promising phytopharmaceutical candidate to support maternal lactation health.

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