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Nusantara Scientific Medical Research Journal
Published by Nusantara Scientific Medical
ISSN : -     EISSN : 29853508     DOI : https://doi.org/10.58549/nsmrj.v2i01.35
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Veterinary
Nusantara Scientific Medical Research Journal (E-ISSN: 2985-3508) is a journal that publishes Focus & Scope research articles, which include: Dentistry Nursery Midwifery Pharmacy Medical Science Biology Chemistry Nutraseutical Functional Food This journal is published by the Nusantara Scientific Medical, which is published April, August and December.
Arjuna Subject : Kedokteran - Farmakologi (Medis)
Articles 23 Documents
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Leukocyte Differentiation Mice (Mus Musculus) Infected with Plasmodium Berghei after Therapy With Sargassum Duplicatum Extract Abdul M Ukratalo; Suyono Lateke
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 01 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (472.787 KB) | DOI: 10.58549/nsmrj.v2i01.29

Abstract

Leukocytes are white blood cells produced by hematopoietic tissue that serves to help the body fight various infectious diseases as part of the immune system. Sargassum duplicatum contains steroid, alkaloid, phenol, flavonoid, saponin, and tannin compounds that can be immunomodulatory. The purpose of this research is to know the effect of methane extract of brown algae Sargassum duplicatum on the differentiation of leukocyte mice (Mus musculus) infected with Plasmodium berghei. Mice weighing 20-30 grams in Plasmodium berghei infection as much as 0.1 ml per head and left to the percentage of parasitemia reaches 1-5%. Then the mice (Mus musculus) were given brown algae methanol extract (Sargassum duplicatum) at doses 10, 100, and 200 mg / g BW for 4 consecutive days. From day 0 to 6 also made a blood smear to calculate the number of leukocytes. Data analysis will be done using ANOVA. The results showed that the administration of brown algae extracts of Sargassum duplicatum influenced in increasing the number of neutrophils, monocytes, and basophils and decreased the number of eosinophils and lymphocytes of mice infected with Plasmodium berghei to near normal range. Dose 200 mg/kg BB methanol extract of brown alga Sargassum duplicatum is a dose that can affect the number of neutrophils, eosinophils, lymphocytes, and monocytes of mice infected with Plasmodium berghei most closely to normal range.
The Effect of Hypertension Exercise on Blood Pressure Reduction in The Elderly at Wisma Seruni UPT PSTW Jember Riski Hidayaturrohkim; Echi Agnes Claudia; Yuzqi Rizqullah; Dimas Anggi Septiyansah; Nanda Leoni Agustin; Fahruddin Kurdi; Septin Wahyu Ersanti
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 01 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.16 KB) | DOI: 10.58549/nsmrj.v2i01.33

Abstract

As the elderly population increases and the aging process they experience, triggers the occurrence of various diseases, especially hypertension. Improper management of hypertension causes a decrease in quality of life and morbidity in the elderly. This study aims to determine the effect of hypertension exercise on the blood pressure of the elderly at Wisma Seruni UPT PSTW Jember. The design of this study used a quasi-experimental with pretest and posttest one group design. The sampling technique used was a total of 8 respondents who met the inclusion criteria. Changes in blood pressure were measured using an aneroid sphygmomanometer and data analysis using the statistical test T-Test Dependent. The results showed that the average systolic blood pressure (SBP) before the first day of therapy was 147.5 mmHg and the second day 138.75 mmHg while the average systolic blood pressure after the elderly hypertension exercise was carried out on the first day of 140 mmHg and the second day 131.25 mmHg, the average diastolic blood pressure (DBP) before the first and second day of therapy was 84.38 mmHg while after the first day of therapy it was 82.5 mmHg and the second day was 80.63 mmHg. Based on the results of the analysis test using the dependent t-test, the SBP results before and after the intervention were 0.000 (p<0.005). There was an effect on the decrease in systolic blood pressure on the first and second day of intervention. Hypertension exercise therapy is an alternative solution to reduce blood pressure in the elderly with hypertension.
Management of Angular Cheilitis in Elderly Patients Erine Tita Febrine; Yassir Ahmad Azzaim
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 01 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.767 KB) | DOI: 10.58549/nsmrj.v2i01.35

Abstract

Angular cheilitis is a common variant of candidal infection affecting the elderly population. Angular cheilitis is an inflammatory lesion characterized by erythema, ulceration, and crusting at the corners of the mouth that begins at the junctional mucocutaneous and extends to the skin surface. Angular cheilitis occurs not only due to candidiasis but also due to reduced occlusal vertical dimensions or due to nutritional deficiencies, such as vitamin B or iron deficiency. The causes of Angular cheilitis are multifactorial of local and systemic etiology. To know the management of Angular cheilitis in elderly patient. Angular cheilitis in elderly patient with decrease of vertical dimension can be treated by local therapy. But eldery patient with multiple underlying systemic and local factors need interdisciplinary management because the symptoms will only reoccur if local factors or systemic factors are not managed.
Formulation and Effectiveness Testing of Mosquito Repellent Spray Combination of Citrusev Oil (Cymbopogon nardus) and Patchouli Oil (Pogostemon cablin) Widya Ariati
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 01 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.281 KB) | DOI: 10.58549/nsmrj.v2i01.65

Abstract

Dengue fever is a health problem caused by the dengue virus dengue virus whose problem has not been resolved. Various attempts have been made to prevent dengue fever, one of which is chemical-based insecticides, but the use of chemicals can cause side effects ranging from mild to severe. The purpose of this study was to increase the use of natural ingredients as an alternative to mosquito repellents to minimize side effects and determine the effectiveness of the spray repelency against Aedes aegypti mosquitoes. This research method used an experimental approach using 20 mosquitoes, which were divided into five groups, namely formulation I (10% lemonggrass oil and 2% pathouli oil), formulation II (10% lemonggrass oil and 4% pathouli oil), formulation III (10% lemonggrass oil and 6% pathouli oil), control (-) ( propylene glycol and ethanol 96%) and control (+) (soffel spray) were each given the same treatment. The mist was sprayed on the arm, put in the test cage, and counted the number of mosquitoes perched on the arm for 5 minutes. The percentage of mosquito repellent power in fomulation I am 69%, formulation II is 76%, formulation III is 92%. The data were analyzed by using one-way ANOVA using the LSD (least significant difference) test; there were substantial differences between the treatment group and the level of effevtiveness of the repulsion againts the Aedes aegypti mosquito.
Antioxidant Activity Test of Caulerpa racemosa Extract from Takalar District Using the FRAP (Ferric Reducing Antioxidant Power) Method Andi Ulfiana Utari; Nurhikma A; Eka Astuti
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 01 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.305 KB) | DOI: 10.58549/nsmrj.v2i01.67

Abstract

Sea grapes or Caulerpa racemosa contain alkaloids, flavonoids, tannins, phenols and steroids. These compositions work as antioxidants. Antioxidants are compounds that can contribute one or more electrons to free radicals, so that the free radicals can be suppressed. The goal of this study was to determine the antioxidant activity of sea grape (Caulerpa racemosa) extract using the FRAP method. Extraction of sea grapes (Caulerpa racemosa) applied maceration and methanol methods. Absorbance of antioxidant activity was measured using a UV-VIS spectrophotometer at a wavelength of 700 nm. The results showed that sea grape extract (Caulerpa racemosa) had an antioxidant activity of 152 mg AAE/g extract. It means that in each gram of extract, it is equivalent to 152 mg of ascorbic acid.
Antioxidant Effectiveness Test on The Formulation of Combination Facial Soap Ingredients of Ethanol Extract Lemon Peel Citrus limon and Forest Honey Apis dorsata Sriyanty Sadsyam; Nasrawati Basir; Arafah Nurfadillah; Nurhikmah Awaluddin; Selviana
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 01 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (591.56 KB) | DOI: 10.58549/nsmrj.v2i01.69

Abstract

Citrus limon and Apis dorsata are claimed to have several active compounds namely: alkaloids, flavonoids, tannins and saponins. These compounds are known to have antioxidant activity in preventing skin damage due to free radicals and preventing premature aging. In this study, Citrus limon and Apis dorsata were formulated into facial soap ingredients. The purpose of this study was to find out whether the ethanol extract formulation in the lemon peel and the Apis dorsata forest honey has the effectiveness of antioxidants in preventing the free radicals. This research was an experimental study with physical and chemical evaluation of ingredients. The DPPH test was used to determine the antioxidant activity of the ingredients. This research used three types of formulation of Ethanol Ethanol Extract Formulation were lemon and honey forest, they were : FI (5%: 2%); FII (5%: 3%) and FIII (5%: 4%). The results of the DPPH test respectively were FI 6,16; FII 5,53 and FIII 4.39. The ingredients of Facial Soap Combination of Ethanol Extract Lemon Feel and Apis dorsata had the best antioxidant and antioxidant energy in Formula III with concentration of 5%: 4%
Lip Cream Formulation from Miana Leaf Extract (Coleus scutellarioides L.) As A Natural Dye Vera Estefania Kaban; Nasri Nasri; Hariyadi Dharmawan Syahputra; Junius Gian Ginting
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 02 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v2i02.80

Abstract

Abstrack The miana leaves (Coleus scutellarioides L.) contain flavonoids that can provide specific dyes. The purpose of the study was to formulate miana leaf extract in lip cream preparations as natural dyes. The use of natural lip cream dyes is a solution to overcome the problem of synthetic lip cream dyes. One of the plants such as the miana leaves contains secondary metabolites, one of which is flavonoids which can provide dyes. The natural colors found in miana leaves can be used as natural dyes in cosmetics. The purpose of the study was to determine at what concentration the miana leaves produced the most optimal physical quality of color in the preparation of lip cream. The method of the research includes the manufacture of ethanol extract of miana leaves (Coleus scutellarioides L.) by maceration for 5 days with 96% ethanol solvent and followed by remeseration with the same solvent. The extract formulas used were 5%, 10%, and 15%. The evaluations included organoleptic, homogeneity test, physical test, pH test, irritation test and color preference test. The results of the lip cream preparation, the results of the organoleptic examination were declared to have a semi-solid dosage form, a distinctive odor and varied colors F1, cream color, F2 salmon red, F3 brick red, homogeneity examination results were declared homogeneous, the results of observation of the preparation did not state that there was no change on the shape, color and odor of the preparation, the average pH test results were 4.1, the test results were declared non-irritating, the result of the color preference of the three formulas that the panelists preferred was a concentration of 15% because the color was clear and very soft. Miana leaf ethanol extract can be made as a colorant in lip cream preparations.
Computational Study of E-Compound from the Vitex Family as Novel Potential Anti-Alzheimer Agents: An in Silico Study Syahputra, Hariyadi Dharmawan; Nasri, Nasri; Kaban, Vera Estefania
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.93

Abstract

The degenerative disease of memory that most attacks the frontal lobe is Alzheimer's. Therapy for Alzheimer's is mostly done by targeting an increase in the amount of acetylcholinesterase in the synapse cleft by inhibiting the enzyme acetylcholinesterase. The purpose of this study is to conduct a comparative study of vitexifolin E compounds from the vitexium plant family with donepezil to obtain more precise and targeted drug candidates in Alzheimer's therapy. The results showed that donepezil compounds have a more active probability (0.53) of being carcinogenic compared to vitexifolin E with the web-based application Protox II. Tests with in silico studies found that the hydrogen bonding results of vitexifolin E had values close to those of donepezil drugs, as well as RMSD results with receptors between donepezil and vitexifolin E (1,781; 1,281) and free energy obtained (-6.9; -7.8). Based on these results, it can be concluded that vitexifolin E compounds can have good enough potential to be developed in implementing the treatment of Alzheimer's disease therapy.
Antidiabetic Activity Test of Ethanol Extract of Bandotan Leaves (Ageratum conyzoides L.) in Alloxan-Induced White Rats Puput, Puput Virgia Ningrum; Erida Novriani; Simanjuntak, Nerly Juli Pranita
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.96

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels, causing significant morbidity and mortality globally. Indonesia is one of the countries with the highest prevalence of diabetes. This study aimed to evaluate the antidiabetic activity of ethanol extract from Bandotan leaves (Ageratum conyzoides L.) in alloxan-induced diabetic white rats. This experimental research used 30 white rats divided into six groups: normal control (distilled water), negative control (distilled water+alloxan), positive control (glibenclamide 0.65 mg/kg BW+alloxan), and three groups receiving ethanol extract of Bandotan leaves (EEBL) at doses of 100, 200, and 400 mg/kg BW with alloxan induction. Extraction of Bandotan leaves was carried out using the maceration method using 96% ethanol, resulting in a yield of 37,35%. Phytochemical screening showed the extract contained alkaloids, steroids, quinones and saponins. Induction of diabetes was carried out by intraperitoneal injection of alloxan 30mg/kgBB. Blood sugar levels were measured on days 5, 10, 15, 20, 25, 30 after induction. The results showed that administration of EEDB significantly (p<0,005) reduced blood sugar levels with the best effect at a dose of 400mg/kgBB. The ethanol extract of bandotan leaves was proven to have effective antidiabetic activity in alloxan- induced mice, with the potential for development as an affordable and easily accessible alternative diabetes therapy.
Histopathological Features of the Pancreas in Alloxan-Induced Diabetic White Rats Treated with Bandotan (Ageratum conyzoides L.) Extract Hasibuan, Fitriah Parmadami; Novriani, Erida; Simanjuntak, Nerly Juli Pranita
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.99

Abstract

Damage to pancreatic β-cells can lead to hyperglycemia, a hallmark of diabetes mellitus. Ageratum conyzoides L. (bandotan), a plant from the Asteraceae family, is traditionally used in herbal medicine due to its rich content of secondary metabolites. This study aimed to evaluate the histopathological profile of pancreatic tissue in alloxan-induced diabetic rats following treatment with ethanol extract of bandotan leaves. The research employed a true experimental design with a posttest-only control group. A total of 24 white rats were randomly divided into six groups: normal, negative control (aquadest + alloxan), positive control (glibenclamide 0.65 mg/kg BW), and three treatment groups receiving bandotan extract at doses of 100, 200, and 400 mg/kg BW, respectively. Bandotan leaves (4–5 kg) were extracted using ethanol, and histopathological observations were performed under a light microscope at 100x and 400x magnification. Pancreatic damage was scored and analyzed using descriptive statistics. The mean pancreatic damage scores were as follows: negative control group = 1.25; positive control group = 1.00; 100 mg/kg BW group = 1.00; 200 mg/kg BW group = 0.25; 400 mg/kg BW group = 0.00; and normal group = 0.00. The results indicate that the 400 mg/kg BW dose of Ageratum conyzoides L. extract was the most effective in preventing pancreatic damage, with histological features comparable to those of the normal group.

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