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Puspawan Hariadi
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Sinteza
Published by Universitas Hamzanwadi
ISSN : -     EISSN : 27978133     DOI : https://doi.org/10.29408/sinteza
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Sinteza, ISSN (online) 2797-8133, is a peer-reviewed journal in pharmacy. Established 2021, the journal is an open access of published articles to support greater exposure of scientific knowledge. Sinteza published online twice a year by Faculty of Health, Universitas hamzanwadi. Sinteza accepts various fields of research in pharmacy including community and clinical pharmacy, pharmaceutics, pharmacology, toxicology, pharmacokinetics, pharmaceutical chemistry, and pharmaceutical biology. Manuscript accepted in Sinteza written in both Bahasa Indonesia and English
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol. 5 No. 2 (2025): August" : 8 Documents clear
Identifikasi Profil Metabolit Sekunder Subfraksi Teraktif Daging Buah Kepundung (Baccaurea racemosa) menggunakan High Resolution Mass Spectrometry Maelina, Cici Okta; Permatasari, Lina
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.29205

Abstract

Baccaurea racemosa (kepundung) is a tropical plant with potential as a source of bioactive compounds. This study aimed to identify the secondary metabolite profile of the most active subfraction of kepundung fruit pulp using High Resolution Mass Spectrometry (HRMS). MS analysis was performed with Heated Electrospray Ionization (H-ESI) positive ionization mode. Compound identification was performed using Thermo Scientific™ software. HRMS analysis revealed the presence of 1,149 compounds, with the ten most abundant being L-pyroglutamic acid, senkyunolide H, trans-acotinic acid, glutarate, zerumbone, choline, cuminaldehyde, D-(+)-camphor, N-methyl-2-pyrrolidone, and nicotinic acid. These compounds have been reported to have pharmacological activities, especially as antimicrobial and antifungal agents. These findings support the potential use of kepundung fruit pulp as a promising natural source for phytopharmaceutical development.
The Potential of Catechin-Containing Plants as Antihyperlipidemic Treatment: A Review Amaryl Dyas, Riyadh Aqilsya; Romadhonsyah, Fitra; Jumaryatno, Pinus
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30116

Abstract

Hyperlipidemia is a condition characterized by elevated levels of cholesterol and triglycerides. Hyperlipidemia can lead to vascular disorders affecting the heart and brain, potentially resulting in severe complications such as coronary heart disease and stroke. A range of treatment strategies are employed to manage this condition encompassing the use of drugs as well as traditional medicinal approaches. Among these, the use of medicinal plants presents a promising option which considering relatively safe owing to their natural origin and minimal risk of significant side effects, as well as their bioactive compounds. Catechin is one of secondary metabolites commonly found in plants which showed various biological activities that potential for medicinal use. The aim of this review was to provide a comprehensive review of existing literature regarding the catechin-containing plants in lowering cholesterol and triglyceride levels. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was employed to select literature obtained from reputable online databases such as Google Scholar, PubMed and Science Direct which were published from 2015 to 2025. A narrative analysis was performed to assess the selected literatures. Based on literature screening, 200 articles were identified of which 14 were selected for inclusion in the review based on predefined criteria. This study highlighted the therapeutic potential of medicinal plants containing catechins which exhibit efficacy in reducing cholesterol and triglyceride levels. Medicinal plants may offer an effective herbal remedy for reducing cholesterol and triglyceride levels, with catechins may have a contribution to this activity.
Enkapsulasi Kurkumin dalam Matriks Beads Kitosan-Karaginan yang Tertaut-Silang dengan Glutaraldehida menggunakan Asam Laurat sebagai Pengemulsi Shadiq, Zhilal; Ardani, Muhamad Sofi; Wardani, Nur Indah; Angeline, Annisa Yuliana; Ningrum, Sari Sekar
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30137

Abstract

Curcumin (diferuloylmethane), the primary bioactive compound in turmeric (Curcuma longa), is a natural polyphenol with proven pharmacological properties. Its safety and biodegradability, along with multifunctional health benefits, have been well-documented. However, curcumin exhibits poor water solubility. Consequently, curcumin shows low systemic bioavailability and rapid urinary excretion. A carrier matrix is essential to improve bioavailability and prolong systemic retention of curcumin, and one of carrier matrix that can be utilized is a bead matrix. In this study, bead matrices were prepared by combining a chitosan solution with lauric acid and carrageenan solutions and then dropping the mixture into a sodium hydroxide solution, which acts as an ionic neutralizing agent during bead formation. The encapsulation process was conducted by immersing the formed bead matrices in curcumin and glutaraldehyde solutions to facilitate crosslinking reactions with chitosan. The resulting bead matrices were analyzed using FT-IR spectroscopy to determine the interactions and bonds formed between the materials used. The results indicated that the encapsulation efficiency of curcumin was influenced by the concentrations of chitosan and lauric acid, with higher concentrations of both components leading to increased encapsulation efficiency.
Bioactive Compound Profiling of Ethyl Acetate Fraction from Oil Palm (Elaeis guineensis Jacq.) Leaves using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS) Setiawan, Deni; Hadi, Samsul; Mahdi, Nur; Mardiati, Nurul; Normaidah; Hadiah Akbar, Nabila; Rasyid Ridha, Muhammad; Apriliany, Fitri
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30147

Abstract

Oil palm leaves could yield various health benefits, potentially leading to innovative applications in natural remedies, supplements, and dietary products. Targeted extraction and sophisticated analytical methods have become necessary for investigating bioactive compounds in plant materials. The combination of liquid chromatography and high-resolution mass spectrometry (LC–HRMS) makes for a potent technique for analyzing a wide range of metabolites, allowing for the precise and sensitive identification of various plant compounds. This investigation aimed to examine the active compounds in the ethyl acetate fraction of Elaeis guineensis leaves using LC–HRMS to identify potential new avenues for drug research. The simplicia was extracted by completely immersing 500 g of granules in acetone for three days. The crude extract was fractionated with n-hexane, ethyl acetate, and n-butanol solvents to separate components according to their polarity. The ethyl acetate part was analyzed using LC–HRMS with specific settings, including a temperature of 30°C and a gas flow rate of 11.01 L/min. The extract yield from dense oil palm leaves was 32.5 g, equivalent to 6.5%. Subsequently, the components were separated by fractionating the complete yield. The n-hexane fraction yield was 7.085 g or 21.83%, the ethyl acetate fraction yield was 3.38 g or 10.4%, the n-butanol fraction yield was 8.84 g or 27.2%, and the remaining fraction yield was 3.93 g or 12.1%. In conclusion, oil palm leaves are a prospective source of zingerol compounds, suggesting potential to be used as an alternative to rhizomes.
Sifat Fisik Sediaan Masker Gel Peel-Off Ekstrak Kulit Mentimun (Cucumis sativus. L) Wahyudi, Ari; Nurullaili Efendi, Yuli; Nurul Hidayah, Titi
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30213

Abstract

Cucumber peel (Cucumis sativus L.), often considered an agricultural waste, contains significant levels of flavonoids with antioxidant properties that can prevent premature skin aging. This study aimed to formulate and evaluate the physical properties of peel-off gel masks made from cucumber peel extract in three different concentrations: F1 (0.5%), F2 (1%), and F3 (1.5%). This study was conducted experimentally. The extracts were obtained through maceration using 96% ethanol and incorporated into the Peel-Off mask formulations. The physical quality of the mask formulations was assessed through organoleptic evaluation, homogeneity, spreadability, adhesion, pH, and drying time tests. The results showed that all formulations met the desired criteria. All three formulations showed consistent color, aroma, and viscosity for up to four weeks. The homogeneity test ensured uniform distribution of ingredients without visible lumps. Spreadability values ​​ranged from 5.2 to 5.3 cm, within the optimal range of 5–7 cm. The pH value of all formulations was 6, which is within the safe range for skin application. Adhesion tests showed increased adhesion time with higher extract concentrations, ranging from 15.3 to 17.3 seconds. Drying times for all formulas were within the acceptable range of 15–30 minutes. In conclusion, the peel-off gel masks formulated with cucumber peel extract exhibited suitable physical characteristics and potential for practical cosmetic use, with F3 offering slightly superior performance in some parameters.
Pengembangan Yogurt Bunga Telang (Clitoria ternatea L.) menggunakan Pemanis dan Penstabil: Studi Sensoris dan Fisikokimia Aprianti, Indah; Najini, Robby
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30877

Abstract

Yogurt is a fermented dairy product typically produced using lactic acid bacteria such as Lactobacillus bulgaricus and Streptococcus thermophilus. It is widely recognized for its health benefits, particularly in supporting gut microbiota balance. In recent years, incorporating natural ingredients into yogurt formulations has gained increasing attention, as consumers seek functional foods with added health value. One such ingredient is telang flower, which has been recognized for its richness in antioxidants and anthocyanins. Moreover, it contains polyphenolic compounds like catechins, which are associated with improved metabolic activity and increased fat oxidation, potentially supporting weight control. Ongoing innovations in yogurt development aim to enhance its flavor, texture, and stability, often by incorporating sweeteners and thickening agents. This study aimed to evaluate the sensory properties and consumer acceptability of telang flower yogurt formulated with varying concentrations of natural sweetener (honey) and thickening agent/stabilizer (carboxymethyl cellulose, CMC), and to characterize the physical and chemical attributes of the optimum formula. Four formulations were developed using different concentrations of honey (0%, 10%, 15%, and 20%) and CMC (0%, 1%, 1.5%, and 2%). Formulation FIV, consisting of 20% honey and 2% CMC, achieved the highest level of preference among all tested variants. A vibrant purple color, dense texture, pleasantly acidic aroma, and well-balanced sweetness contributed to its superior sensory profile. This formula exhibited favorable physicochemical characteristics, with a pH of 4.34 and a viscosity of 1910 cP. Increasing honey and CMC concentrations were found to improve both consumer acceptability and the overall sensory.
Evaluasi Perilaku Tenaga Vokasi Farmasi dalam Pemberian Informasi Obat di Apotek Jaringan X Se-Kota Pekanbaru Periode 2023-2024 Aryani, Fina; Vanisa, Septia; Muharni, Septi; Triagustini, Tiara
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30967

Abstract

Providing drug information is a crucial component in pharmaceutical services that aim to ensure the safe and rational use of medications. However, the practice of providing information by pharmacy technicians in pharmacies is often not optimal, especially in educational aspects related to patient safety. The purpose of this study was to evaluate the behavior of pharmacy technicians in providing drug information to patients at X Network Pharmacies in Pekanbaru City. This research is a quantitative descriptive study with a cross-sectional approach. A total of 32 pharmaceutical technicians became respondents, selected through a total sampling method. Data were collected using a structured observation sheet that included 15 indicators of drug information provision. Data were analyzed descriptively and presented in the form of a frequency distribution and a percentage. The results showed that the behavior of providing drug information by pharmaceutical technicians was still relatively low. Most of them only provided basic information, such as the name of the drug (78.12%), the time of consumption (71.87%), and instructions on how to use the drug (65.62%). Meanwhile, important information such as side effects, drug interactions, storage methods, and compliance with the use of drugs is almost not conveyed at all (≤10%). The behavior of pharmaceutical technicians in providing drug information still falls short of ideal pharmaceutical service standards. Continuous training, strict adherence to Standard Operating Procedures (SOPs), and supervision by the pharmacist-in-charge are necessary to enhance service quality and patient protection.
Formulasi Mouthwash Kulit Jeruk Pontianak (Citrus nobilis Lour. Var. microcarpa) dan Uji Aktivitas terhadap Bakteri Streptococcus mutans Ropiqa, Meri; Kurniawan, Hadi; Mayesa, Sabila
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.31603

Abstract

Preserving dental and oral hygiene is essential to maintain the overall function of the oral cavity. Essential oil extracted from Pontianak orange peel shows potential as a safe and effective component for oral healthcare when incorporated into a mouthwash formulation. This research was conducted to evaluate the potential of Pontianak orange peel essential oil as an antibacterial mouthwash effective against Streptococcus mutans. The study was conducted by formulating mouthwash preparations using different concentrations of Pontianak orange peel essential oil: 3%, 4%, and 5%, followed by evaluation of physical properties including organoleptic characteristics, homogenity, pH level, sedimentation, specific gravity, and viscosity. The antibacterial properties were tested using  the disc diffusion method.The physical evaluation results showed that the mouthwash had a sweet taste, green color, a citrus peel aroma with a hint of mint; it was homogeneous, with no sedimentation; had a pH value ranging from 5.13 ± 0.02 to 5.25 ± 0.02; specific gravity ranging from 0.9968 ± 0.06 to 1.0424 ± 0.00 g/ml; and viscosity ranging from 1.717 ± 0.02 to 1.920 ± 0.01mPa.s. All formulations met the physical property requirements of a good mouthwash to ensure comfort during use. The largest inhibition zone was observed at the highest essential oil concentration (5%), with a diameter of 8.04 ± 1.05 mm, which falls under the category of moderate antibacterial activity. This study indicates that a mouthwash containing 5% Pontianak orange peel essential oil is effective in inhibiting the growth of Streptococcus mutans.

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