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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 3 (2023)" : 60 Documents clear
Penetapan kadar flavonoid total ekstrak etanol daun bunga melati (Jasminum sambac (L.) Sol. ex Aiton) dengan spektrofotometri Uv-Vis Hastri Kholifah; M. Pandapotan Nasution; Anny Sartika Daulay; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.201

Abstract

Traditional medicine uses plants with a natural ingredient content as its raw material. The bioactive compounds found in plants are secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, steroids, and saponins. One of the plants containing secondary metabolite compounds is jasmine. This study aims to determine the chemical compounds contained in the ethanol extract and the total flavonoid content of the ethanol extract of jasmine leaves using the UV-Vis spectrophotometric method. The stages of this research included processing plant simplicia, making ethanol extract, examining characteristics, screening phytochemicals, and determining the total flavonoid content of the ethanol extract of jasmine leaves using the UV-Vis spectrophotometric method. Extract jasmine flower leaves by maceration method using 96% ethanol solvent; the extract obtained was concentrated using a rotary evaporator; then the total flavonoid content was determined using the UV-Vis spectrophotometry method. The research shows that the ethanol extract of jasmine flower leaves (Jasminum sambac (L.) Sol. ex Aiton) contains several secondary metabolite compounds, such as flavonoids, glycosides, alkaloids, saponins, steroids, and tannins. A number of steps were taken to find out how many flavonoids were in the ethanol extract as a whole. These included finding the maximum wavelength of quercetin, the operational time, making a quercetin calibration curve, and using UV-Vis spectrophotometry to determine how many flavonoids were in the extract. The analysis results reveal that the total flavonoid content in the ethanol extract of jasmine flower leaves is approximately 40.10911 ± 0.5878 mg QE/g.
Analisis aktivitas antioksidan ekstrak etanol daun jeruk kuok (Citrus nobilis L.) dengan metode DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Nurul Hasanah; Rafita Yuniart; Haris Munandar Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.204

Abstract

When the body is excessively exposed to free radicals, the need for antioxidants increases as the body lacks sufficient protection. Some secondary metabolites in plants that can act as antioxidants include flavonoids, alkaloids, and tannins. This research aims to identify secondary metabolite compounds present in the raw material and extract of Citrus nobilis L. (kuok orange) leaves and evaluate antioxidant activity by determining IC50 values. This study employs several methods, including analyzing crude characteristics, phytochemical screening, and antioxidant activity testing using the DPPH (1,1-Diphenyl-2-picrylhydrazyl) method with spectrophotometry UV-Visible. The characterization results of the natural material indicate a water content of 6.66%, a water-soluble compound content of 19.64%, an ethanol-soluble compound content of 24.67%, a total ash content of 4.44%, and an acid-insoluble ash content of 0.66%. These findings align with values documented in the existing literature on MMI. Phytochemical screening results reveal that the crude material and ethanol extract of Citrus nobilis L. (kuok orange) leaves contain various chemical compounds, including alkaloids, flavonoids, saponins, tannins, glycosides, and steroids. The IC50 value for the ethanol extract of Citrus nobilis L. leaves is approximately 40.4587 g/mL, categorizing it as very strong. This indicates that the ethanol extract of Kuok orange leaves possesses secondary metabolite compounds with a highly potent antioxidant capability.  
Skrining fitokimia, formulasi dan uji mutu fisik nanoserum ekstrak bonggol nanas (Ananas comosus (L.) Merr) Rahma Maulidia Fitri; Minda Sari Lubis; Gabena Indrayani Dalimunthe; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.207

Abstract

Nanoserum is a slightly viscous transparent or semi-transparent preparation whose particle size is smaller than conventional serum. The purpose of this study was to find out that pineapple hump extract contains secondary metabolites, has physical quality and has a good level of stability in the form of nanoserum. The method used in this research is experimental, the sample used is pineapple hump. The data collected is in the form of quantitative and qualitative. The results showed that pineapple hump extract contains secondary metabolites of alkaloids, flavonoids, tannins, saponins, steroids, glycosides. Organoleptic test all formulas have a clear and transparent color. In the particle size and polydispersibility index tests (F0), (F1), (F2), (F3), all formulas showing particle size and polydispersibility index met the requirements of <1000 nm and polydispersibility index <0.5. Percent transmittance test (F0), (F1), (F2), (F3), all formulas have clear and transparent visual appearance according to the requirements of 90%-100%. There was no change in the stability level of nanoserum in the organoleptic test, the particle size test and the polydispersibility index (F0), (F1), (F2), (F3). There is a change in particle size and polydispersibility index afterCyling test, however, it is still categorized as good because it is in the range of quality requirements, namely <1000 nm and the polydispersibility index <0.5.
Pengaruh pemberian air rebusan daun binahong (Anredera cordifolia) terhadap penyembuhan luka perineum pada ibu nifas Muthia Sari Mardha; Endriani Syafitri; Desilisi Handayani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.210

Abstract

Background: Data from the World Health Organization (WHO) records approximately 2.7 million cases of perineal wound pain in postpartum mothers. The projected figure is expected to reach 6.3 million by the year 2020. The issue of perineal wound pain is particularly significant in the Asian region, where around 50% of all cases occur. In Indonesia, about 75% of mothers who give birth via the vaginal route experience perineal wound pain. In this context, 57% of mothers experience pain in the area of the perineal wound, with 28% undergoing episiotomies and 29% experiencing spontaneous perineal tears. The purpose of this study was to find out whether there is an impact of decoction of binahong plants on the recovery of tears in the birth canal in postpartum mothers.Methods: Variations in this study are quasi-experimental or quasi-experimental with the Post-test Only Control Group research design.Data were obtained by distributing questionnaires, while data analysis used the Paired Sample T Test The sample in this study was 22 respondents.Results: The statistical test results indicate the influence of administering boiled binahong leaf infusion (Anredera cordifolia) on the healing of perineal wounds in postpartum mothers at Lena Barus Clinic, East Binjai Subdistrict, with a p-value of 0.000. Conclusion: This study concludes that there is an impact of administering boiled binahong leaf infusion on the healing of perineal wounds in postpartum mothers. It is hoped that healthcare facilities can consider the provision of boiled binahong leaf infusion as part of complementary therapy to aid in the recovery process of perineal tears in postpartum mothers.
Pengaruh Rendaman Air Hangat Pada Kaki Terhadap Tingkat Insomnia Pada Lansia Di Puskesmas Desa Terjun Tahun 2023 Endryani Syafitri; Muthia Sari Mardha; Rini Syahrani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.211

Abstract

Background: Insomnia in the elderly population is generally associated with physical and psychological factors when the body begins to experience vulnerability and mental well-being becomes less stable. Many elderly individuals face these changes unprepared, leading to mental burdens that ultimately affect sleep quality and potentially trigger insomnia issues. Objective: to find out the effect of soaking feet in warm water on the level of insomnia in the elderly at the Puskesmas Waterfall Village before and after soaking in warm water in the experimental and control groups. Methods: quasi-experiments with unequal control groups. The sample consisted of 20 respondents who were divided into 2 groups, namely 10 experimental groups and 10 control groups. Using univariate and bivariate data analysis with a parametric test, namely paired sample T-test. Results: the mean insomnia after a warm bath in the experimental group was 1.60, while in the control group (post-test) it was 2.00 with a mean difference of -1.400 and a p-value of 0.050 (=0.05). Conclusion: showed that the effect of a warm bath on the level of insomnia was different in the experimental and control groups. Elderly people are advised to do it 2 times a week to reduce insomnia.
Efek pemberian ekstrak etanol daun sintrong (Crassocephalum crepidioidies) terhadap penurunan berat badan tikus jantan Muharni Saputri; Salmah Handayani Lubis; Fenny Hasanah; Siti Muliani Julianty; Muflihah Fujiko; Ernawaty Ginting; Anggi Salsabilah Nasution; Kiki Mariana Batubara
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.213

Abstract

One of the medicinal plants that has the effect of reducing obesity is the sintrong plant. This plant has tannins, saponins, polyphenols, and flavonoids so that it can reduce blood glucose levels as an antidiabetic effect and can reduce weight. The purpose of this study was to see the occurrence of weight loss in test animals by administering ethanol extract of sintrong leaves and to find out whether the different doses of sintrong leaves can reduce body weight in male white rats. The research method was carried out experimentally, then testing the effectiveness of the ethanol extract of sintrong leaves using 25 rats which were divided into groups I to V with varying doses of 250 mg, 500 mg, and 750 mg, and carried out statistically by the Tukey method. The results of this acquisition when compared with the comparison group are not much different. Based on the result obtained, group V was given a suspension of ethanol extract of sintrong leaves at a dose of 750 mg/kgBW and the comparison group was given orlistat haven’t significant difference based on a statistical test with α > 0.05 so it could be concluded that there was a decrease in body weight in rats after administration of ethanol extract of sintrong leaves at a dose of 750mg/kgBW.
Hubungan perilaku perawat dalam menerapkan edukasi pasien rawat inap di RSU Delia Kabupaten Langkat tahun 2022 Andini Mentari Tarigan; Dyna Safitri Rakhelmi Rangkuti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.221

Abstract

Health education is an educational activity carried out with the aim of changing a person's behavior from unhealthy to healthy behavior. Based on the initial survey conducted through interviews and observations (observations) in the inpatient unit of 10 nurses, it was found that 7 nurses did not provide a complete education, 3 other nurses had provided education but attitudes towards patients tended to pay less attention. The purpose of this study was to determine the relationship between nurse behavior in implementing inpatient education at Delia General Hospital, Langkat Regency. This type of research is quantitative by using an analytic survey method with a cross-sectional approach. The population in this study were all nurses totaling 60 people, and the samples taken using the total sampling technique were 60 people. Data analysis used univariate and bivariate analysis with the chi-square test statistic. The results of the chi-square test analysis showed that the p-value of knowledge variable obtained p-value = 0.000, attitude p-value = 0.000, and action p-value = 0.000 towards implementing inpatient education at Delia General Hospital, Langkat Regency. This study concludes that there is a relationship between knowledge, attitudes and actions towards implementing inpatient education at Delia General Hospital, Langkat Regency. RSU Delia Langkat Regency is recommended to carry out planning, assess the educational needs of patients, and evaluate the effectiveness of the education conducted. In providing education to patients and families, a well-planned preparation is necessary so that healthcare personnel have a clear understanding of how to prepare the appropriate equipment and resources to meet the actual needs of patients.  
Deteksi cemaran Staphylococcus aureus pada ayam krispy lokal di sekitar salah satu universitas kota Medan Yayuk Putri Rahayu; D. Elysa Putri Mambang; Haris Munandar Nasution; Adelia Ramadani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.222

Abstract

Chicken meat is more in demand by consumers because it is easy to process, can be accepted by all levels of society and has an economical price. Food poisoning can be caused by enterotoxin contamination caused by Staphyococcus aureus. Management of chicken meat that is not up to standard and unhygienic can affect human health. The purpose of this study was to identify the presence of pathogenic bacteria S. aureus in crispy fried chicken meat from roadside carts and local fast food at one of Medan city University and to analyze the contamination value of S. aureus bacteria whether it meets the Indonesian National Standard (SNI) < 1X102 CFU/ml. The research method is employed to detect the presence of S. aureus in samples using both Baird Parker Agar Base (BPA) and Egg Yolk media simultaneously. Quantification of S. aureus contamination is carried out through the application of the Total Plate Count (TPC) method. Findings from two samples of local fried chicken, namely samples A and B, indicate a positive result for the presence of S. aureus, with contamination levels exceeding the threshold of 1 x 102 CFU/ml. This leads to non-compliance with the established SNI standards. Conversely, in the case of local crispy fried chicken samples C and D, the results indicate a negative presence of the S. aureus pathogenic bacteria, with contamination levels not exceeding the threshold of 1 x 102 CFU/ml. Therefore, these results comply with the stipulated SNI standards.
Formulasi dan uji sifat fisik lulur krim ekstrak etanol bunga kecombrang (Etlingera eliator (Jack) R.M. Smith) Rina Kurniaty; Asri Ainun; Mutia Farida; Saiful Azhari; Salman Salman; Mahmudi Mahmudi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.223

Abstract

Kecombrang plant (Etlingera eliator (Jack) R.M. Smith), has bioactive compounds of polyphenols, alkaloids, flavonoids, steroids, saponins and essential oils. The purpose of this study, to make a cream scrub formulation from ethanol extract of kecombrang flowers that meets the standards and benefits on the skin. The method of this study, by varying the concentration of ethanol extract of kecombrang flowers 5% and 10% with modified formulations adding amylum oryzae as a scrub and without the addition of amyulum oryzae. The results of the 28-day study based on the parameters, in the organoleptical test had a stable shape, odor, and color, in the homogeneity test showed a homogeneous preparation, the pH test had a stable value of 7, the spreadability test had an average value of 5 cm, stable results in room or low temperature storage (2-8oC). Hedonic test results with parameters, aroma, texture, color, and effectiveness, namely formulation I 10% with an average scale value of 5, which means very like is a formulation with the addition of amylum oryzae as a scrub. Formulation results with the addition of amylum oryzae affect the preparation of abrasive formulations. The results of the skin effectiveness test, in the moisture test using a skin analyzer with an average value of moist volunteer skin at week 4, and the volunteer's skin color is slightly brighter. In conclusion, the cream scrub formulation has a good formulation, kecombrang flower extract has the effect of brightening the skin and moisturizing the skin.
Persepsi orang tua mengenai pengenalan bahasa inggris pada anak usia dini di Desa Baru Kecamatan Batang Kuis Ani Deswita Chaniago; Utary Dwi Listiarini; Linda Hernike Napitupulu; Syafrizaldi Syafrizaldi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.224

Abstract

Introduction : The focus of this research is to find out how parents see the importance of learning English for young children. Methods: This research is a qualitative type using a descriptive approach through focus group discussions (FGD) and was carried out naturally in Baru Village, Batang Kuis District, North Sumatra. Results: The results showed that out of 15 respondents, most parents believed that 80% was important for young children to learn English, while some did not know that foreign languages could be taught from an early age. In addition, 20% more learning English at an early age improves children's memory and brain formation, and children will have greater curiosity if taught English. Conclusion: Most of the respondents have a good perception and strongly agree for the introduction of English in early childhood considering that English is very important at this time.

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