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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 75 Documents
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Search results for , issue "JPS Volume 8 Nomor 3 (2025)" : 75 Documents clear
Perbandingan Kandungan Fenolik dan Aktivitas Antioksidan pada Varian Seduhan Teh dan Varian Teh Kombucha Secara Spektrofotometri Visible Maghfirah , Dini; Pulungan , Ainil Fithri; Ridwanto, Ridwanto; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.952

Abstract

One of the most widely consumed aromatic beverages in the world is tea. Tea shoots are rich in polyphenolic compounds that function as antioxidants. Not many people know that tea can be fermented with a type of bacteria and yeast culture that can be consumed as a drink for health known as kombucha tea. The health benefits of consuming kombucha tea as anti-carcinogenic, anti-diabetic, detoxification, increased immune response, treating stomach ulcers and lowering cholesterol levels as well as high blood pressure. The purpose of this study was to determine the total phenolic content and antioxidant activity as well as the comparison of total phenolic content and antioxidant activity in tea brewing variations with kombucha tea variations. The methods carried out include testing the total phenolic content and antioxidant activity using the DPPH method on tea brewing variants and kombucha tea variants by visible spectrophotometry.mThe results of total phenolic content in black tea, green tea, and oolong tea were 24,480 mgGAE/g, 26,538 mgGAE/g, and 38,427 mgGAE/g, respectively, while kombucha black tea, green tea, and oolong tea were 39,264 mgGAE/g, 58,581 mgGAE/g, and 64,299 mgGAE/g, respectively. Brewed black tea, green tea, and oolong tea have antioxidant activity with IC50 values of 105,68 ppm in teh moderate category, 81,59 ppm in teh strong category, and 56,25 ppm in the strong category, respectively. In kombucha black tea, green tea, and oolong tea have antioxidant activity with IC50 values respectively 101,60 ppm with moderate category, 55,82 ppm with strong category, and 39,69 ppm with very strong category. While teh vitamin C comparator has antioxidant activity with an IC50 value of 3,22 ppm with a very strong category.
Pengaruh Ekstrak Etanol Daging Buah Pala (Myristica Fragrans Houtt) Pada Histopatologi Jantung Tikus Wistar Hiperglikemik Nur, Amran; Fiskia, Ermalyanti; Hi Yusuf, Muhammad Fakhrur Rajih; A. Disi, Muhammad Zulfian; Mursin, Nita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.517

Abstract

The heart is an organ significantly impacted by diabetes mellitus problems, as elevated free radical generation and oxidative stress from hyperglycemia activate the apoptosis and necrosis pathways in cardiac myocytes. This study aimed to ascertain the histological characteristics of the cardiac tissue in rats subjected to hyperglycemia following the administration of ethanol extract from nutmeg fruit flesh (Myristica fragrans Houtt). This study employed rice as a diabetes inducer in 25 rats, categorized into 5 treatment groups: group 1 received Na-CMC, group 2 received metformin, group 3 received a dosage of 100 mg/KgBW, group 4 received a dosage of 200 mg/KgBW, and group 5 received a dosage of 300 mg/KgBW. The detected data included alterations in body weight, blood glucose levels, organ mass, and cardiac histology. The data were evaluated employing the One-Way ANOVA test at a 95% confidence level (p<0.05). The findings indicated that all groups treated with nutmeg fruit flesh ethanol extract exhibited a substantial enhancement in the histopathology of rat hearts compared to the negative control group 0,03 (p<0.05). The administration of nutmeg fruit flesh extract can ameliorate histopathological damage to the hearts of hyperglycemic rats at doses of 100 mg/KgBW, 200 mg/KgBW, and 300 mg/KgBW, indicating that nutmeg fruit flesh may serve as a cardioprotective drug in diabetic subjects.
Analisis Logam Berat pada Jamu Pegal Linu yang Beredar di Kota Banda Aceh Farida, Mutia; Safrina, Nurul; Kurniaty, Rina; Azhari, Saiful; Mahmudi, Mahmudi; Yusuf , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.606

Abstract

Background: Jamu pegal linu (traditional Indonesian herbal medicine for muscle and joint pain) is widely consumed to relieve muscle and bone discomfort. However, there are concerns about heavy metal contamination, particularly lead (Pb) and mercury (Hg), in some products circulating in Banda Aceh City. Such contamination poses serious health risks, including organ damage and poisoning, necessitating thorough analysis to ensure product safety. Objective: This study aimed to detect and measure Pb and Hg levels in jamu pegal linu samples sold on Diponegoro Street, Banda Aceh, and compare them with the safety limits set by the Indonesian Food and Drug Authority (BPOM RI). Methods: A total of 23 samples were qualitatively analyzed using KI, NaOH, and HCl reagents (for Pb) and HNO₃ and KI (for Hg). Positive samples were further analyzed quantitatively using Atomic Absorption Spectrophotometry (AAS). Method validation included linearity, precision, accuracy, LoD, and LoQ assessments. Results: Qualitative testing revealed Pb and Hg contamination in 12 samples. Pb levels ranged from 1.45–9.17 mg/kg (below BPOM’s threshold of ≤10 mg/kg), while Hg levels ranged from 0.14–1.37 mg/kg, with six samples exceeding the safe limit (≤0.5 mg/kg). The highest Hg concentration (1.37 mg/kg) was found in an unregistered product. Conclusion: Most jamu pegal linu products in Banda Aceh contain heavy metals, particularly Hg, at unsafe levels. Strict regulatory oversight, especially for unregistered products, is crucial to safeguard public health.
Efektivitas Media Video dan Leaflet dalam Edukasi DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) dan Beyond Use Date: Studi Kuasi-Eksperimen Hasanah , Fenny; Lubis, Salmah Handayani; Dasopang , Eva Sartika; Aisyah, Teti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.644

Abstract

Background: The increasing practice of self-medication and home drug storage carries the potential for medication management errors, including improper drug disposal. Lack of public understanding of DAGUSIBU (Acquire, Use, Store, Dispose) protocols and Beyond Use Date (BUD) may lead to drug misuse and environmental contamination due to improper disposal methods that violate the Drug Awareness Family Movement (Gerakan Keluarga Sadar Obat/GKSO) guidelines. Objective: To examine the impact of educational interventions on public knowledge of DAGUSIBU and BUD, and to compare the effectiveness of video versus leaflet media. Methods: A quasi-experimental study with pretest-posttest design was conducted. Purposive sampling was used to select 100 respondents from Kotamatsum I Subdistrict. Data were analyzed using Wilcoxon test (educational impact), Chi-Square test (demographic correlations), and Mann-Whitney test (media comparison). Results: The educational intervention significantly improved participants' knowledge of DAGUSIBU and BUD (p < 0.001). Gender significantly influenced knowledge improvement (p = 0.005), while age, education level, and occupation showed no significant effects. Video proved more effective for DAGUSIBU content (mean score 53.94 vs 47.06), whereas leaflets showed marginally better results for BUD material (50.56 vs 50.44).Conclusion: Both video and leaflet-based education effectively enhanced community knowledge. Videos are recommended for DAGUSIBU campaigns, while leaflets serve as suitable supplementary materials for BUD education.  
Uji Efektivitas Sediaan Facial Wash Acne Gel Ekstrak Etanol Daun Nangka (Artocarpus heterophyllus Lamk.) Terhadap Bakteri Staphylococcus aureus Athaillah, Athaillah; Pritiwanti, Venni; Chandra, Putra; Affan Silalahi, Ali
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.787

Abstract

Background: Jackfruit leaves (Artocarpus heterophyllus Lamk.) contain antimicrobial compounds such as flavonoids, tannins, and saponins, which can damage bacterial cytoplasmic membranes and denature cellular proteins. This potential supports the development of a facial wash gel using jackfruit leaf extract as a natural antibacterial alternative. Objective: This study aimed to evaluate the effectiveness of a facial wash gel containing jackfruit leaf extract (Artocarpus heterophyllus Lamk.) in inhibiting the growth of Staphylococcus aureus ATCC® 25923. Methods: This experimental study included sample preparation, identification, extraction, phytochemical screening, and gel formulation evaluation (organoleptic test, homogeneity, spreadability, foam height, pH, irritation, and cycling test). Antibacterial activity was tested against S. aureus, with a positive control (Himalaya (Brand) Facial Wash) and a negative control (DMSO). Results: The extract yield was 11.26%, positively detecting flavonoids, saponins, tannins, steroids, and triterpenoids. The gel formulations (F1-F3) were semi-solid, dark green, and had a characteristic jackfruit leaf aroma, with a pH of 5–6. Homogeneity tests confirmed uniform consistency, with the highest foam height in F3 (3.7 cm) and optimal spreadability in F1-F2 (6 cm). No irritation was observed, and the gel remained stable in cycling tests. The antibacterial test showed the highest inhibition at 12% extract concentration (92.3%), while the formulated gel also effectively inhibited S. aureus growth. Conclusion: Jackfruit leaves can be successfully formulated into a stable and safe facial wash gel with effective antibacterial activity against Staphylococcus aureus.
Suplementasi Asam Folat pada Wanita Hamil Trimester Pertama untuk Pencegahan Preeklampsia: Studi Kohort Retrospektif Kamri, Andi Maulana; Putra , Bayu; Kosman, Rachmat; Basri, Putri Septiani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.901

Abstract

Preeclampsia is a disorder characterized by hypertension and proteinuria that manifests during gestation. Various vitamins can influence food consumption during pregnancy. Folic acid supplementation is known to reduce preeclampsia risk, yet adherence remains low among pregnant women. The objective of the research is to identify risk variables and dosage efficacy associated with folic acid utilization. This study employs an retrospective cohort study and utilizes retrospective data collection. Data was gathered from Cahaya Ibu Pharmacy Store in Makassar, encompassing a total of 164 patients. A chi-square statistical study indicated a substantial risk association between pregnant women and the onset of hypertension in comparison to nonpregnant individuals, with a p-value of 0.001. Pregnant women had twice the risk, as shown by an odds ratio of 1.9. The study of Fisher's test data indicates a correlation between patient age and hypertension condition. The findings indicate no substantial correlation between the two variables, with a p-value of 0.523. The findings indicate a substantial correlation between the mitigation of raised blood pressure risk and the consumption of folic acid. The early use of folic acid during pregnancy planning significantly diminishes the likelihood of preeclampsia. Risk factors for preeclampsia include insufficient folic acid consumption, the duration of folic acid supplementation, and the pregnancy status of individuals with a disease risk of up to 98%. Less at age 30 years old, the consumption of folic acid may reduce the risk.
Uji Aktivitas Ekstrak Etanol Daun Bandotan (Ageratum conyzoides L) Terhadap Penyembuhan Luka Bakar Pada Tikus (Rattus norvegicus) Dengan Diabetes Melitus Afika, Nur; Yunus , Muhammad; Novriani , Erida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.935

Abstract

Burn wounds in patients with diabetes mellitus experience impaired healing due to chronic hyperglycemia. This study aims to identify phytochemical compounds, analyze the characteristics of crude drugs, and test the activity of ethanol extracts of bandotan leaves (Ageratum conyzoides L.) on burn wound healing in rats (Rattus norvegicus) with diabetes mellitus, including histological evaluation of wound tissue. Screening results showed that the extract contains active compounds such as alkaloids, flavonoids, tannins, saponins, quinones, and steroids. Herbal material characterization met standards for moisture and ash content but did not meet standards for water-soluble and ethanol-soluble extract content. The extract gel formulation was tested at three concentrations (5%, 10%, 15%). Efficacy tests showed that the 15% gel accelerated wound healing by 100% by day 15, with histological findings indicating increased numbers of fibroblasts, collagen fibers, and capillary blood vessels. This study concludes that ethanol extract of bandotan leaves has potential as an effective wound healing agent, particularly in diabetic conditions.
Formulasi Yoghurt Sinbiotik dengan Inkorporasi Pati Uwi Ungu Termodifikasi: Evaluasi Sineresis, Viabilitas Bakteri Probiotik, dan Daya Terima Organoleptik Pangaribuan , Apriliyani Putri; Saputri , Muharni; Tambunan , Ika Julianti; Muzakkir, Muzakkir; Sembiring , Fanny Rizki; Indriana , Meutia; Salman, Salman
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.939

Abstract

Background: Yogurt quality improvement can be achieved through synbiotic formulations combining probiotic bacteria (Lactobacillus bulgaricus, Streptococcus thermophilus, Lactobacillus rhamnosus) with prebiotics from modified purple yam starch (Dioscorea alata). This plant contains 7.54% inulin and has potential as a natural stabilizer, but its utilization in synbiotic yogurt remains suboptimal. This study aims to evaluate the effect of modified starch incorporation on probiotic viability, physical stability, and sensory acceptance. Objective: This research aimed to examine the capability of modified purple yam starch as a prebiotic source in synbiotic yogurt, focusing on its impact on syneresis, bacterial viability, and organoleptic properties. Methods: An experimental study using a Completely Randomized Design (CRD) with six treatments. The process included purple yam starch extraction, starch modification via autoclaving (110°C and 121°C), yogurt fermentation using three bacterial strains, and evaluation of pH, syneresis, Total Plate Count (TPC), and hedonic tests by 20 panelists. Data analysis involved descriptive statistics, Mann-Whitney, and Spearman correlation tests. Results: Yogurt formulations with modified yam starch yielded optimal pH (6.81 with L. rhamnosus) and highest syneresis (30.02%). Bacterial viability reached 431 × 10³ CFU/mL (10⁻² dilution) for L. rhamnosus. Organoleptic tests showed the highest scores for aroma (6.90 ± 0.31) and a significant correlation between taste-thickness (ρ=0.52; p<0.05). Color was consistent (score 6), while texture preference varied (scores 5-7). Conclusion: Modified purple yam starch effectively functions as a prebiotic and stabilizer in synbiotic yogurt, supporting probiotic viability and sensory acceptance. This formulation holds promise as a functional food product utilizing local ingredients.
Pengaruh Variasi Lama Perendaman dan Suhu Penggilingan terhadap Kadar Protein Susu Kedelai Mufida , Nadiya Syafiah; Hanwar , Dedi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.949

Abstract

Soy milk, an extract from soybeans, significantly contributes to human nutritional needs, particularly as a source of plant-based protein. The protein quality in soy milk is highly influenced by processing parameters, including soybean soaking duration and grinding temperature. This study aimed to determine the optimum combination of soaking time and grinding temperature to maximize soy milk's protein content. The effects of these two factors were evaluated using Response Surface Methodology (RSM) with a Central Composite Design (CCD). Experiments were conducted for 13 experimental combinations, replicated three times. Protein content was determined by the Lowry method, while pH measurements were also performed to monitor quality. Grinding temperatures ranged from 25°C to 80°C and soaking times varied from 6 to 12 hours, using Grobogan soybean variety as the main raw material. Other parameters such as soybean quantity, water volume, soaking temperature, and boiling and grinding times were set as controlled variables. Optimization results using Design-Expert software indicated that the optimum formulation was achieved at a grinding temperature of 61°C and a soaking time of 9 hours 46 minutes. Under these optimum conditions, the resulting soy milk exhibited a protein content of 3.1% (w/w) and a pH of 7.02, both meeting established soy milk quality standards.
Potensi Farmakologis Genus Chloranthus Sebagai Agen Antioksidan, Sitotoksik, Dan Anti-Inflamasi: Sebuah Tinjauan Sistematis Wildan Firdaus, Muhammad; Haryoto, Haryoto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.950

Abstract

The Chloranthus genus (Chloranthaceae family) has been traditionally used in Asian medicine as an anti-inflammatory agent, but recent scientific exploration reveals broader pharmacological potential. This systematic review aims to evaluate the latest experimental evidence on the antioxidant, cytotoxic, and anti-inflammatory activities of Chloranthus-derived compounds and elucidate their molecular mechanisms. Studies were selected through structured database searches using specific keyword combinations and screened using rigorous inclusion-exclusion criteria. The findings highlight a predominance of sesquiterpenoids, particularly lindenane-type (monomers, dimers, and trimers), which consistently exhibit anti-inflammatory effects via inhibition of NF-κB and MAPK pathways and modulation of the NLRP3 inflammasome. Antioxidant activity through the Nrf2/Keap1 pathway and cytotoxic effects against cancer cells were also frequently reported. Notably, several compounds demonstrated dual actions, suppressing both ROS (Reactive Oxygen Species) production and proinflammatory cytokines, emphasizing their relevance in treating diseases involving oxidative stress and inflammation. These results support Chloranthus as a promising natural source of multitarget bioactive compounds. Future research should adopt a multidisciplinary approach to further elucidate molecular targets, validate in vivo efficacy, and explore novel biological resources.

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