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Journal of Pharmaceutical and Sciences.

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Published by Universitas Tjut Nyak Dhien

ISSN : - EISSN : 26563088 DOI : https://doi.org/10.36490/journal-jps.com

Core Subject : Health, Science, Agriculture, Engineering,

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 616 Documents

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Tingkat Pengetahuan Mengenai Kepatuhan Minum Obat Pada Pasien Hipertensi Rawat Jalan Di Puskesmas “X” Banyuwangi Tahun 2022 Isma Oktadiana; Siti Fatimah Sultan; Rena Meutia; Cut Intan Annisa Puteri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Hypertension is an increase in blood pressure in the arteries that exceeds normal limits with an increase in systolic blood pressure> 140 mmHg and diastolic blood pressure> 90 mmHg. The level of knowledge about hypertension is one of the factors that can affect adherence to lifestyle and treatment of hypertension. This study aims to determine the level of knowledge and medication adherence in hypertensive patients and to determine the relationship between the level of knowledge on medication adherence in hypertensive patients at the "X" Health Center in Banyuwangi. This research was conducted using a descriptive cross sectional method. Sampling was carried out using purposive sampling method. The results obtained were analyzed using the univariate method based on the patient's demographic characteristics and bivariate using the Spearman test from the SPSS 28 program. The number of patients with outpatient hypertension at the "X" Banyuwangi Health Center for the April-May 2022 period was 80 respondents taken from 100 patients. The results obtained showed that the patient's level of knowledge about hypertension was high at 60% (48 respondents), moderate 33% (26 respondents) and low at 7% (6 respondents). Likewise, the level of adherence to taking medication was also relatively high, namely 88 % (70 respondents), moderate 13% (10 respondents) and low 0% (0 respondents). The conclusion obtained is that there is a very strong and one-way significant relationship between the level of knowledge of the disease and the level of adherence which shows a correlation of 0.900.

Hubungan Pengetahuan dan Sikap Dengan Kepatuhan Minum Obat Anti Diabetes Pada Pasien Diabetes Melitus di Puskesmas PB Selayang II Selfianna Rosalina Br Ginting
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Hyperglycemia as a result of abnormal insulin secretion is a hallmark of diabetes mellitus, a metabolic condition, the objective of this study was to ascertain the connection between knowledge, attitudes, and medication adherence. The kind of exploration utilized by specialists is insightful observational examination with a cross-sectional exploration plan. The majority of people with diabetes mellitus were between the ages of 61 and 70, had mostly completed high school (up to 100, or 46.5%), worked as farmers (up to 79, or 36.7%), and were women (up to 108, or 50.2%). Knowledge was mostly negative (78.1%), attitudes were mostly disagreeable (79.1%), and compliance was mostly disobedient (72.1%), according to the study's findings. The chi square statistical test revealed p values of 0.039 for knowledge and 0.024 for attitude. This demonstrates that the p-value is less than or equal to 0.05. From that point, it tends to be inferred that there is a connection between information, mentalities and consistence at the PB Selayang II Wellbeing Community

Penggunaan Obat Berpotensi Hepatotoksik Pada Pasien Sirosis Hati: Suatu Telaahan Ariesta Kirana Efmisa; Armenia Armenia; Dedy Almasdy
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Liver cirrhosis is a pathological liver disease characterized by the formation of scar tissue and regenerative nodules in liver cells. This condition leads to changes in the shape and size of the liver, accompanied by increased pressure in the veins and reduced blood flow in the portal vein. Liver cirrhosis is the seventh leading cause of death. Drugs are the main cause of liver damage. More than 900 drugs, toxins and herbs are reported to cause liver damage. The purpose of this review article is to summarize the results of previous studies on the use of hepatotoxic drugs in patients with liver cirrhosis. Data sources for this study were identified through searching Google Scholar, PubMed and Science Direct using the keywords "hepatotoxic drugs" and "liver cirrhosis" in articles published between 2011-2022. Finally, 10 articles were obtained and analyzed. The results of this review article show that liver cirrhosis patients are still often prescribed potentially hepatotoxic drugs. Some commonly prescribed drugs include paracetamol, omeprazol, ranitidine, ceftriaxon, ciprofloxacin, atorvasatin, metformin, and amiodarone.

Analisis Senyawa Obat Vankomisin dalam Plasma Darah dengan Berbagai Metode Elvira Julia elvira julia; Arline Rahmadianti Kusumawardhani; Anggraini Anggraini; Nolla Olipia Elva Megrian; Marsah Rahmawati Utami; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Vancomycin is one of antibiotic that used to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). The recommended concentration for vancomycin is 15-20 mg/L every 8-12 hours in the blood. Vancomycin has a narrow therapeutic index so that small changes in dose can lead to significant changes in drug response. Therefore, monitoring of drug therapy is recommended to optimize vancomycin concentrations. Vancomycin levels in blood plasma have been measured using a variety of analytical techniques, the two that are most frequently employed are high performance liquid chromatography (HPLC) and immunoassay methods. This review intends to give information on the two analytical methods and what is appropriate to learn about the comparison of the two analytical methods on vancomycin levels in blood plasma. The results of the review that has been carried out are that the main difference between the HPLC method and the immunoassay is in the basic principles of the analytical technique. The immunoassay method (FPIA and RIA methods) is more appropriate to use than the HPLC method because it conforms the results of the analysis, especially in the range of concentrations and sensitivities obtained.

Analisis dan Validasi Obat Metformin Dalam Plasma Manusia Menggunakan Metode HPLC Mulidini Mulidini; Asri Yuniar Dwi Nanda; Nissa Khalida Hanum; Lina Nurfadhila; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Analytical method validation is a process that ensures accurate, specific, reproducible and stable analysis of the analytical range appropriate to the intended use. Analytical method validation include all procedur for that demonstrate quantitative measure of analytes such as from plasma. Determination of the concentration of a drug in plasma is complex because plasma is a complex matrix. The drug identified was metformin. Metformin is a drug orally antihyperglycemic agent used in the management of type II diabetes mellitus. Methods for quantitation of metformin in human plasma or in pharmaceutical form, one of which uses High Performance Liquid Chromatography (HPLC). HPLC is a liquid chromatography technique used to process various mixture components. This article review aims to make it easier for readers and future researchers to determine the presence of metformin in human plasma by using the HPLC analysis method accurately. This research method uses the literature review method using national journals and international journals through the google scholar database. Methods by KCKT or HPLC that can be used to validate the determination of metformin levels in plasma include RP-HPLC, HPLC, HPLC-UV, and U-HPLC. The most commonly used method with the best validity, efficiency and time estimation is RP-HPLC..

Review: Analisis Senyawa Obat Warfarin dalam Plasma Darah dengan Metode HPLC/KCKT Siti Nafisa; Siti Rohmah; Yumareta Anggun Nihan; Lina Nurfadhila; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Warfarin is a synthetic derivative of coumarin whose use as an oral anticoagulant generally used to prevent and treat blood clots, prophylaxis also the treatment of pulmonary embolism, and thrombosis of venous, prophylaxis and treatment prophylaxis of thromboembolic complications from atrial fibrillation or replacement of heart valve, and the risk of death from recurrent myocardial infarction, and thromboembolic events after myocardial infarction can be reduced. Warfarin is a narrow therapeutic index of oral anticoagulants where if there is a slight change in the level of warfarin in the blood, a change in the effective response can occur. Many analytical techniques have been developed for the analysis of warfarin levels in blood plasma, for example using High-Performance Liquid Chromatography coupled with ultraviolet/fluorescence detection, SFC-MS/MS, LC-MS/MS, CZE with ultraviolet detection, and MEKC-ESI–MS. The test method used for monitoring this Review Article has the purpose of reviewing and comparing analytical methods/detection techniques used for the analysis of warfarin in blood plasma. The HPLC method has several advantages in the analysis of warfarin drug levels, such as ease, accuracy, effectiveness of analysis time, and advantages of high sensitivity and selectivity.

Pengujian Gel Antiseptik Infusa Daun Kelor Terhadap Jumlah Angka Kuman Serta Evaluasi Fisik Sediaannya Asiska Permata Dewi; Kony Putriani; Yulia Yesti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Moringa leaves (Moringa oleifera L.) is a plant which has benefit as anti-bacteria, anti-inflammation, and virus infection. Moringa leaves contain secondary metabolic compounds such as flavonoids, phenol, tannin, saponin, alkaloids, and triterpenoids. This research aimed to find out the effectiveness of the antiseptic gel of moringa leaves infusion on the number of germs, and its physical preparation and evaluation. The research method carried out on testing the number of germs was by counting the number of bacteria colonies which still grow in Nutrient Agar media after smeared with antiseptic gel of moringa leaves infusion, then evaluated for its physics gel trait covering organoleptic, pH, homogeneity, spreadability, and consistency. The testing result showed that in the germ count test at F1, F2, and F3, the average bacteria colony which still grew after incubation was in the amount of 137, 113, and 49 colonies. Testing in the positive control (Nuvo®) and negative control (gel basis), the average bacteria colony which still grew were in the amount of 17 and 173 colonies. The organoleptic test showed the gel form as semi-solid, greenish in colour, and the typical smell of moringa leaves, pH was in the range of 4,5 – 6,5, not seen coarse grain in gel preparations (homogeneous), spreadability around 5,1 cm – 5,5 cm and phase separation did occur in consistency test. Thereby, the higher the infusion concentration of moringa leaves in antiseptic gel, then the better its antiseptic effectiveness.

Skrining Resep Polifarmasi Secara Klinis Pada Pasien Diabetes Melitus Tipe II Di Rumah Sakit Advent Razoki; Nur Afni Br. Ritonga; Novitaria Br. Sembiring; Elfia Neswita
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

A few examples of clinical criteria include precise indications, duplication therapy, allergies, unexpected drug reactions (ROTD), contraindications, and drug interactions. Staff employees in the pharmaceutical industry screen prescriptions to prevent the occurrence (Medication errors). According to Hindratni et al. (2017), treatment errors occur when medical professionals handle patients while giving them potentially harmful medications. Research Objectives to comprehend the frequency and seriousness of drug interactions that arise when diabetes mellitus drugs are administered in Adventist hospitals. This study uses descriptive research methods and retrospective research designs, which means it looks at the material already gathered and generated from October and December 2022 recipe dataThe 500 or so prescriptions that IFRS Adventist Medan received between October and December 2022 are where the recipes were collected. Five hundred tablets were used as a sample, and 131 met the criteria for inclusion in the clinical screening of polypharmacy prescriptions in patients with type II diabetes mellitus at Adventist hospitals. 100 percent of the 131 prescriptions were correct regarding indications, drug doses, instructions, methods, and duration of use. Three different drugs, or 25% of all medications, have interactions. The drugs they interacted with were found in 4 prescriptions or 72%. The number of pills (65.21%) containing the drugs they interacted with was 5. Six medicines (60.71%) included medications that interacted with one another. There were seven prescriptions (52.94%) that had interactions with drugs.

Skrining Resep Polifarmasi Secara Klinis Pada Pasien Hipertensi Di Rumah Sakit Advent Razoki Razoki; Rezki Sari Harahap; Novitaria Br Sembiring; Elfia Neswita
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Introduction: The use of drugs in inappropriate amounts or doses is known as polypharmacy. The development of polypharmacy and the complexity of drugs currently used in medicine allowed a huge increase in drug interactions. Method: The method used in this study is a descriptive method and data collection is carried out retrospectively. This study was conducted with the aim of finding out more about the description of drug interaction events in patients diagnosed with hypertension. Results: The collected prescriptions were those received by IFRS Advent Medan in October-December 2022 as many as 500 prescriptions. The next step, prescriptions are screened and adjusted to the categories of inclusion and exclusion requirements. Prescriptions that meet the inclusion category are original prescriptions with a minimum of 3 drugs, a total of 132 prescriptions. So in this article, a completeness analysis of polypharmacy prescriptions was carried out based on clinical studies of 132 prescriptions. Conclusion: The accuracy of indications, drug dosage, rules, methods, and duration of use of the complete drug is 100%, The prescription contains 3 drugs, there are 7 interacting prescriptions (54%) out of a total of 13 prescriptions.

Uji Efektivitas Ekstrak Etanol Ikan Gabus (Channa striata) Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan (Mus musculus) Muhammad Gunawan; Safriana Safriana; Andilala Andilala
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Cork fish can help speed up the healing process of diabetes. Diabetes mellitus is a metabolic disease characterized by symptoms of hyperglycemia as a result of impaired insulin secretion and/or increased cell resistance to insulin. The purpose of this study was to determine the ethanol extract of Cork fish (Channa striata) has the most effective effect in lowering blood glucose levels. Methods: experimental research that begins with extracting the meat and skin of the Cork fish by means of percolation, the solvent used is 70% ethanol, the results obtained are ethanol extract of the Cork fish. Tests for decreasing blood glucose levels of mice using 30 mice and divided into 6 groups. Group I (solvent control) Na CMC 0.5%, group II (comparator/glibenclamide), group III (comparison/herbal medicine), group IV, V and VI (treatment of Cork fish ethanol extract dose 0.45; 0.0, 9 and 1.8 g/KgBB). Blood sugar levels of each group were statistically analyzed using the One Way ANOVA method and Duncan's Post-Hoc test using SPSS. Statistical test results for blood glucose levels between the glibenclamide, herbal medicine and ethanol extract of Cork fish showed a significant difference with an α value > 0.05. From the results of the study it can be concluded that the ethanol extract of Cork fish has glucose-induced blood glucose lowering activity in mice with an effective dose of 1.8 g/kgBB.

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Home Page

OAI Link

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Contact Name Salman

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Phone +6285277011177

Journal Mail Official admin@journal-jps.com

Editorial Address Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location Kota medan, Sumatera utara INDONESIA

Abstract

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Contact Name
Salman

Contact Email
salman.kimia@gmail.com

Phone
+6285277011177

Journal Mail Official
admin@journal-jps.com

Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location
Kota medan,

Sumatera utara

INDONESIA