cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
 10   11   12   13   14 
Review Artikel: Validasi Metode Analisis Penetapan Kadar Parasetamol Dalam Sampel Biologis Dengan Berbagai Metode Tiwi Ambarati; Najla Yusiana Wahyudi; Saarah Hamidah Asmara Indratno; lina Nurfadhila; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.42 KB) | DOI: 10.36490/journal-jps.com.v6i2.157

Abstract

Paracetamol is one of the most widely used pain relievers and analgesic drugs by the public. Examination of drug concentrations in biological samples using appropriate methods is necessary to ensure drug quality and optimize drug therapy. Therefore, this literature study was conducted with the aim of determining paracetamol levels in biological samples and testing its validity with various methods. Literature research was carried out by searching for several research journal articles that had been published in 2013-2023, which were selected according to the inclusion and exclusion criteria. Six journals were obtained regarding the validation of analytical methods for determining paracetamol levels in biological samples using various methods such as Gas Chromatography-Mass Spectrometry (GC-MS), Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS), Mass Spectrometry-High Performance Liquid Chromatography (HPLC- MS), and Mass Spectrometry Ultra High-Performance Liquid Chromatography (UHPLC-MS). From the above review it can be concluded that the method of analyzing paracetamol compounds in biological samples can be carried out with these four methods where the results of the analytical methods namely accuracy, selectivity, linearity, precision, LOD, and LOQ all meet the requirements or set criteria.
Analisis Kualitatif Senyawa Parasetamol Pada Sampel Biologis Menggunakan Metode Gas Chromatography - Mass Spectrometry (GC-MS) Siti Nuriah; Mutia Desvi Putri; Sri Rahayu; Chalisya Vanya Advaita; Lina Nurfadhila; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.433 KB) | DOI: 10.36490/journal-jps.com.v6i2.158

Abstract

In this review article, an analysis was carried out regarding the use of the Gas Chromatography - Mass Spectrometry (GC-MS) method in the qualitative analysis of paracetamol compounds in various biological samples such as blood, serum, hair, and urine. Paracetamol is a non-opioid analgesic drug used to relieve mild to moderate pain. The method used in writing this article is a literature study using primary data in the form of national journals from the Google Scholar and Sinta databases. The search was carried out using keywords related to the qualitative analysis of paracetamol compounds using the GC-MS method on biological samples. The purpose of reviewing this article is to compare the treatment and preparation processes of various biological samples used in the qualitative analysis of paracetamol compounds using the Gas Chromatography - Mass Spectrometry (GC-MS) method, such as blood, serum, hair, and urine. The results of the study of several journals showed that there were several biological samples used in the qualitative analysis of paracetamol using the GC-MS method, namely blood, serum, hair and urine. Each biological sample has different preparation and extraction procedures according to the characteristics of the matrix. It can be concluded that of the four samples, hair samples can show positive results in a longer period of time while blood and urine samples can only provide drug information for a few days.
Review artikel: Metode Analisis obat Tuberkulosis Dalam Plasma Darah Datu Muhammad Cordova; Shiyami Aulia Nur Darmawan; Mutiara Alfiyah; Marsah Rahmawati Utami; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.61 KB) | DOI: 10.36490/journal-jps.com.v6i2.160

Abstract

Tuberculosis is a respiratory disorder that is contagious and is caused by an infection with the bacterium Mycobacterium tuberculosis (aerobic bacteria). Treatment of tuberculosis usually uses first-line drugs, namely isoniazid, rifampicin, ethambutol and pyrazinamide. The purpose of this study was to review the effectiveness of developing HPLC or UPLC methods with UV and MS detectors to review tuberculosis drug concentrations in biological blood plasma samples. The author's search method in compiling the results of a journal review regarding the development of methods for analyzing anti-tuberculosis drugs (OAT) in biological blood samples using databases from Google Scholar and Pubmed®. A total of 26 relevant journals will be used for discussion in the journal review. The results obtained are the most widely used method in the analysis of OAT using HPLC/UPLC mass and ultraviolet detectors in a biological sample, blood plasma. It has been reported in several studies that the UPLC method has increased sensitivity as indicated by a decrease in LOD and LOQ values compared to the HPLC method.
Perbandingan Metode Analisis Kadar Senyawa dan Toksisitas Merkuri (Hg) dalam Sampel Biologis Priscinya Christiana Debora; Sofianti Hidayat; Mochamad Galuh Ryandha; Marsah Rahmawati Utami; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.507 KB) | DOI: 10.36490/journal-jps.com.v6i2.162

Abstract

Mercury or mercury (Hg) is a type of metal as an organic and inorganic compound that can be found in nature and is spread in rocks, ores, soil, water and air. Mercury in the body can be detected in biological materials such as urine, blood, breast milk and hair. This study aims to analyze the content and toxicity of mercury (Hg) in biological samples such as blood, hair, urine and breast milk with various analytical methods including CV-AAS, AAS, CV-AFS, ICP-MS, FI-CV-AAS, and Mercury Analyzers. Data collection was based on the Literature Review by collecting several published research journals both at national and international levels which were filtered according to inclusion and exclusion criteria using the PRISMA method (Preferred Reporting Item for Systematic Review and Meta-Analysis). The method used depends on the needs of the analysis, its sensitivity and availability. Of the several methods used, AAS or atomic absorption spectrophotometry is the most commonly used method, because this method is simple and considered fast for analyzing mercury levels in biological samples.
Artikel Review: Analisis Obat Metamfetamin Dalam Sampel Rambut Dengan Berbagai Metode Syifa Khairunnisa; Eka Wulan Galuh Pratiwi; Anggi Ayu Pratama; Marsah Rahmawati; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.16 KB) | DOI: 10.36490/journal-jps.com.v6i2.164

Abstract

Methamphetamine is a narcotic substance commonly known as shabu - shabu, which can damage the central nervous system and even cause death so that its distribution is restricted in Indonesia. The content of methamphetamine in the body can be analyzed using biological samples, one of which is hair. Hair is a part of the body that is commonly used to prove the presence of methamphetamine in the body because in the hair a drug can last for a long time, up to months. Writing a review of this article aims to make it easier for readers and researchers. The method of writing a review of this article is by conducting a literature search of research related to the analysis of methamphetamine in biological hair samples. Based on the results of a review of the journal, analysis of methamphetamine in hair samples can be carried out qualitatively and quantitatively with several methods that can be used to detect methamphetamine, including the marquis method, Gas Chromatography Mass Spectroscopy (GC-MS), Graphene Oxide Assisted Membrane Electron Extraction (EME) with Chromatography Gas (GC), and FE-GC/MS.
Validasi Metode Analisis Senyawa Obat Dalam Sampel Biologis (Urine) Shinta Puspa Dwiyanti; Diva Afiah Hanifa Irawan; Zuyyinna Alya Abbas; Marsah Rahmawati Utami; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.098 KB) | DOI: 10.36490/journal-jps.com.v6i2.165

Abstract

Urine is one of the selected specimens because the content of metabolites and drugs in urine is relatively high. In addition, the easiest and most stable sample to examine is a urine sample. The aim of this study was to determine a valid analytical method for analyzing drug compounds in biological samples of urine. The research method used was to conduct a literature study on several credible journals with journal criteria for the last 10 years regarding determining drug levels in human urine. The final results were obtained from five different analytes, namely Trimethoprim (TMP), ciprofloxacin, acetaminophen, methanol, and opiates which have been validated using several validation methods namely; HPLC with Photodiode Array Detector (PDA), HPLC with fluorescence detector, capillary electrophoresis with UV detector, spectrofluorometric, Gas Chromatography-Mass Spectrometry (GC-MS), GC-FID, and Spectro photo densitometry using human samples urine, all have met the validation requirements. So, it can be concluded that the biological sample of human urine is quite accurate as the sample used in the analytical validation method.  
Uji Efektivitas Ekstrak Etanol Daun Labu Siam (Sechium edule (Jacq.) Swartz) Sebagai Penyembuh Luka Sayat pada Tikus Putih (Rattus norvegicus) Charly J. Watung; Christel N. Sambou; Jabes W. Kanter; Reky R. Palandi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.093 KB) | DOI: 10.36490/journal-jps.com.v6i3.168

Abstract

Herbal plants refer to plant species that can be used as medicinal herbs, either individually or in combinations, believed to prevent and facilitate wound healing. One such herbal plant commonly used by the community is the leaves of Chayote (Sechium edule (Jacq.) Swartz), believed to accelerate the healing of wounds. This research aims to determine the effectiveness of ethanol extract from Chayote leaves (Sechium edule (Jacq.) Swartz) in healing incision wounds in white rats (Rattus norvegicus). The samples used were 15 male rats. A 1 cm incision wound was made on the rats' backs using a surgical blade. The research employed a Completely Randomized Design (CRD) with 5 treatments: negative control, positive control (10% povidone iodine), and 3 concentrated extracts (5%, 10%, 15%) with 3 repetitions each. The treatments were administered twice a day for seven days. The calculation of wound healing percentage in rats based on the research results indicated that Chayote leaf extract with a concentration of 15% showed 100% effectiveness in healing incision wounds in white rats.
Formulasi sediaan body lotion dari ekstrak etanol buah bit (Beta vulgaris L.) sebagai pelembab kulit dan antioksidan Tri Putri Ananda; Yessi Febriani; Sudewi Sudewi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.51

Abstract

Background; Antioxidants are molecules that can prevent cell damage by free radicals. Beets (Beta vulgaris L.) are known to contain flavonoids which are antioxidants. This study aims to examine the antioxidant activity and skin moisturizing effect without skin irritation in a product formulated as a body lotion from the ethanol extract of beets (Beta vulgaris L.) at a certain concentration. Methods; This research was conducted using an experimental method using beetroot (Beta vulgaris L.) test material obtained by soaking 96% ethanol extract made in body lotion preparations with concentrations of 1.5%, 2%, 2.5% and blank samples. Sample and preparation tests included phytochemical screening, homogeneity test, inoculum pH test, emulsion type test, inoculum stability test, irritation test, water content test and antioxidant activity test. Result; The results showed that beet-based body lotion (Beta vulgaris L.) was a homogeneous preparation with an M/A emulsion and had a pH range immediately after preparation of 6.2 - 6.3 and a pH after cycle test was 6.2 - 6.3. Formula with a concentration of 2.5% (F3) is able to provide moisture in the wet category with a recovery rate of 27.74% lower than similar hand lotions that are applied to wet areas with a recovery rate of 28.18%. The ethanol extract of beets at a concentration of 2.5% (F3) had an IC50 valueof 118.101 µg/mL which indicated a moderate antioxidant class, while the ethanol extract of beets had an IC50 valueof 36.869 µg/mL which was classified as a very strong antioxidant. All body compositions based on ethanol extract of beetroot do not irritate the skin
Formulasi sediaan pewarna pipi menggunakan pewarna alami kopigmentasi biji kesumba keling (Bixa orellana L.) dengan angkak merah Salman Salman; Sudewi; Aprilia Ulfa; Rahma Yulia; Meutia Indriana
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.63

Abstract

Background; annatto (Bixa orellana L.) is a plant planted in the house or roadside gardens, containing alkaloids, flavonoids, and carotenoids. Red yeast rice is a natural product from China, resulting from traditional fermentation. This study aims to determine the co-pigmentation of annatto and red yeast rice seeds in the form of ethanol extract, which can be formulated as a natural dye into blush on preparations that, at specific concentrations, produce natural colors that meet the requirements and do not cause skin irritation. Methods; the study used an experimental approach using the test material of annatto seeds (Bixa orellana L.) and red yeast rice. The study was initiated by sampling, plant identification, Simplicia processing, and co-pigmentation of annatto (Bixa orellana L.) and red yeast rice seeds by maceration using 96% ethanol extract, p; phytochemical screening was carried out. The basic modified formulation of blush on a ratio of 1:2 between annatto seeds and red yeast rice seeds was made in 3 preparations with a concentration of 3%, 6%, and 9%, and blank. Examination of the physical quality of the preparation includes color dispersion test (homogeneity), polish test, stability test, and irritation test. Result; the results of the study concluded that the copigmentation of annatto (Bixa orellana L.) seeds and red yeast rice in the form of ethanol extract could be formulated into blush on preparations as natural dyes, which are homogeneous, easy to apply,y and stable for 12 days of storage. Produces different colors depending on the concentration contained in the preparation of the cheek dye. The co-pigmented cheek dyes made from ethanol extract of annatto (Bixa orellana L.) and red yeast rice seeds were non- irritating to the skin.
studi penggunaan pewarna kopigmentasi biji kesumba keling (Bixa orellana L.) Dan Angkak Merah Dalam Formulasi Suspensi Parasetamol Salman Salman; Sudewi Sudewi; Jazilul Amira; Meutia Indriana
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.64

Abstract

Background; Annatto seeds (Bixa orellana L.) is a plant originating from the Americas, which is widely cultivated in tropical and subtropical areas. Red yeast rice is white rice that has undergone a fermentation process from rice and mold (Monascus purpereus). This study aims to determine the copigmentation of annatto seeds (Bixa orellana L.) and red yeast rice in the form of ethanol extract that can be formulated as a dye into paracetamol suspension which at certain concentrations can produce colors that meet the requirements and are able to provide color stability. Methods; His study used an experimental method, using the test material of annatto seeds (Bixa orellana L.) and red yeast rice with a ratio of 1:2 using maceration method using 96% ethanol solvent, formulated into paracetamol suspension preparations with concentrations of 0.25%, 0.50% , 0.75%, as well as blanks. Examination of the physical quality of the preparation includes, organoleptic examination, determination of the pH of the preparation, observation of the stability of the preparation against storage, and viscosity test. Result; The results showed that the seeds of annatto seeds (Bixa orellana L.) and red yeast in the form of ethanol extract could be formulated as a dye into the preparation of paracetamol suspension. Copigmented paracetamol suspension preparations of ethanol extract of annatto seeds (Bixa orellana L.) seeds and red yeast rice with a ratio of 1:2 are stable preparations and have a pH range of 4.1-4.4 and pH after cycling test 4.0-4.3 . Has a different color for each concentration contained with a viscosity of 102.0-136.0 dPa.s. The preparation of paracetamol suspension of formula I with a concentration of 0.25% produces a red color (+), the preparation of formula II with a concentration of 0.50% produces a red color (++), the preparation of formula III with a concentration of 0.75% produces a red color (++ +) and white blank preparations.

Page 12 of 62 | Total Record : 616

 10   11   12   13   14 

Filter by Year

2018 2025


Reset
Filter By Issues
All Issue JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue