cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
 11   12   13   14   15 
Evaluation of Coffee Mistletoe Leaf Ethanol Extract on Burn Healing Activity on White Male Rat M. Rifqi Efendi; Diah Riski Gusti; Annisa Dhita Syahrial; Mesa Sukmadani Rusdi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.72

Abstract

Burns are injuries that can be caused by heat (fire, hot liquids/fats, hot vapors), radiation, electricity, or chemicals. Coffee mistletoe leaves (Loranthus ferruginous Roxb) are one type of plant that contains secondary metabolite compounds, such as flavonoids, tannins, saponins, alkaloids, and phenolics, which play a role in the burn healing effects. This research was conducted using an experimental research method with a Completely Randomized Design (CRD) and a post-test only control group design approach. A total of 25 rats were divided into five treatment groups for the study. The groups included a positive control group treated with Bioplacenton gel, a negative control group treated with yellow vaseline, and three experimental groups treated with different concentrations of ethanol extract of coffee mistletoe leaves. The concentrations used were 5% (P1), 10% (P2), and 15% (P3). The burn healing activity and hydroxyproline content were observed as outcome measures. The data were presented as mean ± SD and analyzed using one-way ANOVA. Subsequently, Duncan's multiple rank test was performed to determine any significant differences. A significance level of p<0.05 was considered to define statistically significant results. The results of the study showed that ethanol extract of coffee mistletoe leaves has an effect as a burn treatment, with the best concentration found at 15% concentration, which had a healing percentage of 62.5%, although its effectiveness did not exceed that of the positive control group (72,48%). The hydroxyproline content of the coffee mistletoe leaf extract group demonstrated significant difference when compared to control negative groups, especially P1 group (53.62±6.52 μg/mL), and statistically not different with positive control (64.34 ±6.02 μg/mL). For the P2 and P3 groups, the hydroxyproline content were increased but did not reach significant value. Wound-healing activity owing to its richness in various effective chemical compounds present in the extract such as phenolics, saponin, flavonoid and alkaloid. Further investigation is necessary to identify and understand these additional components and their mechanisms of action in the healing process.
Isolasi dan identifikasi dengan gen 16s rRNA bakteri endofit dari tanaman pepaya (Carica papaya L.) serta uji aktivitas antibakterinya Irwandi; Lola Azyenela; Hera Purnama Sari; Epi Supri Wardi; Diza Sartika
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.82

Abstract

Endophytic bacteria live symbiotically in host plant tissues and can produce the same bioactive compounds as their host plants, including antibacterial agents. This study aimed to isolate and test the antibacterial activity of endophytic bacteria from the Carica papaya plant and to carry out molecular identification using the 16S rRNA gene against bacterial isolates with the most excellent antibacterial activity. A total of six isolates of endophytic bacteria were successfully separated through the purification process. Through microscopic identification using gram staining, all endophytic bacterial isolates belong to gram-positive bacteria. The results of the antibacterial activity test showed that the six isolates of papaya plant endophytic bacteria could cause the growth of Escherichia coli bacteria but not against Staphylococcus aureus bacteria. The average diameter of the inhibition zone against Escherichia coli bacteria is as follows: RB1: 9.35 mm; RB2: 9.4mm; RB3: 9.15mm; CB1: 9.1mm; CB2: 9.2mm; CB3: 8.8mm; FB1: 8.45mm; FB2: 8.75mm; and FB3: 8.6mm. All papaya plant endophytic bacterial isolates had an inhibition zone categorized as weak. Bacterial isolate RB2, which has the most excellent antibacterial activity, is identified molecularly as Bacillus cereus.
Aktivitas hepatoprotektor ektrak etanol daun durian ((Durio zibethinus Murr.) pada mencit yang diinduksi parasetamol Puspa Dwi Pratiwi; Nazrah Tiara; Intan lestari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.92

Abstract

Durian (Durio zibethinus Murr.) have been studied and reported has antioxidant activity and its potential as hepatoprotector. This study was determined the hepatoprotector activity and effective dose of ethanol extract of durian (Durio zibethinus Murr.) leave on mice. This experiment was experimental study using completely randomized design (CDR) with a post-test only control group design used 35 mice were divided into 5 treatment groups: negative control (NaCMC), positive control (acetaminophen 5.07 mg/20g bodyweight), treatment 1 (125 mg extract/kg bodyweight), treatment 2 (250 mg extract/kg bodyweight), and treatment 3 (500 mg extract/kg bodyweight). Secondary metabolites of extract, SGPT and SGOT of mice’s blood, and histopathology of mice’s liver was observed. This study showed that extract contained alkaloid, flavonoid, phenolic, and saponis. From SGPT and SGOT value, the results showed that the higher the extract was given, the level of SGPT and SGOT value decreased. Our study revealed that ethanol extract of durian leaves has activity as hepatoprotector and the effective dose was 500 mg/kg bodyweight.
Factors Associated with Unsuccessful Treatment of Bedaquiline and or Delamanid Based Regimens in Multidrug-Resistant Tuberculosis: A Review Nugraha Putra, Oki; Faizah, Ana Khusnul; Wijayanti D.N, Nani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.140

Abstract

Background: Multidrug-resistant tuberculosis (MDR-TB) is a serious health concern that is difficult to treat, requiring long and complex treatment with highly effective drugs. An all-oral regimen, bedaquiline and or delamanid have already shown low unsuccessful treatment in patients with MDR-TB. Method: We comprehensively reviewed factors associated with unsuccessful treatment (death, treatment failure, and loss to follow-up) related to all oral regimen containing bedaquiline and or delamanid in patients with MDR-TB. We conducted a scoping review under the PRISMA guideline for scoping review. Results: We included seven observational studies that met the inclusion criteria. Four studies reported the concomitant use of bedaquiline and delamanid. Unsuccessful treatment ranged from 7.8% to 36.6% in regimens containing bedaquiline, delamanid, or both at six months or after treatment completion. Low rates of treatment failure and loss to follow-up were reported in the included studies. Elderly, being underweight (BMI < 18.5 kg/m2), and hepatitis C coinfection among MDR-TB patients were associated with unsuccessful treatment in most studies. None studies reported pre-XDR and XDR-TB as risk factors for unsuccessful treatment. Conclusion: In MDR-TB patients receiving regimens containing bedaquiline and delamanid, age, BMI, and hepatitis C coinfection were associated with unsuccessful treatment.
Penetapan kadar flavonoid total ekstrak etanol buah asam kandis (Garcinia xanthochymus) dengan metode spektrofotometri Uv-Vis dan LCMS Hanafis Sastra Winata; Hendri Faisal; Muhammad Andry; Nurul Aulia; Muhammad Amin Nasution; Ika Julianti Tambunan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.159

Abstract

Background: Kandis acid fruit (Garcinia xanthocymus Hook. f ex T. Anderson) is a plant of the Clusiase family with many species. Kandis acid fruit has various biological and pharmacological activities such as cytotoxic, anti-inflammatory, antimicrobial, antifungal and antioxidant. Purpose: To determine the content and total flavonoid content of tamarind kandis using quercetin as a reference standard. Method: This study used the TLC (Thin Layer Chromatography) method in qualitative analysis with the parameter Rf, then used the spectrophotometric method in the quantitative analysis with the parameter total flavonoid content (Value of mg QE/g sample) and the LCMS method (Liquid Chromatography Mass Spectrometry) with the parameter retention time (Rt). Result: Shows that tamarind kandis has an Rf value of 0.86 which states that tamarind kandis is positive for flavonoids with a reference standard of quercetin, total flavonoid content of 34.8364 mg QE/g sample with a standard deviation of 0.4355 and a percentage of 0.6967% and has five types of flavonoid compounds namely methyl dihydro quercetin, 1,5-Dihydroxy-3-methoxy xanthone, Afzelechin, Myricetin-3-O-ß-D-galactopiranoside, and Myricetin 7-glucoside. Methyl dihydro quercetin is the largest flavonoid with a composition of 49.57% with a retention time of 0.485 minutes. Conclusion: The identified total flavonoids have different types and levels
Review: Perbandingan Validasi dan Kadar Amlodipin dalam Sampel Plasma Darah pada Kromatografi Cair Kinerja Tinggi dan Kromatografi Cair Spektrometri Massa Deborah Chennia Lau; Tiara Cinta Amelia; Diara Ravika Hadjami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.166

Abstract

Amlodipine has a high bioavailability, a large volume of distribution, and a sufficiently long elimination half-life of 35 to 50 hours so that low plasma concentrations of amlodipine are achieved after oral administration. One of the methods used to quantify amlodipine levels is High-Performance Liquid Chromatography and Liquid Chromatography Mass Spectrometry. This review aims to compare the validation of the two methods according to the parameters and determine the advantages and disadvantages of each process in terms of accuracy in identifying samples of amlodipine in blood plasma. An article review was conducted by collecting data from 2013 to 2023 using the Google Scholar and ScienceDirect databases filtered according to the inclusion and exclusion criteria. Seven journals could be compared according to the parameters of precision, accuracy, linearity, limit of detection and quantification. Better precision and accuracy are in the High-Performance Liquid Chromatography method, and good linearity is in the Mass Spectrometry Liquid Chromatography method. Liquid Chromatography Method Mass Spectrometry is easier to detect amlodipine levels because it can detect concentrations of more minor sample levels.  
Resistensi Obat Aspirin Terhadap Pasien Penyakit Jantung Koroner: Sebuah Literature Review Mally Ghinan Sholih; Munir Alinu Mulki; Ain Luthfiannisa; Esti Syahrin; Moza Aulia Syifni; Muhammad Naufal Nurhadi Hidayat; Safira Rosyidah; Salma Alviyah; Muhammad Raka Tresna
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.167

Abstract

In Indonesia, coronary heart disease is the largest contributor to mortality with a prevalence related to cardiovascular disease. Using drugs from a combination of fibrinolytics, anticoagulants, and antiplatelets can overcome acute coronary heart disease. The most commonly used therapy is the antiplatelet class in the form of aspirin as a treatment for the management of cardiovascular disease and its prevention. However, several studies have stated that aspirin is a conventional antiplatelet which sometimes has the potential to cause failure and is ineffective for the treatment of coronary heart disease, so that it can be said to be aspirin resistance. Article writing method review This study uses scientific literature. The steps taken begin with collecting various journal references through the database PubMed Identifier (PMID), google schoolar, and science direct within the last 10 years (2013-2023). The keyword in the literature search is aspirin resistance, aspirin resistance coronary disease, and aspirin coronary heart diseases. Based on the results of reviews that have been reviewed, it shows that there are resistance mechanisms and factors that influence aspirin resistance in coronary heart disease patients.
Review jurnal: pola perbandingan pengobatan farmakologi penderita dispepsia di beberapa rumah sakit Mally Ghinan Sholih; Munir Alinu Mulki; Sophy Wulandari; Putri Wahyu Primasti; Giga Anugerah Arsylrakhmatika; Nurlita Dwi Putri Prihasti; Amanda Maharani; Roudotul Jannah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.170

Abstract

Dyspepsia is a common complaint often found in the community and among patients who come to clinical practice. Symptoms of dyspepsia include abdominal discomfort, nausea, vomiting, burning, bloating in the upper digestive tract, early satiety, fullness after eating, and belching. This literature review compared prescription patterns in dyspepsia patients from several hospitals. The research method began with a literature search through the PubMed and Google Scholar databases within the specified year range and using the keywords dyspepsia, pattern, treatment, and drug. The conclusion is that there are many uses for generic drugs and different types of drugs in treating patients with dyspepsia. Factors influencing the management of dyspepsia in inpatients include gender, reported clinical symptoms, class of antiulcer therapy, differences in the number of drugs, and drug dosage forms.  
Review artikel: efektivitas penggunaan fototerapi terhadap rinitis alergi pada ibu hamil Mally Ghinan Sholih; Munir Alinu Mulki; Annisa Frastica Septi; Muhammad Ja'far Ash Shidiq; Nariyyah Fitriana; Shalum Putriyani; Yuni Lili Indriyani; Yuniar Fathil Ilmi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.171

Abstract

Rhinitis is an inflammation of the mucous membrane of the nose that affects millions of people worldwide. Although there has been much research and development related to the management of rhinitis, there are still challenges in achieving effective treatment and optimal symptom control. The purpose of writing this article is to achieve effective treatment and optimal control of rhinitis symptoms. The writing method used is literature review by collecting primary references from international journals published in the last 10 years (2013-2023). Referrals are selected through the pubMed database with relevant keywords.  The results and discussion of this study include information on allergic rhinitis, rhinitis of pregnancy, hormonal changes during pregnancy, and commonly used medications. In the treatment of gestational rhinitis, the use of phototherapy can be the right choice. Based on articles that have been reviewed, it shows that treatment with phototherapy is more effective in overcoming the symptoms of allergic rhinitis. Phototherapy has a good effect on immunosuppressants and immunomodulators that can suppress the body's immune activity and also relieve inflammation.  
Formulasi Dan Uji Stabilitas Sabun Padat Transparan Ekstrak Biji Pala (Myristica fragrans Houtt) Fauziah Fauziah; Nurmalia Zakaria; Azmalina Adriani; Nazirah Nazirah; Khamdiyah Indah Kurniasih
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.172

Abstract

Transparent solid soap is a solid texture soap. Solid soap formulated with the addition of nutmeg extract serves as a drug agent to treat infections of the skin that cause bacteria. This study aims to determine the formulation and stability of the solid soap from the nutmeg seed extract. The research method is an experimental method. The treatments used were concentrated in formula 1 (0.5%), formula 2 (1%) and formula 3 (1.5%). The research parameters were organoleptic test, pH test, foam stability test, moisture content test. The results showed that the form of transparent solid soap from nutmeg seed extract was very dense, varied in color, namely clear chocolate (Formula 1), brown (Formula 2) and dark chocolate (Formula 3) with a less nutmeg odor. This soap has a pH of 11 and has different levels of foam. Formula 1 with initial foam height of 6.7 cm and final foam height of 5.5 cm (moisture content 5.17%). Formula 2 has a foam height of 7.4 cm and a final foam height of 5.8 cm (water content 4.99%), while formula 3 has a foam height of 8 cm and a final foam height of 6.3 cm (moisture content is 4.96%). The conclusion is the transparent solid soap made from nutmeg extract has met the soap requirements as stipulated by the Indonesian National Standard for the soap stability test (SNI 3532-2016).

Page 13 of 62 | Total Record : 616

 11   12   13   14   15 

Filter by Year

2018 2025


Reset
Filter By Issues
All Issue JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue