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Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
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INDONESIA
Journal of Pharmaceutical and Sciences.
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Articles 616 Documents
Uji Efektitivitas Sediaan Gel Ekstrak Daun Kemangi (Ocimum basilicum L) Terhadap Penyembuhan Luka Sayatan Tikus Putih (Rattus nornvegicus) Anastasia Walukow; Douglas N. Pareta; Silvana L. Tumbel; Joke L. Tombuku; Christel N. Sambou
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.173

Abstract

Natural wealth has a variety of herbal plants, plants that are included in it efficacious as medicine. Traditional medicine, is an ingredient or herb that is usually used as traditional medicine and is used to accelerate the healing of diseases, one of the plants used to accelerate wound healing is basil leaves (Ocimum basilicum L.). This study aimed to determine the effectiveness of basil leaf gel preparations against wound healing in white rats (Rattus norvegicus). The test animals used were 15 rats. A 1 cm cut wound is made on the back of the mouse using a scalpel. The method used in this study is in the form of laboratory experiments. This study used a Complete Randomized Design (CDR) consisting of 5 treatments, including 1 negative control, 1 positive control (bioplacenton), and 3 stratified concentrations, namely 5% concentration gel, 10% concentration gel and 15% concentration gel with 3 repetitions each. The treatment is carried out for 7 days. The results of measuring wound diameter in rats based on the results showed that basil leaf extract gel concentration of 15% provided a healing effect more effective than other extracts.
Uji Efektivitas Etanol Daun Pandan (Panandus amarylifolius Roxb) Sebagai Penyembuhan Luka Sayat pada Tikus Putih (Rattus norvegicus) Priska C. Londoran; Jabes W. Kanter; Christel N. Sambou; Hariyadi Hariyadi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.174

Abstract

An incision is a wound that splits the skin area due to being cut by a sharp object. Indonesian people use medicinal plants very much in traditional or modern medicine. One of the plants that can be used as a medicinal ingredient is fragrant pandan leaves which can accelerate the wound healing process. This study aims to determine the level of effectiveness of pandan leaf extract as a healer for cuts. This study used 15 white rats which were then slashed on their backs using a 1 cm long scalpel with a depth of ± 2 mm. This study used a laboratory experiment using a completely randomized design consisting of 5 treatment groups, including 1 negative control, positive control (10 percent povidone iodine) and 3 graded concentrations, namely pandan leaf extract concentrations of 5.10 to 15 percent with 2 each. repetition times. The results of measuring the length of the wound in rats showed that fragrant pandan leaf extract with a concentration of 10 percent and 15 percent had the same effectiveness.
Uji perbandingan efektivitas ekstrak daun kemangi (Ocimum sanctum ) dan daun mint (Mentha arvensis) sebagai insektisida larva nyamuk Aedes aegypti Ali Napiah Nasution; Mahwina Yusari Harahap; Erika Auria Sinaga; Salsabila Bizlany Harahap
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.175

Abstract

Mosquitoes are vectors of various parasitic and viral diseases, especially in tropical and subtropical regions. A mosquito is a type of small insect that belongs to the family Culicidae. They are known for their annoying nature and bite humans as well as other animals to obtain blood as a food source. Female mosquitoes need protein contained in the blood to develop and lay their eggs. This study is a laboratory experiment, with a true experimental post-test only control group design which aims to compare the effectiveness of basil leaf extract ocimum sanctum. and mint leaves of mentha arvensis. As an insecticide of mosquito larvae Aedes Aegepty. At a concentration of 5% basil extract of dead larvae is 40% and mint leaf extract is 24% of dead larvae. At a concentration of 10%, mint extract of dead larvae 32%, while basil leaf extract 56% of dead larvae. At a concentration of 15% mint leaf extract of larvae that died 60% while basil leaf extract 60% of larvae died, and at a concentration of 25% mint leaf extract of larvae that died 64% while basil leaf extract 72% of larvae died. The results showed that basil leaf extract was more effective as an insecticide for Aedes aegpyti mosquito larvae than basil leaf extract. The higher the concentration of mint leaf extarak and basil leaf extract, the higher it is effective as an insecticide of Aedes aegpyti mosquito larvae.
Skrining Fitokimia Dan Analisis Kadar Kafein Pada Kopi Bubuk Jenis Arabika Di Kota Takengon Menggunakan Spektrofotometri Ultraviolet Muhammad Andry; Fahma Shufyani; Muhammad Amin Nasution; M. Fariz Fadillah; Ika Julianti Tambunan; Firman Rezaldi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.176

Abstract

Background: Coffee is a type of plant that contains caffeine and can be made into a delicious drink. Currently, coffee is the world's most popular drink after water and tea. The stuay aimed was to determine the caffeine content in Arabica ground coffee circulating in the Takengon market according to Indonesian national standards (SNI 01-7152-2006). This research was experimental by taking samples purposively. The research method used was phytochemical screening, qualitative analysis, and ultraviolet spectrophotometry at a wavelength of 273nm. The specified validation parameters were precision, linearity, LOD and LOQ. The results of the phytochemical screening of sample A in the Meyer test treatment obtained negative results but the others were positive. And in sample B, all tests were positive. In the three qualitative analyses tests on samples A and B, the results were positive. The average yield of quantitative analysis in sample A was 11.632 mg once and the daily concentration was 34.897mg. while in sample B the level was 6.663 mg once and drank 19.989mg per day. Validation test results obtained linearity r2 = 0.998, LOD and LOQ namely 0.882µg/ml and 2.94µg/ml, RSD value of 1.11%. Based on the conclusion, sample A and sample B met the requirements according to SNI 2006 (50mg once and 150mg daily) and also met the requirements according to the Pharmacopoeia Edition III, namely a maximum dose of 500 mg once and 1.5g daily.
Formulasi sediaan krim lulur dari sari wortel (Daucus carota L.) sebagai anti aging Fahma Shufyani; Muhammad Andry; Rida Evalina Tarigan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.177

Abstract

Background; Carrots are famous for the high beta carotene content in the fruit along with other vitamins, namely vitamin B and vitamin E. Vitamin E's role in the skin includes antioxidant, maintaining skin moisture, sun protection, and wound healing process. As a natural antioxidant, vitamin E is able to counteract free radicals and oxygen molecules. Objective:  To find out carrot juice (Daucus carota L.) can be formulated as a scrub cream as anti-aging and to find out at what concentration is the most effective in the preparation of carrotle scrub cream (Daucus carota L.) as anti-aging. Methods: This type of research was conducted experimentally. This research includes collecting respondents, measuring moisture content, smoothness, pores, blemishes, and wrinkles on the skin of respondents, making carrot juice, making scrub preparations from carrotle and evaluating preparation tests. Results: The use of scrub cream preparations containing carrotle (Daucus carota L.) concentration of 15% for 4 weeks showed changes in skin condition for the better with increased water content of 19.3 to 40 (107.25%), smoother skin smoothness of 36.3 to 20.6 (43.25%), shrinking pores 64 to 20.6 (67.81%), many blemishes were reduced 51 to 11.3 (77.97%), wrinkles that were reduced on the respondent's skin showed better results obtained, namely changes in wrinkles 45 to 13.6 with a recovery percent of (69.77%). Conclusion: The conclusion of this study is that carrottle (Daucus carota L.) can be formulated as a scrub cream as anti-aging.
Literature Review: Potensi Pemanfaatan Minyak Alami Dalam Inovasi Formulasi Kosmetik Arline Rahmadianti Kusumawardhani; Nur Komala Fitri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.178

Abstract

The utilization of natural oils as primary and additional raw materials has long been practiced in the cosmetics industry. Natural oils are known to be rich in nutrients and beneficial properties, making them suitable for the production of beauty and skincare products. The main objective of this literature review is to identify recent developments, identify and address issues that may arise in formulating products using natural oils, and explore opportunities in utilizing natural oils in cosmetic formulations. This literature review conducted by searching national and international journal articles from the period of 2012 to 2023, selecting those that were relevant to the topic and conducting a comprehensive analysis. Based on the literature review, it was found that natural oils have proven potential in innovating cosmetic formulations due to their natural and organic benefits, as well as being more environmentally friendly compared to chemical ingredients, although challenges that require solutions exist. Furthermore, through further research and innovation in the utilization of natural oils, superior and high-quality cosmetic formulations can be developed in the future.
Pemanfaatan Ekstrak Etanol Kulit Buah Naga Merah (Hylocereus polyrhizus) Dalam Sediaan Krim Lulur Sebagai Pelembab Alami Kulit Indra Ginting; Muhammad Andry
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.179

Abstract

Background: Flavonoid chemicals, vitamins A, C, and E, and polyphenols are found in the skin of red dragon fruit (Hylocereus polyrhizus), which may be utilized as a source of natural antioxidants to fight free radicals and give a moisturizing effect on the skin. Objective: In this study, an ethanol extract of red dragon fruit peel with concentrations of 1%, 3%, and 5% will be used to create a scrub cream preparation. Method: Experiments were used in this study. Organoleptic, homogeneity, dispersion, irritation, stability (cycling), and moisture efficacy tests were among the assessment procedures used to assess the scrub cream formulation. Results: The preparations all have a semisolid consistency, a vanilla scent, and a variety of hues, including white in the blank formula, cream in formulas F1 and F2, brownish cream in recipe F3, and light brown in formula F3. All of the prepared were uniform and did not bother the skin. With a pH range of 5.7–5.9, all preparations satisfied the criteria. With a dispersion of 5.6-7.9, the dispersive power of all preparations fulfilled the standards. There was no discernible change in the stability test during the riding test. The F3 scrub cream preparation had the biggest rise in skin water content from the F0, F1 and F2 preparations, which was 29.4% at week 4 after using the preparation, according to the findings of the moisture efficacy test. Conclusion: The study's findings indicated that red dragon fruit peel extract might be used to create a scrub cream preparation that can moisturize the skin and has passed physical assessment standards.  
Evaluasi tingkat pengetahuan pasien terhadap penggunaan obat diabetes mellitus tipe II dirawat jalan rumah sakit Advent Medan Windi Darantika; Rena Meutia
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.180

Abstract

The importance of one's health cannot be overstated, especially in today's world where many individuals suffer from numerous illnesses, including diabetes mellitus. Is there a correlation between patients' degree of awareness regarding the use of type II Diabetes Mellitus medications at Medan Adventist Hospital? is how the problem from this study is formulated. The goal of the study was to ascertain how patients' level of familiarity with the usage of type II Diabetes Mellitus medications at Medan Adventist Hospital correlated with their condition. This study is cross-sectional and analytical descriptive in nature. Patients with type II Diabetes Mellitus in the outpatient facility of Medan Adventist Hospital were surveyed prospectively in order to collect data. Data from patient medical records is also used in data collection. The study's findings include the knowledge of patients based on their age, gender, education level, occupation, length of suffering, medical history, and knowledge level. The findings are based on the knowledge levels of 100 respondents, of whom 42 (42%), 50 (50%), and 8 (8%), respectively, had good levels of knowledge, good levels of knowledge that were sufficient, and inadequate levels of knowledge. According to the findings of a study done at Medan Adventist Hospital, type II Diabetes Mellitus patients there had an average level of knowledge about drug use, with 50 respondents (or 50%) falling into this category.
Review artikel: Uji Efektivitas Ekstrak Daun Teh Hijau Sebagai Antibakteri Nur Komala Fitri; Arline Rahmadianti Kusumawardhani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.181

Abstract

Introduction: Tea is a plant that comes from the Theaceae family, the part of the tea plant that is commonly used as traditional medicine is the leaves, empirically drinking steeped tea leaves has properties for lowering blood pressure, preventing cancer and can reduce stress. Green tea is a type of tea leaf obtained by heating or using hot steam on older tea leaves compared to white tea. Purpose: the effectiveness of green tea leaf extract as an antibacterial based on several studies that have been conducted. Method: Article review with publication range 2013-2023. Results: Green tea leaf plants contain flavonoid compounds with the catechin subclass, catechins have antibacterial activity. Grkeen tea leaves will be extracted and then the catechin compounds will be separated from the main extract using KLT. Conclusion: From the awareness that has been made, it can be said that the catechin compounds contained in green tea leaf extract have antibacterial benefits, this is indicated by the presence of a clear zone in the experiment with the diffusion disc, then the clarity in the direct inoculation test, and the decrease in the number of bacterial colonies is measured by using a colony counter.
Uji efektitivitas sediaan gel ekstrak bonggol pisang goroho putih (Musa acuminafe, sp) terhadap penyembuhan luka bakar tikus putih (Rattus nornvegicus) Martina G. Laloan; Douglas N. Pareta; Selvana S. Tulandi; Yessie K. Lengkey; Christel N. Sambou
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.184

Abstract

Natural wealth has a variety of herbal plants, plants that are included in it efficacious as medicine. Traditional medicine, is an ingredient or herb that is usually used as traditional medicine and is used to accelerate the healing of diseases, one of the plants used to accelerate wound healing is the white goroho banana weevil (Musa acuminafe, sp). This study aimed to determine the effectiveness of banana weevil gel preparations against healing burns in white rats (Rattus norvegicus). The test animals used were 15 rats. A burn of 2.5 cm was made on the back of the mouse using metal coins. The method used in this study is in the form of laboratory experiments. This study used a Complete Randomized Design (RAL) consisting of 5 treatments, including 1 negative control, 1 positive control (bioplacenton), and 3 stratified concentrations, namely 5% concentration gel, 10% concentration gel and 15% concentration gel with 3 repetitions each. The treatment is carried out for 14 days. The results of measuring wound diameter in rats based on the results showed that banana weevil extract gel concentration of 15% provided a healing effect more effective than other extracts.