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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Formulasi dan uji karakteristik tablet effervescent buah belimbing wuluh dengan variasi konsentrasi asam sitrat dan asam tartat Ambarwati, Nadya; Nur, Fikria Marfuatin; Hidayah, Fufut Nurul
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.989

Abstract

Background: Averrhoa bilimbi L. is a natural source of vitamin C with potential as an antioxidant. Effervescent tablets are a popular dosage form in which the choice of acid sources, such as citric acid and tartaric acid, is critical due to their hygroscopic properties that affect the physical characteristics and stability of both granules and tablets. Objective: This study aimed to formulate and evaluate the effect of varying concentrations of citric acid and tartaric acid combinations on the physical characteristics of granules and effervescent tablets of Averrhoa bilimbi powder. Methods: The study employed the dry granulation method. Four tablet formulas with different ratios of citric acid and tartaric acid were prepared. The granules were evaluated for flowability, angle of repose, and moisture content. The resulting tablets were tested for organoleptic properties, weight uniformity, size uniformity, hardness, friability, and dissolution time. Data were statistically analyzed. Results: The evaluation showed that all granule characteristics (flow time 1.36–1.56 seconds; angle of repose 9.95°–13.50°; moisture content 3.298%–4.622%) met the requirements. All tablet evaluation parameters (weight uniformity, size uniformity, hardness, and dissolution time 1.27–1.36 minutes) also complied, except for friability (1.401%–2.832%), which exceeded the specified limit (>1%). Statistical analysis indicated that acid concentration variations had a significant effect (p-value < 0.05) on all tested parameters except tablet friability (p-value > 0.05). Conclusion: It can be concluded that variations in citric acid and tartaric acid concentrations significantly affect the characteristics of Averrhoa bilimbi effervescent granules and tablets, except for friability. The nonconformity observed in friability testing is presumed to be influenced by other formulation factors such as the type and concentration of binders and lubricants. Further studies on formula optimization, vitamin C content analysis, and accelerated stability testing are recommended.
Review Article: Pharmacological Activities and Bioactive Potential of Chinese Betel Leaf (Peperomia pellucida L. (Kunth.)) Razoki, Razoki; Lister, INE; Mutia, Maya Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1000

Abstract

Background: Peperomia pellucida L. Kunth (sirih cina) is a traditional medicinal plant used to treat various ailments. Its broad pharmacological potential needs to be consolidated from various publications to provide a comprehensive overview. Objective: This review aims to analyze and synthesize recent scientific evidence on the pharmacological activities, bioactive compounds, and potential applications of Pperomia pellucida. Methods: This systematic review was conducted by searching electronic databases (Google Scholar, PubMed, ScienceDirect, Scopus) using relevant keywords. From the search results, 21 original research articles published between 2015-2025 that met the inclusion criteria were analyzed descriptively and qualitatively. Results: The analysis revealed that Peperomia pellucida possesses diverse pharmacological activities, including anti-inflammatory, antibacterial, antifungal, antioxidant, anticancer, antidiabetic, antihypercholesterolemic, and osteogenic effects. These activities are supported by bioactive compounds such as flavonoids, tannins, alkaloids, and saponins. Its ethanolic extract has proven effective in in vitro and in vivo tests, including in topical formulations like creams and acne serums. Preliminary safety profiles indicate non-toxic properties. Conclusion: Peperomia pellucida shows great potential as a natural raw material for developing herbal medicines and cosmetics. Further research, such as human clinical trials and the development of technology-based formulations, is necessary to ensure its long-term safety and efficacy.
Hubungan Dukungan Keluarga dan Kondisi Psikologis Ibu Dengan Tingkat Keberhasilan Pemberian ASI Eksklusif di Desa Paya Geli Sinaga, Onike Lavionika; Irfani, Putri; Wahyudi, Putri Salsabilla; Hasibuan, Rabiatul Adawiyah; Siregar , Debi Novita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1013

Abstract

Background: Breast milk (ASI) is the ideal source of nutrition, containing antibodies and bioactive substances that support infant growth, development, and immune function. Despite its substantial benefits, many mothers fail to exclusively breastfeed. Family support and maternal psychological conditions are strongly suspected to influence the success of exclusive breastfeeding. Objective: This study aims to analyze the relationship between family support and maternal psychological conditions with the success of exclusive breastfeeding in Paya Geli Village. Methods: This quantitative study employed a cross-sectional design involving 32 mothers with infants aged 0–6 months. Data were collected using questionnaires and analyzed through univariate and bivariate analyses with Chi-Square and Fisher’s Exact tests. Results: Analysis of this limited sample showed a statistically significant association between family support (OR = 106.8; 95% CI: 10.0–1149.0; p < 0.001) and maternal psychological conditions (OR = 53.3; 95% CI: 2.7–1046.6; p = 0.0003) with exclusive breastfeeding success. However, the wide confidence intervals (CIs) indicate considerable uncertainty in the estimates. Conclusion: Family support and maternal psychological conditions are critical determinants of exclusive breastfeeding success. Community-level health promotion programs should prioritize these factors to improve exclusive breastfeeding coverage. Policy implications warrant further investigation with larger and more representative samples.
Hubungan pemberian makanan pendamping air susu ibu (MP-ASI) dini dengan kejadian diare pada bayi usia 0-6 bulan di klinik Pratama Evi Azzahra, Nasywa Firja; Sari , Delia Permata; Sapitri , Anggiani; Simamora , Apriyanti; Tondang, Kesya Nirina; Paninsari, Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1014

Abstract

Background: The global coverage of exclusive breastfeeding remains low (44%). The situation in Indonesia, particularly in North Sumatra, is concerning, where 68.4% of children under two years receive complementary feeding (CF) too early. This practice may increase the risk of diarrhea due to the immaturity of the infant’s gastrointestinal tract. Preliminary findings at Evi Primary Clinic showed that 17 out of 20 infants under six months experienced diarrhea, along with evidence of early CF practices. Objective: This study aimed to analyze the association between early complementary feeding and the incidence of diarrhea among infants aged 0–6 months at Evi Primary Clinic. Methods: An observational analytic study with a cross-sectional design was conducted. A total sampling technique was applied to 35 mothers with infants aged 0–6 months. Data were collected using questionnaires and analyzed using the Chi-Square test. Results: A total of 19 infants (54.3%) received early complementary feeding, and 18 infants (51.4%) experienced diarrhea. Bivariate analysis revealed that 15 out of 19 infants (42.8%) who received early complementary feeding suffered from diarrhea. The statistical test showed a p-value of 0.001 (α<0.05). Conclusion: There is a statistically significant association between early complementary feeding and the incidence of diarrhea among infants aged 0–6 months at Evi Primary Clinic. Therefore, education on the appropriate timing of complementary feeding is essential to prevent diarrhea in infants.
Pengaruh Program Pemberian Makanan Tambahan (PMT) Berkelanjutan Terhadap Perbaikan Gizi Stunting di Kota Binjai Manik, DiniLa Putri Olina Br.; Armansyah , Andini septiana; Gulo , Nanda Putri Berlian; Garamba, Indah Purnama Sari; Zai , Lady Angelita; Paninsari , Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1016

Abstract

Background: Stunting remains a serious public health problem in Indonesia, including in Binjai City, with a prevalence rate that continues to fluctuate and requires effective intervention. Stunting is caused by chronic malnutrition and results in growth failure. The Supplementary Feeding Program (PMT) is a specific intervention expected to improve the nutritional status of toddlers. Objective: This study aims to analyze the effect of the continuous Supplementary Feeding Program (PMT) on improving the nutritional status of stunted toddlers in Binjai City. Methods: This study used a quasi-experimental design (one-group pretest-posttest). The research population was 44 stunted toddlers registered in the Binjai City Stunting Reduction Acceleration Team (TPPS) program. Data was collected through direct anthropometric measurements (body weight and height) before and after the 90-day PMT intervention. Data were analyzed using the Wilcoxon Signed Rank Test. Results: The results showed a statistically significant improvement in the toddlers' nutritional status after the PMT intervention. This was evidenced by an increase in the indicators of body weight (p < 0.001), height (p < 0.001), W/A index (p = 0.002), H/A index (p < 0.001), and W/H index (p < 0.001). Conclusion: The continuous Supplementary Feeding Program (PMT) was proven effective in improving the nutritional status of stunted toddlers. This program can be used as a reliable strategy in efforts to accelerate the reduction of stunting rates in Binjai City.  
Studi Molecular Docking Luteolin dan Turunannya untuk Mengidentifikasi Potensi Inhibitor ER-α pada Kanker Payudara Atwon, Fasha Jamil; Da'I , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1022

Abstract

Breast cancer remains one of the leading causes of cancer-related mortality worldwide, with estrogen receptor alpha (ER-α) serving as a primary therapeutic target in hormone-dependent subtypes. Resistance to current endocrine therapies underscores the need for alternative compounds with improved efficacy and safety. Luteolin, a naturally occurring flavonoid, has gained attention as a potential anticancer agent, but its structural modifications may alter biological activity. This study evaluated the binding affinity and interaction profiles of luteolin and its glycosylated derivatives (luteolin 7-glucuronide and luteolin 7-O-glucoside) against ER-α using molecular docking (PDB ID: 7UJ8). The results revealed that luteolin consistently exhibited stronger binding affinity (−7.2 to −8.0 kcal/mol) and stable RMSD values compared to its derivatives, though it remained significantly weaker than the reference drug 4-hydroxytamoxifen (−8.9 to −9.4 kcal/mol). Structural analysis demonstrated that luteolin’s superiority arises from its ability to maintain extensive hydrophobic and π–π stacking interactions within the ER-α binding pocket. In contrast, glycosylation introduced bulky polar substituents that disrupted hydrophobic contacts and reduced binding affinity. These findings highlight luteolin as the most promising scaffold among the tested compounds and underscore the structural basis for why glycoside derivatization diminishes ER-α binding. Future work should focus on enhancing luteolin’s bioavailability without compromising its key hydrophobic interactions to advance its potential as a lead candidate for breast cancer therapy.
Faktor-Faktor yang Berhubungan Dengan Kejadian Stunting pada Anak Usia Dini di Wilayah Kerja Puskesmas Buhit Kecamatan Pangururan Kabupaten Samosir Tahun 2024 Sinurat , Arni Wetty; Manurung , Kesaktian; Sembiring, Rinawati; Rochadi, Kintoko; Sinaga, Janno
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1024

Abstract

Background: Stunting is a health problem resulting from chronic malnutrition over a long period. Although it serves as the district capital, Pangururan Sub-District still has a relatively high stunting prevalence, with 154 out of 2,460 measured toddlers (6.26%) affected. Identifying associated factors is necessary to design targeted interventions. Objective: This study aims to analyse the factors associated with the incidence of stunting in early childhood children in the working area of Buhit Community Health Centre, Pangururan Sub-District, Samosir Regency. Methods: This study used a cross-sectional design conducted in the working area of Buhit Community Health Centre. The study population consisted of mothers with toddlers in the area, with a sample size of 96 mothers selected using accidental sampling. Data were collected through questionnaires and anthropometric measurements and analysed using the Chi-Square test and logistic regression. Results: Bivariate analysis results showed significant relationships between maternal nutritional status (p=0.000), parenting patterns (p=0.000), maternal education level (p=0.000), family income level (p=0.003), and exclusive breastfeeding (p=0.029) with the incidence of stunting. Multivariate analysis indicated that maternal education level was the most dominant variable (p=0.013; OR=12.814), meaning that mothers with low education levels had a 12.8 times higher risk of having stunted children. Conclusion: Maternal nutritional status, parenting patterns, maternal education, family income, and exclusive breastfeeding were significantly associated with stunting, with maternal education level being the dominant factor. Therefore, stunting prevention efforts in this region should prioritise health education targeting mothers with low educational backgrounds.
Eksplorasi Kualitas Hidup dan Kepercayaan Obat terhadap Ketidakpatuhan Pasien Hemodialisis Suryaman, Sulistia; Cholisoh, Zakky
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1029

Abstract

Background: Poor medication adherence is common among hemodialysis patients and is associated with adverse clinical outcomes. However, factors such as health-related quality of life (QoL) and medication beliefs remain underexplored as determinants of non-adherence in this population. Objective: This systematic review aims to synthesise the evidence regarding the relationship between QoL, medication beliefs, and pharmacological non-adherence in patients undergoing hemodialysis (HD). Methods: A comprehensive literature search was conducted using electronic databases (PubMed, Scopus, and Google Scholar) for observational studies published between January 2015 and July 2, 2025. Studies were included if they involved adult hemodialysis patients and examined QoL and/or medication beliefs concerning pharmacological non-adherence. Results: Six observational studies, encompassing 1,698 hemodialysis patients from various countries, met the inclusion criteria. The synthesised evidence indicated that poorer QoL (particularly depression and poor sleep quality), higher burden of physical symptoms, and specific medication beliefs (e.g., concerns about side effects and low perceived necessity of medications) were significantly associated with increased non-adherence. Conclusion: Non-adherence among hemodialysis patients is influenced by the complex interaction of psychosocial factors, including QoL and individual medication beliefs. To improve adherence, interventions should be developed to target these factors through health education, psychological support, and patient-centred care. Further integrative and contextual research is needed to strengthen understanding and develop more effective interventions.
Korelasi Kadar Vitamin C, Cholecalciferol dan Kadar Malondialdehid Antara Kejadian Abortus Dengan Kehamilan Normal : Studi Observasional Manila, Hartati Deri; Yona Amir , Aprima; Meysetri , Fafelia Rozyka
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1032

Abstract

Introduction: Abortion is a pregnancy complication that contributes significantly to maternal morbidity and mortality. Approximately 73 million abortions occur annually worldwide, with the estimated abortion rate in Padang city in 2024 reaching 58.7%. Abortion remains a challenge in obstetrics. The relationship between vitamin C deficiency, cholecalciferol, and elevated MDA levels and abortion remains debated, given the complex pathophysiological mechanisms. Objective: to determine the correlation between vitamin C, cholecalciferol, and malondialdehyde levels between abortion and normal pregnancy. Method: This study is a comparative study of two unpaired groups with a cross-sectional approach to analyze the average levels of Vitamin C, cholecalciferol, and MDA. The population in this study was pregnant women diagnosed with abortion and all women with normal pregnancies with a gestational age of ≤ 20 weeks who were treated in the delivery room of RSUD dr. M. Zein, RS. dr. Reksodiwiryo Padang, RSUP M. Djamil Padang, RS. Rasidin Padang with a sample size of 30. Data analysis was carried out using an Independent Samples T-test. Results: The results of this study showed that Vitamin C levels were lower in the abortion group than in the control group, a significant difference (p = 0.001). Cholecalciferol deficiency was more pronounced in the abortion group, a significant difference compared to normal pregnancies (p = 0.002). MDA levels were very high in the abortion group, a significant difference (p = 0.001). Conclusion: There is a significant correlation of Vitamin C and cholecalciferol levels between the occurrence of abortion and normal pregnancy, and there is a significant correlation of malondialdehyde levels between normal pregnancy and the occurrence of abortion.
Bioaktivitas dan Efek Kesehatan Bawang Hitam terhadap Enzim Reduktase Hidroksi Metilglutaril-KoA Pada Tikus Putih Jantan Obesitas Ibrahim, Ibrahim; Yerizel , Eti; Endrinaldi, Endrinaldi; Revilla, Gusti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1039

Abstract

Obesity is a condition of abnormality or excess fat accumulation in adipose tissue. HMG-CoA reductase is an enzyme that can catalyse HMG-CoA into mevalonate, which is needed in cholesterol biosynthesis. Inhibition of the HMG-CoA reductase enzyme is an effective drug target mechanism to overcome dyslipidemia. Black garlic, which is high in antioxidants such as SAC, flavonoids, and polyphenols, is an effective mechanism. This study tested the bioactivity and health effects of black garlic on the activity of HMG-CoA reductase enzyme. This type of experimental study on male rats uses a post-test control-only group design. The sample in this study was 25 experimental animals divided into five groups, group negative control with a regular diet, group positive control with a high-fat diet, group treatment 1 with a high-fat diet and black garlic dose of 200 mg/rats, group treatment 2 with a high-fat and black garlic diet dose of 400 mg/rats, and group treatment given a high-fat diet and black garlic dose of 800 mg/rats. The results of the study showed that the average value and standard deviation of HMG-CoA in the negative control group were 1,044 and 0.088, the positive control group 2,136 and 0.487, the 1 group treatment 1,292 and 0.194, the 2 group treatment 1,296 and 0.206 and the three treatment group 1,201 and 0.201 nmol/min/mg protein. Based on the results of the hypothesis test, the significance level for the five groups was 0.004, indicating a significant difference in the average HMG-CoA levels in groups K1, K2, P1, P2, and P3. Black garlic significantly decreased HMG-CoA reductase activity in rats fed a high-fat diet, supporting its potential as a natural therapeutic agent for dyslipidemia management.

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