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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 555 Documents
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Evaluasi Penggunaan Eritropoetin (EPO) yang dikaitkan dengan Clinical Outcome pada Pasien Hemodialisis di RSUP Prof. R. D . Kandou Manado. Rambi, Firly Kartika Yuni; Ramatillah , Diana Laila
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1043

Abstract

Background: Chronic kidney disease (CKD) is a health issue that occurs in almost all parts of the world, and the number of patients continues to increase. CKD patients undergoing hemodialysis often experience anemia, which affects their quality of life and increases the risk of morbidity and mortality. Erythropoietin (EPO) is used to treat anemia, but its effectiveness can be affected by nutritional status, combination therapy, and other factors. Objective: To determine the profile of EPO therapy in CKD patients at the Dahlia Hemodialysis Unit at RSUP Prof. Dr. R.D. Kandou. Methods: An observational study with a retrospective cohort design (January–December 2020 with follow-up until December 2024) and a prospective design (October–December 2024). Patient medical records were processed and analyzed descriptively and analytically using Independent T-Tests, ANOVA, ANCOVA, and Kaplan-Meier survival analysis. Results: 209 patients undergoing therapy, 109 male (52.15%) and 100 female (47.85%). The average increase in post-treatment hemoglobin levels (Hb Post) compared to pre-treatment levels (Hb Pre) was 16.28%. Independent T-Test showed no significant difference in Hb levels between males and females (p>0.05). ANOVA Test showed a significant difference in Hb Post levels between age groups (F(7,201)=3.517; p=0.001). ANCOVA analysis showed that Hb Pre was the primary predictor of Hb Post (F=161.151; p<0.001). Conclusion: EPO therapy increases hemoglobin levels in CKD patients, with the response influenced by age and Hb Pre, but not by gender. Hb Pre levels are the primary predictor of treatment success.
Pengaruh Pemberian Teh Bevuzingiber (Beta vulgaris dan Zinger officinale) pada Pasien Hipertensi Tingkat I di Wilayah Kerja UPT Puskesmas Way Kandis Tahun 2025 Janah , Widya Miftakhul; Astuti, Dewi Woro; Hervidea, Radella
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1054

Abstract

Background: Hypertension is a major global health issue characterized by a persistent increase in arterial blood pressure, leading to severe complications. Stage I hypertension is defined as systolic blood pressure of 140-159 mmHg and diastolic pressure of 90-99 mmHg. The high prevalence of hypertension in the work area of UPT Puskesmas Way Kandis necessitates effective and accessible non-pharmacological interventions, such as the use of local ingredients like beetroot (Beta vulgaris) and ginger (Zingiber officinale). Objective: This study aimed to analyze the effect of consuming Bevuzingiber tea (a combination of Beta vulgaris and Zingiber officinale) on reducing blood pressure in patients with stage I hypertension. Methods: This study used a quantitative quasi-experimental design with a pretest-posttest control group approach. The sample consisted of 36 stage I hypertension patients selected through purposive sampling. They were divided into two groups: an intervention group (n=18) given Bevuzingiber tea and a control group (n=18) given antihypertensive medication. The intervention was conducted for 7 days. Blood pressure was measured before and after the intervention. Data were analyzed using the Wilcoxon Signed-Rank Test. Results: The results showed a significant reduction in blood pressure in the intervention group. The average systolic blood pressure decreased from 152.00 mmHg to 113.89 mmHg, and diastolic pressure decreased from 91.50 mmHg to 74.17 mmHg. Statistical analysis confirmed a significant difference with a p-value of 0.000 (<0.05). The intervention group also showed more consistent reductions compared to the control group. Conclusion: Bevuzingiber tea is effective in reducing blood pressure in patients with stage I hypertension and can be recommended as a complementary non-pharmacological therapy. It is suggested that future researchers focus on patients under 65 years of age and directly observe respondents' activities and other factors influencing blood pressure.
Determinan Kejadian Hipertensi pada Masyarakat Pedesaan di Wilayah Kerja Puskesmas Simarmata Kecamatan Simanindo Kabupaten Samosir 2024 Sibarani , Melda; Siagian, Mindo Tua; Anita , Surya; Dachi , Rahmat Alyakin; Tarigan, Frida Lina
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1057

Abstract

Background: Hypertension is a major global health issue and a significant risk factor for cardiovascular and renal diseases. Data from the Samosir Regency Health Office in 2022 indicated a high prevalence of hypertension (30%) among adults in Simanindo District, highlighting a critical local public health concern. Objectives: This study aimed to identify the determinants associated with the incidence of hypertension in the working area of the Simarmata Public Health Center, Simanindo District, Samosir Regency. Methods: A quantitative study with a cross-sectional design was conducted. A sample of 95 respondents was selected proportionally from four villages. Data on Body Mass Index (BMI), alcohol consumption, smoking habits, and dietary patterns were collected through interviews and measurements. Data analysis employed the Chi-square test and multivariate logistic regression. Results: The study revealed significant relationships between hypertension and BMI (p=0.000), alcohol consumption (p=0.000), smoking habits (p=0.000), and dietary patterns (p=0.018). Multivariate analysis identified smoking habit as the most dominant factor, with smokers having 9.758 times higher odds of developing hypertension (Exp(B) = 9.758; 95% CI: 2.697–35.303). Conclusion: Smoking habit is the most dominant determinant of hypertension in this community. It is recommended that the head of the Simarmata Public Health Center enhance the role of health workers in providing health education, particularly on the dangers of smoking and its impact on hypertension, to reduce its incidence.
Isolasi dan Karakterisasi Nano Hemiselulosa dari Tandan Kosong Kelapa Sawit (Elaeis guineensis Jacq.) Ritonga , Septi Ani; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1058

Abstract

Background: Empty Fruit Bunches (EFB) of oil palm (Elaeis guineensis Jacq.) are a significant agricultural waste from the palm oil industry, currently underutilized. EFB contains lignocellulosic components, including hemicellulose (22.84%), which has potential applications in the pharmaceutical sector as a hydrophilic polymer. Objective: This study aimed to isolate and characterize hemicellulose and nano-hemicellulose from oil palm EFB using an environmentally friendly green chemistry method with low-concentration reagents. Methods: This experimental research began with the purposive sampling of EFB. Hemicellulose was isolated using a sequential process with 0.1 N NaOH, 0.1 N HCl, and 70% ethanol. The resulting hemicellulose was then nano-sized using a ball mill technique. Characterization included organoleptic tests, solubility tests, Fourier Transform Infrared (FTIR) spectroscopy, Particle Size Analyzer (PSA), and Scanning Electron Microscope (SEM). Results: The isolation process from 500 g of EFB powder yielded 16.7 g of hemicellulose, with a yield of 3.34%. FTIR analysis identified key functional groups (O-H, C-H, C=O, C-O, C=C) in both hemicellulose and nano-hemicellulose, confirming their chemical similarity. SEM analysis at 500x magnification revealed a more regular particle structure with distinct cavities, indicating a swelling effect from the alkali treatment. PSA confirmed the nano-scale size of the processed particles. Conclusion: Hemicellulose and nano-hemicellulose were successfully isolated from oil palm EFB using a simple green chemistry method. The characterized nano-hemicellulose showed properties suitable for potential development as a carrier in pharmaceutical formulations.
Kombinasi Formulasi Simplisia Serbuk Daun Seroja (Nelumbo nucifera Gaertn.) Dengan Serbuk Rimpang Jahe (Zingiber officinale) Dalam Sediaan Teh Celup Sebagai Minuman Kesehatan Fitri , Khairani; Khairani , Tetty Noverita; Tarigan , Rida Evalina; Ananda , Sheila Rizka; Arista , Eni
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1078

Abstract

Introduction: Indonesia is a tropical country with high humidity that supports the growth of various plants, including medicinal herbs such as lotus leaves and ginger. Objective: This study aims to formulate a combination of powdered lotus leaves (Nelumbo nucifera Gaertn.) and powdered ginger rhizome (Zingiber officinale) into tea bag preparations and to evaluate their quality. Methods: The study employed an experimental method. Testing was conducted based on the Indonesian National Standard (SNI) parameters for tea bags, including organoleptic evaluation, moisture content test, total ash content test, acid-insoluble ash test, water-soluble extractive test, and hedonic test. Results: The concentrations of lotus leaf powder and ginger powder formulated were 100:0 (F0), 90:10 (F1), 80:20 (F2), 70:30 (F3), 60:40 (F4), and 50:50 (F5). The hedonic test results indicated that formula F5 (50:50) was the most preferred by the panelists compared to other formulas, with the highest average score. However, overall, the commercial tea (positive control) still obtained a higher preference score. Conclusion: The combination of lotus leaf powder and ginger rhizome powder was successfully formulated into tea bag preparations. Formula F5 (50:50) was selected as the best among all tested formulations, although its preference level remained lower than that of commercial tea.
Hubungan Pengetahuan, Pola Asuh Pemberian Makan Dan Sanitasi Lingkungan Terhadap Kejadian Stunting Balita Usia 24-59 Bulan Di Wilayah Kerja Puskesmas Buhit Kabupaten Samosir Tahun 2025 Siboro , Vinny Aslinar; Rochadi , Kintoko; Sinaga, Janno; Manurung, Kesaktian; Bancin , Dewi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1084

Abstract

Background: Stunting is a chronic nutritional problem with profound implications for the quality of human resources. Multiple factors, including parental knowledge, feeding practices, and environmental sanitation, influence this condition. The working area of the Buhit Community Health Center (Puskesmas Buhit) in Samosir Regency continues to face challenges in addressing stunting, making the identification of dominant factors essential for targeted interventions. Objective: This study aims to analyze the relationship between parental knowledge, feeding practices, and environmental sanitation with the incidence of stunting among children aged 24–59 months, and to identify the most influential factor in the Buhit Community Health Center service area, Samosir Regency, in 2025. Methods: This research employed an observational analytic design with a cross-sectional approach. The study population comprised all children aged 24–59 months (n = 577). A total of 88 respondents were selected using simple random sampling and the Slovin formula. Data were collected through questionnaires and anthropometric measurements, and analyzed using Chi-square tests and logistic regression. Results: Bivariate analysis revealed a significant association between parental knowledge (p = 0.000), feeding practices (p = 0.000), and environmental sanitation (p = 0.004) and the incidence of stunting. Multivariate analysis revealed that feeding practices were the most dominant factor (OR = 105.463; 95% CI = 13.888–800.848). This indicates that children with inadequate feeding practices have a 105.463-fold higher risk of stunting compared to those with good feeding practices. Conclusion: A significant relationship exists between parental knowledge, feeding practices, environmental sanitation, and the incidence of stunting. The most dominant factor is feeding practices. Therefore, stunting prevention interventions in this area should focus on improving parents’ understanding and implementation of appropriate feeding practices.
Identifikasi Drug Related Problems (DRPs) Pada Pasien Penyakit Ginjal Kronis di Instalasi Rawat Inap Rumah Sakit X Surakarta Tahun 2024 Mubarok, Afrizal; Fortuna, Tista Ayu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1075

Abstract

Background: Chronic kidney disease (CKD) is a condition characterized by impaired kidney function lasting at least three months. In patients with chronic kidney failure, the use of multiple medications has the potential to increase the risk of drug-related problems (DRPs), which can hinder the expected effectiveness of therapy. Objective: This study aims to determine the incidence of DRPs in patients with chronic kidney disease treated at the inpatient facility of Hospital X in Surakarta. Methods: This study employed a cross-sectional methodology and a non-experimental design. Data were collected retrospectively through the medical records of patients with chronic kidney disease treated at the inpatient facility of Hospital X in Surakarta. Data analysis was performed univariately by describing and analyzing the study variables. DRPs were identified based on the Pharmaceutical Care Network Europe (PCNE) classification. Results: The most common comorbidity was anemia at 27.93%, while the most frequently used drug class was vitamins and minerals at 24.70%. Of the 108 patients analyzed, 12 patients experienced at least one DRP (11.11%). In total, 15 cases of DRPs were identified with code P1.3 (problem) and codes C3.1, C3.2, C3.3, and C3.4 (causes) from those 12 patients. Conclusion: This study shows the occurrence of DRPs in patients with chronic kidney disease treated at Hospital X in Surakarta.
Analisis Escherichia coli dan Zat Kimia pada Minuman Es Jagung Khairani , Tetty Noverita; Fitri , Khairani; Tarigan, Rida Evalina; Khairani, Cut; Natasya, Alfa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1079

Abstract

The addition of inappropriate food additives (BTM) such as artificial sweeteners, and synthetic dyes which are added intentionally by food vendors is one of the problems that cause food not suitable for consumption because it can cause health problems. The purpose of this study was to analyze the dyes, sweeteners and E.coli in corn ice drinks sold in Pakam. The study design uses qualitative laboratory analysis. The population in this study is the corn ice traders in the city of Lubuk Pakam, amounting to 5 traders. The sample consisted of 5 traders who were in the Regent's Office, Galang Street, Segangular Field, Labu Beach and Ahmad Dahlan Street. The work procedure is by checking the coloring agent, sweetener and Escerichia coli examination. The results of laboratory tests revealed that the coloring agents in samples A and E contained Tartrazine and in samples B, C and D contained Tartrazine and Sunset Yellow, sweeteners were found in samples C and E and in samples A, B and D were not found to contain artificial sweeteners and 5 samples (100%) showed a total value of escerichia coli <3 APM / ml per ml sample. The conclusion in this study is that corn ice drinks sold in the city of Lubuk Pakam use coloring agents and sweetening agents that are permitted based on the Republic of Indonesia Ministerial Regulation No. 033 of 2012 and containing Escerichia coli of <3 APM / ml are still within the allowed limits in accordance with the Indonesian National Standard (SNI) and the Head of Indonesian National Drug and Food Control Agency Regulation No. HK.00.06.1.52.4011.
Strategi Promosi Kesehatan Melalui Program PHBS: Studi Pada Dinas Kesehatan Sarolangun Provinsi Jambi Hamonangan, Jan Effendi; Dachi, Rahmat Alyakin; Sitorus, Mido Ester J.; Nababan, Donal; Sinaga, Taruli Rohana
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1108

Abstract

The purpose of this research is to explore in more depth all matters related to the Health Promotion Strategy through the PHBS Programme, namely Health Education, Disease Prevention and Health Protection. This type of research is qualitative research. Research involves in-depth interviews, document review, and direct observation. The informants in this study were the Head of Public Health, the holder of the health promotion programme and the community in Sarolangun. In this study, triangulation was employed by asking questions to informants and by examining written documents and field circumstances to validate the interview results. Processing research data with the in-depth interview method. The results showed that the health education strategy had an impact on individual behaviour, achieved through mass media, collaboration with puskesmas, doctors, and community groups. The disease prevention strategy has a positive effect on increasing community awareness and participation in disease prevention through health screening programs, immunisation, and environmental hygiene campaigns, which elicit a positive community response. The health protection strategy focuses more on providing hygiene facilities, forming health protection policies, and collaborating across sectors. However, challenges such as limited infrastructure and low community compliance need to be addressed through educational approaches, facility expansion, and stricter supervision to ensure programme sustainability and greater community impact.
Faktor Risiko Kejadian Stunting Pada Anak Usia Balita di Wilayah Kerja Puskesmas Mogang Kecamatan Palipi Kabupaten Samosir Tahun 2024 Duyo, Rosita; Zuska, Fikarwin; Sitorus , Mido Ester J.; Ketaren , Otniel; Manurung , Kesaktian
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1109

Abstract

Background: Based on the 2023 Indonesian Health Survey (SKI) in Samosir Regency, the prevalence of stunting was 22.4%, with Palipi District recording the highest rate. As of August 2024, the incidence of stunting in Palipi District reached 14.34% (182 toddlers). Although there has been a decline, stunting remains a priority program in Samosir Regency. Objective: This study aims to analyze the risk factors associated with the incidence of stunting among toddlers in the working area of Mogang Public Health Center, Palipi District. Method: This research employed a quantitative design with a cross-sectional approach conducted in the working area of Mogang Public Health Center in 2024. The study sample consisted of 93 mothers with toddlers, selected using accidental sampling techniques. Data were analyzed using univariate, bivariate (Chi-Square test), and multivariate (logistic regression) analyses. Results: The bivariate analysis revealed significant relationships between maternal nutritional status (p=0.000), parenting pattern (p=0.000), maternal education level (p=0.000), family income level (p=0.002), and household sanitation conditions (p=0.000) with the incidence of stunting. However, multivariate analysis identified only three dominant and independent variables: maternal education level (p=0.014; Exp(B)=26.410), parenting pattern (p=0.001), and household sanitation condition (p=0.023). Conclusion: Maternal education level, parenting pattern, and household sanitation are proven to be the dominant factors influencing stunting. Mothers with low education levels are 26 times more likely to have stunted children. Preventive efforts should prioritize interventions targeting these three factors through focused health education programs.

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