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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 555 Documents
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Pengaruh Edukasi Booklet terhadap Kepatuhan Minum Obat pada Pasien Hipertensi Peserta Prolanis di Puskesmas Butang Baru Kabupaten Sarolangun Sari, Trisia Mayang; Sari, Yelly Oktavia; Wahyuni, Fatma Sri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.911

Abstract

Background: Hypertension is a global health problem with a high prevalence and is a significant risk factor for cardiovascular disease. Low medication adherence remains a challenge in the long-term management of hypertension. Health education is a key strategy to improve patients’ understanding and adherence. Booklets are considered a potential educational medium for delivering information in a structured manner. Objective: This study aims to analyse the effect of booklet media education on medication adherence among hypertensive patients participating in the Prolanis program at Butang Baru Public Health Centre, Sarolangun Regency. Methods: This research employed a pretest-posttest control group experimental design. Fifty-six respondents were evenly divided into the intervention group (received booklet-based education) and the control group (received no intervention). Medication adherence was measured using the MARS-5 questionnaire. Data were analysed using the Wilcoxon Signed Ranks test. Results: There was a significant improvement in adherence in the intervention group. The percentage of patients with high adherence increased from 7.14% to 53.57%, while the low adherence category decreased from 25% to 0%. Conversely, the control group showed no meaningful changes. Statistical analysis confirmed these findings, with a p-value = 0.000 (p < 0.05), indicating that the booklet intervention significantly improved adherence. Conclusion: Education through booklet media was proven effective in improving medication adherence among hypertensive patients. Therefore, booklets can be applied as a practical and beneficial intervention strategy to support the success of chronic disease management programs such as Prolanis in primary health care settings.
Pengaruh Edukasi Terhadap Pengetahuan Pada Pasien Lansia Hipertensi di Rumah Sakit Umum Daerah Padang Pariaman Naluri , Lisma; Nasif , Hansen; Sari, Yelly Oktavia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.913

Abstract

Hypertension is a prevalent chronic condition among the elderly, and improving patients' knowledge is a crucial factor in achieving successful therapy. This study aimed to evaluate the effect of educational interventions on knowledge among elderly hypertensive patients at Padang Pariaman General Hospital. A one-group pre-test post-test design was used involving 97 elderly participants who received education through pharmacist-led counseling sessions. Knowledge levels were assessed using the Hypertension Knowledge-Level Scale (HKLS). The Wilcoxon signed-rank test showed a significant improvement in knowledge after the intervention (p < 0.05). Before counseling, most participants had low knowledge, but this improved significantly post-education. The study concludes that structured educational interventions effectively enhance the knowledge of elderly hypertensive patients, and should be incorporated into routine pharmaceutical care.
Uji Aktivitas Antibakteri Sediaan Mouthwash Dari Ekstrak Daun Peppermint ( Mentha piperita L.) dan Daun Jarak Cina ( Jatropha multifida L.) Terhadap Streptococcus mutans Putri , Adilla; Nasution, Muhammad Amin; Lubis , Minda Sari; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.917

Abstract

Background: Mouthwash is a liquid preparation that plays an important role in maintaining oral health. An ideal formulation should possess antibacterial effectiveness, physicochemical stability, and acceptable organoleptic properties. Streptococcus mutans is the primary pathogenic bacterium responsible for halitosis and dental caries. Peppermint (Mentha piperita L.) and physic nut (Jatropha multifida L.) leaves are known to contain bioactive compounds such as flavonoids, saponins, and tannins, which have potential antibacterial activity. Objective: This study aimed to formulate peppermint and physic nut leaf extracts into a stable mouthwash preparation and evaluate its antibacterial activity against Streptococcus mutans. Methods: The extracts were prepared using maceration with ethanol as a solvent. The mouthwash formulations were developed with three variations of extract concentrations (2%, 2.5%, and 3%). The preparations were then evaluated for their physical stability (organoleptic properties and pH) and tested for antibacterial activity against S. mutans using the Kirby-Bauer disc diffusion method. Inhibition zone data were statistically analyzed using ANOVA and Duncan’s test. Results: Physicochemical evaluation showed that all formulations remained stable over 28 days of observation, with a pH of 6, which is compatible with the oral cavity. Antibacterial testing demonstrated an increase in inhibition zone diameter with higher extract concentrations: 10.33 mm (2%), 11.1 mm (2.5%), and 11.9 mm (3%). These results were comparable to the positive control, Betadine gargle (11.95 mm). The negative control showed no inhibition zone. Statistical analysis revealed significant differences (p < 0.05) among the concentrations. Conclusion: The combination mouthwash containing peppermint and physic nut leaf extracts at a concentration of 3% was found to be the most stable formulation and exhibited the strongest antibacterial activity, comparable to the commercial reference product. Thus, this combination extract has potential to be developed as a natural antibacterial agent for oral health.
Penetapan Kadar Asam Klorogenat dan Aktivitas Antioksidan Ekstrak NADES dari Biji Kopi Hijau Robusta (Coffea canephora) Menggunakan Metode MAE dan UAE sebagai Bahan Baku Kosmetik Alishlah, Tanfidz; Nuri, Nuri; Dianasari, Dewi; Rahman Hakim, Arif
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.937

Abstract

Antioxidants are essential for protecting skin cells from free radicals, causing oxidative damage, and supporting human skin’s health. Natural antioxidants are abundant in plants, particularly in Robusta green coffee beans (Coffea canephora), which are rich in chlorogenic acid (CA), a key contributor to antioxidant properties. Efficient extraction methods are necessary to obtain these bioactives effectively. Advanced extraction technology, such as Ultrasound-Assisted Extraction (UAE) and Microwave-Assisted Extraction (MAE), enhances mass transfer and reduces processing time compared to conventional methods. This study quantified chlorogenic acid using Thin Layer Chromatography-Densitometry (TLC-densitometry) and evaluated the antioxidant activity using the DPPH method of NADES (betaine–triethylene glycol) liquid extracts from Robusta coffee green beans extracted via UAE and MAE. Chlorogenic acid concentration of MAE (3.64 mg CA/g extract ± 0.06) was higher than that of UAE (2.69 mg CA/g extract ± 0.04). The antioxidant activity (IC₅₀) values were 3266.66 μg/mL ± 67.97 (UAE) and 2598.05 μg/mL ± 29.42 (MAE), indicating higher efficiency for MAE. When expressed as chlorogenic acid equivalents in NADES extracts, IC₅₀ values were 9.04 μg/mL ± 0.13 (UAE) and 9.44 μg/mL ± 0.07 (MAE). NADES-MAE could be a promising method to acquire raw materials with high antioxidant activity, especially for cosmetic formulation.
Pengaruh Intervensi Apoteker terhadap Pengetahuan, Tingkat Kepuasan dan Outcome Terapi Pasien Swamedikasi Commond Cold di Apotek Kasih Agape Tarigan, Eunike Victorita; Wiryanto, Wiryanto; Dalimunthe, Aminah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.941

Abstract

Self-medication for minor illnesses such as the common cold is generally done by the community. In situations like this, the role of pharmacists is very important in providing education to improve patient safety. This study aims to analyze the effect of pharmacist intervention (pretest-posttest) on the level of knowledge and outcome of self-medication therapy for common cold patients at Kasih Agape Pharmacy Medan. This study used a quasi-experimental design with a one-group pretest-posttest design approach on the knowledge and outcome indicators, while the patient satisfaction indicator used a descriptive quantitative research design. The sample consisted of 50 patients who were in the intervention group (pretest-posttest), randomly selected using a purposive sampling technique. The intervention was given in the form of pharmacist education and counseling. Data were collected using a questionnaire that had been tested for validity and reliability. The results of the analysis showed that there was a significant increase in the level of knowledge (p <0.05) and outcome of therapy (p <0.05) in the intervention group compared to the pretest and posttest. These results can also be seen as increasing patient knowledge, and the outcome of therapy can have an impact on increasing patient satisfaction. This study shows that pharmacist intervention can effectively improve the quality of self-medication for the common cold in patients. This study emphasizes the importance of the active role of pharmacists in providing education to support safe, rational drug use and improve therapeutic outcomes.
Pengaruh Edukasi Media Booklet Terhadap Pengetahuan Pasien Diabetes Melitus Tipe 2 Peserta Prolanis Di Puskesmas Lima Kaum I Kabupaten Tanah Datar. Rani, Jihan Shasika; Sari , Yelly Oktavia; Wahyuni, Fatma Sri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.945

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion or function. The prevalence of T2DM is increasing globally, including in Indonesia. However, patients’ knowledge regarding disease management remains relatively low. Continuous education is considered an essential strategy to improve disease control.  Objective: This study aimed to analyze the effect of education using booklet media on improving knowledge among T2DM patients enrolled in the Chronic Disease Management Program (Prolanis) at Lima Kaum I Public Health Center, Tanah Datar Regency. Methods: The study employed a pretest-posttest control group design involving a total of 48 respondents, divided into an intervention group (received the booklet) and a control group. The research instrument used was the SDKS INA 1 questionnaire to assess patients’ knowledge. Data were analyzed using the Chi-Square test and the Wilcoxon test. Results: showed a significant increase in patients' knowledge after the educational intervention using the booklet (p=0.000; p<0.05). Conclusion: Therefore, booklet media is proven to be an effective educational tool for enhancing knowledge among patients with Type 2 Diabetes Mellitus.
Analisis Hubungan Faktor Sosiodemografi dan Sosioekonomi Dengan Tingkat Kepatuhan Pengobatan Pasien Diabetes Melitus Tipe 2 di Puskesmas Damai Berdasarkan MMAS-8 Nuurositha, Nuurositha; Wahyuni , Fitri Ayu; Erwina , Wiwi; Rahman , Rifazul Aulia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.954

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease requiring long-term therapy. Patient adherence to medication plays a crucial role in preventing complications. Unfortunately, the level of medication adherence among T2DM patients remains suboptimal and is influenced by various factors, including sociodemographic and socioeconomic factors. This study aims to analyze the association between sociodemographic and socioeconomic factors and medication adherence in T2DM patients at Puskesmas Damai, Balikpapan City. A cross-sectional design was applied with total sampling of all T2DM patients at Puskesmas Damai meeting the inclusion criteria. The Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire was used to assess medication adherence. Data were analyzed using univariate and bivariate methods, with chi-square tests for associations. Bivariate analysis showed that gender (p = 0.021) and age (p = 0.039) were significantly associated with medication adherence. Meanwhile, education level (p = 0.428), employment status (p = 0.865), and income (p = 0.836) were not significantly associated. Understanding the factors influencing patient adherence can inform the design of more effective interventions to improve medication adherence and treatment outcomes in T2DM patients.
Drug-Related Problems Pada Penyakit Paru Obstruksi Kronis: Literatur Review Fahmi, Muhammad Zaini; Karuniawati, Hidayah; Ismail, Wan Ismahanisa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.955

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of global morbidity and mortality, with a continuously increasing health burden. The complexity of long-term therapy in COPD increases the risk of Drug-Related Problems (DRPs), which can affect patient clinical outcomes. This literature review was conducted descriptively by searching articles in the PubMed, Scopus, Google Scholar, and ScienceDirect databases using keywords related to DRPs and COPD. The selection was made on publications from the last 10 years (2015–2025) relevant to the topic and available in full text. Based on studies by Li et al., (2019) and Apikoglu-Rabus et al., (2016), the classification of DRPs according to PCNE V9.0 mainly included aspects of medication safety (54.2%), inappropriate drug selection (up to 8.7%), excessive dosage (19.9%), excessive duration of therapy (17.7%), and errors in the drug use process (up to 63.3%). Patient factors such as non-compliance (25%) and incorrect inhalation techniques were the main contributors to the occurrence of DRPs. Inappropriate use of medications, drug-herb interactions, and lack of therapy monitoring were also consistently found. The findings suggest that DRPs significantly worsen symptom control and increase the risk of exacerbations. Pharmacists are critical in identifying, preventing, and managing DRPs through patient education, therapy review, and ongoing therapy monitoring. DRPs in COPD patients are a serious challenge that requires a multidisciplinary approach. Ongoing education, monitoring of therapy rationality, and collaboration between healthcare professionals are needed to improve patient safety and the effectiveness of COPD treatment.
Kejadian Drug-Related Problems Pada Pasien Rawat Inap dengan Diabetes Melitus Berdasarkan Kriteria PCNE : Literatur Review Febriani, Rizkina Elistya; Karuniawati, Hidayah; Rahman, Anees Ur
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.956

Abstract

Non-communicable chronic diseases such as diabetes mellitus (DM) are a significant health burden worldwide. In the treatment of DM patients, long-term drug use is inevitable and increases the risk of Drug-Related Problems (DRPs). The presence of DRPs can affect the effectiveness of therapy and the risk of side effects in hospitalized DM patients. This review aims to evaluate various studies conducted on DRPs in hospitalized DM patients based on the Pharmaceutical Care Network Europe (PCNE) classification. A systematic search of relevant articles in the last 10 years through the SpringerLink, ScienceDirect, Scopus, and PubMed databases. Irrelevant studies, review articles, and no data on DRP classification using PCNE or outpatients will be excluded. The review found four articles discussing DRP classification using PCNE in hospitalized DM patients. The number of DRPs varied, ranging from 253 to 873 cases. The proportion of patients experiencing at least one DRP was also relatively high, ranging from 48.1% to 84.5%. The most common problem was treatment ineffectiveness (P1.2), which accounted for more than half of the DRPs in the three studies reviewed, namely 62.0%, 79.6%, and 52.7%. The most common cause of DRPs came from the patient-related domain (C7.1) at 71.85%. Other domains that caused DRPs were the Drug use domain (C6.1) at 62.0%, other domains (C9) at 40.9%, the drug selection domain (C1.6) at 26%, and the dose selection domain (C3.5) at 25.9%. The occurrence of DRPs is a significant problem in the management of diabetes mellitus, especially in the hospital environment. The ineffectiveness of therapy is the main problem of DRPs. The high number of DRPs from other domains indicates that many causes of DRPs are not classified explicitly in the PCNE category.
Analisis Hubungan Kepatuhan Farmakologis dan Kepatuhan Diet Rendah Natrium dengan Tekanan Darah Pasien Hipertensi di Beberapa Puskesmas Kabupaten Banyumas Ristiana, Zahra Amalia; Fauziah , Fauziah; Setianingsih , Siti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.967

Abstract

Introduction: Hypertension is a chronic condition that requires long-term management through adherence to pharmacological therapy and a low-sodium diet. Both factors play an essential role in controlling blood pressure and preventing complications. Methods: This study employed a quantitative observational design with a cross-sectional approach conducted in February 2025 at four public health centers in Banyumas Regency. A total of 70 hypertensive patients enrolled in the PROLANIS program were selected using purposive sampling. Data were collected through interviews and health status documentation, then analyzed using the Chi-Square test and odds ratio (OR). Results: No significant relationship was found between pharmacological adherence and blood pressure (p systolic = 0.131; p diastolic = 0.434). Conversely, a significant association was observed between adherence to a low-sodium diet and blood pressure (p systolic = 0.000; p diastolic = 0.003). Odds ratio analysis indicated that patients adhering to a low-sodium diet were 1.86 times more likely to achieve controlled blood pressure compared to those who were non-adherent. Conclusion: Adherence to a low-sodium diet has a greater influence on blood pressure control than medication adherence. Therefore, educational interventions emphasizing the importance of dietary management and consistent medication intake should be optimized to improve the effectiveness of hypertension therapy in primary health care settings.

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