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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Evaluasi Penggunaan Obat Antihipertensi pada Resep Pasien BPJS RSUD Kota Mataram yang Ditebus di Apotek KF 134 Pejanggik dan KF 458 Catur Warga Berdasarkan ATC/DDD dan DU 90% Hamzani, Yogi Mujizat; Andayani , Tri Murti; Dewi, Lucia Vita Inandha
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1028

Abstract

Background: Hypertension is a persistent condition of high blood pressure (systolic >140 mmHg or diastolic >90 mmHg). As a chronic disease requiring long-term treatment, the therapy for hypertensive patients needs to be evaluated regularly. Objective: This study aimed to determine the consumption profile of antihypertensive drugs using the ATC/DDD and DU 90% methods and to assess their compliance with the National Formulary (FORNAS). Methods: This research used a cross-sectional design with retrospective data collection. The samples were prescriptions for BPJS hypertension patients from Mataram City Hospital for the period of January-December 2024, redeemed at KF 134 Pejanggik Pharmacy and KF 458 Catur Warga Pharmacy. The data were analyzed using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) and Drug Utilization 90% (DU 90%) methods. Results: The results showed that the most consumed antihypertensive class was ARBs, specifically candesartan, with a value of 13,082.25 DDD/1000 PPD at KF 134 Pejanggik and 7,215.33 DDD/1000 PPD at KF 458 Catur Warga. The drugs included in the DU 90% segment were candesartan, ramipril, amlodipine, and bisoprolol at both pharmacies, with the addition of valsartan at KF 134 Pejanggik. Compliance with drug use guidelines for FORNAS was 92% at KF 134 Pejanggik Pharmacy and 90% at KF 458 Catur Warga Pharmacy. Conclusion: The use of antihypertensive drugs in both pharmacies is in accordance with FORNAS, with high compliance percentages, indicating rational drug prescribing practices.
Pengaruh pemberian ekstrak rimpang kunyit (Curcuma longa L.) sebagai neuroprotektor terhadap gambaran histopatologi sel otak tikus putih (Rattus norvegicus) jantan galur wistar model alzheimer Balqis, Ferisha Aulia; Maulina, Meutia; Novalia, Vera
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.798

Abstract

Alzheimer’s disease is a neurodegenerative disorder that leads to cognitive decline and memory loss, eventually impairing daily activities. Turmeric (Curcuma longa L.) has neuroprotective potential due to its curcumin content, which possesses anti-inflammatory, antioxidant, and neuroprotective properties. This study aims to examine the effect of different doses of turmeric rhizome extract on the histopathological features of brain cells in Wistar rats (Rattus norvegicus) induced with Alzheimer’s disease. An experimental study with a post-test only control group design was conducted using simple random sampling. A total of 24 male Wistar rats were divided into four groups: K1 (Alzheimer-induced without treatment), K2 (administered 20 mg/kgBW memantine), P1 (Alzheimer-induced with 36 mg/kgBW turmeric extract), and P2 (Alzheimer-induced with 54 mg/kgBW turmeric extract). The results showed the highest percentage of cell necrosis in K1 (19.7%), while the lowest was in K2 (1.67%), followed by P2 (2.5%) and P1 (5%). The Kruskal-Wallis test indicated a significant difference between groups p = 0.030 (p < 0.05). The Post Hoc Mann-Whitney test revealed a significant difference between K1 and both K2 and P2. These findings suggest that turmeric rhizome extract at a dose of 54 mg/kgBW has a neuroprotective effect by reducing neuronal necrosis in Alzheimer-induced rats. However, no significant difference was observed between the memantine-treated group and the turmeric extract-treated groups. There was no significant difference between the group given memantine treatment and the group given turmeric rhizome extract (Curcuma Longa L.).
Analisis faktor yang mempengaruhi perilaku seksual pada remaja SMA kota Lhokseumawe Lubis, Putri Sabrina; Khairunnisa , Cut; Wahyuni , Hendra
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.799

Abstract

Adolescent sexual behavior is an important issue in health education. This can be influenced by knowledge, attitudes, the role of parents, peers, information media, religion, and the role of teachers and schools. This study aims to analyze the factors that affect the sexual behavior of adolescents of Lhokseumawe City State High School. This research method uses a descriptive analytical research design with a cross-sectional approach. The sample in this study was 342 students of Lhokseumawe City State High School. Sampling used stratified random sampling technique and data collection was carried out using a questionnaire. The results of the study showed that most teenagers were in the age range of 17-19 years and most were female, the sexual behavior of high school teenagers in Lhokseumawe City showed that most were not involved in deviant sexual behavior. Factors that influence the sexual behavior of high school teenagers in Lhokseumawe City show that adolescent knowledge is generally good. Most show positive attitudes, have good parental roles, are significantly influenced by peers, and only a few access information media related to pornography. The data obtained were analyzed using the Chi-square test. This proves that there is a significant relationship between knowledge, attitude, parental role, peer role, and information media with adolescent sexual behavior in Lhokseumawe City State High School. with the results of the study showing p < (0.05). Thus, the research is expected to contribute positively to understanding and addressing deviant sexual behavior among adolescents and to support the development of better protection policies for adolescents in Lhokseumawe.
Pengaruh Perbedaan Gelling Agent terhadap Karakteristik Fisik Masker Gel Peel Off Ekstrak Daun Murbei (Morus alba L.) Rahmiati, Nur; Afra , Fairuz Yaumil; Dharmayati , Evy; Septiani , Dewi Ayu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1019

Abstract

Mulberry leaves extract (Morus alba L.) has an IC50 of 8.35 µg/mL which is classified as a very strong antioxidant so it can be used as an active substance in cosmetic preparations such as Peel Off gel masks. An important component in Peel Off gel preparations is Gelling Agent. The type and concentration of each Gelling Agent can affect the characteristics of the preparation. The purpose of this study was to determine the effect of different Gelling Agents on the physical characteristics of Peel Off gel mask preparations from mulberry leaf extract. Mulberry leaves were extracted using the maceration method with 70% ethanol solvent. Peel Off gel mask preparation is made in 9 formulas, namely formula 1-3 using Gelling Agent gelatin, formula 4-6 using Gelling Agent HPMC, formula 7-9 using Gelling Agent Carbopol 940. Physical characterization of the preparation includes organoleptic, homogeneity, pH, spreadability, adhesive power, viscosity and stability test Cycling Test. The results showed that all formulas had the same organoleptic before and after the stability test, formula 1-3 showed inhomogeneity after the stability test was carried out. The pH of formula 1-6 is in the good pH range (5.62-6.37) while F7-9 has a pH value of 7.04-7.31, the spreadability of the preparation decreased along with the increase in the concentration of Gelling Agent, namely from 17 g.cm/sec to 12 g.cm/sec for a load of 150 g, and the increase in the concentration of Gelling Agent affects the results of adhesive power and viscosity of the preparation. The viscosity values of F1-F3 are 3,666-110,000 mPa.s, F4-F7 with a range of 11,333-49,666 mPa.s, and F7-F9 44,333-162,333 mPa.s. Based on the results of the study, it can be concluded that the difference in Gelling Agent in Peel Off gel mask preparations can affect the physical characteristics of the preparation.
Pengaruh Pemberian Ekstrak Etanol Herba Anting-Anting (Acalypha indica) terhadap Ekspresi GLUT 2 pada Pankreas Tikus Diabetes Toding, Ficanata Adhiguna; Islamiati , Utami; Wulandari, Ayu; Nugroho , Agung Endro; Widodo, Gunawan Pamudji; Patala , Recky
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.597

Abstract

Background: Anting-anting herb (Acalypha indica L.) has been traditionally known for its antidiabetic properties. Its mechanism of action is presumed to involve the regeneration of damaged pancreatic β-cells; however, its effect on the expression of GLUT-2, a key glucose transporter in insulin secretion, remains to be further investigated. Objective: This study aimed to analyze the effect of ethanol extract of Anting-anting herb on GLUT-2 protein expression in pancreatic β-cells of Streptozotocin–Nicotinamide–induced diabetic rats. Methods: This laboratory experimental study used 25 male rats (Rattus norvegicus), randomly assigned into five groups: normal control, negative control (diabetes + 1% CMC), positive control (diabetes + glibenclamide 0.45 mg/kg BW), treatment 1 (diabetes + extract 100 mg/kg BW), and treatment 2 (diabetes + extract 200 mg/kg BW). Diabetes was induced intraperitoneally with Streptozotocin (50 mg/kg BW) and Nicotinamide (110 mg/kg BW). The treatments were administered orally for 14 days. GLUT-2 expression in pancreatic tissue was quantitatively analyzed using immunohistochemistry, and protein density was measured with ImageJ software. Data were analyzed using one-way ANOVA. Results: Phytochemical analysis revealed that the extract contained flavonoids, tannins, saponins, and steroids. The group treated with 200 mg/kg BW extract showed a significant increase in GLUT-2 protein density (11,608,400 molecules/µm²) compared with the negative control group (5,074,533 molecules/µm²) (p < 0.05). This value was even higher than that of the positive control (glibenclamide), which showed a density of 10,626,864 molecules/µm². Conclusion: Administration of ethanol extract of Anting-anting herb at a dose of 200 mg/kg BW significantly increased GLUT-2 expression in pancreatic β-cells of diabetic rats. This enhancement is strongly presumed to contribute to the antidiabetic mechanism of Anting-anting herb.
Review Artikel: Evaluasi Efektivitas Perbandingan Preparasi Sampel Pada Instrumen Spektrofotometri Serapan Atom (SSA) Untuk Menganalisis Logam Timbal Putri, Indah Syah; Damara , Dandy Satria; Akifah , Muthia Nur; Utami , Marsah Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.672

Abstract

Lead (Pb) is a hazardous substance that has the potential to damage human health and the environment. This article evaluates the effectiveness of two sample preparation methods, namely wet digestion and dry digestion, in analyzing lead using Atomic Absorption Spectrophotometry (AAS) through a literature review, obtaining data using Google Scholar's “Publish or Perish” feature with the keywords lead, AAS, sample preparation, and method validation. Inclusion criteria are journals published within the last 10 years, while exclusion criteria are  journals that use methods other than AAS, focusing on other metals, or do not involving sample preparation methods involving destruction. The wet destruction method involves dissolving the sample in acid, while the dry destruction method uses high-temperature heating to form dry ash. The dry destruction method demonstrates better analytical performance than wet destruction, based on the parameters of recovery (98.5–104.2%), accuracy (absolute deviation <2%), and precision (%RSD <5%). These results indicate that dry destruction provides more accurate, precise, and consistent analysis, as well as more reliable quantification of elements such as heavy metals, compared to wet destruction, which tends to produce variations between replicates. Therefore, the dry destruction method is recommended for lead analysis using SSA because it is more effective and efficient.
Tinjauan Literatur: Analisis Sintesis dan Efektivitas Senyawa Kalkon serta Turunannya sebagai Agen Antibakteri Damara , Dandy Satria; Akifah , Muthia Nur; Putri , Indah Syah; Utami , Marsah Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.681

Abstract

Chalcones are flavonoid compounds that have attracted attention in the development of antibacterial agents. This literature review aims to examine the synthesis and effectiveness of chalcone compounds and their derivatives as antibacterials. Through descriptive analysis, chalcone synthesis was carried out using several methods, one of which was the condensation between benzaldehyde and acetophenone, followed by structural modification to produce various chalcone derivatives. The antibacterial activity of chalcone compounds and their derivatives was tested against bacteria such as S. aureus, E. coli, B. substillis, and other types of bacteria. The results of the review of several literatures obtained online through Google, Google Scholar, and Publish or Perish were carried out using the keywords "Synthesis", "Chalcone", and "Antibacterial" with publications from the last 10 years (2014-2024) with a total of 8 references used. The study showed that changes in the structure of chalcones, such as the addition of hydroxyl and methoxy groups, can affect antibacterial activity. Some chalcone derivatives also showed promising antibacterial activity, although their effectiveness varied depending on the type of bacteria tested.
Tinjauan Literatur: Pengaruh Parameter Metode Kromatografi Lapis Tipis untuk Identifikasi Kafein dalam Kopi Hariadi, Nayla Nur Azkia; Basmalah, Nur; Laprilski , Dewi Hanun; Azzahra , Khaerunisa; Mulki , Munir Alinu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.683

Abstract

Background: The rising consumption of coffee in Indonesia necessitates reliable methods for caffeine analysis to ensure product quality and safety. Thin Layer Chromatography (TLC) is a simple, effective, and polarity-based technique widely used for the qualitative identification of compounds like caffeine in coffee. However, the results of TLC analysis are highly dependent on several methodological parameters. Objectives: This literature review aims to identify and analyze the critical parameters of the TLC method—including the mobile phase, stationary phase, visualization techniques, and sample preparation—that influence the effectiveness of caffeine identification in coffee. Methods: A systematic literature review was conducted using online databases (Google Scholar, PubMed, Semantic Scholar, and Crossref). Articles from the last ten years were selected based on inclusion and exclusion criteria, resulting in nine primary studies for in-depth analysis. Results: The review confirms that silica gel 60 F254 is the most effective stationary phase. The composition of the mobile phase is crucial; a mixture of dichloromethane:methanol (9.5:0.5) was found to be optimal for separating caffeine, yielding Rf values within the ideal range of 0.3–0.7. Visualization under UV light at 254 nm successfully detected caffeine as dark spots. Sample preparation techniques, particularly reflux and ultrasonic extraction, significantly enhanced extraction efficiency and detection sensitivity. Factors such as mobile phase stability, spotting technique, and sample matrix were also identified as key influencers on the chromatographic results. Conclusion: TLC is an efficient and cost-effective method for the qualitative identification of caffeine in coffee. Its success is determined by the optimization of critical parameters, primarily the mobile phase composition. While excellent for initial screening, TLC requires complementary techniques for precise quantitative analysis. Future work should focus on standardizing these parameters to improve the reproducibility and reliability of caffeine analysis using TLC.
Formulasi dan Evaluasi Mutu Fisik Serta Uji Aktivitas Antiinflamasi Sediaan Balsem Stik Ekstrak Etanol Daun Bakung (Crinum asiaticum L.) Ramadhan , Yusril; Yuniarti , Rafita; Lubis , Minda Sari; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.892

Abstract

Background: Spider lily leaves (Crinum asiaticum L.) contain bioactive compounds, such as flavonoids, which are known for their anti-inflammatory properties. Developing a convenient topical formulation like a stick balm could provide an effective and practical alternative for treating inflammation. Objective: This study aimed to formulate a stick balm containing ethanol extract of spider lily leaves (EESL) and evaluate its physical quality and anti-inflammatory activity. Methods: The extract was obtained by macerating the leaves in 96% ethanol. Stick balm formulations were prepared with varying concentrations of EESL: F0 (base), F1 (1%), F2 (3%), and F3 (5%). The physical quality of the formulations (homogeneity, pH, spreadability, melting point) was evaluated. Anti-inflammatory activity was tested on 24 male white rats induced with carrageenan. The rats were divided into six groups: negative control (induced only), positive control (commercial Geliga balm), F0, F1, F2, and F3. Paw edema volume was measured every hour for 6 hours. Results: All stick balm formulations met the physical quality standards. The anti-inflammatory test showed that the F3 formulation (5% EESL) exhibited the highest activity, with an edema reduction of 0.007 mm, which was equivalent to the positive control group (0.007 mm). The anti-inflammatory effect was concentration-dependent, with lower efficacy observed in the F2 and F1 groups. Conclusion: The ethanol extract of Crinum asiaticum L. leaves can be successfully formulated into a stable stick balm. The 5% EESL stick balm demonstrated significant anti-inflammatory activity that was comparable to a commercial product, making it a promising natural alternative for topical anti-inflammatory therapy.
Interaksi Obat Potensial pada Sirosis Hati: Tinjauan Pola dan Faktor Sosiodemografi Amni , Hudiyah; Fitria, Najmiatul; Sari, Yelly Oktavia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.910

Abstract

Liver cirrhosis is a chronic condition characterised by the formation of regenerative nodules and fibrotic tissue resulting from prolonged liver damage. This condition is frequently accompanied by comorbidities and complications, often leading to the use of multiple medications (polypharmacy). Polypharmacy increases the risk of potential drug interactions, which may worsen clinical outcomes. This study aimed to describe the patterns of possible drug interactions and the sociodemographic characteristics of hospitalised patients with cirrhosis at Dr M. Djamil Central General Hospital in Padang. A cross-sectional study was conducted using prospectively collected data from patient medical records. A total of 579 medications used by 50 patients were classified into three categories: cirrhosis-specific drugs (48.9%), symptomatic treatments (43.2%), and medications for comorbid conditions (7.95%). Analysis with drugs.com showed potential drug interactions in 96% of patients, most commonly moderate–to–minor combinations (48%), followed by major, moderate, and minor interactions (22%). In comparison, moderate interactions only and major moderate combinations occurred in 18% and 9% of patients, respectively.  In terms of sociodemographic characteristics, most patients were male (58%), under 65 years old (64%), had more than one comorbidity (52%), had a basic education level (32%), were still employed (56%), and did not engage in high-risk social behaviors such as smoking or alcohol consumption (48%).

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