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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 782 Documents
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Uji Efektivitas Nefroprotektive Ekstrak Buah Kopi (Coffea arabica L.) Terhadap Gambaran Histopatologi dan Penanda Inflamsi Pada Tikus Yang Diinduksi Gentamisin Anas Tasya Glori Br Ginting; Asyrun Alkhairi Lubis; Refi Ikhtiari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1354

Abstract

Gentamicin is an aminoglycoside antibiotic widely used in the treatment of severe bacterial infections; however, its clinical application is limited due to nephrotoxic effects. Gentamicin-induced nephrotoxicity is closely associated with oxidative stress and inflammatory responses, which contribute to tubular damage and renal dysfunction. Coffee fruit (Coffea arabica L.) contains various bioactive compounds, including phenolics, flavonoids, and polyphenols, which exhibit antioxidant and anti-inflammatory activities and may provide renal protection. This study aimed to evaluate the nephroprotective effectiveness of coffee fruit extract against gentamicin-induced kidney injury in rats based on histopathological features and inflammatory markers. This experimental in vivo study used male Wistar rats divided into five groups: normal control, gentamicin control, and gentamicin combined with coffee fruit extract at doses of 100, 200, and 400 mg/kg body weight. Gentamicin was administered intraperitoneally to induce nephrotoxicity, while the extract was given orally for 14 days. Serum interleukin-6 (IL-6) levels were measured using enzyme-linked immunosorbent assay, and kidney tissues were examined histopathologically using hematoxylin–eosin staining. The results showed that gentamicin significantly increased serum IL-6 levels and caused moderate renal histopathological damage. Administration of coffee fruit extract significantly reduced IL-6 levels at doses of 200 and 400 mg/kg body weight (p<0.05) and improved renal histopathological features in a dose-dependent manner, with the highest dose showing the most pronounced protective effect. In conclusion, coffee fruit extract demonstrates nephroprotective potential against gentamicin-induced renal injury by reducing inflammatory responses and improving kidney histopathology.
Efek Fitokimia Bunga Marigold (Tagetes erecta) Terhadap Fotoaging: Tinjauan Literatur Sistematis Ni Putu Windi Sukma Putri; Agus Eka Darwinata; Ni Made Linawati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1442

Abstract

Photoaging is a major contributor to premature skin aging and is primarily caused by chronic exposure to ultraviolet (UV) radiation. UV induced oxidative stress, inflammation, and extracellular matrix degradation result in wrinkles, pigmentation, and loss of skin elasticity. This systematic review aimed to evaluate the phytochemical mechanisms of Tagetes erecta and assess its potential clinical relevance in preventing photoaging. A systematic literature search was conducted in PubMed, Science Direct, and Europe PMC for studies published between 2016 and 2026, following PRISMA 2020 guidelines. Studies were included if they investigated Tagetes erecta or phytochemical compounds known to be present in Tagetes erecta (e.g., lutein, zeaxanthin, flavonoids, phenolic acids) in UV-induced photoaging models. The findings indicate that Tagetes erecta contains bioactive compounds that reduce reactive oxygen species (ROS), enhance endogenous antioxidant defenses, suppress matrix metalloproteinase (MMP) expression, and preserve collagen integrity. Clinical studies evaluating carotenoids and related phytochemicals also found in Tagetes erecta reported improvements in minimal erythema dose, skin elasticity, hydration, pigmentation, and wrinkle appearance. Notably, only one study directly investigated Tagetes erecta in the context of photoaging, however, the available evidence is still limited and insufficient to establish strong clinical conclusions. Therefore, current clinical evidence remains largely indirect. Overall, Tagetes erecta represents a promising phytochemical source with strong mechanistic support, although further well-designed clinical studies are required.
Hubungan Kadar Delta Like Ligand 1 (DLL-1) Serum dan Cairan Serebrospinal (CSS) Terhadap Derajat Keparahan Meningitis Tuberkulosis Abdul Razak; Syarif Indra; Restu Susanti; Yuliarni Syafrita; Reno Bestari; Gunawan Septa Dinata
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1514

Abstract

Tuberculous meningitis (TBM) is an infection caused by Mycobacterium tuberculosis (M.tb) affecting the meninges, characterized by high morbidity rates. The prognosis of TBM is partially determined by clinical severity, classified according to the British Medical Research Council (BMRC) scale. Delta Like Ligand 1 (DLL-1) is a transmembrane protein that plays a role in the formation of lipid cells, which are essential for the survival, virulence, and defense of M.tb against the host immune system. DLL-1 expression can be induced by the stimulation of M.tb cell walls in response to the human immune system. This study aims to analyze the correlation between DLL-1 levels in the serum and cerebrospinal fluid (CSF) with the clinical severity of TBM patients. A cross-sectional study was conducted involving 30 TBM patients treated at M. Djamil Central General Hospital, Padang, from October 2025 to January 2026. Serum and CSF DLL-1 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method, while TBM severity was assessed based on the BMRC criteria. Data analysis was performed using SPSS version 26.0 with a significance level of p < 0.05. The results of the analysis showed no significant difference in serum DLL-1 levels (p = 0.129) or CSS DLL-1 levels in relation to the severity of TBM (p = 0.097).
Ekstraksi Kitosan dari Jamur Tiram (Pleurotus ostreatus) serta Karakterisasi Fisikokimia dan Uji Aktivitas Antibakterinya Dahlia Hasibuan; Ridwanto Ridwanto; Anny Sartika Daulay; Ainil Fithri Pulungan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1533

Abstract

Background: Chitosan is a biopolymer derived from the deacetylation of chitin, which is generally obtained from crustacean waste. However, the utilization of more environmentally friendly alternative sources such as oyster mushrooms (Pleurotus ostreatus) has recently been developed. Chitosan exhibits biocompatible, biodegradable properties and antibacterial activity, making it potentially applicable in the food and pharmaceutical industries. Objective: This study aims to extract and characterize chitosan from oyster mushrooms and to evaluate its antibacterial activity against Escherichia coli. Methods: The study was conducted through extraction stages including deproteinization, depigmentation, demineralization, and deacetylation. Chitosan characterization included functional group analysis using FTIR, as well as physicochemical parameter testing such as yield, moisture content, ash content, and solubility. Antibacterial activity was tested using the disc diffusion method at various chitosan concentrations (0.3%, 0.5%, 0.7%, and 0.9%). Results: The obtained chitosan had a degree of deacetylation of 80.64%, indicating successful conversion of chitin into chitosan. The physicochemical characteristics met quality standards, with a yield of 52.84%, moisture content of 0.666%, and ash content of 0.416%. Chitosan was soluble in 2% acetic acid. Antibacterial testing demonstrated inhibitory activity against Escherichia coli, with inhibition zones ranging from 10.1 to 14.2 mm, categorized as strong. Conclusion: Chitosan extracted from oyster mushrooms exhibits good physicochemical characteristics and promising antibacterial activity, indicating its potential as an environmentally friendly alternative material for applications in the food and pharmaceutical fields.
Analisis Edukasi Konvensional Kelas Ibu Balita Dengan Metode Digital Micro Learning Berbasis Video Interaktif Terhadap Perawatan Tali Pusat Di Desa Binaka Wilayah Kerja UPTD Puskesmas Gunungsitoli Idanoi Cahayani Bawaulu; Hadirmanwati Gea; Fani Gea; Indrawati Waruwu; Wiyola Yolanda; Debora Paninsari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1535

Abstract

Background: The high rate of umbilical cord care practices that do not follow standards is influenced by cultural Background: The high rate of umbilical cord care practices that do not follow standards is influenced by cultural factors, limited knowledge among mothers and families, restricted access to health services, and home births assisted by traditional birth attendants. Objective: To analyze the comparison between conventional mother-toddler class education and interactive video-based digital micro learning methods on umbilical cord care. Methods: This study used a quasi-experimental design with two groups (posttest-only non-equivalent control group design). The population consisted of 22 mothers with infants aged 0–7 days in Binaka Village, selected through purposive sampling. Data collection instruments included questionnaires and a checklist sheet. Data analysis used an independent t-test. Results: Statistical analysis showed a p-value of 0.039, which is less than the significance level α (0.05), indicating a significant difference between conventional Mother-Toddler Class education and interactive video-based digital micro learning methods on umbilical cord care. Conclusion: Interactive video-based digital micro learning can be considered an alternative or even a more effective strategy for providing education to mothers of newborns. Healthcare providers, particularly midwives and nurses, can integrate interactive digital media into educational programs to enhance mothers' understanding and skills in umbilical cord care.
Perbandingan Aktivitas Antioksidan Senyawa Flavonoid dari Ekstrak Daun Kelor (Moringa Oleifera L.) Menggunakan Metode Spektrofotometri Uv-Vis Puteri Rahma Maharani; Izmi Haura Syahida; Munir Alinu Mulki
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.677

Abstract

The bioactive compounds found in moringa leaves (Moringa oleifera L.) can function as natural antioxidants to protect cells from damaging free radicals. The purpose of this study is to ascertain the antioxidant activity of moringa leaves according to the type of solvent, analyze the relationship between antioxidant capacity and concentration of active compounds, and determine the best solvent. Extraction was carried out using ethanol, methanol, and aquades solvents, followed by testing antioxidant activity using UV-Vis spectrophotometry method on DPPH radicals. The content of phenols, flavonoids, and tannins in the extract was measured to understand their contribution to antioxidant activity Based on the results of the study, the extract containing ethanol solvent showed the most powerful antioxidant activity, with an IC50 value of 103.98 ppm. In conclusion, the type of solvent has a significant effect on the antioxidant activity of moringa leaves, with ethanol solvents being the most effective option. This research strengthens the potential of moringa leaves as a natural source of antioxidants that can be utilized for applications in the pharmaceutical and health fields, although further research is needed to optimize extraction techniques and the development of moringa oleifera leaf-based product
Uji Aktivitas Antibakteri Gel Kombinasi Ekstrak Etanol Daun Sintrong (crassocephalum crepidioides (Benth.) S.Moore) Dan Bawang Daun (Allium fistulosum L.) Apriana Ulan Dari MS; Hindri Syahputri; Haris Munandar Nasution; Zulmai Rani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1148

Abstract

Skin diseases are the most common type of skin disease in tropical countries like Indonesia. One of the main causes is bacterial infection. Sintrong leaves (Crassocephalum crepidioides (Benth.) S. Moore) and scallion (Allium fistulosum L.) contain secondary metabolites with antibacterial potential. The objective of the research was to determine the antibacterial activity of sintrong leaf extracts (Crassocephalum crepidioides (Benth.) S. Moore) and scallion (Allium fistulosum L.) formulated in gel form. This research was experimental in nature with the preparation of gel preparations using variations in the ratio of sintrong leaf extract (Crassocephalum crepidioides (Benth.) S.Moore) and spring onion (Allium fistulosum L.) (2:3, 2:2, 3:2). Evaluation parameters included organoleptic tests, homogeneity, pH, viscosity, spreadability, and adhesiveness. Antibacterial activity was tested by the disc diffusion method on Staphylococcus aureus and Staphylococcus epidermidis using clindamycin as a positive control and gel base as a negative control. The results showed that all formulas met the physical criteria of gel preparations with a pH of 5.1–5.8, viscosity of 23726–38580 cPs, spreadability in the range of 5–7 cm, and adhesiveness of >4 seconds. Antibacterial activity showed a zone of inhibition in all formulas, with the largest diameter in formula F3 (3:2), with an average inhibition diameter of 18.23 ± 0.67 mm on Staphylococcus aureus and 17.51± 0.30 mm on Staphylococcus epidermidis, which is categorized as strong.
Uji Aktivitas Antidiabetes Infusa Daun Sukun (Artocarpus altilis) Pada Mencit Putih Jantan (Mus musculus) Yang Diinduksi Aloksan Kanne Dachi; Muharni Sahputri; Khaira Ulfida Afrida
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1174

Abstract

Diabetes mellitus is a degenerative disease and has become a national as well as international health problem. An unhealthy lifestyle is a primary trigger for the onset of diabetes. Synthetic antidiabetic drugs are one therapeutic option, but their side effects lead patients to switch to natural remedies, such as using breadfruit leaves (Artocarpus altilis) by consuming their decoction. Therefore, this study aims to investigate the potential of breadfruit leaves as an antidiabetic agent in vivo. This experimental research used mice as the test animals. Identification of the plant and test animals was conducted. Subsequently, simplicia powder from the breadfruit leaves was produced and its secondary metabolites were identified. Test preparations, including alloxan suspension, metformin suspension, Na-CMC suspension, and breadfruit leaf infusion, were then prepared. Five treatment groups were established, each consisting of 3 mice. The mice were induced with diabetes, and their blood glucose levels were checked over 15 days, with the data analyzed statistically. The results confirmed the validity of the breadfruit plant and the mice. The identification of secondary metabolites showed positive results for alkaloids, flavonoids, glycosides, tannins, and saponins. The 15% breadfruit leaf infusion significantly reduced blood glucose levels (p < 0.05), and its effect was not significantly different from metformin. This indicates that the 15% concentration demonstrated the most potent antidiabetic effect among the three concentrations tested. However, the interpretation of these results is limited by the small sample size in this preliminary study. In conclusion, the 15% breadfruit leaf infusion has the potential to be developed as a herbal antidiabetic agent.
Artikel Tinjauan: Sediaan Ekstrak Daun Kelor (Moringa oleifera L.) dalam Menurunkan Kadar Glukosa Darah pada Tikus (Rattus norvegicus) yang diinduksi Aloksan Biandra Cinta Ramadhani; Dia Septiani; Gita Novianti Lismawana; Hanifah Nur Widodo
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1184

Abstract

This study aims to evaluate the effectiveness of Moringa oleifera L. leaf extract preparations in lowering blood glucose levels in alloxan-induced white rats (Rattus norvegicus) through a Systematic Literature Review (SLR) approach. The review process followed the PRISMA 2020 guidelines, with a literature search conducted on the PubMed, ScienceDirect, and Google Scholar databases for the 2015–2025 period. Out of 472 identified articles, nine studies met the inclusion and exclusion criteria for further analysis.The review results indicate that all studies reported a significant decrease in blood glucose levels after the administration of Moringa oleifera leaf extract, both in the form of water extract and ethanol extract. The effective dose used ranged from 200–800 mg/kg body weight, with the highest effectiveness observed at doses of 400–450 mg/kg and an administration duration of 14–28 days. The water extract provided a faster glucose-lowering effect, while the ethanol extract showed more stable and longer-lasting results.The anti-hyperglycemic mechanism of Moringa oleifera leaf extract includes the stimulation of insulin secretion, the protection of pancreatic $\beta$-cells against oxidative stress, and the enhancement of insulin sensitivity in target tissues. The content of flavonoids, saponins, tannins, and chlorogenic acid plays a crucial role in regulating glucose metabolism and increasing antioxidant activity. Overall, this review confirms that Moringa oleifera L. has strong potential as a candidate for a safe and effective natural anti-diabetic phytopharmaca. However, further research with standardized extraction methods and in-depth molecular analysis is still needed to strengthen the scientific basis for its utilization.
Perbandingan Efektivitas Metode Penyuluhan Langsung dan Pemberian Leaflet terhadap Peningkatan Pengetahuan tentang Narkoba pada Remaja Achmad Dwityanto Oktaviansyah; Muhammad Luthfi Prasetyo; Nurul Mutmainah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1263

Abstract

Background: Drug abuse among adolescents is a serious public health problem. Health communication strategies such as direct counseling and leaflet distribution are commonly used, yet their comparative effectiveness remains underexplored. Objective: To compare the effectiveness of direct counseling versus leaflet distribution in improving adolescents’ knowledge about drug abuse. Methods: This experimental study used a two-group pre-test post-test design involving 62 adolescents at Mandhanisiwi Orphanage, Purbalingga. Group I (n=31) received direct interactive counseling (100 minutes), while Group II (n=31) received leaflets (100 minutes self-study). Knowledge was measured using a validated 20-item true-false questionnaire. Data were analyzed using Wilcoxon and Mann-Whitney tests. Results: Both groups showed significant knowledge improvement after intervention (p=0.000 for Group I; p=0.001 for Group II). The mean post-test score of Group I (80.81±7.86) was significantly higher than that of Group II (74.35±10.78) with p=0.022 (Mann-Whitney). Conclusion: Direct counseling is more effective than leaflet distribution in improving adolescents’ knowledge about drug abuse prevention. This method is recommended as the primary educational strategy in school- or community-based drug prevention programs.

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