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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 752 Documents
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Penetapan Kadar Tanin Daun Mangkokan (Polyscias scutellaria (Burm.f.) fosberg) Dan Daun Jambu Biji (Psidium guajava L.) Secara Spektrofotometri UV-Visible Putri Yupa Hasibuan; Anny Sartika Daulay; Ridwanto Ridwanto; Ainil Fithri Pulungan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.972

Abstract

Tannins are secondary metabolites belonging to the polyphenol group that exhibit important biological activities, including antioxidant, antibacterial, and anti-inflammatory effects. Mangkokan leaves (Polyscias scutellaria) and guava leaves (Psidium guajava) have long been traditionally used; however, quantitative data regarding their tannin content, particularly in relation to different extraction methods, remain limited. This study aimed to determine total tannin content and identify tannin types in 70% ethanol extracts and infusions of both plants using UV-Vis spectrophotometry. The methodology included phytochemical screening, identification of hydrolyzable and condensed tannins using specific reagents, and quantitative determination of total tannin content using the Folin–Ciocalteu method with gallic acid as a standard. Measurements were carried out at a maximum wavelength of 769 nm, with a regression equation of y = 0.2186x + 0.0024 and a coefficient of determination (R²) of 0.994. The results showed that all samples contained both hydrolyzable and condensed tannins. The highest tannin content was found in the ethanol extract of guava leaves (17.7998 ± 0.0789 mg/g), while the lowest was observed in the infusion of mangkokan leaves (14.0788 ± 0.1986 mg/g). These findings indicate that the type of solvent and extraction method significantly affect tannin yield, with 70% ethanol being more effective than water. In conclusion, both mangkokan and guava leaves have potential as natural sources of tannins, with ethanol extraction providing more optimal results. UV-Vis spectrophotometry proved to be an accurate, sensitive, and reliable method for the quantitative analysis of tannins in plant materials.
Formulasi, Evaluasi Dan Penentuan Nilai SPF Sediaan Body Lotion Ekstrak Etanol Kopi Arabika Jenis Longberry Fanny Anggreany Santosa; Rafita Yuniarti; Minda Sari Lubis; Zulmai Rani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1503

Abstract

Background: Exposure to ultraviolet (UV) radiation can cause skin damage such as erythema, premature aging, and skin cancer. Although sunscreens are widely used, synthetic UV filters may cause side effects. Therefore, alternative natural ingredients with antioxidant activity are needed, such as Arabica coffee beans (Coffea arabica), which are rich in polyphenols, particularly chlorogenic acid, as potential sunscreen agents. Objective: This study aims to formulate a body lotion containing ethanol extract of longberry-type Arabica coffee beans, evaluate its physical properties, and determine its Sun Protection Factor (SPF) value in vitro. Methods: This experimental study included phytochemical screening, extraction using 96% ethanol, and SPF determination using a UV-Vis spectrophotometer with the Mansur method. The body lotion was formulated with varying extract concentrations of 0–3% and evaluated for organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesiveness, emulsion type, stability, and irritation test. Results: The extract contained alkaloids, flavonoids, tannins, saponins, steroids, and glycosides. The highest SPF value of the extract was 36.727 at a concentration of 1000 ppm (ultra protection category). The best formulation was found at a 3% concentration with an SPF value of 10.554 (maximum protection category). All formulations met physical quality requirements and showed no irritation. Conclusion: The ethanol extract of longberry-type Arabica coffee beans has potential as a natural sunscreen active ingredient. Increasing the extract concentration is directly proportional to the increase in SPF value, with the 3% formulation showing the best performance.
Isolasi dan Penetapan Flavonoid Total Pada Daun Keji Beling (Strobilanthes crispus L.) Menggunakan Metode Spektrofotometri UV-Vis Mappa, Moh Rivaldi; Bahi, Rizky Resvita R.; Istiqomah, Huwaidah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.904

Abstract

Keji beling (Strobilanthes crispus L.) has several therapeutic activities such as anticancer, antimicrobial, treating diabetes mellitus, cholesterol, and kidney stones. Flavonoids are the main compounds that contribute to the therapeutic activities of keji beling. Along with its therapeutic activities, flavonoids are complicated by physicochemical properties that make these compounds difficult to identify specifically. This study aims to isolate and identify flavonoid compounds in keji beling leaves using UV-Vis spectrophotometry. The method used was experimental, including qualitative and quantitative analysis, with stages including maceration, phytochemical screening, fractionation, thin-layer chromatography (TLC), column chromatography, preparative thin-layer chromatography (PTLC), and UV-Vis spectrophotometry. The extraction results showed a yield of 11.8%. The phytochemical screening test showed positive results for flavonoid compounds. The fractionation process produced two layers, namely polar and nonpolar layers. TLC results with the best solvent ratio (9:1) showed an Rf value of 0.72. Column chromatography provided good separation results. PTC produced blue-white, orange, red, and purple spots. The results of quantitative analysis of total flavonoids using UV-Vis spectrophotometry with quercetin as a standard showed an average of 11.438 mg QE/g extract and a standard deviation (SD) of ± 0.0058 mg QE/g and %RSD of 0.05%, indicating a very good level of method precision with a maximum wavelength of sample absorbance at 433 nm.
Tinjauan potensi aktivitas ramuan herba sambiloto, herba meniran, dan daun kumis kucing dalam penanganan diabetik neuropati: Narative Review Sari, Anita Purnama; Sundhani , Elza; Wahyuningrum, Retno
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.940

Abstract

Diabetic neuropathy is one of the most common microvascular complications among patients with diabetes mellitus, characterized by damage to peripheral nerves due to persistently high blood sugar levels, excessive oxidation and inflammation. Conventional treatments are often not effective enough in comprehensively addressing this problem, so strategies using medicinal plants are emerging as promising options. This study aims to review the potential pharmacological activities of three medicinal plants, namely sambiloto (Andrographis paniculata), meniran (Phyllanthus niruri), and cat's whisker (Orthosiphon aristatus), in the treatment of diabetic neuropathy. This study was conducted using the Narrative Review method with a literature search of two databases PubMed and ScienceDirect with an interval of publication years 2016-2026. A total of 16 articles were selected. The three types of plants showed significant pharmacological properties, including as antioxidants, anti-inflammatory, hypoglycemic, and neuroprotective. Sambiloto functions through andrographolide compounds that inhibit the NF-κB pathway and increase Nrf2 antioxidant activity. Meniran has an effect in lowering blood glucose levels and increasing the performance of antioxidant enzymes. Cat whisker plays a role in glucose control, kidney care, and inflammation in the system.  The results of this study are expected to provide an overview of additional therapies in overcoming diabetic neuropathy through the workings of Sambiloto, meniran, and cat's whiskers have complementary potential. The combination of these three plants offers a diverse approach, but further research is needed to assess synergistic effects, safety, and the most appropriate formulation as a modern herbal treatment.
Uji Uji Aktivitas Antibakteri Ekstrak Etanol, Fraksi n-Heksan Dan Etil Asetat Daun Seminyak (Champereia manillana (Blume) Merr.) Terhadap Bakteri Enterococcus faecalis Pratama, Alvin; Nasution, Haris Munandar; Pulungan, Ainil Fithri; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1200

Abstract

Background: Bacterial resistance to antibiotics has become a global concern, prompting the exploration of alternative antibacterial agents derived from natural sources. Enterococcus faecalis is a pathogenic bacterium frequently associated with root canal treatment failure due to its high resistance level. Seminyak leaves (Champereia manillana (Blume) Merr.) are known to contain secondary metabolites with potential antibacterial activity; however, studies based on solvent fractionation remain limited. Objective: This study aimed to evaluate the antibacterial activity of the ethanol extract, n-hexane fraction, and ethyl acetate fraction of seminyak leaves against Enterococcus faecalis. Methods: An experimental study was conducted through plant identification, preparation of simplicia, extraction using the maceration method with 96% ethanol, and liquid–liquid fractionation using n-hexane and ethyl acetate. Phytochemical screening was performed qualitatively and confirmed by thin-layer chromatography (TLC). Antibacterial activity was assessed using the disc diffusion method at concentrations of 15%, 30%, and 45% with three replications. Dimethyl sulfoxide (DMSO) 10% was used as the negative control, while chlorhexidine (standard concentration) served as the positive control. Data were analyzed using One-Way ANOVA followed by Tukey HSD post hoc test. Results: Phytochemical screening revealed that the ethanol extract contained alkaloids, flavonoids, tannins, saponins, and steroids. The n-hexane fraction predominantly contained nonpolar compounds (alkaloids and steroids), while the ethyl acetate fraction contained more diverse semi-polar compounds. Antibacterial testing showed that all samples exhibited activity against Enterococcus faecalis. The highest inhibition zone diameters at 45% concentration were 14.1 ± 0.21 mm (ethanol extract), 10.3 ± 0.17 mm (ethyl acetate fraction), and 8.5 ± 0.14 mm (n-hexane fraction). Statistical analysis indicated significant differences among treatments (p < 0.05). Conclusion: The ethanol extract, ethyl acetate fraction, and n-hexane fraction of seminyak leaves exhibit antibacterial activity against Enterococcus faecalis. The ethanol extract showed the highest activity, followed by the ethyl acetate and n-hexane fractions. These findings suggest that antibacterial compounds are more dominant in polar to semi-polar fractions.
Interaksi antara Herbal dan Antidiabetik Oral pada Penderita Diabetes Melitus: Tinjauan Mekanisme Aksi Shidiqiyah , Nurul Hafizha; Herlaesa , Shofiatulfuadah Retnaningrum; Piola, Okta; Hariadi, Nayla Nur Azkia; Basmalah, Nur; Putri , Mukarromah Dita; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1207

Abstract

The increasing use of herbal products among patients with diabetes mellitus highlights the need for a clear understanding of their potential interactions with oral antidiabetic drugs (OADs). Such interactions may be synergistic or may pose risks, particularly hypoglycemia. To identify the mechanisms underlying interactions between herbal products and OADs and to assess their relevance in the management of type 2 diabetes mellitus. A literature search was conducted through Google Scholar, PubMed, and ScienceDirect using keywords related to herbal products, oral antidiabetic drugs, and drug interactions. Articles were selected based on inclusion criteria (2015–2025, original research, human subjects with type 2 diabetes mellitus or animal models, English or Indonesian language, and involving OADs) and relevant exclusion criteria. The most frequently reported interactions were pharmacodynamic, particularly the combination of Cinnamomum verum, Curcuma longa, and Momordica charantia with metformin or sulfonylureas, which enhanced insulin sensitivity, activated AMPK, or stimulated insulin secretion, potentially increasing the risk of hypoglycemia. Pharmacokinetic interactions were also identified, such as ginseng-induced modulation of the OCT1 transporter, which may influence metformin accumulation. Several other herbal products, including Aloe vera, demonstrated glucose-lowering activity; however, evidence of direct interactions with OADs remains limited, suggesting a primarily supportive role. Interactions between herbal products and oral antidiabetic drugs have important clinical implications, as they may alter both therapeutic efficacy and safety. Close monitoring and patient education are essential, alongside further research to clarify interactions that remain insufficiently documented.
Implementasi Edukasi Apoteker Untuk Meningkatkan Pengetahuan, Kepatuhan Dan Keberhasilan Terapi Pada Pasien Hiperurisemia Di Farmasi Komunitas Sinaga, Vera Natalia; Wiryanto, Wiryanto; Khairunnisa, Khairunnisa
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1271

Abstract

Hyperuricemia is a condition characterized by elevated uric acid levels that may lead to gout arthritis and metabolic complications. Therapeutic success is strongly influenced by patients’ knowledge and adherence, highlighting the important role of pharmacist-led education in community pharmacy settings. This study aimed to evaluate the effect of pharmacist education on improving knowledge, medication adherence, and treatment success among hyperuricemia patients. A quasi-experimental pretest–posttest study with a control group was conducted involving 170 patients (85 intervention and 85 control) recruited through consecutive sampling. The intervention group received structured pharmacist education and counseling, while the control group received usual care. Outcomes were assessed at baseline and after a 14-day follow-up period. Patient knowledge was measured using a validated questionnaire, adherence was assessed using the MARS-5, and treatment success was evaluated through changes in pain intensity (VAS), serum uric acid levels, and treatment satisfaction using the TSQM-9.The Wilcoxon and Mann–Whitney U tests showed significant improvements in the intervention group compared to the control group. The intervention group demonstrated increased knowledge (Δ3.37), improved adherence (Δ3.67), greater reduction in uric acid levels (Δ1.25 mg/dL), more substantial pain reduction—particularly in disruptive pain (37% vs 13%)—and higher treatment satisfaction (95.29% vs 62.35%).In conclusion, a short-term pharmacist-led educational intervention with a 14-day follow-up effectively improves knowledge, adherence, and therapeutic outcomes in hyperuricemia patients in community pharmacies, supporting its feasibility for routine implementation.
Persepsi Apoteker dan Pengetahuan Apoteker Dalam Manajemen Farmasi Terhadap Pelayanan Kefarmasian Secara Online Pada Apotek Di Kota Medan Panjaitan, Magdalena; Wiryanto, Wiryanto; Khairunnisa, Khairunnisa
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1273

Abstract

Digital transformation is driving significant changes in pharmaceutical services, including the utilization of online drug consultation and sales services. This study aims to analyze the influence of pharmacists' perceptions and knowledge on online pharmaceutical services and to strengthen quantitative findings thru qualitative results. The method used was a nested mixed method sequential explanatory approach, with the initial stage involving a survey of 200 pharmacists, followed by in-depth interviews with 20 informants consisting of 10 pharmacists who had been providing online pharmaceutical services for more than 3 years and 10 pharmacists who had not yet provided online pharmaceutical services but had more than 3 years of work experience as pharmacists. The data analysis results show that perception significantly influences online pharmacy services (p < 0.001), as does knowledge (p < 0.001). A coefficient of determination of 42.6% (0.426) indicates the significant role of both variables. The interview results with the sources explain the data analysis findings: pharmacists emphasize the importance of technological readiness, regulatory compliance, clear SOPs, and digital competency development as requirements for implementing online pharmaceutical services. This research confirms that strengthening the capacity of pharmacists and the pharmaceutical management system is the foundation for the successful transformation of digital pharmacy services in community pharmacies. This study concludes that pharmacists' perceptions and knowledge significantly influence the quality of online pharmaceutical services. The results of interviews with sources explain the data analysis, showing that technological readiness, regulatory compliance, and pharmacists' digital competence are the main foundations for the successful implementation of online pharmaceutical services in community pharmacies.
Efektivitas Dua Model Intervensi Medication Therapy Management (MTM) dalam Meningkatkan Pengetahuan, Kepatuhan, dan Luaran Klinis pada Pasien Hipertensi Perangin-angin, Arihta Sri; Harahap, Urip; Dalimunthe, Aminah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1274

Abstract

Hypertension is a major contributor to morbidity and mortality in Indonesia and worldwide. The success of hypertension therapy is strongly influenced by patient knowledge and medication adherence. The 2023 Indonesian Health Survey reported a hypertension prevalence of 30.6% among adults, with a prevalence of 24.4% in North Sumatra. Medication Therapy Management (MTM) represents a strategic approach to optimizing hypertension treatment outcomes. This study aimed to evaluate two MTM intervention models—direct interaction and audio-visual—and assess their effects on knowledge, medication adherence, and clinical outcomes among hypertensive patients at the Aviati Clinic, Medan. This quasi-experimental comparative study employed a three-group pretest–posttest design involving 126 hypertensive patients. Participants were allocated into a control group receiving usual care without structured education, a direct interaction MTM group, and an audio-visual MTM group. Patient knowledge was assessed using the HKLS questionnaire, adherence was measured using the MARS-5 questionnaire, and clinical outcomes were evaluated through blood pressure measurements. Data were analyzed using the Kruskal–Wallis test followed by Bonferroni post hoc analysis. The results demonstrated that both MTM intervention models significantly improved knowledge, medication adherence, and clinical outcomes compared with the control group (p < 0.001). Although both intervention groups were effective, the direct interaction MTM model produced a greater reduction in systolic blood pressure than the audio-visual intervention. These findings indicate that structured MTM interventions, particularly those delivered through direct interaction, are effective in improving therapeutic outcomes in patients with hypertension.
Integrasi Strategi Genomik Presisi dan Perspektif Etika Islam dalam Pencegahan Stunting: Fokus pada Jalur Hormon Pertumbuhan–IGF-1 Qur’ani , Hifdzil; Nisa, Nasywa Khoirun; Pratama, Pramudya; Kasasiah , Ahsanal; Malau, Jekmal
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1320

Abstract

Stunting remains one of the major chronic nutritional problems in Indonesia. The national prevalence of stunting has decreased from 37.2% in 2013 to 19.8% in 2024; however, this figure is still above the World Health Organization threshold (<20%) and has not yet reached the national target of 14%. The interaction of nutritional, environmental, and genetic factors influences stunting. Genetic variations within the Growth Hormone–Insulin-like Growth Factor One pathway play a significant role in regulating linear growth in children; disruptions in this pathway can increase vulnerability to stunting. In addition, the majority of Indonesia's population adheres to Islam, making religious values a strategic potential for strengthening health interventions. This review article examines the integration of scientific approaches, focusing on genetics and Islamic values, in stunting prevention by highlighting polymorphisms in the IGF1, IGF1R, and GHR genes and their relevance to the principles of maqāsid al-sharī‘ah, particularly hifz al-nasl (protection of lineage). The analysis is conducted using a descriptive-analytical approach based on recent scientific literature and Islamic references, including the Qur’an, prophetic traditions, and scholarly exegesis. The findings indicate a strong alignment between scientific approaches and Islamic teachings, including the importance of adequate nutrition during pregnancy, exclusive breastfeeding, consumption of lawful, nutritious food, genetic screening efforts consistent with the values of divine decree, and vitamin D supplementation to support Insulin-like Growth Factor One levels. This integration has the potential to enhance community acceptance of stunting-prevention programs, strengthen moral and spiritual motivation, and support the achievement of national stunting-reduction targets. Thus, an approach that combines precise genomics and Islamic values may serve as a contextual and sustainable strategy in shaping a generation that is healthy, intelligent, and spiritually resilient.

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