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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 710 Documents
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Kajian Sistem Pelaporan Farmakovigilans Berdasarkan Pelaporan Rumah Sakit Di Sumatera Utara Pada Rentang 2019-2024 Nasution, Mai Syaroh; Wiryanto , Wiryanto; Wangge , Grace
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1212

Abstract

Pharmacovigilance safeguards patient safety, yet hospital ADR reporting in North Sumatra remains limited. This research to assess compliance with BPOM’s 10 completeness criteria and identify determinants that support or hinder implementation. Methods: A mixed methods approach with a sequential explanatory design was applied. descriptive analysis of 2019-2024 e-MESO reports and in-depth interviews with hospitals categorized as Complete, Incomplete, and Non-reporting. Results: Out of 210 hospitals, only 11 (5%) actively reported through e-MESO, producing 50 reports, 98% complete and 2% incomplete. About 74% were spontaneous reports, mostly skin reactions, with 40% serious cases in elderly patients. Qualitative analysis revealed seven main themes: understanding, reporting process, barriers, management support, e-MESO system, expectations, and interprofessional collaboration. Conclusion: While individual report completeness is high, system-level participation is low, so full compliance with the 10 criteria is not yet achieved. Reporting quality is largely shaped by managerial support, organizational readiness, and interprofessional collaboration. Recommended actions include expanding SOP-based reporting on the 10 criteria, appointing a clinical pharmacist as the person-in-charge, conducting cross-profession training, and coordinating e-MESO technical issues with BPOM particularly strengthening type-C hospitals.
Efek Farmakologis Ekstrak Daun Cleome gynandra L. : Sebuah Tinjauan Sistematis Pitaloka, Kadek Ayu Intan; Wardana, I Nyoman Gede; Sumardika, I Wayan; Widhiartini, Ida Ayu Alit
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1287

Abstract

Background: Cleome gynandra L. is a leafy medicinal plant widely used in traditional medicine across Asia and Africa. Although its rich phytochemical profile has attracted growing scientific interest, the existing evidence on its pharmacological effects remains fragmented and inconsistent across studies. Objective: This systematic review aims to synthesize and critically evaluate the pharmacological effects of C. gynandra leaf extract reported over the past decade. Methods: A systematic literature search was conducted in PubMed, ScienceDirect, and Medline for articles published between January 2016 and December 2025, following the PRISMA guidelines. Studies reporting the pharmacological activities of C. gynandra leaf extract using in vitro or in vivo approaches were included. Data extraction and quality assessment were performed independently by two reviewers. Results: A total of seven studies met the inclusion criteria. The findings consistently demonstrated that C. gynandra leaf extract possesses antioxidant, antibacterial, anticancer, hepatoprotective, and antimalarial activities, which are largely attributed to its diverse phytochemical constituents, including flavonoids, phenolic compounds, and triterpenoids. However, substantial heterogeneity was observed across studies in terms of extraction methods, experimental designs, dosage regimens, and outcome parameters. All available evidence remains at the preclinical stage, with no clinical trials identified. Conclusion: The current evidence suggests that C. gynandra leaf extract exhibits promising pharmacological potential. Nevertheless, the high degree of methodological variability and the absence of clinical studies preclude definitive conclusions regarding its therapeutic efficacy and safety. Future research should prioritize standardized methodologies, mechanistic investigations, and well-designed clinical trials to validate the medicinal value of this plant.
Validitas Awal instrumen European Quality of Life (EQ-5D-5L) versi Indonesia pada kualitas hidup penderita hepatitis B Hasniah, Hasniah; Perwitasari , Dyah Ariani; Supadmi , Woro
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1292

Abstract

Health-related quality of life (HRQoL) is an important aspect in the management of chronic diseases such as hepatitis B, considering the long disease course and the risk of complications including cirrhosis and hepatocellular carcinoma. The European Quality of Life instrument (EQ-5D-5L) is widely used globally to assess quality of life; however, psychometric evidence in patients with hepatitis B in Indonesia remains limited. This study aimed to evaluate the preliminary validity and reliability of the Indonesian version of the EQ-5D-5L among patients with hepatitis B in primary healthcare settings. This study employed an observational design with a cross-sectional approach involving 42 female patients with confirmed HBsAg positivity who participated in a hepatitis B early detection program at primary health centers in Banjarmasin City between April and October 2025. Data were collected using the EQ-5D-5L questionnaire, the EQ visual analogue scale (EQ-VAS), and a demographic characteristics form. Reliability was assessed using Cronbach’s alpha, while construct validity was evaluated using item–total correlation with a significance threshold of r-table = 0.304. Statistical analyses were performed using SPSS version 26. The results indicated that the EQ-5D-5L questionnaire demonstrated good internal consistency with a Cronbach’s alpha value of 0.799. All items showed item–total correlations greater than the r-table value (0.304), indicating that all domains were valid. Correlation analysis revealed a significant relationship between EQ-VAS scores and the EQ-5D-5L utility index (r = 0.669; p < 0.001), suggesting adequate construct validity. Within the limitations of this study, the Indonesian version of the EQ-5D-5L demonstrates potential as a tool for measuring quality of life among female patients with hepatitis B in primary healthcare settings.
Formulasi dan Uji Efektivitas Sediaan Gel Ekstrak Buah Bit (Beta vulgaris L) Terhadap Penyembuhan Luka Tikus Model Diabetes Yang Diinduksi Aloksan Maharani, Kinanti; Ginting, Astriani Natalia Br.; Banggar, Roy Indrianto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1322

Abstract

Introduction: Diabetic ulcers are serious complications of diabetes mellitus that are difficult to heal due to hyperglycemia, oxidative stress, and infection. Beetroot (Beta vulgaris L.) contains betalains, flavonoids, and polyphenols which possess antioxidant and anti-inflammatory activities to accelerate tissue regeneration. Objective: This study aims to formulate beetroot ethanol extract into a gel preparation and test its effectiveness on wound healing in alloxan-induced diabetic rat models. Methods: This experimental study included beetroot extraction using 96% ethanol maceration, phytochemical screening, and gel formulation with varying extract concentrations (5%, 10%, and 15%). Thirty male rats were induced with alloxan (150 mg/kgBW) to reach a diabetic state, then given a 2 cm incisional wound. Rats were divided into 6 groups: Normal, Negative Control (gel base), Positive Control (Chloramphenicol), and extract gel groups of 5% (F1), 10% (F2), and 15% (F3). Wound length was observed for 14 days. Results: Phytochemical screening showed the extract was positive for alkaloids, flavonoids, saponins, steroids, and tannins. Physical evaluation of the preparation (pH, homogeneity, viscosity, and spreadability) met SNI standards. The effectiveness test results showed significant differences ($p < 0.05$) between treatment groups. The F3 group (15%) showed the best healing rate, comparable to the positive control and normal groups, with an average wound length of 0 mm by day 14. Conclusion: Beetroot ethanol extract gel has good physical stability, and the 15% concentration is the most effective in accelerating wound healing in diabetic rat models.
Uji Efektivitas Ekstrak Daun Kelor (Moringa oleifera) dalam Menurunkan Kadar Asam Urat pada Mencit (Mus Musculus) Yang Diinduksi Hati Ayam Sidauruk , Resti Novita; Novriani , Erida; Lubis , Razoki
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1328

Abstract

Background: Hyperuricemia is a metabolic disorder with an increasing prevalence and a risk of developing into gout if not properly treated. The use of allopurinol as a conventional therapy is effective in lowering uric acid levels; however, it may cause side effects, thus safer natural-based therapeutic alternatives are needed. Moringa leaves (Moringa oleifera) are known to contain bioactive compounds with potential antihyperuricemic activity. Objective: This study aimed to evaluate the effectiveness of Moringa leaf extract in reducing uric acid levels in mice (Mus Musculus) with hyperuricemia induced by chicken liver. Methods: This laboratory experimental study with a controlled group design used 30 mice divided into six groups (n = 5): normal control, negative control (5% Na-CMC), positive control (allopurinol 10 mg/kgBW), and three treatment groups receiving Moringa leaf extract at doses of 70, 140, and 280 mg/kgBW. Hyperuricemia was induced using chicken liver. Uric acid levels were measured daily for 7 days using a Multicheck Nesco® device. Data were analyzed using One-Way ANOVA followed by the Tukey Post Hoc test with a significance level of p < 0.05. Results: Chicken liver induction successfully increased uric acid levels in mice in all treatment groups (baseline levels of 3.26–3.42 mg/dL increased to 8.20–8.30 mg/dL). Moringa leaf extract showed a gradual and dose-dependent reduction in uric acid levels. The dose of 280 mg/kgBW provided the most optimal reduction effect (from 8.22 mg/dL to 3.44 mg/dL on day 7; p < 0.05), approaching the effectiveness of the positive control allopurinol (from 8.30 mg/dL to 3.52 mg/dL). Phytochemical screening confirmed the presence of active compounds such as flavonoids, alkaloids, saponins, phenols, and triterpenoids which play a role in inhibiting the xanthine oxidase enzyme. Conclusion: Moringa leaf extract effectively reduces uric acid levels in mice induced with hyperuricemia, with the dose of 280 mg/kgBW being the most optimal. Moringa leaf extract has potential to be developed as a natural-based antihyperuricemic therapeutic alternative.
Isolasi Protein dan Bakteri Asam Laktat dari Pangan Tradisional Dali Ni Horbo yang Dimodifikasi sebagai Kandidat Probiotik Natasya, Balqis; Meha , Lasminar; Lubis , Asyrun; Lubis , Razoki; Piska , Finna
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1367

Abstract

Background: Dali ni horbo is a traditional North Sumatran food made from buffalo milk that has potential as a source of protein and lactic acid bacteria (LAB). Its high nutritional content and fermentation process make it a promising candidate for functional food development with probiotic properties. Objective: This study aimed to isolate and characterize proteins and LAB from dali ni horbo produced using different treatments, namely pure buffalo milk, the addition of pineapple juice, and the addition of citrus juice. Methods: Protein isolation was carried out using the ammonium sulfate precipitation method, while LAB were isolated on MRS agar supplemented with CaCO₃. Protein characterization was performed using biuret, ninhydrin, and xanthoprotein tests. LAB characterization included Gram staining, catalase test, and bile salt tolerance test. Results: The results showed that the protein isolate obtained using pineapple as a coagulant had the highest yield (2.3321 g) compared to citrus (1.8516 g). All protein isolates tested positive for biuret, ninhydrin, and xanthoprotein, indicating the presence of peptide bonds, amino acids, and aromatic groups. A total of 18 LAB isolates were obtained, all of which were Gram-positive, rod-shaped, catalase-negative, and tolerant to bile salts. Conclusion: Dali ni horbo has strong potential as a source of protein and probiotic candidates, indicating its applicability as a functional food to support health.
Penetapan Kadar Kurkuminoid Dalam Jamu Serbuk Yang Mengandung Simplisia Rimpang Kunyit (Curcuma domestica Val.) yang Beredar di Kota Medan Siregar, Muhammad Alfariz Baihaqi; Harun , Fathur Rahman; Ridwanto, Ridwanto; Daulay , Anny Sartika
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1485

Abstract

Background: Kunir asem herbal medicine is a traditional beverage widely consumed by the community to relieve menstrual pain due to the content of turmeric (Curcuma domestica Val.) which contains active compounds with analgesic, antipyretic, and anti-inflammatory properties. However, information regarding curcuminoid levels in powdered herbal medicine products circulating in the community remains limited, particularly in Medan City. Objective: This study aimed to identify the presence of curcuminoids in powdered herbal medicine containing turmeric rhizome circulating in Medan City and to determine the compliance of their levels with quality requirements according to the Indonesian Herbal Pharmacopoeia Second Edition 2017. Methods: A total of 10 samples of powdered herbal medicine containing turmeric rhizome were collected from five sub-districts in Medan City (Medan Johor, Patumbak, Deli Tua, Medan Baru, and Medan Polonia) using simple random sampling technique. Sample extraction was carried out by maceration using 96% ethanol solvent. Qualitative analysis of curcuminoids was performed using Thin Layer Chromatography (TLC) method with chloroform:methanol (95:5) as mobile phase and curcumin standard as comparison. Determination of curcuminoid levels was conducted using UV-Vis Spectrophotometry method at a maximum wavelength of 425 nm. Results: Qualitative analysis results showed that all samples were positive for curcuminoids, indicated by Rf values close to or equal to the Rf value of curcumin standard (0.78), ranging from 0.76-0.82. The quantitative analysis results showed that among the ten samples tested, three samples (SJ-A 0.66%, SJ-B 0.29%, and SJ-I 0.28%) had curcuminoid levels below the minimum requirement, while seven other samples (SJ-C 5.73%, SJ-D 7.50%, SJ-E 9.13%, SJ-F 5.94%, SJ-G 4.66%, SJ-H 8.02%, and SJ-J 6.07%) met the requirements. Conclusion: All samples of powdered herbal medicine containing turmeric rhizome circulating in Medan City were positive for curcuminoids; however, three out of ten samples (30%) did not meet the quality requirements for curcuminoid levels according to the Indonesian Herbal Pharmacopoeia Second Edition 2017, which specifies not less than 3.82%. This indicates the need for more stringent quality control of herbal medicine products circulating in the community.  
Artikel Tinjauan: Perbandingan Metode KLT, KCKT, dan Spektrofotometri UV-VIS untuk Deteksi dan Kuantifikasi Paraben Pada Kosmetik Widodo, Hanifah Nur; Mulki, Munir Alinu; Ramadhani, Biandra Cinta; Ramadani, Salsabila
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1193

Abstract

Parabens are widely used preservatives in cosmetic products to inhibit microbial growth; however, excessive exposure has been associated with endocrine disruption and skin irritation. This study reviews and compares analytical methods used for the identification and quantification of parabens in cosmetic products, namely Thin Layer Chromatography (TLC), UV–Vis spectrophotometry, and High-Performance Liquid Chromatography (HPLC). Literature searching was conducted through PubMed and Google Scholar for studies published between 2015 and 2025. Ten articles met the inclusion criteria as original research utilizing one of the three analytical methods. TLC is effective for preliminary qualitative identification based on Rf values but is less suitable for quantitative analysis. UV–Vis spectrophotometry allows rapid determination of paraben levels within a λmax range of 254–258 nm and provides reliable results for relatively simple matrices. HPLC generally demonstrates the highest sensitivity, specificity, and accuracy, commonly employing C18 columns, methanol–aquadest mobile phases, retention times of 3–11 minutes, and high linearity (R² ≥ 0.999). Several studies also reported paraben levels exceeding the safety limits established by BPOM RI, highlighting the importance of chromatographic confirmation in cosmetic surveillance. Therefore, the selection of analytical methods should follow a fit-for-purpose approach based on analytical objectives, matrix complexity, and regulatory requirements to ensure product safety.
Gel Pembersih Wajah Berbasis Ekstrak Daun Sengani: Inovasi Herbal untuk Terapi Anti-Jerawat yang Menargetkan Cutibacterium acnes Candrika, Candrika; Fauzi, Ziza Putri Aisyia; Puteri, Cut Intan Annisa; Damanik, Ferina Septiani; Utami, Dinda Sari; Hartini, Putri Tri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1454

Abstract

Senggani is a traditional Asian plant commonly used as an alternative medicine, particularly in Indonesia. The leaves of the senggani plant contain secondary metabolites, including tannins, alkaloids, flavonoids, and saponins. Among these, tannins and flavonoids are believed to have antibacterial properties. This study investigates whether a facial wash gel made from the ethanol extract of senggani leaves possesses stable properties and meets established standards. Additionally, the study aims to evaluate its antibacterial activity against Cutibacterium acnes, the bacteria responsible for acne. A maceration method with 70% ethanol was used to prepare the ethanol extract from senggani leaves. This extract was then formulated into a facial wash gel using carbopol polymer at 5%, 7.5%, and 10%, followed by tests to assess its antibacterial activity. The antibacterial activity was determined using the disc diffusion method at the same concentrations. The results indicated that the diameter of the bacterial inhibition zone was 9.93 mm at 5%, 11.66 mm at 7.5%, and 13.93 mm at 10%. The gel preparation of the ethanol extract from senggani leaves demonstrated stable properties, with physical stability evaluations confirming compliance with the quality standards for facial washes set by Indonesian national regulations. Furthermore, the senggani leaf ethanol extract gel effectively inhibited the growth of Cutibacterium acnes, indicating its potential as an effective face wash.
Peran protektif bromelain dan flavonoid dalam kulit nanas terhadap kerusakan sel kulit akibat paparan sinar UV: Sebuah tinjauan sistematis. Wulandari , Ni Putu Mirah Ayunda Kartika; Linawati , Ni Made
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1487

Abstract

Exposure to ultraviolet (UV) radiation is a significant cause of skin cell damage through DNA damage, oxidative stress, and the activation of inflammatory pathways. Skin protection generally relies on sunscreens, but increasing interest in natural agents has driven the exploration of bioactive compounds derived from agricultural waste such as pineapple (Ananas comosus) peel. Pineapple peel contains flavonoids and bromelain with antioxidant, anti-inflammatory, and photoprotective potential. This systematic review aims to assess the scientific evidence regarding the protective role of these compounds against UV-induced skin damage. A literature search was conducted using PubMed, ScienceDirect, ProQuest, and Google Scholar in accordance with PRISMA guidelines. The inclusion criteria were in vitro, in vivo, and formulation studies evaluating the effects of pineapple peel extracts on skin damage parameters, including oxidative stress, cytokine modulation, antioxidant enzymes, and sun protection factor (SPF). Eight studies met the criteria. The results showed that formulations containing pineapple peel extract, such as creams, gels, lotions, or biocomposites demonstrated SPF ranging from low to ultra levels of protection. Flavonoids play a role in scavenging free radicals, reducing reactive oxygen species (ROS), and modulating anti-inflammatory effects. Bromelain supports the viability of UV-exposed fibroblasts and enhances the effectiveness of synthetic sunscreens such as octyl methoxycinnamate. Pineapple peel shows strong potential as a source of natural active ingredients for photoprotection through the activity of flavonoids and bromelain. However, further research with standardized designs and clinical trials is needed before it can be applied in sustainable cosmetic and therapeutic formulations.

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