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Nawanto A. Prastowo
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INDONESIA
Journal of Urban Health Research
Published by Universitas Katolik Indonesia Atma Jaya
ISSN : -     EISSN : 29644194     DOI : https://doi.org/10.25170/juhr.v1i1
Core Subject : Health,
Medicine & Pharmacology
The journal open-access electronic journal. JUHR is a peer-reviewed journal. The journal aims to improve discussion and dissemination of knowledge in the fields of medicine, health, and pharmacy in order to improve the health outcomes of urban populations. JUHR accepts manuscripts written in English only
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 35 Documents
 1   2   3   4 
Evaluating The CURB-65 Score for Prognostic Assessment in COVID-19 Patients: A Systematic Review Astiarani, Yunisa; Sari, Gabriella Aninda Puspita; Kristian, Kevin
Journal of Urban Health Research Vol. 3 No. 2 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i2.6640

Abstract

Introduction: Several instruments and biomarkers have been used to assess the severity and predict outcomes in COVID-19 patients, each with varying sensitivity levels. One such tool is the CURB-65 score—an acronym for Confusion, Urea nitrogen, Respiratory rate, Blood pressure, and age ≥65 years—which has traditionally been used to evaluate the severity of community-acquired pneumonia. Its application in COVID-19 patients aims to identify clinical deterioration and assist in risk stratification. Accurate prognosis is essential to guide clinical management and reduce mortality. However, the utility of the CURB-65 score in predicting outcomes in COVID-19 patients remains a subject of debate. This study aims to evaluate the performance of the CURB-65 score in determining the prognosis of patients with COVID-19. Methods:This systematic review was conducted in accordance with PRISMA guidelines. Relevant studies published between 2020 and 2022 were identified through searches using predefined keywords in PubMed, ScienceDirect, and EBSCO databases. Studies of all designs that assessed the CURB-65 score concerning COVID-19 outcomes were considered for inclusion. Results: Ten studies were included in this review, evaluating the CURB-65 score's effectiveness in predicting various outcomes in COVID-19 patients, including overall mortality, 30-day mortality, adverse outcomes, need for organ support, ICU admission and intervention, critical illness, mechanical ventilation, and 72-hour mortality. Seven out of ten studies demonstrated good prognostic performance of the CURB-65 score, with sensitivity greater than 80% or an Area Under the Curve (AUC) exceeding 0.80 for predicting mortality. Conclusion: The CURB-65 score shows promising utility in predicting mortality among COVID-19 patients and may perform better than several other prognostic tools. Its simplicity and accessibility make it a valuable aid in clinical decision-making, although further validation in different populations may be warranted.
Comparison of Effectiveness of Milling Time of Avocado Seed Extract for Lowering Blood Glucose Level in Alloxan-induced Diabetic Rat Manalu, Jojor Lamsihar; Caesarlia, Josephine; Dewi, Rita
Journal of Urban Health Research Vol. 3 No. 3 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i3.7028

Abstract

Introduction:Diabetes Mellitus (DM) is a chronic metabolic disorder with increasing global prevalence. Effective management is crucial to prevent acute and long-term complications. Natural products, including avocado (Persea americana Mill.) seeds, have gained attention for their potential antidiabetic properties due to their rich phytochemical content. Methods: This experimental study used male Sprague Dawley rats, divided into two main groups based on blood glucose status (normal and diabetic), with each group further subdivided based on the milling duration of avocado seed extract (5 and 10 minutes). The extract was administered orally at a dose of 250 mg/kg body weight for seven consecutive days. Blood glucose levels were measured using a glucometer before and after the treatment period. Results: Avocado seed extract demonstrated a glucose-lowering effect in both treatment groups. Rats treated with extract milled for 5 minutes showed a mean reduction in blood glucose of 25.13 mg/dL, while those receiving extract milled for 10 minutes exhibited a greater reduction of 45.88 mg/dL. Although the group treated with the 10-minute extract showed a higher decrease, statistical analysis using the Mann–Whitney U test revealed no significant difference in glucose-lowering efficacy between the two milling durations (P > 0.05). Conclusions:Avocado seed extract, regardless of milling duration, has potential antihyperglycemic effects in alloxan-induced diabetic rats. However, the variation in milling time between 5 and 10 minutes did not significantly influence the extract’s effectiveness. Further research with longer intervention periods, standardized phytochemical content, and inclusion of a positive control is recommended to validate its therapeutic potential. Keywords: Avocado Seed Extract; Blood Glucose; Diabetes Mellitus; Sprague Dawley Rats; Milling Duration
Relationship between Knowledge and Attitude toward BSE Behavior for Early Breast Cancer Detection among Atma Jaya Hospital Nurses Zita Arieselia; Kurniawan, Sandy Vitria; Lonah; Linawati Hananta; Freggy Spicano Joprang; Edward Surjono; Jonny Setiawan; Andrew Liputra; Jennifer
Journal of Urban Health Research Vol. 3 No. 3 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i3.7114

Abstract

Introduction : Breast cancer is a frequently occurring type of cancer in Indonesia, with symptoms of rapid and invasive growth of abnormal cells. Deaths due to this cancer can be reduced by avoiding risk factors and early detection, such as through breast self-examination (BSE). Assessing knowledge, attitudes, and behavior regarding BSE is important for early detection, especially for nurses as health workers. This study assessed the relationship between knowledge and attitudes towards BSE behavior among Atma Jaya Hospital nurses.  Methods: This is an analytical observational study employing a cross-sectional design, involving 105 samples selected through purposive sampling according to established inclusion and exclusion criteria. The variables in this study include knowledge, attitude, and behavior regarding breast self-examination (BSE). Data were collected through the distribution of questionnaires to respondents and will be statistically analyzed using the Chi-Square test (x2) with a significance level (a) = 5%, and the analysis will be conducted using STATA software. Results: Based on the data analysis, there is no correlation between knowledge and attitude toward the practice of breast self-examination (BSE), with p-values of 0.623 and 0.994. Conclusion: There is no significant relationship between Knowledge and Attitude towards BSE Behavior. Keywords:  BSE Attitude - BSE Behavior - BSE Knowledge
Effects of Coffee Consumption on Acne Vulgaris Severity in Atma Jaya Medical Students in Jakarta, Indonesia Natasha, Tiffanie; Wijaya, Lorettha; Djuartina, Tena; Arieselia, Zita
Journal of Urban Health Research Vol. 3 No. 1 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i1.5467

Abstract

Introduction: Acne vulgaris is a common multifactorial skin disease. With diet as one of the possible factors, the rising habit of coffee consumption may have its own effects on acne. In present time, there is a lack of study between coffee consumption and acne vulgaris as well as the relationship between the two topics. This study aimed to analyze the effects of coffee consumption on acne severity. Methods: A cross-sectional study was conducted from September to December 2022 on 106 Atma Jaya medical students in Jakarta, Indonesia, who has acne and consumed coffee in the past month when the study was performed. The students were asked to fill a questionnaire about demographic and filtering questions along with questions about coffee consumption in the past month based on Diet History Questionnaire III (DHQ III). Acne lesion observations on the face, upper back, and chest were then performed on every individual to calculate acne severity based on Global Acne Grading System (GAGS). Results: Students who only drank black coffee tend to have lower acne severity score (mean±SD: 19.69±5.68) than those who drank coffee mixtures beverages (mean±SD: 25.41±5.11) (p-value<0.001). There was a significant negative correlation between acne severity scores and amount of black coffee consumed (p-value=0.001). On the other hand, there was a significant positive correlation between acne severity scores and amount of coffee mixtures beverages consumed (p-value<0.001). Conclusion: The results of this study show that the types and amount of coffee consumed had significant effects on acne vulgaris severity in medical students. Keywords: acne vulgaris - black coffee - coffee mixtures
In Silico Analysis of miRNA in Type 2 Diabetes Mellitus and Colorectal Cancer: Molecular Connections and Biomarker Potential Alexander Ryan Wihardja; Ana Lucia Ekowati; Milas Siswanto, Ferbian
Journal of Urban Health Research Vol. 4 No. 2 (2026): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v4i2.7497

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia caused by insulin resistance and impaired insulin secretion, affecting 537 million adults worldwide in 2021 and projected to reach 783 million by 2045. T2DM increases the risk of malignancies, particularly colorectal cancer (CRC). MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have emerged as molecular links between T2DM and CRC through their roles in proliferation, apoptosis, metabolism, and insulin signaling. Shared pathways, including PI3K/AKT/mTOR and IGF-1 signaling, support common pathogenic mechanisms. Due to their stability and disease-specific expression, miRNAs represent promising biomarkers. This study employs an in silico bioinformatics approach to identify shared dysregulated miRNAs, predict their target genes, analyze relevant molecular pathways, and evaluate their regulatory roles connecting T2DM with CRC development. Methods: This study employed an in silico approach using miRNA expression data from GEO datasets (GSE262614, GSE185845, GSE115513, GSE156732), analyzed with R under the criteria |Log2FC| > 1 and p < 0.05. Differentially expressed miRNAs from each dataset were compared using a Venn diagram to identify consistently dysregulated miRNAs. Target gene prediction was conducted using miRTargetLink 2.0 and miRWalk, followed by validation with mRNA datasets GSE25724 and GSE44076. Pathway enrichment analyses were performed using GO and KEGG through ShinyGO and Enrichr Results:  Analysis revealed that hsa-miR-182-3p was the only miRNA consistently experiencing upregulation in both T2DM and colorectal cancer. From hsa miR-182-3p a total of 9 validated target genes were identified, and most of them are involved in MAPK, mTOR, cell cycle, and insulin signaling pathways which are key pathways implicated in both diseases. Conclusion: This study indicates that hsa-miR-182-3p may serve as a molecular mediator linking the pathophysiological mechanisms of T2DM, such as insulin resistance and hyperinsulinemia, with colorectal cancer tumorigenesis, and may hold potential as a biomarker.

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