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All Journal Journal of Mathematical and Fundamental Sciences Damianus Journal of Medicine Journal of Mechanical Engineering Science and Technology Journal of Urban Health Research Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat
Jojor Lamsihar Manalu
Departement Of Physiology, School Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia.
Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Energy Engineering Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Physics Public Health

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EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) DAN EKSTRAK ASETON DAUN YAKON (Smallanthus sonchifolius) SAMA EFEKTIFNYA DALAM MENURUNKAN KADAR GULA DARAH TIKUS YANG DIINDUKSI ALOKSAN Dylan Putra; Jojor Lamsihar Manalu
Bahasa Indonesia Vol 19 No 2 (2020): Damianus : Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v19i2.1141

Abstract

Introduction: Diabetes mellitus is a disease that affects many people globally, including Indonesia. The prevalence of diabetics in Indonesia increased from 6.9% (2013) to 8.5% (2018). Herbs can be used to lower the glucose concentration, including avocado seeds and yacon leaves that contain flavonoids and astringent compounds.The aim of the study to see the comparison of the effectiveness of avocado seeds extract and yacon leaves extract in reducing blood sugar levels in rats.Methods: This research was an experimental study using rat as animal model. Rats were divided into groups which were given ethanol extract of avocado seed (Persea americana Mill.) and acetone yacon leaf extract (Smallanthus sonchifolius) with various doses i.e. 150mg/kg, 300mg/kg, and 450mg/kg. The rat was given alloxan to induce blood sugar levels increase and the results were observed 2 days before administration of the extract for 5 days. The extraction process was done by maceration method. Data was analysed using One Way Anova.Results: There was a decline in blood sugar levels in each group given the avocado seed extract and yacon leaf extract . However, there was no statistical difference in effectiveness between the extracts.Conclusion: Both avocado seed extract and yakon leaf extract are equally effective in decreasing blood sugar levels in alloxan-induced rats.
PERBANDINGAN EFEKTIVITAS DOSIS EKSTRAK BIJI ALPUKAT YANG DIPROSES DENGAN MILLING TERHADAP PENURUNAN KADAR GULA DARAH PADA TIKUS Clarence Marks Alief; Jojor Lamsihar Manalu
Bahasa Indonesia Vol 19 No 1 (2020): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v19i1.1146

Abstract

Introduction: Diabetes is a metabolic disease of which the pancreas is unable to produce insulin, a hormone that regulates blood sugar level or the body is unable to use insulin effectively. Diabetes causes several problems such as vision impairment, cardiovascular diseases, renal diseases and other illnesses. Diabetes is usually treated with anti-diabetic medication or with insulin. However, nowadays people are looking into alternative treatments which use natural ingredients. One such ingredient, among others is avocado seed (Persea Americana Mill.) extract. Avocado seeds is chosen for this research, as it has astringent and flavonoids which are proven to have anti-diabetic effect. Method: This is an experimental study using Sprague-Dawley strain rats. The rats were separated into 4groups, group as a negative control, and group II, III, and IV as experimental groups. The rats in the test group were injected with alloxan to induce diabetes, then the rats were given avocado seed extract of different concentration every day for five days. The avocado seed extract is obtained by first milling the seeds, so they become soft powder, and then extracting the seed using maceration. Results: Treatment with avocado seed extract caused a decrease in blood sugar level in group II, III, and IV.One Way Anova statistical test resulted in a value of p=0,046 therefore the decrease in blood sugar level wassignificant. However, Tukey HSD statistical test result showed that no test group is significantly different from one another. Conclusion: Treatment with avocado seed extract(dose of 150mg/kg, 300mg/kg, and 450mg/kg) caused adecrease in blood sugar that is statistically significant, however no dose of the avocado seed extract issignificantly more effective than the other
PERBANDINGAN EFEKTIVITAS TEH HIJAU DAN TEH HITAM DALAM MENURUNKAN KADAR TRIGLISERIDA PADA HEWAN COBA MODEL HIPERLIPIDEMIA Monica Regina Ngantung; Rita Dewi; Jojor Lamsihar Manalu
Bahasa Indonesia Vol 19 No 2 (2020): Damianus : Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v19i2.1225

Abstract

Introduction: Hyperlipidemia is the cause of 18% of cardiovascular disease and 56% of ischemic heart disease worldwide. According to the World Health Organization (WHO), in 2017, cardiovascular disease is the leading cause of death worldwide. In its role against cardiovascular disease, green tea and black tea can be used as an alternative treatment in reducing triglyceride levels.Methods: This study is an in vivo experimental. This experiment using 16 Rattus norvegicus rats strain Sprague-Dawley induced with lard and raw quail egg yolk before and divided into two groups; green tea and black tea groups. Treatment is carried out for 17 days and checking the triglyceride level before and after intervention using test strip and tools from Lipid Pro. Data were collected and analyzed using the Shapiro-Wilk test, paired t-test, and unpaired t-test. Results: The results showed that the data were normally distributed (Shapiro-Wilk test p> 0.05). Treatment with green tea and black tea for 17 days led to a significant drop in triglyceride level (paired t-test p <0.05), and there is a significant difference between the effectiveness of the intervention group (unpaired t-test p <0.05).Conclusion: There was a significant decrease in rats’ triglyceride levels in the administration of green tea and black tea, and green tea is more effective than black tea in reducing triglyceride levels on hyperlipidemic Rattus Norvegicus.
Excitation Mechanism in Laser-Induced Plasma at Atmospheric Air Pressure Jojor Lamsihar Manalu; Koo Hendrik Kurniawan; Tjung Jie Lie
Journal of Mathematical and Fundamental Sciences Vol. 37 No. 1 (2005)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/itbj.sci.2005.37.1.1

Abstract

A special interferometric technique has been devised on the basis of rainbow refractometry without the use of an additional and delicate amplitude-splitting setup. This new technique was used for the characterization of plasma induced by a Q-switched Nd-YAG laser on zinc samples under atmospheric air pressure. An unmistakable signal of the density jump was detected simultaneously with the observation of the emission front signal. It was proved that the emission front and the front of the shock wave coincided and moved together with time at the initial stage of the secondary plasma expansion. However, at a later stage, the emission front began to separate from and left behind the shock wave front propagating in the surrounding air. With the use of zinc sample, the experimental results showed that the separation of the emission front and shock wave front took place at about 4 mm above sample surface for laser energy of 26 mJ. It was also found that the separation time increased by increasing the power density which further supported shock wave model. Analysis of the data of the shock front movement along with the emission characteristics has led us to the conclusion that models other than the shock wave model, such as the gas breakdown model, should be excluded, at least for a zinc sample, as not satisfactorily explaining the excitation process in the secondary plasma generated at atmospheric air pressure of 760 Torr.
Effect of Avocado Seed Extract through Milling on Reducing Triglyceride in Hyperlipidemic Rats Rita Dewi Firmansyah; Jojor Lamsihar Manalu; Yulia Tanti Narwati; Maria Dara Novi Handayani; Alexander Yose Ardin Bagas Sulistyo
Journal of Urban Health Research Vol. 1 No. 3 (2023): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v1i3.4617

Abstract

Background : Hypertriglyceridemia is a condition in which there is an increase in triglycerides in the blood. This increase is influenced by foods that contain extra calories. Hypertriglyceridemia can cause disturbances in the body in the form of cardiovascular disease. Methods : The study used experimental methods on male Sprague Dawley rats. The research sample used fourteen rats which were divided into a control group and a treatment group. All experimental mice were induced to become hyperlipidemic by PTU14 gram/kg for 14 day. The control group was not given any treatment. The treatment group was given avocado seed extract 250 mg/kg for 14 day. Avocado seed extract is obtained through crushing and extraction processes. The statistic we used in this study is paired T-test. Results : In the control group, there was no decrease in triglyceride levels with an average of 134.78 mg / dL. In the treatment group there was a decrease in the average triglyceride levels both after seven days of giving avocado seed extract on (day 28) 127.92 md / dL and after fourteen days of giving avocado seed extract on (day 35) 124.21 mg / dL. Conclusion: Giving of avocado seed extract by grinding method for 30 minutes selama sekian hari had an effect in reducing triglyceride levels in hyperlipidemic rats. Keywords: Avocado Seed Extract - Sprague Dawley Rats - Triglyceride Level.
Pengaruh Variasi Ukuran Partikel pada Ekstraksi Biji Alpukat (Persea americana Mill.) Terhadap Penurunan Kadar Trigliserida Pada Tikus Hiperlipidemia Manalu, Jojor Lamsihar; Sukendar, Billy; Arieselia, Zita; Dewi, Rita; Narwati, Yulia Tanti
Bahasa Indonesia Vol 22 No 3 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i3.4333

Abstract

Pendahuluan:  Biji buah alpukat memiliki zat aktif yang dapat menurunkan kadar trigliserida.  Pemanfaatan biji buah alpukat sebagai obat penurun kadar trigliserida masih memiliki potensial yang perlu dikembangkan untuk menjadi salah obat herbal yang alternatif. Metode: Penelitian eksperimental dilakukan terhadap tikus Sprague Dawley, tikus diberikan sediaan propylthiouracil (PTU) selama 14 hari untuk mencapai kondisi hiperlipidemia yang dibagi ke dalam 2 kelompok intervensi. Kelompok pertama diberikan ekstrak biji alpukat yang diekstraksi dengan metode remaserasi dari biji alpukat yang digerus selama 15 menit dan kelompok kedua digerus selama 30 menit. Ukuran partikel didapatkan dari rata-rata diameter 10 partikel biji alpukat secara acak dari setiap variasi waktu penggerusan. Kadar trigliserida dalam darah tikus diukur setelah 14 hari pemberian PTU dan diukur lagi setelah 7 hari, dan 14 hari pemberian ekstrak biji alpukat. Analisis data menggunakan uji paired t-test dan unpaired t-test. Hasil: Rata-rata ukuran partikel biji alpukat pada kelompok 1 sebesar 27,03 µm dan kelompok 2 sebesar 13,50 µm Pemberian ekstrak biji alpukat mampu menurunkan kadar trigliserida secara signifikan dari hari 0-7, hari 0-14, dan hari 7-14 pada kelompok 1 (p<0,05). Hal yang sama ditemukan pada kelompok 2 (p<0,05) selain dari hari 7-14 (p>0,05). Tidak ditemukan perbedaan yang signifikan dalam penurunan trigliserida pada kelompok pertama dan kedua (p>0,05). Simpulan: Pemberian ekstrak biji alpukat dapat menurunkan kadar trigliserida pada tikus. Perbedaan waktu penggerusan dan ukuran biji alpukat yang diekstraksi tidak memengaruhi efektivitas dalam penurunan kadar trigliserida.  
Penurunan Kadar Malondialdehid (MDA) pada Tikus Putih Jantan Hiperlipidemia oleh Pemberian Ekstrak Etanol Bajakah Tampala Joneri, Richie; Manalu, Jojor Lamsihar; Dewi, Rita; Arieselia, Zita
Bahasa Indonesia Vol 23 No 1 (2024): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v23i1.4562

Abstract

Pendahuluan: Penyebab kematian tertinggi di Indonesia adalah stroke dan penyakit jantung koroner. Salah satu faktor risiko adalah hiperlipidemia. Hiperlipidemia berisiko menyebabkan aterosklerosis. Stres oksidatif telah terbukti berperan pada hiperlipidemia dan aterosklerosis. Salah satu biomarker untuk menentukan stres oksidatif adalah malondialdehid (MDA). Penggunaan antioksidan dapat mengurangi kerusakan yang diakibatkan oleh radikal bebas. Bajakah tampala adalah tanaman yang mengandung berbagai metabolit sekunder yaitu flavonoid, fenol, tanin, dan saponin. Metabolit sekunder tersebut berperan sebagai antioksidan dan memiliki efek hipolipidemik. Penelitian ini bertujuan untuk mengetahui efektivitas dari ekstrak bajakah tampala dalam pengobatan penyakit hiperlipidemia. Metode: Penelitian ini adalah studi eksperimental in vivo terhadap tikus dengan metode pre-test dan post-test. Sampel penelitian adalah 12 ekor tikus putih jantan Sprague-Dawley yang sehat dan tidak cacat berusia 8 minggu dengan berat badan ±200 gram. Tikus diinduksi hiperlipidemia selama 21 hari. Setelah itu, kelompok pertama diberikan ekstrak bajakah tampala dan kelompok kedua diberikan simvastatin selama 21 hari. Nilai absorbansi sampel campuran serum dengan reagen MDA assay kit pada panjang gelombang 450 nm, 532 nm, dan 600 nm diukur menggunakan metode spektrofotometri. Kadar MDA dihitung dengan rumus menggunakan nilai absorbansi tersebut. Data dianalisis dengan menggunakan uji T berpasangan dan uji T tidak berpasangan. Hasil: Hasil menunjukkan penurunan yang signifikan pada rerata kadar MDA tikus putih jantan hiperlipidemia yang diberikan ekstrak bajakah tampala (p<0,05). Tidak terdapat perbedaan rerata penurunan kadar MDA yang signifikan antara yang diberikan ekstrak bajakah tampala dengan simvastatin (p>0,05). Simpulan: Pemberian ekstrak bajakah tampala terbukti efektif dalam menurunkan kadar MDA pada tikus putih jantan hiperlipidemia.
Synthesis and In Vitro Testing of Mg-6Zn-xHAp Biocomposites from Beef Bone as Biodegradable Bone Implant Material Manalu, Jojor Lamsihar; Tjhay, Francisca; Kristoforus, Theodora; Aritonang, Sovian
Journal of Mechanical Engineering Science and Technology (JMEST) Vol 8, No 2 (2024)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um016v8i22024p410

Abstract

This study aimed to develop biodegradable Mg-6Zn hydroxyapatite (Mg-6Zn HAp) biocomposites for potential use in bone replacement applications. The hydroxyapatite (HAp) powders, sourced from cow bone, were synthesized through an eco-friendly and cost-effective process, leveraging bioresources for material sustainability. The Mg-6Zn and HAp powders were mechanically mixed through ball milling for six hours to ensure homogeneity. The resultant powder mixture was then subjected to isostatic pressing at a high pressure of 570 MPa, forming a dense coin-shaped composite with a 1.5 cm diameter. This coin was consolidated in a capsule furnace at elevated temperatures for one hour to enhance material integrity. The Mg-6Zn HAp alloy was thoroughly characterized using X-ray diffraction (XRD) to assess phase formation and crystallographic structure, and Scanning Electron Microscopy coupled with Energy Dispersive X-ray Spectroscopy (SEM-EDX) to examine microstructural features and elemental composition. For composite preparation, varying amounts of HAp (5%, 8%, and 12%) were incorporated into the Mg-6Zn matrix. SEM analyses revealed a uniform distribution of HAp particles along the boundaries of matrix particles, enhancing composite structure and stability. Results demonstrated that with an increase in HAp content, there was a corresponding improvement in the relative density and hardness of the composites. The corrosion rate decreased with higher HAp content, indicating improved biocompatibility and stability in physiological environments. This suggests that the Mg-6Zn HAp biocomposites, with their tailored microstructure and enhanced mechanical properties, hold promise for use in biodegradable bone replacement applications.
Perbandingan Aktivitas Antibakterial Ekstrak Panas dan Ekstrak Dingin Biji Alpukat terhadap Bakteri S. aureus dan MRSA Adhitama, Antonius Yudhistira; Dewi, Rita; Lieputra, Andrew Adhytia; Narwati, Yulia Tanti; Manalu, Jojor Lamsihar
Bahasa Indonesia Vol 24 No 2 (2025): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v24i2.6701

Abstract

Pendahuluan: Penyakit infeksi yang disebabkan oleh mikroorganisme patogen, termasuk Staphylococcus aureus dan Methicillin-resistant Staphylococcus aureus (MRSA), menjadi masalah kesehatan global dengan angka kematian tinggi. Biji alpukat (Persea americana Mill.) mengandung senyawa dengan potensi antibakterial, seperti flavonoid dan tanin. Penelitian ini bertujuan untuk membandingkan aktivitas antibakterial ekstrak biji alpukat yang diperoleh melalui teknik ekstraksi dingin (remaserasi) dan panas (refluks) terhadap Staphylococcus aureus dan MRSA. Metode: Penelitian adalah penelitian eksperimental in vitro. Ekstraksi simplisia biji alpukat dilakukan dengan metode remaserasi (dingin) dan refluks (panas). Dilanjutkan dengan uji fitokimia kualitatif metode penampisan terhadap flavonoid, alkaloid, saponin, dan tanin. Uji kuantitatif dengan metode UV-Vis terhadap senyawa Flavonoid. Uji aktivitas antibakterial dilakukan dengan uji difusi sumuran. Analisis statistik menggunakan uji non parametrik. Hasil: Ekstrak biji Alpukan memiliki metabolit sekunder flavonioid, alkaloid, saponin, dan Tanin. Ekstrak digin memiliki jumlah flavonoid dengan rata-rata 3,932 mgQE/g. Ekstrak panas memiliki jumlah flavonoid dengan rata-rata 2,288 mgQE/g. Ekstrak dingin dan ekstrak panas biji alpukat memiliki aktivitas antibakterial jika dibandingkan dengan kontrol negatif pada konsentrasi 25% (p<0,05). Uji aktivitas antibakteri menggunakan metode difusi sumuran menunjukkan bahwa ekstrak dingin dan panas memiliki efektivitas yang tidak berbeda signifikan terhadap kedua jenis bakteri pada berbagai konsentrasi (p>0,05). Hasil ini mengindikasikan bahwa kedua metode ekstraksi dapat menghasilkan ekstrak dengan aktivitas antibakteri yang setara. Simpulan: Ekstrak biji alpukat, baik melalui metode ekstraksi dingin (remaserasi) maupun panas (refluks), memiliki aktivitas antibakteri terhadap Staphylococcus aureus dan MRSA. Tidak terdapat perbedaan signifikan antara kedua metode ekstraksi dalam menghambat pertumbuhan kedua bakteri​.
Comparison of Effectiveness of Milling Time of Avocado Seed Extract for Lowering Blood Glucose Level in Alloxan-induced Diabetic Rat Manalu, Jojor Lamsihar; Caesarlia, Josephine; Dewi, Rita
Journal of Urban Health Research Vol. 3 No. 3 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i3.7028

Abstract

Introduction:Diabetes Mellitus (DM) is a chronic metabolic disorder with increasing global prevalence. Effective management is crucial to prevent acute and long-term complications. Natural products, including avocado (Persea americana Mill.) seeds, have gained attention for their potential antidiabetic properties due to their rich phytochemical content. Methods: This experimental study used male Sprague Dawley rats, divided into two main groups based on blood glucose status (normal and diabetic), with each group further subdivided based on the milling duration of avocado seed extract (5 and 10 minutes). The extract was administered orally at a dose of 250 mg/kg body weight for seven consecutive days. Blood glucose levels were measured using a glucometer before and after the treatment period. Results: Avocado seed extract demonstrated a glucose-lowering effect in both treatment groups. Rats treated with extract milled for 5 minutes showed a mean reduction in blood glucose of 25.13 mg/dL, while those receiving extract milled for 10 minutes exhibited a greater reduction of 45.88 mg/dL. Although the group treated with the 10-minute extract showed a higher decrease, statistical analysis using the Mann–Whitney U test revealed no significant difference in glucose-lowering efficacy between the two milling durations (P > 0.05). Conclusions:Avocado seed extract, regardless of milling duration, has potential antihyperglycemic effects in alloxan-induced diabetic rats. However, the variation in milling time between 5 and 10 minutes did not significantly influence the extract’s effectiveness. Further research with longer intervention periods, standardized phytochemical content, and inclusion of a positive control is recommended to validate its therapeutic potential. Keywords: Avocado Seed Extract; Blood Glucose; Diabetes Mellitus; Sprague Dawley Rats; Milling Duration
Co-Authors Adhitama, Antonius Yudhistira Alexander Yose Ardin Bagas Sulistyo Aritonang, Sovian Caesarlia, Josephine Clarence Marks Alief Dylan Putra Evi Ulina Margaretha Situmorang Heidy Heidy Joneri, Richie Julia Rahadian Koo Hendrik Kurniawan Kristoforus, Theodora Lieputra, Andrew Adhytia Maria Dara Novi Handayani, Maria Dara Novi Mariani Santosa, Mariani Monica Regina Ngantung Narwati, Yulia Tanti Narwati, Yulia Tanti Nawanto Agung Prastowo Paul, Clara Stephanie Rika Haryono Rita Dewi Rita Dewi Rita Dewi Firmansyah Sudiyono, Nelson Sukendar, Billy Tjhay, Francisca Tjung Jie Lie Yantho, Erwin Zita Arieselia