Molekul: Jurnal Ilmiah Kimia
The MOLEKUL is dedicated to fostering advancements in all branches of chemistry and its diverse sub-disciplines. It aims to publish high-quality research encompassing a wide range of topics, including but not limited to Pharmaceutical Chemistry, Biological Activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry. By providing a platform for rigorous scientific inquiry and dissemination of knowledge, the journal strives to contribute to the understanding, innovation, and practical applications of chemistry in various fields. We encourage submissions that explore new methodologies, elucidate fundamental principles, address pressing challenges, and demonstrate the potential for real-world impact. Our journal welcomes original research articles, reviews, and perspectives from researchers, scholars, and professionals across the global scientific community, promoting interdisciplinary collaboration and the advancement of chemical sciences. The scope of this journal encompasses a wide range of topics within the field of chemistry, with a particular focus on advancing knowledge and innovation in the following areas: 1. Theoretical Chemistry and Environmental Chemistry: This includes theoretical studies, computational modeling, and experimental investigations related to chemical reactivity, molecular structures, spectroscopy, and the environmental fate and impact of chemicals. 2. Materials Synthesis for Energy and Environmental Applications: The journal welcomes research on the synthesis, characterization, and application of materials for energy storage, catalysis, solar energy conversion, pollution mitigation, and sustainable environmental technologies. 3. Isolation, Purification, and Modification of Biomolecules: Manuscripts addressing the isolation, purification, and modification of biomolecules, such as proteins, nucleic acids, carbohydrates, and lipids, along with their applications in areas such as biotechnology, drug discovery, and diagnostics, are of particular interest. 4. Fabrication, Development, and Validation of Analytical Methods: The journal encourages submissions focusing on the development and optimization of analytical techniques, including chromatography, spectroscopy, electrochemistry, and mass spectrometry. Topics may include method validation, sample preparation, quality control, and applications in diverse fields.
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<![CDATA[Analysis of Petroleum Products Spill Potential Impact (Gasoline and Diesel Fuels) on Soil Fertility Quality Around Pertamina Rewulu-Cilacap Pipeline Bantul-Yogyakarta ]]>
<![CDATA[Muthohharoh, Thaifah]]>;
<![CDATA[Latumahina, Linda Johana]]>;
<![CDATA[Suyanta, Suyanta]]>;
<![CDATA[Suherman, Suherman]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.5402
<![CDATA[This research focused on analyzing the potential impact of petroleum products spill (gasoline and diesel fuels) on soil fertility quality around PERTAMINA Rewulu-Cilacap Pipeline Bantul, Yogyakarta. The objectives of this study were to analyze the change of soil fertility parameters that are contaminated by gasoline and diesel fuel oils, compared to uncontaminated soil as control. Soil samples were collected from Pertamina Rewulu-Cilacap around the pipeline. Some physico-chemical properties that reflect soil fertility were determined using standard physico-chemical methods and Total Petroleum Hydrocarbon (TPH) using Gas Chromatography. Soil samples were divided into three points (I, II, and III) based on taken places. The study started with analysis of physical and chemical properties of the soil, then petroleum products (gasoline and diesel) were added to the soil samples. The contaminated soil and control then analyzed for identify the fertility quality and TPH content. The results showed that petroleum product contamination increases N, P, and reduces K concentrations in the soil. The sample in point III had the highest values of TPH concentration without any additional petroleum products. After addition of a dose of 13% gasoline, the concentration of TPH in point I, II, and III increased by 0.036%, 0.08% and 0.008%. With the addition of 15% diesel in the sample, the TPH concentration of point I, II, and III increased by 0.892 %, 1.198%, and 0.91%.]]>
<![CDATA[Cholestan Steroids from The Stem Bark of Aglaia angustifolia Miq and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines ]]>
<![CDATA[Hutagaol, Ricson Pemimpin]]>;
<![CDATA[Mozef, Tjandrawati]]>;
<![CDATA[Fajriah, Sofa]]>;
<![CDATA[Primahana, Gian]]>;
<![CDATA[Supratman, Unang]]>;
<![CDATA[Harneti, Desi]]>;
<![CDATA[Hidayat, Ace Tatang]]>;
<![CDATA[Awang, Khalijah]]>;
<![CDATA[Shiono, Yoshihito]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6205
<![CDATA[With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties. This research objective was to find secondary metabolites that have activity as anti-breast cancer compounds from endemic Indonesian Aglaia, such as Aglaia angustifolia Miq. Two cholestan type steroids, stigmast-5en-3α-acetat (1), as a new steroid with α-sterochemistry of acetyl moiety at C-3 and 23a-homostigmast-5en-3β-ol (2), with unusual side chain were isolated for the first time from the stem bark of Aglaia angustifolia Miq or known as segara tree in Kalimantan. The chemical structures of two steroids were identified with spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, NOESY, 1H-1H COSY) and HRTOF-MS, as well as by comparing with previously reported spectral data. These two steroids were isolated for the first time from this genus. Steroids 1 and 2 were evaluated for cytotoxic activity against MCF-7 breast cancer cells and showed weak activity with IC50 values of 829.0 and 903.0 µg/mL, respectively.]]>
<![CDATA[Synthesis, Characterization, and Antibacterial Activity Test of Geothermal Silica/AgNO3 Thin Film ]]>
<![CDATA[Astuti, Yayuk]]>;
<![CDATA[Rahayu, R.A. Yunita Suci]]>;
<![CDATA[Arnelli, Arnelli]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6431
<![CDATA[Geothermal silica waste offers convenient, economical, and environmentally friendly material with high hydrophobicity to produce thin films. Silica-thin films from geothermal waste using the sol-gel method, though, no addition of AgNO3 was conducted for antibacterial functions. This study aims to produce silica-thin films from geothermal waste with the addition of AgNO3 and analyze the antibacterial activity. The procedures carried out in this research were (i) an acid leaching process using HNO3; (ii) the production of silica thin film with and without the addition of AgNO3; (iii) thin film characterization including a water contact angle measurement (WCA), XRF, FTIR, XRD and SEM-EDX on silica thin film samples with and without the addition of AgNO3; and (iv) antibacterial activity test. The results show the optimum HNO3 concentration for the acid leaching process was 20%, yielding 99.08% SiO2 by mass. The WCA of the silica thin film in the presence and absence of AgNO3 reached a value of ±160°, indicating the addition of AgNO3 did not decrease the contact angle of the silica thin film. This research employed smart deconvolution of IR Spectra using Fityk software which reveals a higher area ratio for Si-O-Si relative to Si-OH. Furthermore, it was observed that the silica thin films exhibited an amorphous morphology, both without and with the addition of AgNO3, with Ag discovered to be dispersed on the thin film. However, despite the presence of Ag, both TF20 and TF20+Ag samples were found to be ineffective in inhibiting bacterial growth, as evidenced by bacteria-free zones on the samples.]]>
<![CDATA[Morelloflavone and Molecular Docking from Stembark of Chisocheton lasiocarpus and Its Cytotoxic Activity Against Breast Cancer Mcf-7 Cell Lines ]]>
<![CDATA[Nurlelasari, Nurlelasari]]>;
<![CDATA[Harneti, Desi]]>;
<![CDATA[Maharani, Rani]]>;
<![CDATA[Darwati, Darwati]]>;
<![CDATA[Mayanti, Tri]]>;
<![CDATA[Farabi, Kindi]]>;
<![CDATA[Hanafi, Muhammad]]>;
<![CDATA[Supratman, Unang]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6845
<![CDATA[Chisocheton is a plant of the Meliaceae family which has been known as a source of limonoids, triterpenoids, steroids, alkaloids and phenolics. This plant is the second largest in the Meliaceae, with 53 species widely distributed in tropical and subtropical regions including Indonesia. From this genus, compounds that have interesting activities have been found, including anti-inflammatory, antimalarial, cytotoxic, antitumor and anticancer. One of the species that has the potential to find new compounds is Chisocheton lasiocarpus because there are still few phytochemical studies. This study aims to inform the structural elucidation of one of the compounds from the stem bark of C. lasiocarpus, namely morelloflavone and its cytotoxic potential against breast cancer cells using the in silico method against ER-α receptors (PDB code: 3ERD), ER-β (PDB code: 1QKM). ) and HER-2 (GDP code: 3PP0).]]>
<![CDATA[Isolation and Identification of Cellulolytic Bacteria from Gut of Horn Beetle Larvae (Oryctes rhinoceros L.) ]]>
<![CDATA[Riskawati, Riskawati]]>;
<![CDATA[Natsir, Hasnah]]>;
<![CDATA[Dali, Seniwati]]>;
<![CDATA[Baharuddin, Maswati]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6848
<![CDATA[The horn beetle larvae (Oryctes rhinoceros L.) contain symbiotic bacteria that are used to digest and degrade cellulose as food so that it has the potential to produce cellulase enzymes. This study aims to isolate, characterize and identify microbial symbionts from horn beetle larvae that have the potential to produce cellulase enzymes.The methods in this study include morphology and physiology identification of bacteria, qualitative and quantitative activity tests and species determination using 16S rRNA sequencing technique. Based on the results of morphological observations, five bacterial isolates were taken which has the potential as a cellulase producer is indicated by the presence of a clear zone that is produced when a qualitative test is carried out using congo red staining with different cellulolytic indices. Based on the quantitative bacterial activity test using UV-Vis, the highest activity was found in PES3 isolates at 1.62 x 10-2 and PES5 at 1.61 x 10-2. Species determination results found that PES3 isolates belonged to the genus Acinetobacter and PES5 belonged to Pseudomonas. In addition to the isolates obtained for the environment and the industrial sector, cellulolytic bacteria can provide added value such as hydrolyze cellulose waste into alternative fuels.]]>
<![CDATA[Synthesis and Evaluation of Some Sulfonamide-Substituted of 1,3,5-Triphenyl Pyrazoline Derivatives as Tyrosinase Enzyme Inhibitors ]]>
<![CDATA[Herfindo, Nofal]]>;
<![CDATA[Frimayanti, Neni]]>;
<![CDATA[ikhtiarudin, Ihsan]]>;
<![CDATA[eryanti, Yum]]>;
<![CDATA[zamri, Adel]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6936
<![CDATA[Pyrazoline is well-known as heterocycles compound that can exhibit many biological effects. In this work, we synthesized a series of sulfonamide-substituted 1,3,5-triphenyl pyrazoline compounds as a promising tyrosinase inhibitor agent. These compounds prepared by multicomponent reaction of corresponding aldehyde, ketone, and hydrazine using seal-vessel reactor. Pyrazolines compound were tested for their tyrosinase inhibitor activity through in vitro assay. The test result found that compound 4c, 4d, and 4e possessed better tyrosinase inhibitory activity compared to the reference drug, kojic acid. Compound 4c exhibited the strongest tyrosinase inhibitory effect with an IC50 value of 30.14 µM. The results suggested that hydroxyl and methoxy substituent at para position are preferable. Furthermore, molecular docking studies result match the pattern of in vitro assay where the compound will provide a stronger binding interaction and lower binding free energies.]]>
<![CDATA[Isolation and Molecular Identification of Amylolytic Bacteria from Oryctes rhinoceros L. Larvae Decomposing Empty Palm Oil Fruit Bunches ]]>
<![CDATA[Uto, Sahriani]]>;
<![CDATA[Arfah, Rugaiyah]]>;
<![CDATA[Dali, Seniwati]]>;
<![CDATA[Baharuddin, Maswati]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6957
<![CDATA[Oryctes rhinoceros L. is an organism that helps the decomposition of oil palm empty fruit bunches (OPEFB). In the larvae's intestines, there are symbiotic bacteria that are used in the process of food degradation in the digestive system, one of which is amylolytic bacteria. This study aims to isolate and molecular identify amylolytic bacteria that produce amylase enzymes from horn beetle larvae. The techniques are used to screen and isolate bacteria from horn beetle larvae. Bacterial identification was accomplished by microscopically identifying amylase-producing bacterial isolates, performing biochemical tests on selected bacterial isolates, quantifying amylase enzyme activity, and molecularly identifying 16S rRNA. The results of screening and bacterial isolation obtained five isolates. The largest amylolytic bacterial colony index value was obtained in the EA3 isolate, which was 1.370 mm. Bacterial isolates with the highest activity were found in isolates coded EA1 and EA2, namely 0.049 U/mL and 0.0479 U/mL. According to the findings of 16S rRNA molecular identification, isolates EA1 and EA2 had similarities with the bacteria Ochrobactrum sp. and Pseudomonas mendocina.]]>
<![CDATA[Green Synthesis of Gold Nanoparticles using Peronema canescens Leaves Extract and Their Catalytic Performance for Dyes and Nitro Compounds ]]>
<![CDATA[Falahudin, Aswin]]>;
<![CDATA[Insin, Numpon]]>;
<![CDATA[Yudha S, Salprima]]>;
<![CDATA[Adfa, Morina]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.6972
<![CDATA[The most interesting and well-known research in the field of gold nanomaterials synthesis is the use of "green chemistry" to prepare gold nanoparticles (AuNPs). In this study, Peronema canescens leaf extract was used as the synthesis medium to successfully produce AuNPs in a way that was cheap, quick, and good for the environment. A UV-visible spectrophotometer, particle size analysis (PSA), and transmission electron microscopy (TEM) were used to find out more about the AuNPs that were prepared. The UV-visible spectrophotometer showed a surface plasmon resonance peak at 532 nm, which proves https://www.fortyouncewines.com/ that AuNPs exist in the solution. TEM and PSA both showed that the AuNPs were mostly spherical and had an average diameter of 14.9 nm, respectively. In the presence of NaBH4, the AuNPs were found to speed up the reduction of rhodamine B (RhB), metanil yellow (MY), and 4-nitrophenol (4-NP). The results show that the AuNPs that were prepared in a new way worked very well and could be used in catalysis.]]>
<![CDATA[Antibacterial Peptide from Chymotrypsin Hydrolysate of Jatropha Seeds with RP-HPLC Fractionation ]]>
<![CDATA[Andriana, Zehan]]>;
<![CDATA[Wahyuningsih, Tutik Dwi]]>;
<![CDATA[Raharjo, Tri Joko]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.7080
<![CDATA[Antimicrobial peptide (AMP), as a new antibiotic agent, has promising prospects in overcoming the problem of resistance. AMP production can be carried out by proteolytic enzymes. Protein from castor bean (R. communis) is toxic, so it can potentially be a source of AMP. This study aims to obtain protein hydrolysate from the castor bean (R. communis) using several extraction methods, including SDS dialysis, SDS-gel filtration, trifluoroacetic acid (TFA), and acetone precipitation. Chymotrypsin enzyme was used to hydrolyze the protein, and the peptide hydrolysate was fractionated using RP-HPLC. The peptide fraction was tested for its antibacterial activity by agar diffusion and microdilution methods, and the most active fraction was identified for its amino acid sequence by LC-HRMS. The results showed that the acetone precipitation extraction method was the best method, with a degree of hydrolysis of 83.9%. The active fractions 6 and 10 of RP-HPLC had IC50 values of 14.1 and 14.5 µg/mL for E. coli and 13.3 and 14.4 µg/mL for S. aureus, respectively. NVLRGKGMASL peptides were found in fraction 10, and GIILLSSK, NMIAKR, and LLDILTKK peptides were found in fraction 6 with an alpha helix secondary structure that can cause membrane damage. The peptides NVLRGKGMASL, GIILLSSK, NMIAKR, and LLDILTKK are thought to have potential as antibacterial compounds.]]>
<![CDATA[Phytochemical Constituent and Cytotoxic Activity of Eusideroxylon zwageri Teijsm & Binn Extract and Sub-Fraction on Human Breast Cancer Cell Line T47D ]]>
<![CDATA[Kurniawan, Yayan Rabbani]]>;
<![CDATA[Santoni, Adlis]]>;
<![CDATA[Suryati, Suryati]]>
<![CDATA[ Molekul Vol 18 No 2 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.2.7112
<![CDATA[Eusideroxylon zwageri Teijsm. & Binn T has been reported to have bioactivity, one of which is the potential as an excellent cytotoxic agent using the BSLT method. So far, stage tests using cancer cells and analysis of the content of secondary metabolites have not been reported, Therefore, it is essential to analyze the content of secondary metabolites using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) and determination of cytotoxic activity using Brine Shrimp Lethality Test (BLST) mwthod with various solvent polarities. Then separation by bioassay-guided isolation using column chromatography of the active extract assay BSLT. Furthermore, the cytotoxic activity of the active extract and the active isolate was tested against T47D cancer cells with Microculture Tetrazolium (MTT) method. The results of the analysis of the content of secondary metabolites using LC-MS/MS identified senbusine B and 6,7-Dehydroartemisinic acid on hexane extract, while the ethyl acetate extract produced 4 compounds, and 15 compounds were identified in the methanol extract. The results of the cytotoxic activity test using the BSLT method on each extract showed that the hexane extract was the most active, with an LC50 of 17.56 mg/L. Furthermore, the cytotoxic activity of hexane extract against T47D cells showed weak activity with an IC50 value of 237.5 mg/L, while the AB1 sub-fraction showed moderate activity with an IC50 value of 138.4 mg/L. The results of the analysis using HPLC indicated that the active isolate in the form of sub-fraction AB1 contained the compound senbusine B.]]>
