Molekul: Jurnal Ilmiah Kimia
The MOLEKUL is dedicated to fostering advancements in all branches of chemistry and its diverse sub-disciplines. It aims to publish high-quality research encompassing a wide range of topics, including but not limited to Pharmaceutical Chemistry, Biological Activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry. By providing a platform for rigorous scientific inquiry and dissemination of knowledge, the journal strives to contribute to the understanding, innovation, and practical applications of chemistry in various fields. We encourage submissions that explore new methodologies, elucidate fundamental principles, address pressing challenges, and demonstrate the potential for real-world impact. Our journal welcomes original research articles, reviews, and perspectives from researchers, scholars, and professionals across the global scientific community, promoting interdisciplinary collaboration and the advancement of chemical sciences. The scope of this journal encompasses a wide range of topics within the field of chemistry, with a particular focus on advancing knowledge and innovation in the following areas: 1. Theoretical Chemistry and Environmental Chemistry: This includes theoretical studies, computational modeling, and experimental investigations related to chemical reactivity, molecular structures, spectroscopy, and the environmental fate and impact of chemicals. 2. Materials Synthesis for Energy and Environmental Applications: The journal welcomes research on the synthesis, characterization, and application of materials for energy storage, catalysis, solar energy conversion, pollution mitigation, and sustainable environmental technologies. 3. Isolation, Purification, and Modification of Biomolecules: Manuscripts addressing the isolation, purification, and modification of biomolecules, such as proteins, nucleic acids, carbohydrates, and lipids, along with their applications in areas such as biotechnology, drug discovery, and diagnostics, are of particular interest. 4. Fabrication, Development, and Validation of Analytical Methods: The journal encourages submissions focusing on the development and optimization of analytical techniques, including chromatography, spectroscopy, electrochemistry, and mass spectrometry. Topics may include method validation, sample preparation, quality control, and applications in diverse fields.
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<![CDATA[The Sesquiterpenoids from Aglaia cucullata Peel Fruit and Their Cytotoxic Activities Against B16-F10 and HeLa Cancer Cell Lines ]]>
<![CDATA[Supratman, Unang]]>;
<![CDATA[Anjari, Intan Hawina]]>;
<![CDATA[Harneti, Desi]]>;
<![CDATA[Naini, Al Arofatus]]>;
<![CDATA[Farabi, Kindi]]>;
<![CDATA[Anwar, Risyandi]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.7900
<![CDATA[Sesquiterpenoids are terpenoid derivative compounds that have a diverse chemical structure and pharmacological effects. Sesquiterpenoids can be found in many plants of Aglaia which is the large source of natural compounds in the Meliaceae family. This research was aimed to elucidate the structure of sesquiterpenoids from the peel fruit of Aglaia cucullata and their cytotoxic activities against two human cancer cell lines. The n-hexane extract was separated and further purified by various chromatographic methods to yiled three sesquiterpenoids. The structure of these sesquiterpenoids were identified by spectroscopy analysis including MS, IR, 1H-NMR, 13C-NMR and DEPT as well as compared with spectral data which reported previously. The sesquiterpenoid compounds 1-3 were identified as spathulenol (1), alismol (2), and 10-oxo-isodauc-3-en-15-al (3). The cytotoxic activity of three sesquiterpenoid compounds were tested against HeLa cervical cancer cell and B16-F10 skin cancer cell using the PrestoBlue method. Compound 2 exhibited the highest activity against both HeLa and B16-F10 cancer cell lines with IC50 48.11 μg/mL and 57.05 μg/mL, respectively.]]>
<![CDATA[Antimicrobial Activity of Natural Solid Soap with a Combination of Liquid Cheese Waste, Turmeric (Curcuma longa), and Dragon Fruit (Hylocereus polyrhizus) Peel ]]>
<![CDATA[Estikomah, Solikah Ana]]>;
<![CDATA[Suranto, Suranto]]>;
<![CDATA[Susilowati, Ari]]>;
<![CDATA[Masykuri, Mohammad]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.8039
<![CDATA[Yoghurt whey is a product from fermented cheese liquid waste. Yoghurt cheese liquid waste has been known to contain lactoferrin. Lactoferrin functions as an antimicrobial. yoghurt made from whey has not been widely utilized as a solid soap ingredient. This research focuses on producing solid natural soap made of yoghurt whey with added natural dye turmeric and dragon fruit peel, soap quality testing, and analysis of the soap's antibacterial activity toward Staphylococcus aureus. The solid soap was processed through the saponification reaction between palm oil, coconut oil, zaitun oil, and canola oil with sodium hydroxide. Variations of yogurt whey used in this study yoghurt 25%,75%,100% whey) was added natural dye (turmeric and dragon fruit peel). The quality test was done by determining free alkali, water content, pH, and foam height. Antibacterial activity test using the well diffusion method. The result shows that the quality test yoghurt soap meets with INS (Indonesia National Standard) 2016, for all the criteria. Performs inhibition against bacteria Staphylococcus aureus. Yoghurt whey is potently used as an antibacterial agent in the manufacture of natural solid soap.]]>
<![CDATA[Production, Characterization, and Toxicity Test of L-asparaginase from Vibrio alginolyticus Bacterial Symbiont of Green Algae Caulerpa lentillifera ]]>
<![CDATA[Kasturiasih, Ni Putu]]>;
<![CDATA[Ahmad, Ahyar]]>;
<![CDATA[Arfah, Rugaiyah A.]]>;
<![CDATA[Khairunnur, Siti]]>;
<![CDATA[Soekamto, Nunuk Hariani]]>;
<![CDATA[Taba, Paulina]]>;
<![CDATA[Hala, Yusafir]]>;
<![CDATA[Karim, Harningsih]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.8153
<![CDATA[L-asparaginase is an enzyme that can be used as an anticancer therapeutic agent. This study aimed to optimize fermentation time for production, optimization, and to test the toxicity of L-asparaginase from Vibrio alginolyticus (V. alginolyticus) bacterial symbiont of green algae Caulerpa lentillifera (C. lentillifera). The activity of L-asparaginase enzyme assay and the toxicity test were done by using the Nessler method and the Brine Shrimp Lethality Test (BSLT) method respectively. The results show L-asparaginase with 66 hours of fermentation time indicates the highest enzyme activity. L-asparaginase mentioned has an optimum enzyme activity of 17.99 U/mL for 30 minutes of incubation time at 37 °C, and pH 7.5. The BSLT results show LC50 value of 17.83 μg/mL indicating the enzyme is bio-toxic with high-level toxicity, which can continue for cytotoxicity tests on cancer cells.]]>
<![CDATA[Extract of Rhoeo Discolor Leaf as a Reducing and Stabilizing Agent in the Synthesis of Silver Nanoparticles ]]>
<![CDATA[Gusrizal, Gusrizal]]>;
<![CDATA[Sayekti, Endah]]>;
<![CDATA[Radianti, Sri]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.8249
<![CDATA[Silver nanoparticles (AgNPs) have been synthesized using Rhoeo discolor leaf extract as a reducing and stabilizing agent. AgNPs were synthesized by adding silver nitrate to the extract of Rhoeo discolor and incubating it in a boiling water bath. The change in color of the mixture from clear to yellow indicated AgNPs formation. The synthesized AgNPs were spherical and showed an absorption peak at around 410-420 nm. The size of particles was distributed from 92 to 485 nm with an average size of 176 nm, and the polydispersity index was 0.185. The stability test showed that synthesized AgNPs were stable for three months of storage at ambient temperature. The extract of Rhoeo discolor were responsible for reducing silver ion and stabilizing the synthesized AgNPs.]]>
<![CDATA[Characteristic of Natural and Acid-activated Clay From Hatu Village, Mollucas Province: FTIR, XRD, XRF, SEM-EDX, TEM, and BET Analysis ]]>
<![CDATA[Sekewael, Serly Jolanda]]>;
<![CDATA[Maahury, Mirella Fonda]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.8316
<![CDATA[Research on the chemical and physical characteristics of natural and acid-activated clay from Hatu Village had been carried out using FTIR, XRD, XRF, SEM-EDX, TEM, and BET surface area analyzer instruments. The natural clay had activated with 0.25 M sulfuric acid for 3 hours using the reflux method, then calcined with 700 Watt microwave radiation for 10 minutes. Overall, FTIR data show tetrahedral and octahedral functional groups that create clay minerals. There is a decrease in absorption intensity due to acid's influence, which dissolves cations in the octahedral and interlayer clay. The XRD analysis shows the Hatu natural clay contains montmorillonite, alumina, kaolinite, quartz, and illite minerals. Broadening and decreasing the intensity of diffraction peaks due to treatment by acid and calcination. SEM images of natural clay before and after activation-calcination shows the morphology of porous and layered material, while the mapping of the surface of natural clay shows irregular and rough material topography. The EDX spectra showed four elements with the most extensive composition: O, Si, Al, and Fe. XRF data confirmed three components that have the highest mass percent, namely SiO2, Al2O3, and Fe2O3. Dealumination occurs at 0.95% due to activation by sulfuric acid along with calcination. TEM images clearly show the multilayered silicate materials. The higher nitrogen gas uptake by activated-calcinated natural clay is proportional to the large surface area and total pore volume.]]>
<![CDATA[Encapsulation of Jeruju Leaves Ethanol Extract (Acanthus ilicifolius L.) and It's Antiinflammatory Activities Against Carrageenan-Induced Mice ]]>
<![CDATA[Tarigan, Indra Lasmana]]>;
<![CDATA[Kharisma, Tiara]]>;
<![CDATA[Bemis, Restina]]>;
<![CDATA[Sutrisno, Sutrisno]]>;
<![CDATA[Latief, Madyawati]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.8820
<![CDATA[Jeruju (Acanthus ilicifolius) leaves ethanol extract contains flavonoids that function as an antiinflammatory source. So it is necessary to research to increase the utilization of ethanol extract of Acanthus ilicifolius leaves (A. ilicifolius L.) in encapsulations to increase the stability of antiinflammatory chemical compounds. Concentrated dyestuff extracts are often unstable, so they need to be converted into solid form, and one technique that can be done is encapsulation. Encapsulation aims to protect sensitive components of the material and reduce the degradation of active compounds in the material. The research method begins with preparing samples to be extracted with ethanol solvent, extract phytochemical screening tests, validation determination tests for the analysis method of ethanol extract levels of jeruju leaves, encapsulated formulations, encapsulated physics and chemical properties test and anti-inflammatory tests. In this research, the secondary metabolite compounds contained in the ethanol extract of Jeruju Leaves were flavonoids, phenolics, steroids, and saponins. The determination of the validation of the analysis method of ethanol extract levels of jeruju leaves was obtained by measurement using a UV-vis spectrophotometer and obtained extract levels of 1367,831 mg/g. This research used maltodextrin coating material for encapsulation formulation because it has low viscosity in many ratios, high solubility, has no taste. The freeze-dryer method was used in this study because it produces better drying quality than other drying methods. The physical property test was carried out by analysis using FTIR and SEM while the chemical properties of encapsulation obtained the highest yield proportion of 58.81%, and the highest solubility proportion of 98.76%. Anti-inflammatory testing is carried out using male mice as test animals. Anti-inflammatory testing in mice based on the Rat hind paw oedema method. The average percent inhibition of each dose administered is calculated based on the data results. The high average percent inhibition obtained for Diclofenac Na is 80%. In the research Encapsule 1:12, the 120 mg/KgBW dose had a significant percentage of inhibition of 75.55%, with Na Diclofenac dose of 10 mg/KgBW being 80%.]]>
<![CDATA[Screening The Anticancer Activity for New Schiff Bases of Natural Steroids ]]>
<![CDATA[Selman, Nawfal Abdul Samad]]>;
<![CDATA[Abbas, Layla Jasim]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.8859
<![CDATA[The significance of cholesterol and ergosterol (provitamin d2) in biological systems has prompted interest in these compounds as pharmaceuticals. It has been reported on the effective straightforward synthesis of Schiff base modifications of cholesterol aldehyde and ergosterol aldehyde and their assessment as possible agents against cancer (esophagus natural cell lines and human cancer cells). Through a process called Steglish esterification, the initial cholesterol and ergosterol are converted into their respective aldehyde derivatives, by reacting with amines such as 2-amino 6-fluoro benzothiazole, carbohydrazide, and thiosemicarbazide, these aldehyde derivatives are transformed into the appropriate Schiff base derivatives, and then their anticancer activity is checked using the MTT (Microculture Tetrazolium Assay) assay method. For the purpose of analyzing their cytotoxic effects, these compounds were tested on cancerous (SK-GT-4, human esophageal adenocarcinoma) and normal (normal cell line, Rat Embryonic fibroblast (REF)) cell lines. The MTT assay results revealed that the compounds (a1, a2, c1, c2, compound 1) were more harmful to human esophageal cancer cell line than to healthy cell line other than compounds (t1, t2, compound 2, ergosterol and cholesterol alone). Overall, our research indicated that provitamin D2 (ergosterol), a1, a2, c2, t2, compound 1, had a growth-inhibiting effect on both cell lines compared to c1, t1, compound 2, and cholesterol alone.]]>
<![CDATA[Antioxidant and Antiatherogenic Responses of Black Solo Garlic in Alloxan-Induced White Rats ]]>
<![CDATA[saryono, Saryono]]>;
<![CDATA[Proverawati, Atikah]]>;
<![CDATA[Jehloh, Latifah]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.9027
<![CDATA[The association between the consumption of black solo garlic (SG) and the increase in antioxidant enzymes and the ability to prevent atherogenicity has not been studied much. This study aims to examine the antioxidant and antiatherogenic capacities of black solo garlic in aloksan induced rats. This study used a true experimental design with a pre- and post-test approach with a control group design. The sample of 30 Wistar rats was randomly divided into 6 groups: a healthy control, a negative control, treatment at doses of 6.5, 13.5, and 26 g/KgBW, and positive controls receiving vitamin C at a dose of 1 g/kgBW. The outcomes demonstrated that following the induction, MDA, CRP, LDL, and IL-6 levels increased, while SOD and GSH-Px enzyme levels decreased. After treatment with black solo garlic for 14 days, there was an increase in the enzymes SOD and GSH-Px, as well as a significant decrease in levels of MDA, IL-6, CRP, and LDL in experimental animals. The SG dose of 13.5 g/kg BW is the most effective dose in this study. The active compounds in SG function as antioxidants in preventing atherogenic events.]]>
<![CDATA[Glycine-modulated Zirconium Perylene-based Metal-Organic Framework for Rhodamin B Photocatalytic Degradation ]]>
<![CDATA[Zulys, Agustino]]>;
<![CDATA[Defania, Mella]]>;
<![CDATA[Gunlazuardi, Jarnuzi]]>;
<![CDATA[Adawiah, Adawiah]]>
<![CDATA[ Molekul Vol 18 No 3 (2023) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2023.18.3.9126
<![CDATA[Photocatalysis employing Metal-Organic Framework (MOF) material may degrade Rhodamin B pollutant. MOF photocatalytic activity can be adjusted by altering the ligands, metal ions, and modulators. This research aims to synthesize glycine-modulated zirconium perylene-based metal organic framework (Zr-PTCA-Gly) for Rhodamin B photocatalytic degradation under visible light irradiation. The activated Zr-PTCA-Gly exhibits good catalytic activity to degrade Rhodamine B with a 95% degradation efficiency.]]>
