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Current Biomedicine
Published by Institut Pertanian Bogor
ISSN : 29628490     EISSN : 29854784     DOI : https://doi.org/10.29244/currbiomed
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary
Aim. Current Biomedicine aims to publish scientific article in the biomedical fields. Scope. Current Biomedicine will publish widely relevant topic in the field of biology (life science), directly or indirectly, support the improvement of human health. These fields include, but are not limited to: anatomy, physiology, histology, embryology, genetics, pharmacology, toxicology, pharmacy, parasitology, pathology, microbiology, clinics, radiology and imaging, surgery, experimental surgery, reproduction, ethnomedicine, phytopharmaceuticals, biotechnology, biomedical engineering, bioinformatics, public health, epidemiology, legislation and bioethics, and one health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol. 3 No. 2 (2025): July" : 8 Documents clear
Efficacy of tamarind leaf infusion (Tamarindus indica L.) as an antidiarrheal agent in mice Nababan, Ratna Kristiani; Sutardi, Lina Noviyanti; Rahma, Anisa; Mustika, Aulia Andi
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.53

Abstract

Asam jawa merupakan tanaman herbal yang memiliki khasiat untuk mengobati berbagai penyakit, namun belum ada penelitian ilmiah mengenai aktivitas infusa daun asam jawa sebagai antidiare. Penelitian ini bertujuan untuk menentukan konsentrasi infusa daun asam jawa yang efektif dalam memberikan efek antidiare pada mencit. Penelitian ini juga bertujuan untuk menganalisis kandungan senyawa metabolit sekunder. Penelitian ini menggunakan 30 ekor mencit yang dibagi menjadi 5 kelompok yang terdiri dari kontrol negatif (Tween 80 [1%]), kontrol positif (Loperamid HCl), dan tiga kelompok yang diberi perlakuan infusa daun asam jawa dengan konsentrasi bertingkat (25%, 50 %, dan 100%). Parameter yang digunakan dalam metode proteksi usus adalah frekuensi buang air besar, konsistensi feses, waktu awal terjadinya diare, durasi, dan waktu penyembuhan diare. Hasil yang diperoleh menunjukkan ekstrak infusa daun asam jawa sebagai antidiare memiliki kemampuan menurunkan frekuensi defekasi, meningkatkan konsistensi feses, mencegah terjadinya diare, dan memperlama waktu penyembuhan diare. Hasil uji fitokimia dari infusa daun asam jawa mengandung flavonoid, steroid, dan terpenoid. Semua kelompok ekstrak infusa daun asam jawa memberikan hasil yang efektif sebagai antidiare.
Effect of solvent variation on results of antibiotic susceptibility test using the disk diffusion method against Staphylococcus aureus Habibah, Firda Nurul; Sufa, Hafizah Ilmi; Kurniati, Iis; Rismiarti, Zuri
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.60

Abstract

Background Mueller-Hinton agar (MHA) is widely used for disk diffusion tests to assess antibiotic susceptibility in non-fastidious bacteria. The type of water used to prepare the MHA may have affected the test outcomes. Objective This study evaluated the effect of different water types as solvents on the antibiotic susceptibility test results of tetracycline and gentamicin against Staphylococcus aureus. Methods MHA was prepared using four types of water: distilled (control), bottled, reverse osmosis (RO), and municipal tap water (PDAM). Antibiotic susceptibility testing was performed using the Kirby-Bauer disk diffusion method, and data were analyzed using One-Way ANOVA and Tukey’s Post Hoc test. Results The mean inhibition zones for tetracycline were 23.8 ± 0.99 mm (distilled), 23.4 ± 0.37 mm (bottled), 23.0 ± 0.43 mm (RO), and 17.8 ± 1.41 mm (tap), categorized as sensitive except for tap water (intermediate). For gentamicin, the zones were 11.7 ± 0.37 mm (distilled), 12.7 ± 0.77 mm (bottled), 9.8 ± 0.18 mm (RO), and 17.6 ± 1.19 mm (tap), with the first three classified as resistant and tap water as sensitive. The tap water results were significantly different (p<0.05) from those of the other antibiotics. Conclusion The use of non-standard solvents in MHA preparation, particularly tap water, may lead to inconsistent antibiotic susceptibility results. Standardized use of distilled water is recommended to ensure test accuracy and reliability.
Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice Husna, Hanifati; Andriyanto, Andriyanto; Manalu, Wasmen; Mohamad, Kusdiantoro
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.67

Abstract

Background Individuals experience varying levels of fatigue and stamina. Moringa oleifera Lam. Seed extract relieves fatigue due to its high levels of antioxidants and glucosinolate glucomoringin, which reduces intracellular oxidative stress. Objectives This study aimed to determine the effectiveness of infusion of M. oleifera seed as a stamina stimulator in mice. Methods This experiment used 25 male mice divided into five groups (five mice in each group), consisting of M. oleifera seed infusion at doses of 0, 1, 3, and 5 g/kg BW as the negative control and treatment groups, and caffeine at a dose of 6.5 mg/kg BW as the positive control group. Stamina effectiveness was evaluated using a swimming endurance test that measured swimming duration and physiological parameters every 15 min for 2 h after administration. Data were analyzed using analysis of variance (ANOVA) followed by Tukey’s test. Results M. oleifera seed infusion at a dose of 3 g/kg BW had the shortest swimming duration difference (Δ) value, with no difference compared to the 5 g/kg BW and caffeine groups, but was significantly different (P<0.05) compared to the 0 and 1 g/kg BW groups. M. oleifera seed infusion at a dose of 3 g/kg BW also showed a lower delta value for body surface temperature and heartbeat rate compared to the negative control, and a lower delta value for the respiratory rate compared to the 5 g/kg BW group. Conclusion M. oleifera seed infusion potentially maintains stamina performance in mice at a dose of 3 g/kg BW.
Role of PTEN gene in genetic alterations in endometrioid carcinoma Fadhillah, Risti Sifa'
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.76

Abstract

Endometrioid (type I endometrial) carcinoma is the most prevalent form of endometrial cancer and is strongly associated with genetic alterations, particularly involving phosphatase and tensin homolog (PTEN) gene. PTEN protein is a crucial component of the protein kinase B (PKB)/Akt signaling pathway, which plays a significant role in regulating cell cycle arrest and inducing apoptosis. The loss or mutation of PTEN can disrupt this pathway, contributing to uncontrolled cell proliferation and cancer progression. Recent studies indicate that PTEN genetic alterations are not limited to mutations or loss of expression but also involve complex variations such as gene deletions, structural changes, and diverse regulatory disruptions. Genetic alterations involving PTEN are frequently observed in endometrioid-type endometrial carcinomas, particularly in tumors that develop from premalignant lesions. These alterations, whether mutations, deletions, or reduced expression, significantly disrupt the regulation of cell growth and key signaling pathways, thereby driving tumor initiation and progression. By providing a more integrated understanding of the multifaceted genetic changes in PTEN, this review highlights emerging opportunities for early detection, refined risk stratification, and the advancement of gene-targeted therapeutic strategies specifically for the endometrioid subtype of endometrial cancer.
Comparative superovulation outcomes across estrous phases using PMSG-hCG and rFSH-rhCG in mice Maula, Yogi Nikmatul; Salsabila, Cyntia Bella; Pristihadi, Diah Nugrahani; Haq, Noer Muhammad Dliyaul; Boediono, Arief
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.86

Abstract

Background Enhancing stimulation efficiency in mice supports the application of assisted reproductive technologies (ART) for species conservation. Objective This study compared the stimulatory potential of two ART-supporting hormone protocols: the conventional PMSG-hCG combination and recombinant gonadotropins (rFSH-rhCG), a newer generation produced by genetic engineering. Methods Sixty-three female mice from four distinct estrous phases were used in this study. Both hormone regimens, with FSH- and LH-like activities, were administered sequentially between 4:00 and 5:00 pm, at a 47–48 h interval. Stimulation success was evaluated based on the proportion of females showing a positive response and the number of oocytes retrieved. Results The diestrus phase yielded the highest response for both treatments. Approximately 60% of the females responded to PMSG-hCG, and 80% responded to recombinant hormones. The number of oocytes recovered reached 239 in the PMSG-hCG group and 137 in the recombinant group. Interestingly, recombinant hormone administration during estrus induced ovulation of 400 oocytes; however, the efficiency ratio was lower than that during diestrus (30.8 vs 34.3). Conclusion Both PMSG-hCG and recombinant gonadotropins effectively stimulate ovulation. The diestrus phase provides the most consistent results; therefore, diestrus is recommended as the optimal stage for superovulation protocols in mice.
Dieffenbachia seguine extract nanoemulsion as an intranasal inflammation-inducing agent in rats Sa'diah, Siti; Leong , Ke Yong; Mayasari, Ni Luh Putu Ika; Widi, Leliana Nugrahaning; Alfarisi, Hamzah
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.94

Abstract

Background Dieffenbachia seguine (Jacq.) Schott, commonly known as the dumb cane, is a tropical ornamental plant known for its toxic and proinflammatory properties. Its potential as a natural inducer of inflammation warrants further investigation, particularly via the intranasal route. Objective This study aimed to evaluate the proinflammatory effect of D. seguine leaf extract nanoemulsion by measuring the levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in bronchoalveolar lavage fluid (BALF) following intranasal administration in rats. Methods Wistar rats (n= 24) were divided into six groups: water for injection (WFI, negative control); emulsion base; lipopolysaccharide (LPS, positive control); and D. seguine extract nanoemulsions at concentrations of 1%, 2%, and 4%. Each rat received an intranasal instillation, and IL-6 and TNF-α concentrations in the BALF were quantified using ELISA. Results Only the 4% D. seguine nanoemulsion group showed a significant increase in IL-6 and TNF-α levels compared to the control. Lower concentrations (1% and 2%) did not induce significant cytokine elevation. All treatment groups showed significantly lower cytokine levels than the LPS group. Conclusion D. seguine extract nanoemulsion at 4% concentration demonstrates potential as a natural inflammation-inducing agent via the intranasal route, although its effect remains lower than that of LPS.
Evaluation of influenza-specific immunoglobulin Y stability in liquid, solid, and cream-based body care formulations Poetri, Okti Nadia; Setyawati, Yusefin Marcelina; Kal Alfin, Zabrino Wahid; Kalsum, Salsabila; Fathurrahman, Fathurrahman; Rong, Chin Xiao; Nugraheni, Indi Amalia; Kuswanti, Andrea Septiandra
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.98

Abstract

Background Specific immunoglobulin Y (IgY) is widely used in immunotherapy, with expanding applications in body care products. Topically applied influenza-specific antibodies may provide an alternative strategy for preventing respiratory infections. Objective This study aimed to evaluate the stability and biological activity of influenza-specific IgY in various body care products. Methods The biological activity of influenza-specific IgY was evaluated in various body care products at different concentrations. Commercial face mists contained 5% and 10% w/v IgY, face mists and nasal sprays contained 0.5% w/v IgY, lip balm, sunscreen, and hand cream contained 0.1% and 0.25% w/v IgY. The products were stored at room temperature for four weeks, and organoleptic changes were monitored weekly. IgY activity was assessed by enzyme-linked-immunosorbent-assay (ELISA). Results In both face mist products, the aroma gradually became fishy, the color remained stable, and turbidity increased. The biological activity of IgY was still detectable by ELISA at concentrations of 0.5%, 5%, and 10%. In nasal spray, no changes in aroma, color, or turbidity were observed, but IgY activity was not detectable. In lip balm, sunscreen, and hand cream, only slight color changes occurred without any change in aroma, and IgY activity was not detected. Conclusion Influenza-specific IgY retained biological activity in face mist formulations at higher concentrations (≥0.5%) despite observable changes in aroma and turbidity. In contrast, IgY activity was not detected in nasal sprays, lip balm, sunscreen, or hand cream, suggesting that the formulation type and IgY concentration significantly influence its stability and detectability in body-care products.
Front Matter Vol 3 No 2 Current Biomedicine
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.%p

Abstract

Front Matter Vol 3 No 2

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