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Current Biomedicine
Published by Institut Pertanian Bogor
ISSN : 29628490     EISSN : 29854784     DOI : https://doi.org/10.29244/currbiomed
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary
Aim. Current Biomedicine aims to publish scientific article in the biomedical fields. Scope. Current Biomedicine will publish widely relevant topic in the field of biology (life science), directly or indirectly, support the improvement of human health. These fields include, but are not limited to: anatomy, physiology, histology, embryology, genetics, pharmacology, toxicology, pharmacy, parasitology, pathology, microbiology, clinics, radiology and imaging, surgery, experimental surgery, reproduction, ethnomedicine, phytopharmaceuticals, biotechnology, biomedical engineering, bioinformatics, public health, epidemiology, legislation and bioethics, and one health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 49 Documents
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Penarikan naskah: Efek diuretik ekstrak daun alpukat (Persea americana Mill.) pada kadar kalium dan natrium urine tikus Sprague-Dawley Madyastuti, Rini; Nisa, Nunik Nida Choerun; Wientarsih, Ietje
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.10-18

Abstract

Announcement of manuscript withdrawal: The author has voluntarily submitted a request for retraction of the published manuscript. Based on these considerations, the editorial board decided to permanently withdraw this manuscript from circulation, both in print and online.
Kualitas mikrob dan sel somatik dalam susu yang berasal dari peternakan sapi perah di lokasi dataran tinggi dan dataran rendah Herwin; Jannah, Zahratul; Isdoni, Isdoni; Komala, Iyep; Pisestyani, Herwin
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.1-9

Abstract

Background: Consumers have the right to consume safe and healthy fresh milk. One of the factors that affect the productivity and quality of milk is the altitude of the location and environmental conditions around the farm. Objective: This research aimed to determine the differences in microbial quality and the somatic cell count (SCC) in milk between farms in the highlands (Cijeruk Farm, Bogor) and lowlands (Pondok Ranggon Farm, East Jakarta). Methods: This study observed the total plate count (TPC), the number of Staphylococcus aureus, and SCC. Microbial testing was carried out using the plate count method and the somatic cells count used the Breed method. The data were analyzed statistically using Mann-Whitney U and Chi-square. Results: The results showed that TPC, S. aureus, and SCC of milk from Pondok Ranggon located in the lowlands were higher than those of milk from Cijeruk located in the highlands. The average of TPC, S. aureus, and SCC in milk from Cijeruk were 1.6×104 ± 1.5×104 CFU/mL, 1.3×103 ± 4.2×103 CFU/mL, and 1,795,000 ± 1,838,791 cells/mL, respectively. The average of TPC, S. aureus, and SCC in milk from the Pondok Ranggon were 3.5×105 ± 1.0×106 CFU/mL, 1.7×105 ± 6.3×104 CFU/mL and 3,032,222 ± 4,348,654 cells/mL, respectively. This research showed that the location of the rearing area has relationship with S. aureus in milk (P<0.05). Conclusion: It was concluded that microbial status and the somatic cell count are influenced by differences in livestock areas.
Penyembuhan luka sayatan kulit menggunakan topikal balsamum peruvianum pascaoperasi infark miokardium pada babi domestik (Sus scrofa domestica) Febryanto, Agung; Rahmiati, Dwi Utari; Wientarsih, Ietje; Murtiningrum, Fitria Senja; Iman, Bintang Nurul; Noviana, Deni; Gunanti, Gunanti
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.25-32

Abstract

Background: Swine are ideal animal models used for human health and disease research in humans because they have similar anatomy and physiology, one of which is regarding wound healing. Objective: This study aims to determine the effectiveness of balsamum peruvianum on wound healing after myocardial infarction surgery in domestic pigs (Sus scrofa domestica). Methods: The study used five pigs aged 4–5 months, three male and two female. The incision was made using electrocautery in the lateral part of the third and fourth thoracic intercostal spaces, lengthwise from dorsal to ventral. The wound was sutured using Monosyn® 4.0 thread with a subcuticular/intradermal suture pattern. The wound was then given 10% iodine and 10% balsamum peruvianum over the entire surface of the wound twice a day. Recovery was observed on 1st, 4th, 7th, 11th, and 14th days and was scored (grade: 1–4) on macroscopic examination in each pig until day 18th. Results: The observations showed a significant difference in recovery scores on the 11th and 18th days compared to the first day. Conclusion: Topical balsamum peruvianum can be used and is effective for wound healing of skin incisions after myocardial infarction surgery in swine.
Kejadian nematodosis gastrointestinal pada monyet ekor panjang (Macaca fascicularis) di Pusat Studi Satwa Primata LPPM IPB Rosyid, Bahaudien; Darusman, Huda Shalahudin; Retnani, Elok Budi
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.33-45

Abstract

Background: The long-tailed macaque (Macaca fascicularis) is often used as a model animal in biomedical research. Nematodosis is common among non-human primates. Gastrointestinal nematodosis may affect study results or be a potential source of transmission to humans (zoonosis). Objective: The study aimed to identify the type, calculate the degree of infection, and the prevalence of gastrointestinal nematode worms in long-tailed macaques in captivity at the Primate Research Center, Institute for Research and Community Service (PSSP LPPM) IPB University. Methods: Faeces samples from 24 long-tailed macaques were examined using the McMaster and Kato-Katz simple flotation methods. Results: Nine (37.5%) of the 24 samples were infected by trichurid (20.8%), ascarid (12.5%), and strongylid (4.2%), each with an average degree of infection 833.3 ± 923.8, 32 ± 27.7, and 12 ± 17 eggs per gram of faeces (EPG), respectively. The prevalence of nematodosis in long-tailed macaques based on age group and sex was in infants 50%, children 50%, adolescents 16.7%, adults 33.3%, males 33.3%, and females 41.7%. Conclusion: The incidence and degree of gastrointestinal nematodosis infection in long-tailed macaques showed a moderate to low level. These results can be considered in maintenance management, biomedical research, and mitigation of potential transmission risk to humans.
Effect of the partial solar eclipse on the behavior and activity of rats Tarigan, Ronald; Achmadi, Pudji; Bustamam, Isdoni; Santoso, Koekoeh
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.62-69

Abstract

Circadian rhythm is the adaptation response of animals against light alteration that affects various behavioral and physiological responses. Bright light is a danger signal for nocturnal animals because it exposes them more to predators. This research aimed to study the changes in the behavior of rats during the partial solar eclipse (PSE) period. The PSE period occurred across Bogor, Indonesia, on 9 March 2016. The PSE started at 06.19 AM, peaked at 07.21 AM, and ended at 08.30 AM. The light level decreased since the early solar eclipse, then dropped significantly at the peak period. The activities of six mature male Sprague Dawley rats were measured using Opto-Varimex-5 Auto Track System during the PSE period. The measurements were repeated one day after the PSE period as the non-PSE period. There were significant differences (P<0.05) in stereotypic time, burst of stereotypic movement, and horizontal count in the early, peak, and end periods of the PSE period compared with the values at the same time of the non-PSE period. The activities of rats changed during the PSE period. Rats did not rest as in their normal nocturnal behavior during darkness but were more active and stressed because of the rapid change in light level during the PSE period.
Hubungan teknik pemerahan dengan jumlah Escherichia coli pada susu segar dari peternakan sapi perah di KUD Kertajaya, Kabupaten Kediri, Jawa Timur Rahadyan, Raihan Alif; Tyasningsih, Wiwiek; Puspitasari, Yulianna; Permatasari, Dian Ayu; Widjiati, Widjiati
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.19-24

Abstract

Background: The coliform bacteria group is a group of bacteria used as an indicator of food sanitation, one of which is in dairy products. Objective: This study aimed to determine the relationship of milking techniques with the number of Escherichia coli in raw milk compared to the bacterial contamination limit set by the National Standardization Agency. Methods: The design of this study was a descriptive study. Raw milk samples were taken from Lucky Farm and several traditional dairy farms in the KUD Kertajaya area, Kediri Regency, East Java. This study uses the most probable number (MPN) test. Results: The results showed 11 (73.3%) of raw milk samples using conventional milking techniques exceeding the maximum limit of E. coli bacterial contamination determined by the National Standardization Agency (< 3 MPN/mL). However, all 15 samples, or 100% of raw milk samples using machine milking techniques, were negative for E. coli and met the maximum bacterial contamination limit requirements. Conclusion: The milking techniques affect E. coli contamination limits in raw milk. The milk samples taken using machine milking techniques had better results with MPN values ​​< 3 MPN/mL than those taken using conventional milking techniques.
Penyembuhan luka sayatan menggunakan krim ekstrak teripang laut dan kunyit Alpayet, Rahmat; Mustika, Aulia Andi; Rahma, Anisa; Andriyanto; Sutardi, Lina Noviyanti
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.54-61

Abstract

Background: Skin is the outermost layer that covers and protects the body and is vulnerable to trauma, such as wounds. Turmeric and sea cucumbers are known to have properties in wound healing. Objective: This study aims to determine the effectiveness of a mixture of sea cucumber and turmeric extracts in the form of a cream to heal incision wounds in rats. Methods: Twenty-five male white rats, Sprague Dawley strain, and body weights of 250–300 g were anesthetized, and their skins were slashed. The rats were divided into five groups, namely negative control (wounds without treatment), positive controls (wounds treated with Bioplacenton® topically), and three treatment groups (wounds treated with sea cucumber and turmeric extract cream with concentrations of 0.5%, 1%, and 2% topically). Wound healing parameters were observed daily, namely accelerated wound closure and inflammation reduction. Data were analysed descriptively and tested using the non-parametric Kruskal-Wallis’s test. Results: The results showed that the wounds closed completely in all treated groups. Healing time in the group receiving treatment (positive control and concentration treatment of 0.5%, 1%, and 2% were 8.3 ± 1.5 days, 10.3 ± 0.6 days, 9.3 ± 0 .6 days, and 8.3 ± 1.5 days, respectively) faster than the healing time of the group that did not receive treatment (negative control was 12.6 ± 0.6 days). Conclusion: This study showed that sea cucumber and turmeric extract cream has the potential and is effective for wound healing and can be used as an alternative for wound treatment.
Toksisitas akut infusa daun pepaya Calina jantan (Carica papaya L.) pada mencit betina Sari, Nurma; Safika, Safika; Putra, Hamdika Yendri; Andriyanto, Andriyanto
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.46-53

Abstract

Latar belakang: Pepaya (Carica papaya L) merupakan salah satu tanaman yang berpotensi sebagai obat untuk beragam penyakit. Tujuan: Penelitian bertujuan menguji toksisitas akut ekstrak daun pepaya Calina (IPB 9) jantan pada mencit betina dengan menentukan nilai lethal dose 50 (LD50), mengamati pengaruhnya pada organ tubuh mencit, dan menghitung konsentrasi ekstrak yang paling efektif. Metode: Penelitian menggunakan 20 ekor mencit galur DDY yang dibagi secara acak ke dalam 4 kelompok perlakuan, yaitu kelompok kontrol (pemberian akuades) dan kelompok perlakuan pemberian infusa daun pepaya Calina jantan masing-masing dengan dosis 5, 10, dan 15 g/kg BB secara per oral. Pengamatan dilakukan pada mortalitas, gejala klinis, respons fisiologis, bobot badan, dan bobot relatif organ. Hasil: Nilai LD50 menunjukkan pemberian infusa daun pepaya Calina jantan pada mencit betina bersifat tidak toksik. Pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB tidak menimbulkan gejala klinis yang bersifat patologis, perubahan makroanatomi organ, atau kematian. Pemberian infusa tidak menunjukkan efek yang signifikan pada peningkatan atau penurunan bobot badan. Pemberian infusa daun pepaya Calina jantan dengan dosis 10 g/kg BB terbukti paling efektif dalam mempertahankan pertambahan bobot badan secara normal dan tidak bersifat toksik. Simpulan: Berdasarkan penelitian, pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB bersifat tidak toksik dan tidak memengaruhi organ tubuh mencit, dengan dosis efektif sebesar 10 g/kg BB.
Back Matter Vol 1 No 1 Biomedicine, Current
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.v-xi

Abstract

https://doi.org/10.29244/currbiomed.1.1.v-xi
Front Matter Vol 1 No 1 Biomedicine, Current
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.i-iv

Abstract

https://doi.org/10.29244/currbiomed.1.1.i-iv

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