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Astri Desmayanti
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INDONESIA
Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 204 Documents
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The Effect of Differences in Growing Altitude on the Total Flavonoid Content Single Clove Garlic (Allium sativum Linn) Styawan, Anita Agustina; Putra, Rayhantana Rizky
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25924

Abstract

Single garlic belongs to the Amaryllidaceae family and contains flavonoid compounds with antioxidant activity. However, the use of herbal ingredients often shows inconsistent effects because differences in growing locations, such as soil and climate conditions, can influence the amount of flavonoids produced. The purpose of this study was to determine the difference in total flavonoid content of single garlic (Allium sativum Linn) based on the influence of growing locations in Boyolali Regency and Karanganyar Regency. This study used 2 kg of single garlic (Allium sativum Linn) samples, which were then extracted using the maceration method with 96% ethanol solvent. The total flavonoid content was determined using the UV-Vis spectrophotometry method. The results showed that the quantitative test using UV-Vis spectrophotometry obtained a maximum wavelength of 426 nm with a curve equation of y=0.0151x – 0.0033. The average total flavonoid content from Boyolali Regency was 0.5867 mgQE/g and from Karanganyar Regency was 0.5867 mgQE/g and 0.1495 mgQE/g. Based on statistical test data, it was found that the significance value was 0.002, where the result had a P<0.05 value, which means that there was a significant difference in total flavonoid content based on the growing location.
Integration of Molecular Docking in the Identification of Natural Antioxidants: Interaction Study of Jackfruit Leaf Flavonoids with NADPH:FMN Oxidoreductase Reynaldi, Muhammad Andre; Ropiqa, Meri
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26236

Abstract

Oxidative stress plays a critical role in the progression of various degenerative diseases through increased production of reactive oxygen species (ROS), driven in spart by the activity of redox related enzymes such as NADPH:FMN oxidoreductase. Bioactive compounds from jackfruit leaves are known to possess antioxidant potential, yet their molecular mechanisms against specific enzymatic targets remain insufficiently elucidated. This study aimed to evaluate the potential interaction of jackfruit leaf flavonoids morin, oxyresveratrol, and artocarpin with NADPH:FMN oxidoreductase using molecular docking analysis. The 1BKJ protein structure was prepared following standard protocols, and all ligands were optimized prior to performing redocking for method validation. AutoDock Vina 1.2.7 was employed with a 20×20×20 Å grid box area. Redocking produced an RMSD of 0.1469 Å, confirming the reliability of the docking parameters. Docking results revealed that morin (–7.848 kcal/mol) and oxyresveratrol (–7.577 kcal/mol) exhibited stronger binding affinities compared with vitamin C (–5.713 kcal/mol) and artocarpin (–5.577 kcal/mol). The dominant interactions involved Arg15, Arg169, Tyr128, Tyr199, and Tyr200, residues that contribute to the stabilization of ligand protein complexes in silico and may be located near functionally relevant regions associated with redox activity. These findings suggest that jackfruit leaf flavonoids may serve as promising candidates for further investigation as potential modulators of redox related enzymes based on predictive in silico evidence.
Potential Drug Interactions in Outpatients with Hypertension and Comorbid Type 2 Diabetes Mellitus at Arifin Achmad Regional General Hospital Riau Province Husnawati, Husnawati; Rusnedy, Rahmayati; Fadillah, Ma'isyatul; Zulfitri, Reni
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26554

Abstract

Hypertension and diabetes mellitus are degenerative diseases that if not managed properly will lead to other disease complications. This condition can cause polypharmacy which has the potential to cause drug interactions. The purpose of this study is to determine the presence or absence of drug interactions used in the treatment of hypertension patients with comorbidities of type 2 diabetes mellitus at Arifin Achmad Hospital, Riau ProvinceThis study was conducted using a descriptive analysis design by collecting retrospective data. The samples are all outpatients diagnosed with hypertension and coexisting type 2 diabetes mellitus from January to December 2024 who met the inclusion criteria. The total sample in this study was 110 samples. In this study use one variable, drug interaction. The instrument used in this study was a patient’s medical record. The results obtained were analyzed descriptively with online media screening using Drugs.com and Medscape.com sites and textbook screening such as Stockley's Drug Information Handbook (DIH) Drug Interaction, 12th edition, 2019. The data obtained were analyzed descriptively using percentages. The results showed that there were 70 cases of potential drug interactions. The type of pharmacodynamic interaction was 100% and based on severity there were major interactions of 1,43%, moderate 92,86% and minor 5,71%. These findings indicate the potential for drug interactions in outpatients with hypertension and comorbid type 2 diabetes mellitus, particularly pharmacodynamic interactions.
In-Silico Investigation of Compounds from Black Mangrove (Rhizophora mucronata L.) as Inhibitors of Exo-1,3-β-Glucanase in Candida albicans Ririn Puspadewi; Dadan Suryasaputra; Nurrohmana, Rizki
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26579

Abstract

Candida albicans is an opportunistic fungal pathogen responsible for systemic infections that result in considerable morbidity and mortality. The enzyme Exo-1,3 β-glucanase is essential for cell wall metabolism and pathogenicity in C. albicans, rendering it a potential therapeutic target. The study aims to evaluate the effectiveness of bioactive compounds from black mangroves (Rhizophora mucronata L.) as inhibitors of Exo-1,3 β-glucanase using an in silico approach. The test results from 28 black mangrove plant compounds yielded a the free energy value (ΔG) with a the inhibition constant (KI) comparable to that of ibrexafungerp. The four compounds exhibited the following properties: β-amyrin (ΔG) = -8.24 kcal/mol with KI = 908.46 nM, lupeol = -8.19 kcal/mol with KI = 994.44 nM, ethyl-iso allocholate = -7.66 kcal/mol with KI = 2.44 μM, and magnolol = -7.2 kcal/mol with KI = 5.25 μM. The molecular docking test results were evaluated from multiple perspectives, specifically the ΔG value generated post-docking, the KI, and the interactions of amino acid bonds and residues with the receptor. The ADMET prediction test results indicate that the four molecular docking test chemicals exhibit commendable skin penetrating capabilities. Based on the results of the tests, the four compounds, namely Ethyl-isoallocholate, β-amyrin, Magnolol, and Lupeol with β-amyrin, have the potential to become new drug candidates as Exo 1-3-(-glucanase inhibitors) in Candida albicans
Formulation of Theophylline Sustained-Release Tablets with a Combination of Eudragit RS 100 and Lactose Trisnaningtyas, Meysiska; Ikasari, Endang Diyah; Cahyani, Intan Martha
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26837

Abstract

Sustained-release (SR) delivery of Theophylline is pharmaceutically essential due to its narrow therapeutic index and the need to maintain controlled plasma exposure. This study aims to investigate the release kinetics and matrix-modifying roles of Eudragit RS 100 and lactose in three SR tablet formulations of Theophylline. Tablets were produced with the wet granulation method and evaluated for physicochemical properties, dissolution behavior according to USP specifications, and kinetic model fitting. The physicochemical evaluation revealed clear differences among formulations. F-1 exhibited the highest hardness (10.48 ± 0.10 kg/cm²) but excessive friability (2.40 ± 0.01%), whereas F-2 and F-3 showed lower hardness values (8.25 ± 0.03 and 8.03 ± 0.02 kg/cm²) with acceptable friability (0.32 ± 0.03% and 0.34 ± 0.03%). Granule flow properties improved progressively from F-1 to F-3, as indicated by reduced Carr’s Index (16.17 ± 0.16 to 11.58 ± 0.32%) and Hausner Ratio (1.193 to 1.131), accompanied by increased flow rates (12.12 ± 0.03 to 14.48 ± 0.53 g/s) (p < 0.05). These physicochemical differences were reflected in dissolution behavior and drug-release kinetics, confirming the matrix-modifying effects of Eudragit RS 100 and lactose. Kinetic modeling demonstrated formulation-dependent release mechanisms: F-1 showed the highest correlation with the zero-order model (R² = 0.9858), suggesting a near constant drug-release rate, whereas F-2 exhibited the best fit to a second-order model (R² = 0.9635), indicating concentration-dependent release. In contrast, F-3 was optimally described by the Korsmeyer–Peppas model (R² = 0.9545), consistent with anomalous transport governed by combined diffusion and polymer relaxation.
Optimization of Green Ultrasound-Assisted Extraction of Carotenoids from Tagetes erecta L. using Natural Deep Eutectic Solvents (NADES) Andriani, Ni Luh Febby; Yadnya-Putra, Anak Agung Gede Rai; Kusuma Dewi, Luh Putu Mirah
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22717

Abstract

Carotenoids from marigold flowers (Tagetes erecta L.) are commonly extracted using conventional solvents like hexane and ethanol, which may pose environmental and health risks. Based on these considerations, this study aimed to evaluate the potential of Natural Deep Eutectic Solvents (NADES) as greener alternatives and to determine the optimal NADES composition and extraction conditions using Ultrasound-Assisted Extraction (UAE). The most effective NADES was selected based on total carotenoid content, statistically analyzed using one-way ANOVA. Optimization was carried out using Response Surface Methodology (RSM) with a Box–Behnken Design (BBD) to assess the effects of ultrasonic power, extraction time, and temperature. Total carotenoid content was determined by UV-Vis spectrophotometry. Among the tested solvents, the hydrophobic NADES composed of menthol:lactic acid (8:1) showed the highest efficiency (98.48 ± 0.20 mg β-carotene equivalent (BCE)/g dry sample (DS)), outperforming the hydrophilic NADES, hexane, and 80% ethanol. Optimization using Response Surface Methodology with a Box–Behnken Design identified optimal UAE conditions at 100% ultrasonic power, 40 minutes, and 60°C, yielding 304.01 ± 1.60 mg BCE/g DS. These results confirm the effectiveness of NADES as sustainable and efficient solvents for carotenoid extraction from marigold flowers.
Evaluation of Total Phenolic Content, Total Flavonoid Content, and Free Radicals Scavenging Activity of Syzygium polyanthum Wight. Leaves Ramadhan, Yandy Efrianna; Awidarta, Kevin; Endro Unugroho, Agung; Rohman, Abdul
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23084

Abstract

Bay leaves plant (Syzygium polyanthum Wight), from the Myrtaceae family, are traditionally used for their medicinal properties due to bioactive compounds like phenolics, flavonoids, and steroids with antioxidant activity. This study aimed to evaluate the antioxidant potential of bay leaf extract by measuring total phenolic and flavonoid content and assessing free radical scavenging activity. Fresh leaves were collected in Yogyakarta in December 2024, dried, and extracted via methanol maceration, followed by fractionation with n-hexane, ethyl acetate, and aqueous solvents. The Folin-Ciocalteu method was used to measure total phenolic content,iusing gallic acid asiaireferenceistandard, irevealing high phenolic levels, particularly in the ethyl acetate fraction (198.20 ± 0.42 mg GAE/g). The Folin-Ciocalteu method was used to measure total phenolic content, using gallic acid as a reference standard, showing significant flavonoid levels, with the ethyl acetate fraction at 62.06 ± 1.76 mg QE/g. The DPPH assay was utilized to assess antioxidant activity, revealing that the ethyl acetate fraction had the lowest IC50 value (41.71 ±i0.617 µg/mL), demonstrating potent free radical scavenging ability similar to ascorbic acid (9.61 ± 0.138 µg/mL) The ethyl acetate fraction contains a significant amount of phenolics and flavonoids correlated strongly with its antioxidant capacity, highlighting bay leaves as a promising source for herbal medicine development. These findings validate the traditional use of bay leaves and offer updated quantitative data on phenolic/flavonoid levels and antioxidant capacity, highlighting their promise for natural health product development.
Characterization of Purple Corn Anthocyanin Components and Their Pharmacokinetic Profiles through In Silico Study Chayati, Ichda; Nuryadi, Satyo; Purnomo, Hari; Miladiyah, Isnatin
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23226

Abstract

Purple corn contains high levels of bioactive anthocyanins with potential health-promoting effects. This study aimed to quantitatively characterize the anthocyanin profile of an Indonesian purple corn variety and evaluate the pharmacokinetic properties of its major constituents using in silico modelling. The anthocyanin extract was analyzed by HPLC (high-performance liquid chromatography), and concentrations were determined using authentic standards. The pharmacokinetic parameters, including absorption, distribution, metabolism, excretion, and toxicity (ADMET), were predicted using the pkCSM platform, and drug-likeness properties were evaluated based on Lipinski’s Rule of Five. Cyanidin-3-glucoside (0.82 mg/100 g DW), peonidin-3-glucoside (0.38 mg/100 g DW), and pelargonidin-3-glucoside (0.35 mg/100 g DW) were identified as the predominant anthocyanins. In silico ADMET predictions using pkCSM revealed low intestinal absorption, moderate peripheral tissue distribution, and violations of Lipinski’s Rule of Five, indicating limited suitability as conventional oral pharmaceuticals. Nevertheless, the compounds exhibited low predicted toxicity, minimal CYP450 inhibition, and favorable excretion profiles, supporting potential safe use as nutraceuticals or functional food ingredients. This integrated approach demonstrates that experimental phytochemical profiling combined with computational pharmacokinetic analysis provides valuable insight into the properties of anthocyanins beyond standard bioavailability studies. The findings provide a foundation for future formulation strategies, such as encapsulation or delivery enhancement, to improve bioavailability and functional activity in foods or dietary supplements. Overall, anthocyanins from Indonesian purple corn are promising safe natural bioactives, warranting further experimental and translational research.
Validation of Analytical Method for Determining Formaldehyde Levels in Imported Apples Sold in Pontianak City using UV–Vis Spectrophotometry Rizky, Gaudensius; Nugraha, Fajar; Kurniawan, Hadi
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23690

Abstract

The Indonesian government has implemented various efforts to protect food from biological, chemical, and physical contaminants that may endanger public health. Formaldehyde, an aqueous solution containing 37% formaldehyde, is commonly used as an antiseptic, disinfectant, and preservative for biological specimens. However, its misuse in food products, such as imported apples, remains a concern in Indonesia. This study aims to detect and measure formaldehyde levels in imported apples sold in Pontianak City by comparing peeled and unpeeled samples. Qualitative analysis was conducted using Schiff reagent color tests, while quantitative analysis employed UV-Vis spectrophotometry. The results showed the presence of formaldehyde in unpeeled imported apples, with concentrations ranging from 5.23–22.65 mg/kg (1.57–6.80 mg/serving). Meanwhile, peeled imported apples exhibited lower formaldehyde levels, ranging from 2.55–6.75 mg/kg (0.76–2.02 mg/serving) across six districts in Pontianak City. Statistical testing with the Independent Sample T-Test showed a significant distinction between peeled and unpeeled imported apples. Therefore, peeling imported apples prior to consumption may reduce potential exposure to formaldehyde. Consumers are advised to wash apples thoroughly under running water and purchase products from reliable sources to minimize the risk of contamination. Furthermore, strengthened regulatory monitoring and stricter enforcement against the illegal use of formaldehyde in food products are necessary to ensure consumer safety and protect public health.
Evaluation of Acrylamide Levels in Arabica (Coffea arabica) and Robusta (Coffea canephora) Coffee Roasting Variations for Nutraceutical Capsules Juwariyah, Putri Siti; Rachma, Firstca Aulia; Alighiri, Dante
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25012

Abstract

Coffee roasting is an essential process that determines the flavor and aroma of coffee, yet it also contributes to the formation of acrylamide, a carcinogenic compound. Acrylamide is produced as a by-product of the Maillard reaction, which occurs between reducing sugars and amino acids at high roasting temperatures. This study aimed to evaluate acrylamide content in Arabica coffee (Coffea arabica) and Robusta coffee (Coffea canephora) under different roasting levels, and to assess its safety for nutraceutical capsule formulation. The experimental procedure included roasting beans at three levels (light, medium, and dark). Acrylamide analysis was performed using UV-Vis spectrophotometry with the standard addition method. Data were analyzed using Kruskal–Wallis and Mann–Whitney tests with JASP software. Results showed that acrylamide levels increased with increasing roasting time in both Arabica and Robusta coffee. The lowest acrylamide concentrations were observed at 10 minutes of roasting, particularly in the n-hexane fraction measuring 72.1154 µg/kg in Arabica coffee and 109.6825 µg/kg in Robusta coffee, while the highest levels were detected in the water fraction at 20 minutes of roasting, reaching 299.8834 µg/kg in Arabica coffee and 400.5265 µg/kg in Robusta coffee. Statistical analysis confirmed that roasting variations significantly affected acrylamide formation (p < 0.05), whereas no significant difference was found between coffee types (p > 0.05). Although the n-hexane fraction yielded the lowest acrylamide content, ethyl acetate at 10 minutes of roasting was identified as the optimal condition, as it produced relatively low acrylamide levels (124.1045 µg/kg in Arabica and 136.8083 µg/kg in Robusta) while preserving bioactive compounds suitable for nutraceutical formulation. Evaluation of granule quality and capsule characteristics indicated that all parameters met standard requirements. In conclusion, nutraceutical capsules can be formulated from the ethyl acetate fraction of coffee roasted for 10 minutes, ensuring safety and functional benefits.

Page 19 of 21 | Total Record : 204

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