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Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 24606065     EISSN : 25483013     DOI : 10.15408/jkv
Core Subject : Science,
Chemistry
Jurnal Kimia Valensi is a biannual and peer-reviewed open access journal published by Department of Chemistry, Faculty of Science and Technology UIN Syarif Hidayatullah Jakarta. This journal covering all aspect of chemistry.
Arjuna Subject : Umum - Umum
Articles 425 Documents
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Comparative Study of Voltammetric Analysis with UV-Vis Spectrophotometry in Determining the Results of Liquid-Liquid Extraction of Samarium (III) Wyantuti, Santhy; Nurwulanda, Salsha; Mardiah, Najmah; Anggraeni, Anni; Pratomo, Uji; Fauzia, Retna Putri; Bahti, Husein H.
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.38941

Abstract

Rare earth elements (REEs) are garnering significant attention in diverse fields due to their important and fascinating properties. Among these REEs, samarium (Sm) has numerous advantages and benefits. Before using Sm, it must be separated from its natural sources due to the formation of complex compounds with other elements. To achieve this, liquid-liquid extraction emerges as one of the REE separation methods, presenting several advantages, including a streamlined process. Various methods can be used to analyze extraction results, such as ICP-MS and XRF. In comparison, UV-Vis spectrophotometry has significant advantages compared to other methods, it provides a simple approach to determining the level of a substance, and the results given are quite accurate, while differential pulse voltammetry (DPV) is one of the electrochemical analysis methods that is expected to provide faster and accurate analysis results. This study aims to determine the value of analytical parameters, Kd of Sm(III) liquid-liquid extraction results using DPV analysis and UV-Vis spectrophotometry methods. The DPV method yielded LoD 1.24 mg/L,  accuracy 98.39%, and %recovery 106.69%. The extraction data obtained Kd Sm values ranging from 6.0019-7.3860. The UV-Vis spectrophotometry results provided an individual extraction efficiency of Sm(III) of 88.54%. This method obtained LoD 0.71 mg/L, accuracy 96.00%, and %recovery 104.00%.
Synthesis and Characterization of Magnetic Molecularly Imprinted Polymers Targeting Capsaicin Amri, Ahmad Mukhlasul; Azis, Muhammad Yudhistira; Zulfikar, Muhammad Ali
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40808

Abstract

A novel magnetic molecularly imprinted polymers (MMIPs) was developed for the adsorption of capsaicin, a key component of capsaicinoids widely used in food additives and topical pharmaceuticals. Excessive use of capsaicin can lead to respiratory, skin, and oral disorders, necessitating effective monitoring methods. This study aimed to synthesize MMIPs and magnetic molecularly non imprinted polymers (MNIPs) using 4-vinyl pyridine as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker, combined with an initiator in a 1:4:20 molar ratio. Magnetite nanoparticles (Fe3O4) were incorporated to facilitate magnetic separation. Characterization via particle size analyzer (PSA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirmed the successful synthesis of Fe3O4 nanoparticles, MNIPs, and MMIPs. PSA analysis for Fe3O4 nanoparticles showed an average size of 140.2 nm with a polydispersity index (PI) of 0.313, MMIPs showed an average particle size of 746.6 nm and a PI value of 0.397. FTIR spectra revealed characteristic absorption bands at 3429 cm−1 (O-H), 2958 cm−1 (C-H), 1732 cm−1 (C=O), 1155 cm−1 (C-O), and 580 cm−1(Fe-O), indicating successful Fe3O4 modification. SEM-EDS analysis showed non-spherical morphology due to bulk polymerization. TEM image results showed Fe₃O₄ nanoparticles were successfully coated with a molecularly imprinted polymer (MIP). The developed MMIPs effectively have a robust synthesis method and thorough analysis, laying the groundwork for future applications.
Inhibition of Human Acetylcholinesterase (4EY7) using Bioactive Compound from Moringa oleifera: Molecular Docking and Dynamic Studies Utami, Wiji; Apriyanto, Apriyanto; Antari, Laila; Rasyid, Herlina; Fitriani, Ika Nur
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.39840

Abstract

Alzheimer's disease is a neurodegenerative disorder caused by acetylcholine hydrolysis that impairs cognitive brain function. This research aims to determine the interaction and dynamic of ligands from Moringa oleifera on AChE through Lipinski's Rule, ADMET properties, molecular docking calculations, and molecular dynamic simulations. Lipinski's Rule calculation provided ligand limits that adhere to druglikeness properties. ADMET results also showed that several ligands satisfy ADMET properties. Pterygospermine has lower binding energy than the ligand control (-10.28 kcal mol-1) with amino acid residues of TYR133 and GLU202. It indicates a favorable interaction between the AChE receptor and ligand in the inhibition process. Based on molecular docking calculations, pterygospermine inhibits the AChE receptor at the Long, narrow aromatic gorge active site. According to molecular dynamic simulations, the MMPBSA energy for pterygospermine is 37.377 kJ mol-1. The samples showed a total average RMSD of 2 Å, suggesting no significant conformational changes throughout the simulation. The sample's average RMSF value is around 2 Å, suggesting favorable interactions with the receptor during simulation. However, this data is different from the ligand control interaction mode. Molecular dynamic investigations of the pterygospermine ligand in the complex revealed the stability and unfolded effect on the protein. The results of this study propose a candidate anti-Alzheimer's ligand from Moringa oleifera against the AChE receptor. In practice, these results can contribute to research studies exploring natural ingredients from plants with medicinal potential in drug discovery. These results can be validated using further research in vitro and in vivo.
Improvement of Rheological Properties of Modified Asphalt Treated with Residues of Recycled Rubber from Waste Tires and Oxidized by Air Al-Ojar, Roua’a K.; Mahmood, Mahmood E.; Marzena, Salam J.; Jabrail, Fawzi H.
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.41928

Abstract

Asphalt materials loaded with polymer additives have gained particular importance in recent years due to their close association with modification processes and the creation of a clean environment, mainly from plastic wastes in paving and other areas, and they have also caused significant improvement in asphalt properties. It was observed through the research that the rheological properties of the asphalt were improved significantly as added residues of recycled rubber (RRR) from waste tire percentages increased. The observations are apparent from the decrease in permeability of the asphalt and enhance its ductility and elongation. The study focused on modifying the rheological properties of asphalt materials using the residues of the recycled process of rubber (RRR) from waste tires (mainly carbon black, containing residues of rubber extracted from waste tires). The asphalt materials were oxidized in the open system under various conditions of temperature and oxidation time in the presence of a 0.25% (w/w) anhydrous aluminum chloride (AlCl3) catalyst. After determining the optimal conditions for the oxidation process, the added anhydrous AlCl3 catalyst was adjusted to determine its optimal ratio. The modified asphalt samples after oxidation at optimal conditions in the presence of anhydrous AlCl3 catalyst and the recycled rubber (RRR) residues were tested using appropriate measurements. The following measurements of ductility, permeability, softening point, Marshall stability and flow, aging resistance (thin film oven test (TFOT)) and the asphalt content percentages were done, and their results show that the modified asphalt exhibits completely different rheological properties from the original asphalt. The studied N19 and N20 models show availability in paving applications.
Synthesis of Antibacterial Coating Film Based on Eugenol-Allyl Eugenol Copolymer with Chitosan-Gelatin Ngadiwiyana, Ngadiwiyana; Dzahabiyyah, Hana Putri; Ismiyarto, Ismiyarto; Sarjono, Purbowatiningrum Ria
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40944

Abstract

The development of coating film materials based on biopolymers and active antibacterial compounds has attracted attention in the food industries. Food packaging biopolymers can be increased antibacterial properties by adding compound modification of natural ingredients such as eugenol-allyl eugenol copolymer (PEAE). The aims of this study were to synthesize a coating film based on chitosan-gelatin with PEAE and test its antibacterial properties. PEAE synthesis was carried out by polymelirization reaction with the (BF3O(C2H5)2) as catalyst and characterized by FTIR, molecular weight, and solubility. Synthesis of chitosan-gelatin coating films with variations in PEAE concentration of 1.25%, 2.5%, and 3.75% and characterization includes FTIR, SEM, TS, E%, and contact angle. Antibacterial activity is carried out by the turbidimetry method. PEAE was synthesized with the results in the form of brown solids with 94.91% yield, molecular weight of 9,553.98 da, and the melting point of 95-98 °C. Chitosan-Gelatin films with the addition of PEAE produce a thin yellowish film, with a sequential decreased tensile strength, and the percentage value of extension increases with the increase in PEAE concentration. The best antibacterial activity in the film PEAE 2.5, with the percentage of inhibition of Staphylococcus aureus and Escherichia coli of 99.71% and 98.39% respectively.
Synthesis, Characterization, Molecular Docking Studies and Pharmaceutical Evaluation of some Novel [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole Mekky, Athraa Hameed; Hamed, Fadil M.; Hassan, Bassam A.
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40043

Abstract

A new series of fused [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole 4a-4e have been synthesized by many steps. Firstly, benzohydrazide [1] has been synthesized from the reaction of methyl benzoate with hydrazine hydrate. Secondly, the cyclization reaction of benzohydrazide with carbon disulfide in the presence of potassium hydroxide produced 5-phenyl-1,3,4-oxadiazole-2-thiol[2]. Thirdly,5-phenyl-1,3,4-oxadiazole-2-thiol[2] was treated with potassium hydroxide using pyridine to give 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol. Finally, the fused [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole 4a-4e   were synthesized from the reaction of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol[3], with various aromatic aldehydes. The structures of the newly synthesized compounds have been confirmed based on spectral studies. The new novel compounds exhibited anticancer activity docking with C-Met tyrosin kinase receptor as shown by their docking scores ranging between -3.506 to -4.468 Kcal/mol as compared to standard crizotinib binding affinity is to -3.211Kcal/mol for anticancer efficiency. The newly synthesized triazole thiadiazole derivatives were evaluated for their in-vitro cytotoxic activity against human cancer cell lines. It was found that compounds 4b and 4c showed higher cytotoxicity against the MCF-7 cell line and no cytotoxic effect on normal cell line HdFn.
Low-Cost Adsorbent Development: Sulfuric Acid-Activated Teak Sawdust for Effective Methylene Blue Removal Baunsele, Anselmus Boy; Missa, Hildegardis; Siswanta, Dwi; Naat, Johnson N.; Neolaka, Yantus A. B.; Nitti, Fidelis; Lema, Abner Tonu; Basuki, Rahmat; Rahayu, Rahayu
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.41425

Abstract

The expansion of the global textile industry has resulted in a decline in environmental quality. Environmental pollution resulting from textile dye waste may include heavy metals and dyes, which exhibit carcinogenic and mutagenic effects. Many studies have been done to reduce the harm of dyes. Extensive research has been undertaken to mitigate the detrimental effects of dyes. One cost-effective approach for managing dye pollution is the adsorption of methylene blue using sulfuric acid-activated teak sawdust. Teak wood sawdust, a byproduct of the furniture industry that is abundant and underutilized, contains active sites within its constituent compounds, including cellulose, hemicellulose, and lignin. This study was designed to determine the ability of teak sawdust to adsorb methylene blue. In this investigation, the biosorbent will be characterized using fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and scanning electron microscopy-energy dispersive X-ray (SEM-EDX) to analyze its active sites and surface morphology. Additionally, the study aimed to elucidate the impact of variation contact time, pH solution, and alteration in methylene blue concentration on the adsorption capacity for methylene blue, employing a UV-Vis spectrophotometer for measurement. The research results demonstrated that optimal adsorption occurred at a contact time of 30 minutes and a pH of 6, with the adsorption efficiency reaching 99.67% as a function of contact time. The kinetic study was modeled using a pseudo-second-order approach, with a kinetic constant of 79.71 g mg⁻¹ min⁻¹. The maximum adsorption capacity was 1.351 mg g⁻¹, the n value was 1, and the percentage of methylene blue adsorbed reached 99.88%.
Development of a Low-Cost Reflectance Visible Spectrophotometer with Chemometrics for Curcuma xanthorrhiza Roxb. Quality Control Heryanto, Rudi; Iswantini, Dyah; Rohaeti, Eti; Rafi, Mohamad; Rahma, Novia; Hafshah, Nurul; Mardiana, Eni
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40351

Abstract

A simple, portable visible reflectance spectrophotometer was developed for classifying the quality of Curcuma xanthorrhiza Roxb. The device was assembled using consumer electronic components: an LED as the light source, a DVD optical layer as the diffraction grating, and a webcam as the detector, with web-based software (Spectral Workbench) as the signal processor. The spectrophotometer's performance was evaluated using standard Sudan III samples and powdered C. xanthorrhiza samples from two quality classes (A and B). Spectral data were analysed using principal component analysis (PCA) and partial least squares (PLS) regression.  PCA successfully grouped Sudan III samples by concentration and classified C. xanthorrhiza by curcuminoid content. A PLS regression model was developed for quantifying Sudan III, yielding R² values of 0.9909 for both calibration and cross-validation, with RMSEs of 0.3821% and 0.4152%, respectively. The results closely matched those from a commercial spectrophotometer. A PLS-discriminant analysis (PLS-DA) classification model for C. xanthorrhiza was also developed, achieving sensitivity and specificity values of 1. Additionally, semi-quantitative parameters such as decision limit (26.15% B), detection capability (41.06% B), and unreliability range (26.15–41.06% B) were calculated. The classification model showed strong sensitivity, specificity, and detection capabilities within acceptable limits. These findings suggest that this low-cost reflectance spectrophotometer, combined with chemometric methods, holds promise as a practical tool for the quality control of raw herbal materials.
Characterization and Application of Hydroxyapatite From Chicken Egg Shell with Green Template as a Potential Drug Delivery System Irwansyah, Ferli Septi; Nurizal, Abshar Fathur Rochman; Hadisantoso, Eko Prabowo; Zain, Shariffuddin Bin Md
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.41699

Abstract

Hydroxyapatite (HAp) is a calcium phosphate biomaterial widely studied in the medical field because of its good biocompatibility properties. This study aims to identify the effect of increasing variations in banana peel template concentration on the characteristics of hydroxyapatite so that it has the potential as a drug delivery system. This study includes the characterization and application of the potential of the hydroxyapatite drug delivery system with the addition of variations in the concentration of green template. Then, hydroxyapatite was characterized using X-ray diffraction (XRD) and a surface area analyzer (SAA). This study's results indicate that adding a banana peel template affects the characteristics of hydroxyapatite. The higher the template concentration, the smaller the crystallite size, pore size, pore volume, and surface area, but the degree of crystallinity is greater. The results showed that the characterization of hydroxyapatite K15% with a crystal size of 34.73 nm, a degree of crystallinity of 89%, a pore size of 7.2178 nm, a surface area of 30.111 m2/g, and a pore volume of 0.1145 cc/g. The results of the study of the potential of the drug delivery system obtained a loading efficiency value of 67% for ibuprofen. However, the ibuprofen release process results at time intervals tend to be unstable.
Modified Natural Rubber Based on the Sulphur Curing System as Rubber Compound Formulation on Basic Design of Seismic Bearing Cifriadi, Adi; Sugita, Purwantiningsih; Kemala, Tetty; Nikmatin, Siti; Puspitasari, Santi; Falaah, Asron Ferdian; Wijaya, Usman
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.39963

Abstract

Indonesia is highly susceptible to earthquakes, with the southern and western coasts of Java and Sumatra being the most vulnerable regions. Due to this vulnerability, it is necessary to establish a culture of disaster mitigation in the most fertile and heavily populated islands to reduce the number of fatalities and economic losses caused by earthquakes. One of the promising real-world seismic base isolation methods is using a rubber seismic bearing constructed of rubber and metal layers. This study aimed to examine the typical behavior of natural rubber compounds subjected to various sulfur-curing processes as basic designs in the manufacture of rubber seismic bearings. The experiment was carried out by arranging the sulfur curing system into three categories, namely an efficient which applied N-cyclohexyl-2-benzothiazole sulfonamide (CBS)/Sulfur (S) ratio as 1.4/0.15 and 1.4/0.25, semi-efficient with CBS/S ratio of 1.4/1.4 and 1.4/1.7, and conventional with CBS/S ratio of 1.4/3.0 and 1.4/3.5. The results showed that the ideal modification condition for NR macromolecule chain found in seismic-bearing rubber compound was a semi-efficient sulfur curing system with a CBS/S ratio of 1.4/1.4. It suggested that a semi-efficient sulfur curing system was appropriate for developing rubber compound formulation for seismic rubber bearings, mainly for low-damping types.

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