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All Journal Program Kreativitas Mahasiswa - Penelitian Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Jurnal Mitra Kesehatan Pharmaceutical Sciences and Research (PSR) Borobudur Pharmacy Review Journal of Research in Pharmacy and Pharmaceutical Sciences
Ariska Deffy Anggarany, Ariska Deffy
Department Of Pharmacy, STIKES Mitra Keluarga, Bekasi, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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POTENSI BIJI LABU KUNING SEBAGAI AGEN FITOESTROGEN PADA WANITA POST MENSTRUAL Lestari, Beni; Hanif, Naisbitt Iman; Anggarany, Ariska Deffy; Ziyad, Thoriq; Walidah, Ziana; Murwanti, Retno
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (756.169 KB)

Abstract

Osteoporosis and hypercholesterolemia are prevalent condition in menopausal women. The common therapy to prevent the estrogen degrading condition is Hormone Replacement Therapy (HRT). However, HRT possessed various risks. Curcubita pepo L. seed (pumpkin seed) contains lignan secoisolariciresinol and lariciresinol which exhibit estrogenic effect. The aim of this study is to determine the estrogenic effect of Ethanolic Extract of Pumpkin Seeds (EEPS) through in silico and in vivo study. In silico study were conducted by molecular docking of lignan which is secoisolariciresinol and lariciresinol with Estrogen Receptor (ERα and Erβ). In vivo study conducted by using ovariectomized Sprague dawley female rats as a model of postmenopausal women. Blood lipid profile, bone density, and uterine weight were assayed after thirty days. Molecular docking score of secoisolariciresinol and lariciresinol were similar to estradiol. In vivo study found that EEPS increase bone density and uterine weight percentage while also improve the blood profile. In conclusion, these result showed that EEPS is potential to be developed as an osteoporosis and hypercholesterolemia prevention agent. Keywords:  Lime peel, Limonene, Aromatic candles, Repellent
The Effect of Heparinoid as Systemic Prophylactic Anticoagulants on COVID-19 Patient Mortality and Its Safety Profiles: A Systematic Review and Meta-Analysis Anggarany, Ariska Deffy; Sauriasari, Rani; Alkaff, Muhammad; Takhwifa, Famila; Nufus, Hayatun; Paramita, Diana
Pharmaceutical Sciences and Research Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Coagulopathy is one of the complications of COVID-19 and is associated with a higher risk of mortality. However, evidence regarding the effectiveness and safety of anticoagulant therapy in various doses among COVID-19 patients is limited. This systematic review and meta-analysis aims to review and explore the effect of using heparinoids as a systemic anticoagulant at prophylactic doses on mortality in COVID-19 patients. Systematic searches were conducted of various databases (Pubmed, ScienceDirect, SpringerLink, Scopus, and ProQuest) covering the period 2019-2021. We assessed the quality of the articles using the STROBE checklist. Studies with a high risk of bias were excluded before pooled effect size was synthesized with 95% confidence intervals (CI) using random-effects models. From the 12 identified studies (N=8,968), six observational studies (N=7,176) were involved in the meta-analysis. The studies reviewed in the paper used a retrospective cohort design in various settings. The pooled effect size of mortality comparing prophylactic anticoagulant and no anticoagulant in three studies showed that there was an association between using prophylactic anticoagulant and a lower risk of in-hospital mortality (pooled OR= 0.47; 95% CI 0.19-0.76). A prophylactic dose of heparinoid anticoagulant was also associated with lower mortality (pooled OR= 0.51; 95% CI 0.21-0.82) and with lower bleeding events compared to intermediate-to-therapeutic dose anticoagulants. Administration of heparinoid anticoagulants at prophylactic doses was associated with reduced mortality risk in hospitalized COVID-19 patients. Due to the increased risk of bleeding with therapeutic doses, the use of prophylaxis anticoagulant is suggested in COVID-19 patients who are not critically ill.
POTENSI ANTIOKSIDAN INFUSA BUNGA TELANG (Clitoria ternatea), ROSELLA (Hibiscus sabdariffa) DAN DAUN STEVIA (Stevia rebaudiana) SEBAGAI ANTIDIABETES Melania Perwitasari; Sinta Nuriyah Awaliyah; Intan Kurnia Putri; Nofria Rizki Amalia Harahap; Ariska Deffy Anggarany; Reza Anindita; Maya Uzia Beandrade; Dede Dwi Nathalia
Jurnal Mitra Kesehatan Vol. 5 No. 2 (2023): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v5i2.194

Abstract

Reactive Oxygen Species (ROS) can induce oxidation that caused aging and degenerative diseases such as Diabetic Mellitus. To prevent the incident of degenerative disease, antioxidant needed that found in many herbs, especially colored herbs. Butterfly pea, Rosella flower, and Stevia leaf known as herbs contains phenolic and flavonoid. This constituent are responsible as antioxidant activity. Many people consume the herbs by brewing with hot water as infused water. The purpose of this research is to determine antioxidant activity of infused Butterfly pea, Rosella flower, and Stevia leaf by FRAP method. This is non experiment method descriptive with dry herbs of Butterfly pea, Rosella flower, and Stevia leaf infused extract as sample. The research was conducted in September 2022-February 2023 at STIKes Mitra Keluarga Laboratory. The antioxidant activity is expressed as % FRAP activity. Based on the experiment, it knows that % FRAP activity of Butterfly pea, Rosella flower, and Stevia leaf consecutive 55,29% ± 0,0, 69,17% ± 0,12 , 61,55% ± 0,04.
Red onion (Allium ascalonicum L.) skin as an antibacterial on the growth of Staphylococcus aureus Reza Anindita; Elva Dwi Pamungkas; Maulin Inggraini; Melania Perwitasari; Maya Uzia Beandrade; Intan Kurnia Putri; Dede Dwi Nathalia; Nofria Rizki Amalia Harahap; Ariska Deffy Anggarany
Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Vol 8 No 02 (2023): Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Publisher : Biology Education Department, IKIP Budi Utomo, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33503/ebio.v8i02.2558

Abstract

The main bacteria that cause infection in humans is Staphylococcus aureus. Efforts to prevent infectious diseases caused by bacteria can be made by using plant parts that have medicinal potential. One part of the plant that needs to be explored for its potential is the skin of shallot bulbs (Allium ascalonicum L.). This research aimed to determine the effect of red onion skin extract on the growth of S. aureus bacteria. The research design is experimental. The samples in this study were 1 kg of red onion skin and a bacterial sub-culture of S. aureus ATCC: 25923. Extraction was carried out using the maceration method using 96% ethanol solvent and evaporated using a rotary evaporator and water bath. The antibacterial test was carried out by administering 30 µg chloramphenicol (positive control), sterile distilled water (negative control), and red onion skin extract with concentrations of 60%, 65%, 70%, and 75% with 3 repetitions. All treatments were given to S. aureus at 30 µL each using the Kirby-Baeur method. The research instrument was an observation sheet of the diameter of the inhibition zone. Data analysis used One-Way ANOVA. The results of this study show that ethanol extract of red onion skin with concentrations of 60%, 65%, 70%, and 75% was able to produce S. aureus inhibition zone diameters of 3.5 mm, 4 mm, 4.2 mm, and 4.3 mm. The results of the One-Way ANOVA test showed a significance value of 0.15 (sig>0.05), not proven to be able to significantly inhibit the growth of S. aureus. The conclusion shows that red onion skin extract as an antibacterial is not able to significantly inhibit the growth of S. aureus.
Aktivitas farmakologi dan fitokimia ekstrak Moringa oleifera lam. terhadap sistem reproduksi pria dan wanita: scoping review Anggarany, Ariska Deffy
Borobudur Pharmacy Review Vol 5 No 1 (2025): January- June
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v5i1.13889

Abstract

Reproductive health is an important part of life continuity. Moringa oleifera plant is reported to have benefits on growth and reproduction that have been tested on animals, such as steroid alkaloids, alkaloid-pyricine, pyrrolidine, phenolics, steroid glycosides, saponins and triterpenoids. This study aims to demonstrate the pharmacological activity of Moringa oleifera Lam. extract as an antifertility agent in the male and female reproductive systems. This study assessed the phytochemical compounds and antifertility effects of moringa on reproductive parameters in both men and women. This study was conducted through a literature study based on an online database search by combining Boolean search terms (“AND”, “OR”) in the electronic databases PubMed, ScienceDirect and Google Scholar. There were 15 articles that met the inclusion and exclusion criteria of the study. Several phytochemical compounds such as tannins, alkaloids, phenols, flavonoids, saponins and anthraquinones were reported in extracts of both flowers, stems, seeds and leaves of the moringa plant. The effects of these compounds have the potential to improve sperm quality, increase testosterone production in men, and affect hormone levels and estrus cycles in female reproduction. These findings support the role of Moringa oleifera as an antifertility agent in various reproductive parameters in both men and women.
MICROBIAL CONTAMINATION TEST USING THE MOST PROBABLE NUMBER (MPN) METHOD ON SWEET SOY SAUCE AROUND UPN “VETERAN” JAKARTA PONDOK LABU CAMPUS MICROBIAL CONTAMINATION TEST USING THE MOST PROBABLE NUMBER (MPN) METHOD ON SWEET SOY SAUCE AROUND UPN “VETERAN” JAKARTA PONDOK LABU CAMPUS Anggarany, Ariska Deffy; Prasasti, Alisha Dian; Karlina, Amara Ayu; Ningrum, Anisa Puja; Iteh, Aurelie Reginia; Seno, Bimo Asrul; Zahara, Nabilah Siti
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 2 (2024): Vol.3 No.2 DECEMBER (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i2.10997

Abstract

Sweet soy sauce is a fermented soybean product widely used as a traditional Indonesian seasoning. Its production process involves specific microorganisms to develop unique taste, aroma, and texture characteristics. However, poor hygiene and sanitation can lead to microbial contamination, such as Coliform, which may degrade quality and pose health risks. This study aimed to evaluate the microbiological quality of sweet soy sauce using the Most Probable Number (MPN) method. Samples were collected from food vendors around the UPN "Veteran" Jakarta campus and tested using liquid media to detect the presence of Coliform. The results showed that sample 1 (street vendor) had an MPN value of 14 MPN/gram, exceeding the BPOM safety limit (3 MPN/gram), while sample 2 (packaged soy sauce from a minimarket) was within the safety limit at 3 MPN/gram. A confirmatory test detected the presence of Escherichia coli in sample 1 but not in sample 2. Proper product handling, implementation of Good Manufacturing Practices (GMP), and regular microbiological monitoring are necessary to ensure the safety of sweet soy sauce products.
Co-Authors Beni Lestari Dede Dwi Nathalia Elva Dwi Pamungkas Hayatun Nufus Intan Kurnia Putri Intan Kurnia Putri Iteh, Aurelie Reginia Karlina, Amara Ayu Maulin Inggraini Maya Uzia Beandrade Maya Uzia Beandrade Melania Perwitasari Melania Perwitasari Muhammad Alkaff Naisbitt Iman Hanif, Naisbitt Iman Nathalia, Dede Dwi Ningrum, Anisa Puja Nofria Rizki Amalia Harahap Paramita, Diana Prasasti, Alisha Dian Rani Sauriasari, Rani Retno Murwanti Reza Anindita Anindita Seno, Bimo Asrul Sinta Nuriyah Awaliyah Takhwifa, Famila Thoriq Ziyad, Thoriq Zahara, Nabilah Siti Ziana Walidah, Ziana