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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 299 Documents
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KEJADIAN IKUTAN NEUROLOGIS PADA TENAGA KESEHATAN RUMAH SAKIT RUJUKAN COVID-19 PASCA VAKSINASI MRNA-1273 BOOSTER Rakhmad Hidayat; Muhammad Hafiz Aini; Zlatikha Djuliannisaa; Alyssa Putri Mustika; Mohammad Kurniawan; Taufik Mesiano; Al rasyid; Salim Harris
NEURONA Vol 38 No 4 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Vaccine effectivity to decrease COVID-19 transmission has been proven by the decrease in hospitality rate and death rate caused by COVID-19. Nowadays, Indonesian health workers are fully vaccinated for more than six months. The government want to give mRNA-1273 (Moderna) vaccine as the third vaccine dose booster for health workers. The booster’s effect remains unknown, but there are some vaccine side effects. Aim: To know the neurological side effects of the Moderna vaccine that are still unknown and not yet studied in Indonesia. Methods: This study used a prospective cohort with the primary data collected through an online form filled by health workers of Universitas Indonesia Hospital that get Moderna vaccine as a booster. Research data analysis will be carried out through a comparative study through the chi-square method using SPSS 20. Results: The previous history of adverse events following immunization (AEFI) significantly affects the type, the severity degree, and the acceptance of AEFI after the Moderna vaccine booster. BMI and regular medication affect the severity degree of AEFI (P<0.05). Regular medication insignificantly increases the possibility of no side effects. Meanwhile, the use of antipyretic medication for AEFI in????uenced the history of previous AEFI (P<0.05). Discussion: AEFI is any untoward medical occurrence that follows immunisation and does not necessarily have a causal relationship with the usage of the vaccine. Further investigation is necessary to evaluate the correlation between those factors and the AEFI of the Moderna booster vaccine. Keywords: COVID-19, health workers, Moderna vaccine, vaccine side effects
Tinjauan Pustaka AKURASI PEMERIKSAAN LFA CRYPTOCOCCAL ANTIGEN SERUM DIBANDINGKAN DENGAN KULTUR DALAM PENEGAKAN DIAGNOSIS MENINGITIS KRIPTOKOKUS Dimas Seto Prasetyo; Janice Tandraeline; Maria Astika Dewi; Nadia Maretti
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.275

Abstract

Cryptococcosis is an infection caused by Cryptococcus, with the main pathogen is Cryptococcus neoformans. This mainly infects immunocompromised patient, e.g people living with HIV/AIDS. The gold standard for diagnosis is culturing from cerebrospinal fluid but this technique is time-consuming. Besides that, few centers have resources (e.g neurologist) to perform lumbar puncture and patients may have certain contraindication for lumbar puncture, e.g elevated intracranial pressure. There will be a need of simple and less invasive diagnostic method, such as cryptococcal antigen detection using lateral flow assay. The objective of this evidence-based case report is to compare the cryptococcal antigen lateral flow assay from serum in establishing cryptococcal meningitis with conventional culture method from cerebrospinal fluid. Method: Article searching was conducted in Pubmed database (MEDLINE), Embase, and Wiley Online Library. Article screening was done by 3 researcher, using inclusion and exclusion criteria, and examination of article completeness. The full article was also examined for answering the clinical question. Result: From the literature research, we found 2 articles from the database and 1 systematic review from Googlescholar which fulfilled eligibility criteria. The 2 articles were already included in the systematic review so the critical review was only conducted to the systematic review article. The report showed that the cryptococcal antigen detection using lateral flow assay from serum yielded a relatively high sensitivity and specificity (97,9% and 89,5% respectively) Conclusion: The accuracy of cryptococcal antigen detection from serum using LFA in establishing cryptococcal meningitis in HIV patient was comparable to conventional cerebrospinal fluid culture. Keywords: cyrptococcal meningitis, lateral flow assay
FAKTOR-FAKTOR YANG BERPENGARUH PADA PROGNOSIS PASIEN TUMOR OTAK METASTASIS DI RSUD SAIFUL ANWAR MALANG Dotti Inggrianita; Dessika Rahmawati; Rodhiyan Rakhmatiar; Nuretha Hevy Purwaningtyas
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.276

Abstract

ABSTRACT Introduction: Metastatic brain tumor is a critical period for the spread of malignancy originating from other organs. This type of tumor is the most common intracranial tumor. Prognosis for metastatic brain tumors is poor. Karnofsky Performance scale is an assessment of performance status which can be used to know prognosis of patients with brain tumors. Aim To determine the factors that influence the prognosis of metastatic brain tumor patients in Saiful Anwar General Hospital. Methods: The design of this study was cross sectional retrospective. Data were taken based on patient’s characteristics, clinical, radiological factors, primary tumor type and comorbidities from Neurooncology register data in RSUD dr. Saiful Anwar Malang during January 2017 to December 2020. The data were presented in descriptive and analytic using multivariate logistic regression. Result: There were 71 subjects with metastatic brain tumors and had the same proportion of males and females. Based on the assessed factors, there were two variables that significantly correlated. Age <60 years had a correlation with Karnofsky Performance Scale <60 (p: 0.012) (OR: 0.076). Decreased consciousness had a significant correlation with poor prognosis, that is Karnofsky Performance Scale <60 (p: 0.021) (OR: 13.851). Discussions: Factors affected prognosis of metastatic brain tumor in saiful anwar general hospital malang Age < 60 years and altered mental state affect prognosis of patients with metastatic brain tumor in Saiful Anwar General Hospital. Age < 60 years is a good prognosis while decreased of consciousness shows the poor prognosis. Keywords: Karnofsky performance scale, metastatic brain tumor, prognosis.
Gambaran Status Gizi Penderita Tumor Otak Primer dan Metastasis serta Faktor-faktor yang Memengaruhinya Aninditha, Tiara; Tanjung, Gloria; Andayani, Diyah Eka; Aman, Renindra Ananda; Estiasari, Riwanti; Yanuar, Ahmad; Sofyan, Henry Riyanto
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.280

Abstract

Introduction: According to the pathophysiology, weight loss is a specific marker for suspected malignancy. However, this is rarely found in cases of brain tumors. The presence of the blood brain barrier is thought to play a role in differentiating nutritional status in primary and metastatic brain tumors. Therefore, it is necessary to do this research. Aim: Knowing the description, prevalence, differences in nutritional status of patients with primary and secondary brain tumors, and the affecting factors. Methods: Cross-sectional study in patients with primary and secondary brain tumors at Cipto Mangunkusumo General Hospital in 2017-2019. Malnutrition was diagnosed using the GLIM (Global Leadership Initiative on Malnutrition) criteria. Data analysis used Chi-Square/Fisher and multivariate logistic regression. There were 333 subjects: 246 primary and 87 secondary brain tumors. Description of nutritional status of patients with primary brain tumors: 47.6% obese; 6.1% malnutrition; the rest were normal, while in secondary brain tumors: 25.3% were malnourished; 24.1% obese; the rest is normal. Secondary brain tumor at risk of malnutrition with RR 1.257 (95% KI 1.108-1.426), p<0.001. Factors influencing malnutrition were the type of primary/secondary brain tumor, gender, age, decreased consciousness, anorexia, gastrointestinal complaints, intraaxial lesions, multiple lesions, and the location of the lesions involving the frontal lobes. The independently related factor was multiple lesions with an aOR of 3,423 (95% KI 1.124-10.426), p 0.03. Conclusion: The nutritional status of patients with primary and secondary brain tumors was different, with higher levels of malnutrition in secondary brain tumors and higher obesity in primary brain tumors. The number of multiple lesions in the brain affects the occurrence of malnutrition.
FAKTOR –FAKTOR YANG BERHUBUNGAN DENGAN LAMA PERAWATAN RAWAT INAP PASIEN STROKE DI RUMAH SAKIT ATMA JAYA Kezia Nathania Limbong Allo; Budi Riyanto Wreksoatmodjo; Poppy Sasmita
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.284

Abstract

ABSTRACT Introduction:Stroke patients require a comprehensive treatment at the hospital. At the other hand, length of hospitalization is related to the cost of health care and risk of complication. By understanding more about the contributing factors of length of hospitalization, stroke units candevelop better interventions to reduce prolonged hospitalization and toprevent complications during hospital stay. Aims:This study aims to determine the association between demographic characteristics, comorbidities, complications, type of stroke, severity of stroke, and level of consciousness with length of hospitalization among stroke patients in Atma Jaya Hospital. Method:This cross-sectional study was performed on 254 eligible stroke patients in Atma Jaya Hospital during 2014-2019. Assessment of variables based on secondary data from stroke registry.. Prolonged hospitalization was defined as >7 days. Data analysis was performed using Fisher-exact test, Breslow-Day test, Mantel-Haenzel test, and logistic regression test. Result: From a total of 254 respondents, 65 (25.6%) have a prolonged length of hospitalization. Analysis showed that complications, type of stroke, severity of stroke and level consciousness had a significant association with length of hospitalization. The most influential risk factor on prolonged hospitalization was type of stroke, complication and severity of stroke,. Conclusion: There is a significant relationship between complications, type of stroke, severity of stroke, and level of consciousness with length of hospitalization. Hemorrhagic stroke, patient with severe stroke and complication are the dominant factors for prolonged length of hospitalization in stroke patient.
Luaran Pendekatan Operasi Mikroskopis dan Endoskopik pada Pasien Kraniofaringioma di RSUPN Dr. Cipto Mangunkusumo Ashari, Samsul; Saekhu, Mohamad; Tandian, David; Ray, Laode Maly; Nugroho, Setyo Widi
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 4 (2023): Vol 39 No 4 (2023)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i4.286

Abstract

ABSTRACTIntroduction: Advances in neurosurgery technology are rising quickly. The Neurosurgery Department RSCM is currently developing minimally invasive surgical technique using transcranial endoscopy. This minimally invasive procedure have been carried out to date. However, the patient's outcome after surgery is not yet known.Aim: Acknowledging the outcome of microscopic and endoscopic surgical approaches in craniopharyngioma patients at dr. Cipto Mangunkusumo Hospital.Methods: This was a retrospective cohort study of craniopharyngioma patients who underwent either endoscopic or microscopic surgery. This study used a consecutive sampling technique, using samples from 2012 to 2021 at Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. The inclusion criteria were craniopharyngioma patients who were admitted to the hospital for craniotomy tumor removal procedure with an endoscopic or microscopic approach, never had surgery, had diagnosis of craniopharyngioma confirmed by clinical findings and supporting investigation. Exclusion criteria were patients with extracranial problems and endoscopic patients with extensive craniotomy. Demographic data such as age, gender, tumor location, consistency, anatomical pathology results, and history of radiotherapy were recorded. Clinical outcomes were pre- and postoperative complaints, intraoperative bleeding, postoperative complications, and recurrence. Resectability is the size of the tumor pre- and 1-month after surgery. The data were analyzed using SPSS 25.0.Results: Thirty patients were enrolled in this study. A total of 22 subjects (73%) underwent microscopic surgery and 8 subjects (27%) underwent endoscopic surgery. Intraoperative bleeding was found to be significantly smaller on the endoscopic approach than on the microscopic approach (p=0.002). The operation time of endoscopic approach was significantly shorter than microscopic approach (p=0.002). There was no significant difference in pre- and postoperative complaints, postoperative complications, recurrence, resectability and duration of hospitalization in the endoscopic approach compared to the microscopic approach in the management of craniopharyngioma patients.Conclusion: Transcranial endoscopic approach in craniopharyngioma patients has good potential as an option for surgical management of craniopharyngioma patients.Keywords: Craniopharyngioma, Transcranial Endoscopy, Microscopy
ENSEFALOPATI PADA COVID-19 DENGAN MANIFESTASI GANGGUAN PERILAKU DAN KOGNITIF Reza Stevano; Rocksy Fransisca V Situmeang; Evlyne E Suryawijaya
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.309

Abstract

Neurological manifestations of COVID-19 are wide and varied. We report a case of COVID-19-associated encephalopathy with manifestations of behavioral and cognitive changes, seizures, and altered consciousness, in a 47-year-old male previously diagnosed with COVID-19 two weeks prior. Upon physical examination, the patient was found to be agitated and disoriented. The neurological exam was nonfocal. Laboratory tests and a noncontrast head CT revealed normal results, while the nasopharyngeal swab polymerase chain reaction (PCR) was positive. Cerebrospinal fluid (CSF) studies were significant for elevated protein (0.54g/L) with a normal cell and glucose count, and CSF PCR were negative for presence of SARS-CoV-2. The patient received therapy with remdesivir, dexamethasone, heparin, antibiotics, and phenytoin, and was admitted for 8 days with marked improvement. Three weeks later, tests for cognitive function were performed and showed mild deficits in attention and short-term memory. Encephalopathy in COVID-19 can manifest as altered consciousness, seizure, behavioral and cognitive changes. It can emerge even without the presence of known risk factors and occur after the initial acute phase of SARS-CoV-2 infection, which might be due to a persistent immune response as a result of the presence of trace amounts of virus.
EKSTENSI DAN INVASI INTRAKRANIAL TUMOR KULIT KEPALA: TANTANGAN DIAGNOSIS DAN TATALAKSANA Sophie Yolanda; Tiara Aninditha; Henry Riyanto Sofyan; Rahmad Mulyadi
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.312

Abstract

Scalp tumors are quite rare, only 1-2% are malignant and have a tendency for intracranial extension and invasion. This extension can lead to various neurological complications, such as cancer pain, increased intracranial pressure (ICP), and other neurological deficits. A 37-year-old woman presented with decreased consciousness since 2 days earlier. The patient had a history of lump on the top of her head since 4 years, repeated 3 times after resection without previous treatment. On the third recurrence, the tumor was enlarged until it some part of the tumor can be seen depressed against the skull and this part was painful. The pain worsened throughout the entire head accompanied by visual field disturbance of right inferior homonymous quadranopia, right central facial nerve paresis, and right hemiparesis. Contrast head CT scan revealed lobulated heterogeneous lesion in the parietooccipital region, extending to the extraaxial and intracerebral, accompanied by vasogenic edema with destruction of the parietal and occipital bones. The result of histopathology is trichilemmal carcinoma. The patient received morphine drip therapy 10mg/24 hours for the cancer pain, which was then replaced with its patch equivalent dose, dexamethasone 2x10mg IV tapering off gradually according to the clinical condition, gabapentin 2x300mg, and wholebrain radiotherapy (WBRT) 30 Gy in 10 sessions. The patient was discharged in conscious condition and her pain resolved to mild pain. Keywords: cancer pain, increased intracranial pressure, intracranial invasion, scalp tumor
VERBAL FLUENCY SEBAGAI DOMAIN KOGNITIF YANG PALING MEMENGARUHI AKTIVITAS FUNGSIONAL LANSIA DI PULAU JAWA Pricilya H. Wangi; Yvonne Suzy Handajani; Yuda Turana
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.313

Abstract

Introduction: The prevalence of cognitive impairment and functional disability increases with age. Decreases in cognitive subdomains increase the risk of functional disability in the elderly. Aim: Obtain an overview of the ability of the elderly in carrying out functional activities as well as risk factors, especially cognitive disorders in the elderly community on the island of Java. Method: A cross-sectional study using secondary data from the 2014-2015 Indonesian Family Live Survey (IFLS-5) was conducted on respondents aged 60 years or older. Impaired cognitive function was assessed using the Telephone Survey of Cognitive Status (TICS) method. There are several cognitive domains in the TICS with a total score of 0-34, with the possibility of experiencing global cognitive impairment if the score is ≤13. Verbal fluency is said to be impaired with a value of <16. Elderly independence was assessed using the Instrumental Activity of Daily Living (IADL). Result: Obtained 1688 respondents, mostly aged 60-74 years (88.7%), women (54.3%), with less than nine years of education (72.8%), and living in urban areas (58.4%). A total of 26.7% of respondents experienced global cognitive impairment, 73.6% of respondents with impaired verbal fluency, and 28.6% needed assistance doing IADL. The analysis result shows a relationship between several domains of cognitive function and IADL in the elderly on the island of Java. Discussion: Based on multivariate analysis, the most influencing factor for IADL was age, while the cognitive domain that most influenced IADL was verbal fluency. Respondents over 75 years old and impaired verbal fluency were 2,2 and 1,7 times, respectively, at greater risk of developing IADL dependence. Keywords: Cognitive, elderly, instrumental activity of daily living, verbal fluency.
Hubungan Aktivitas Fisik Dengan Nyeri Punggung Bawah Saat Pandemi Covid-19 Pada Mahasiswa fakultas Kedokteran Clara Stephanie Paul; Jimmy Fransisco Abadinta Barus; Ecie Budiyanti; Linda Suryakusuma
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.315

Abstract

Introduction: COVID-19 pandemic changes lifestyle in society, one of the most obvious changes is physical activity. Physical activity has been known as one of risk factors of low back pain. Aims: To determine the relationship between physical activity and complaints of low back pain during COVID-19 pandemic among students at Faculty of Medicine and Health Science Atma Jaya Catholic University. Methods: A cross-sectional study was conducted in February until March 2021 with the studied respondents were preclinic students of Faculty of Medicine and Health Science Atma Jaya Catholic University. Data were obtained through questionnaires by online with Google Forms. Data were analyzed using Chi-Square test with significant level was set at 0,05. Results: Among 109 respondents, 52,3% medical students had moderate physical activity intensity and 27,5% had low back pain complaints. Bivariate analysis found no association between physical activity and complaints of low back pain during COVID-19 pandemic among medical students (p = 0,547). Discussion: There was no significant association between physical activity and complaints of low back pain. However, it was found that the tendency of low back pain was experienced by students who showed decrease in physical activity during the COVID-19 pandemic. Keywords: physical activity, low back pain, COVID-19 pandemic, medical student

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