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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 299 Documents
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PENGARUH VARIASI SNP TERHADAP RISIKO KEJADIAN MENINGIOMA: SEBUAH TELAAH SISTEMATIS DAN META ANALISIS Elvan Wiyarta
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.316

Abstract

Meningiomas are the most common type of extraaxial intracranial neoplasm. Along with the development of genomics, several studies have begun to examine the association of meningioma occurrence with the presence of single-nucleotide polymorphisms (SNPs). This study aims to examine the relationship between SNP and the risk of meningioma. Literature searches were carried out on various databases which were then collected, reviewed, and assessed for eligibility criteria. From the search results, obtained 7 studies to be analyzed statistically. The results of grouping these studies showed that 3 SNPs (rs1801133, rs1805087, and rs4968451) in 3 genes (MTHFR, MTR, and BRIP1) were associated with meningioma risk. Of the 3 SNPs, only rs1801133 aa had a significant association with meningioma risk (pooled OR [95%CI]: 2.32 [1.34-4.02]). This shows that mutations in the MTHFR gene in the SNP rs1801133 in both alleles (aa) cause a person to have a 2.32 times greater risk of developing meningioma than people who do not have this SNP. Keyword: meningiomas; SNPs; genome-wide association study; risk factors; bioinformatics
DERMATOMIOSITIS: DERMATOMYOSITIS ANDRE ANDRE
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.319

Abstract

Dermatomyositis is a rare idiopathic inflammatory myopathy disease. Inflammation in dermatomyositis causes muscle and skin damage. In this case report, a 42-year-old woman was diagnosed as dermatomyositis showing main symptoms of progressive weakness in both arms and legs, also rash on the skin. The diagnosis of dermatomyositis was made based on the criteria of the 239th European Neuromuscular Centre (ENMC) International Workshop 2018. The patient was given steroid and steroid-sparing agent as her primary management. Keywords: dermatomyositis, myopathy, rash, skin
LUARAN PASIEN STROKE ISKEMIK AKUT DENGAN INFEKSI COVID-19 DI JAKARTA Wiwit Ida Chahyani; Murni Sri Hastuti; Malika Malika; Izati Rahmi; Maria Regina Rachmawati; Anwar Wardy Warongan (alm); Siti Airiza Ahmad
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.326

Abstract

ABSTRACT Introduction: Ischemic stroke is a life-threatening neurological complication of coronavirus disease 19 (COVID-19). Research on the outcome of acute ischemic stroke patients with COVID-19 infection in Indonesia has not been widely reported. Aims: We investigated the outcome of acute ischemic stroke patients with COVID-19 infection and the factors that affect these outcomes at the Pasar Minggu Regional General Hospital, which is a special COVID-19 referral hospital in Jakarta, Indonesia. Methods: This was a cross sectional study based on the medical records of acute ischemic stroke patients with laboratory-confirmed COVID-19 infection of those ≥18 years of age, who were hospitalized at the Pasar Minggu Regional General Hospital between March 2020 and June 2021. Chi-squared test and unpaired t-test were used for statistical analyses. Results: Thirty-six patients were included in the study. The majority were ≥50 years old (69.4%), comprising of 58.3% women, and 52.8% revealed National Institute of Health Stroke Scale (NIHSS) score of ≤5. The mortality rate of acute ischemic stroke patients with COVID-19 infection was 16.7%, and in the survivors, the median modified Rankin scale score at discharge was 2(1–5). There was a significant association between the severity of COVID-19 and mortality in acute ischemic stroke patients infected with COVID-19 (P=0.019; Odds ratio 1.5 [95% confidence interval 1.08-2.08]). Discussion: The mortality of acute ischemic stroke patients with COVID-19 infection was high, and the factor of significant influence was COVID-19 disease severity. The majority of acute ischemic stroke patients with COVID-19 who survived had mild disabilities.Keywords: COVID-19, ischemic stroke, outcome.
Arteritis Takayasu Wira Pratama Yasa, Anak Agung Gede; Lina Kamelia, Luh Putu; Lestari, Made Widya
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.328

Abstract

Takayasu Arteritis is a rare autoimmune rheumatic disease that causes chronic granulomatous vasculitis of the large arteries such as the aorta and its branches. The disease is often associated with stroke at young age. The mortality and morbidity rates in young age patients are quite significant. The ability to recognize the disease are based on etiopathology, clinical classification, and diagnostic support. Those are crucial to establish a proper treatment and maintain an adequate prognosis. Takayasu's arteritis remains a challenge because diagnosis is often delayed and there is currently no sensitive and specific gold standard for monitoring inflammatory disease.
Manifestasi Klinis dan Neuroimaging pada Reversible Cerebral Vasoconstriction Syndrome (RCVS) Narithya Julieta, Ni Putu; Pradipta, I Putu Bayu Surya; Kamelia, Luh Putu Lina
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 4 (2023): Vol 39 No 4 (2023)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i4.332

Abstract

Reversible cerebral vasoconstriction syndrome (RCVS) is a headache with normal cerebrospinal fluid findings, and the angiography shows vasoconstriction with or without focal neurological signs. RCVS will improve spontaneously in 3 months. This condition is more common in women, especially in middle age, but is often underdiagnosed. RCVS has a good prognosis with low recurrence, but complications rarely happen that cause sequelae in patients. Diagnosis is based on clinical symptoms, diagnostic criteria, and radiological features of the patient's cerebral vasculature. Cerebral angiography (DSA) has become the gold standard for RCVS examination. For now, there is no effective therapy in RCVS. Complications that often arise are subarachnoid hemorrhage and ischemic stroke.
PENDEKATAN DIAGNOSIS DAN MANAJEMEN CHOREA PADA KONDISI HIPERGLIKEMIA HIPEROSMOLAR NON KETOTIK: LAPORAN KASUS Valentina Tjandra Dewi; Sri Yenni Trisnawati; Dewa Putu Gde Purwa Samatra
NEURONA Vol 39 No 1 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i1.333

Abstract

Abstract Introduction: Chorea can be classified based on its etiology as primary and secondary chorea. Primary chorea is idiopathic/genetic, while secondary chorea is associated with infections, metabolic, endocrine, and immune disorders, or drug-induced. One of the metabolic disorders that can manifest as chorea is hyperglycemic state, which is commonly found in people with uncontrolled diabetes mellitus. Case Report: A 70-year-old man came to the emergency room with involuntary and irregular movements which appeared like dancing movements along his left upper limb. The patient had a history of uncontrolled type-2 diabetes mellitus (DM) and it was known that the blood glucose result on admission was 926 mg / dL and HbA1C 15.4%. Blood glucose regulation was carried out by the endocrinology department with rehydration and administering intravenous rapid acting insulin infusion, later on, the chorea symptoms disappeared within 24 hours after glycemic control and adding of dopamine antagonist drug. Discussion: Hyperglycemia can impair perfusion of the contralateral striatum and disrupt Gamma Amino Butyric Acid (GABA) resulting in excessive inhibition of the subthalamic nucleus and hyperexcitation of the thalamocortical system. When diagnosing chorea, a comprehensive evaluation of patient history, neurological examination, laboratory tests, and imaging are essential. Management of chorea relies on the identification of underlying etiology. Conclusion: Most cases of chorea or hemichorea induced by non-ketotic hyperglycemia have a good prognosis. Blood glucose regulation is the mainstay of therapy, while dopamine receptor antagonist drugs are sometimes required in cases where symptoms are not fully improved. Keywords: chorea, non ketotic hyperglycemia, involuntary movements
Tuli Sensorineural Pasca Meningitis Streptococcus Suis: Sebuah Topik Kajian Strategis Bidang Ilmu Neuroinfeksi Sudewi, AA Raka; Pramitasuri, Tjokorda Istri; Susilawathi, Ni Made; Adi Tarini, Ni Made; Mahardika, I Gusti Ngurah Kade; Sukrama, I Dewa Made
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.341

Abstract

Sensorineural deafness as a result of Streptococcus suis (S. suis) meningitis is a serious hazard to worldwide public health and one of the strategic study concerns in neuroscience. There is currently no treatment plan for sensorineural deafness brought on by S. suis meningitis that can significantly enhance quality of life. Controlling S. suis meningitis-related sensorineural deafness is therefore vital for the area of neurology. This review of the literature seeks to provide an overview of the scientific literature on the epidemiology, etiology, and features of deafness as they pertain to sensorineural hearing loss brought on by S. suis meningitis. Spiral Ganglion Neurons, hair cells in the cochlea, and brain-derived neurotrophic factor in the peripheral auditory system interact with one another in the etiology of sensorineural deafness, according to recent studies.
PERAN KETEBALAN TUNIKA INTIMA MEDIA KAROTIS TERHADAP FUNGSI KOGNITIF PADA WANITA MENOPAUSE Mulia Rahmansyah; Nany Hairunisa; Yudhisman Imran; Pramesti Indri Miranti; Irmiya Rachmiyani; Cylla Revata
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.342

Abstract

Menopause is one of the most important physiological stages in a woman's life; it is a complex process involving the endocrine system and regulating neurological functions. Increasing age is associated with decreased cognitive function. Low estrogen levels after menopause accelerate the process of cognitive decline, and Estrogen plays an important role in vasodilating and anti-inflammatory functions and plays a protective function in the prevalence of Coronary Artery Disease (CAD). Subclinical atherosclerosis is a potential risk factor for impaired cognitive function and dementia in the elderly. The decrease in cerebral blood flow (CBF) due to turbulence that occurs in the sclerotic area and accelerated brain atrophy due to reduced blood supply is evidenced by the results of research that patients who do not clinically show cerebrovascular disease can experience decreased cognitive function due to severe stenosis of the carotid arteries. Assessment of carotid intimal–medial thickness (cIMT) is a non-invasive test to measure atherosclerosis and is widely used to screen for risk factors for cerebrovascular disease. CIMT was measured using ultrasound as a marker of atherosclerosis. CIMT can directly provide an image of blood vessels, allowing for assessing atherosclerosis rather than vessel lumen. Decreased cognitive function has a significant relationship with carotid artery stenosis so CIMT can be used as a predictor of cognitive decline in the elderly, especially in postmenopausal women. Various existing studies confirm a significant relationship between cIMT thickening and cognitive decline. Keywords :Carotid Intima – Media Thickness (CIMT), Cognitive Function, Menopause
ABSES OTAK ASPERGILUS PADA PASIEN IMUNOKOMPETEN : SEBUAH LAPORAN KASUS JARANG Maria Gabriella Sainlia
NEURONA Vol 39 No 2 (2022): Vol 39 No 2 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i2.349

Abstract

Background Central nervous system (CNS) Aspergillosis is a common entity in the last few decades, particularly in immunocompromised population and also following covid-19 infection. As this finding is uncommon and present with atypical symptoms in immunocompetent patient, it is frequently misdiagnosed as tumor or bacterial abscess. Despite difficult diagnosis, challenges in starting and maintaining treatment also complicates patients management. Case A 36 years old, HIV negative, presented with progressive headache and blurry vision for 6 months. Initial brain MRI showed multiple lesion in bilateral frontal lobes with diffuse oedema, suggestive malignancy. Craniotomy removal tumor was performed and yield results of aspergillus sp. from brain tissue histo-pathology. Intravenous Voriconazole was administered for two weeks followed by oral itraconazole for six months. Clinical improvement was seen following antifungal treatment, and patient can return to normal activities on 6-months follow up. Conclusion Aspergillosis brain abscess is rare in immunocompetent host, and often considered as other diagnosis. Aside from surgical procedures, long-term antifungal medication also part of backbone treatment to eradicate infections. Early suspicion and awareness of CNS invasive fungal infection are key to desired outcome. Keywords: Aspergillus, central nervous system infection, antifungal
Neuritis Optik Unilateral sebagai Manifestasi Klinis Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Tannika, Ayudhea; Estiasari, Riwanti; Maharani, Kartika
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.364

Abstract

Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an oligodendrocytopathic autoimmune disorder, characterized by demyelination and inflammation in the central nervous system, especially brain parenchyma and spinal cord. There are three main clinical manifestations in MOGAD: optic neuritis, transverse myelitis, and acute disseminated encephalomyelitis (ADEM). This case report presents a seropositive anti-MOG patient with early manifestation of optic neuritis. A 29 years old man presented with a complaint of blurry right vision and dull pain around his right eye in the last 5 months before hospital admission. Neurological examination revealed a right visual acuity of 2/60 and right relative afferent pupillary defect (RAPD). Brain MRI with contrast revealed an enhancement on the right optic nerve and nonspecific, multiple hyperintense lesions in bilateral frontal and parietal lobes. The patient’s result was reactive for anti-MOG antibody. After the administration of high dose methylprednisolone (1000 mg) for 5 consecutive days, the patient’s visual acuity was slowly improving; supported with an improvement on the Humphrey visual field analyzer. Immunosuppressant agent azathioprine was given as a long-term treatment without any worsening symptoms to this day. Unilateral optic neuritis could be an early clinical manifestation in MOGAD. It is important for clinicians to identify typical and atypical optic neuritis to be able to determine follow-through examination and workup and the associated differential diagnosis. Optic neuritis in MOGAD could be improved by the administration of high dose methylprednisolone, along with immunosuppressant therapy as long-term therapy

Page 21 of 30 | Total Record : 299

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