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Islamudin Ahmad
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Journal of Pharmaceuticals and Natural Sciences
Published by CV. Borneo Citra Kreatama
ISSN : -     EISSN : 30475457     DOI : https://doi.org/10.70392/jpns
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
The Journal of Pharmaceuticals and Natural Sciences (JPNS; ISSN 3047-5457) is a scientific, open-access, peer-reviewed journal published by B-CRETA Publisher (CV. Borneo Citra Kreatama). The journal publishes three issues per year) and is available only in the online format. JPNS publishes full-length original articles and reviews. The scope of the journal is pharmaceuticals and Natural Sciences, including its research and application. Therefore, all published articles will have a unique Digital Object Identifier (DOI) number to guarantee authors regarding long-term archiving. With the DOI, all articles in JPNS will not be affected by changes to the URL currently used.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 25 Documents
 1   2   3 
Impact of Dietary Lead (Pb) on the Human Gastrointestinal Tract: A Review Samsul, Erwin; Muzaqi, Muhammad Choirul; Yotam, Yotam; Putra, Mitosie Gunarsa Caesar; Mutiara, Nur Adinda; Gunawan, Jevon Ecclesia; Rahman, Muhammad Alif; Salsabila, Syifa Kamila
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 2 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i2.4753

Abstract

Lead (Pb), a toxic heavy metal, frequently contaminates food and beverages due to environmental pollution and industrial processes. This study reviews lead's toxic effects on the human gastrointestinal tract through a narrative literature review from credible databases such as PubMed, Elsevier, and Google Scholar. Findings reveal that lead concentrations vary by food type, processing methods, and storage duration. For instance, lead levels in preserved eggs range from 334-1782 mg/kg, exceeding the safe limit (0.25 mg/kg), causing nausea, vomiting, and abdominal pain. Unwashed pears reached 18.5 mg/kg after 12 days, triggering similar symptoms. In contrast, grapes and vegetables showed low lead levels (<0.04 mg/kg) with no significant clinical effects. Food poisoning cases like contaminated candy in schools highlight the urgent need for strict monitoring. This review emphasizes strengthening food safety regulations, raising public awareness, and promoting further research to reduce exposure in the global food supply chain
Review of Antihypertensive Activity of Purslane (Portulaca oleracea L.) Azizah, Rizqi Nur; Putra, Bayu; Suhaenah, Asriani; Saputri, Fadlina Chany; Ahmad, Aktsar Roskiana; Malik, Abdul
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 2 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i2.5461

Abstract

Hypertension is a chronic disease in which blood pressure in the arteries increases. Hypertension is a health problem that has a risk of causing other diseases such as coronary heart disease, kidney failure, nerve dysfunction and stroke. Plants such as purslane (Portulaca oleracea L.) are one of the plants that have benefits in treating disease. The purpose of the review article is to determine the potential of Portulaca oleracea L. as an anti-hypertensive. This research is a Review Journal. The subject of this review is national and international articles indexed nationally and internationally in the last 10 years which discuss the antihypertensive ability of Portulaca oleracea L. by classifying them based on the type of study and test model used in-vivo, the potential of the plant in lowering blood pressure, mechanism of action in treating hypertension, and specific chemical constituents responsible for anti-hypertensive activity. Based on the results of studies conducted on several journal articles, it can be concluded that Portulaca oleracea L. : 1. exhibits promising antihypertensive properties through various mechanisms, including vasodilation, reduction of heart rate, and improvement of endothelial function; 2. Clinical trials and comparative studies indicate that it can significantly reduce systolic blood pressure, making it a potential natural adjunct in managing hypertension; 3. exhibits multiple mechanisms that can help manage hypertension, primarily through its antioxidant, anti-inflammatory, and lipid-regulating properties, 4. contains several bioactive compounds that contribute to its antihypertensive effects such as Asperglaucide (ASP), Oleracein E and Oleracein L, Omega-3 Fatty Acids, Quercetin, and Rutin.
Pharmacognostic and Toxicity Evaluation of Tabar Kedayan (Aristolochia papilifolia Ding Hou) Rootstock Lestari, Seftya Ayu; Iswahyudi, Iswahyudi; Arifuddin, M.; Prabowo, Wisnu Cahyo; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 2 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i2.6275

Abstract

Tabar kedayan (Aristolochia papillifolia Ding Hou.) is an endemic plant from northern Kalimantan and is widely used as traditional medicine by the Dayak people. This study aims to determine the pharmacognostic profile and toxicity data of Tabar Kedayan rootstock. The results showed macroscopically woody stem type, round stem shape, grooved or serrated stem surface, yellow-brown stem color, weak characteristic odor, bitter taste, microscopically found starch grains, calcium oxalate crystals, stone cells, cork cells, tracheids, and wood vessels. Fluorescence analysis under visible and ultraviolet light for Tabar Kedayan rootstock powder with different chemical reagents showed different fluorescence effects. Water content (0.466±0.01%), ethanol content (0.325±0.014%), moisture content (12.40±0.15%), total ash content (1.438±0.15%), and acid insoluble ash content (0.423±0.06%). Phytochemical screening of the chemical compounds of the ethanolic extract showed the presence of alkaloids, terpenoids, saponins, flavonoids, and tannins. The levels of total polyphenols (15.095 ± 1.11 µg GAE/mg sample), total flavonoids (0.184 ± 0.02 µg QE/mg sample), and total alkaloids (0.056 ± 0.02 µg QAE/mg sample) were found. The brine shrimp lethality (BSLT) assay results showed the highest LC50 value by the n-hexane fraction with an LC50 value of 17.660 µg/ml.
Antibacterial Activity of Kersen Leaf Extract (Muntingia calabura Linn.) Against Salmonella typhi and Staphylococcus aureus Using Bioautography Method Maharani, Dhea Nur Fadillah; Almeida, Maria; Arifian, Hanggara; Ibrahim, Arsyik; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 2 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i2.8694

Abstract

Kersen (Muntingia calabura Linn.) is a plant with a large population in Indonesia. Thus, the abundance of this number can be used as a source of raw materials for medicine. Kersen has many benefits, especially in the leaves as an antibacterial. The purpose of this study was to determine the extract yield, compound groups, and antibacterial activity against Salmonella typhi and Staphylococcus aureus. Antibacterial activity was measured using the well method and TLC Bioautography. The results showed an extract yield of 19.77%. The TLC profile identified flavonoid, alkaloid, tannin, and steroid compound groups. Kersen leaf extract showed antibacterial activity against Salmonella typhi and Staphylococcus aureus with moderate to strong antibacterial power at concentrations of 40%, 50%, and 60%. The groups of compounds suspected of playing a role in antibacterial activity are flavonoids, alkaloids, tannins, and steroids. This study shows that kersen leaf extract has the potential as an antibacterial agent against Salmonella typhi and Staphylococcus aureus bacteria.
Identification of paracetamol compound in traditional herbal medicine for muscle pain relief using thin layer chromatography - Densitometry Aulia, Dini Angelina Putri; Supandi
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 2 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i2.7685

Abstract

Traditional medicine consists of substances or formulations derived from plants, animals, minerals, and galenic preparations or mixtures of these materials that have been used for generations as therapy and can be implemented according to the norms applicable in society. The pharmaceutical chemical that is often added to herbal medicine for muscle pain relief is paracetamol. This research aims to prove the presence or absence of the chemical drug paracetamol in the herbal medicine for muscle pain relief found in the Koja District. A total of 10 samples were selected through purposive sampling from herbal stores within the area. The analysis was conducted qualitatively using color reaction test and quantitatively using Thin Layer Chromatography-Densitometry. Color reaction tests indicated that two samples were positive for paracetamol. Analysis using thin-layer chromatography indicated that 3 samples had Rf  values ranging from 0.3-0.35, close to the standard Rf  value. Based on the analysis results using Thin Layer Chromatography-Densitometry, the herbal samples that tested positive for containing paracetamol were identified according to the maximum wavelength of the samples that matched the maximum wavelength of paracetamol at 247 nm in samples (S5), (S7), and (S9). The TLC-densitometry method can be used to analyze the presence of paracetamol in traditional herbal medicine for muscle pain relief.

Page 3 of 3 | Total Record : 25

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