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Journal of Pharmaceuticals and Natural Sciences
Published by CV. Borneo Citra Kreatama
ISSN : -     EISSN : 30475457     DOI : https://doi.org/10.70392/jpns
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
The Journal of Pharmaceuticals and Natural Sciences (JPNS; ISSN 3047-5457) is a scientific, open-access, peer-reviewed journal published by B-CRETA Publisher (CV. Borneo Citra Kreatama). The journal publishes three issues per year) and is available only in the online format. JPNS publishes full-length original articles and reviews. The scope of the journal is pharmaceuticals and Natural Sciences, including its research and application. Therefore, all published articles will have a unique Digital Object Identifier (DOI) number to guarantee authors regarding long-term archiving. With the DOI, all articles in JPNS will not be affected by changes to the URL currently used.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 25 Documents
 1   2   3 
Anti-inflammatory Effect of n-Hexane Fraction of Kentut leaves (Paederia scandens L.) on Male White Rats (Rattus novergicus) Yazid, Muhammad Ilfan; Rijai, Laode; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/mpbb3e50

Abstract

The anti-inflammatory effect of fart plant leaf extract (Paederia scandens L.) on white rats (Rattus norvegicus) has been carried out. This research shows that the effective dose of the n-hexane fraction of P. scandens leaf extract provides the best anti-inflammatory effect on white rats' feet soles. The study used an artificial edema formation method and periodically measured the volume of white mice's legs using a plethysmometer. The doses used for the extract are 100mg/200g BW, 150mg/200g BW, and 200mg/200g BW. The research data was observed visually. The effective dose of P. scandens leaf extract, which has the best anti-inflammatory effect, is 150mg/200g BW.
In Vitro Free Radical Scavenging Activity of Lagerstroemia speciosa PERS leaves on 1,1-diphenyl-2-picrylhydrazyl Rezqiyana, Gita Anna; Rijai, Laode
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/2y5gxp24

Abstract

This study aims to determine the yields and free radical scavenging activity based on IC50 value of the extract and the fraction of Lagerstroemia speciosa Pers leaves. The leaves of L. speciosa were macerated using 96% methanol and then practioned using different kinds of solvent based on its polarity including n-hexane, ethyl acetate, and n-butanol. The result showed that the yield of methanol extract obtained from L. speciosa levaes was 5.45% of dried samples obtained, the fraction of n-hexane 19.12%, the fraction of ethyl acetate 4,7%, and the fraction of n-butanol 1.93%. Testing of antioxidant activity is performed with the 1,1-Diphenyl-2- Picryl Hydrazyl (DPPH) by spectrophotometry UV-Visible. Absorbanse measurement was conducted with spectrophotometry at the wave lenght of 516 nm. Data was analyzed with linear regresion to obtain value of IC50. The result of research showed that the extract and fractions of L. speciosa leaves have activity as an antioxidant with the IC50 value of methanolic extract L. speciosa leaves was 12.5 ppm, n-hexane fraction was 18.75 ppm, ethyl acetate fraction was 21.87 ppm, n-butanol was 8.37 ppm.
Inventarytation of Medicinal Plants in Leang-Leang Village, Bantimurung District, Maros Regency Iriani, Rahma; Amin, Asni; Nur Azizah, Rizqi
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/ha3xrv83

Abstract

This study aimed to obtain data, information, and an inventory of medicinal plant species used by the community in Leang-Leang Village. The type of research used was descriptive qualitative research using purposive sampling. Data collection techniques were completed through questionnaires and interviews with 96 Leang- Leang Village respondents. The results reported 43 types of medicinal plants comprising 31 families utilized by the people of Leang-Leang Village to maintain health and treat 24 types of certain diseases. The people of Leang-Leang Village utilized the medicinal plants through the leaves, stems, rhizomes, tubers, roots, sap, fruit, and flowers, with the highest percentage of 78% on the leaves, for instance: guava leaves, soursop leaves, miana leaves, and other types of leaves. The most commonly used method of processing medicinal plants was by boiling, with a percentage of 69%. Besides, it was drunk as the most common way of consumption, with a rate of 77%.
Tyrosinase Inhibitory Activity of The Extracts from Garcinia lateriflora Blume var. Javanica Boerl, Garcinia fruticosa Lauterb, and Garcinia xanthochymus Ambarwati, Neneng Siti Silfi; Elya, Berna
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/drty6950

Abstract

Tyrosinase overexpression in humans increases melanin production in the skin, which may have hyperpigmentation-causing effects. In this study, various extracts from the Garcinia lateriflora Blume var. Javanica Boerl, Garcinia fruticosa Lauterb, and Garcinia xanthochymus plants were tested for their ability to inhibit the tyrosinase enzyme. The results showed that the G. fruticosa Lauterb stem bark hexane extract had the highest activity followed succesively by the G. lateriflora Blume var javanica Boerl leaf methanol extract, G xanthochymus mesocarp hexane extract, G. xanthochymus mesocarp methanol extract. The results show that the G. fruticosa Lauterb stem bark hexane extract has the highest tyrosinase inhibitory activity (45.61 ± 1.58%) among the four extracts and the tyrosinase inhibitory activity of kojic acid (65.07 0.86%).
Pharmacognosic Study and Determination of Marker Compounds Soursop Leaves (Annona muricata) M. Arifuddin; Faisal, Muhammad; Samsul, Erwin; Hikmawan, Baso Didik; Prabowo, Wisnu; Ahmad, Islamudin; Ibrahim, Arsyik
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/zjthbv92

Abstract

Soursop (Annona muricata) is reported to have great efficacy in traditional medicine in Indonesia so it is very vulnerable to being faked or sold as low quality. Apart from having a delicious fruit taste, Soursop leaves have also been used as an effective cancer medicine by the public and have been scientifically proven so that Soursop can be used as a phytopharmaceutical product. Therefore, it is necessary to carry out research to determine pharmacognosy parameters and marker compounds as ingredients needed to obtain the authenticity of simplicia and plant extracts. This research includes macroscopic and microscopic examination of leaves, macroscopic and microscopic examination of simplicia, fluorescence characteristics of simplicia, determining the solubility of methanol extract in various non-polar and polar solvents as well as the characteristics of marker compounds that can be used as alternatives to existing marker compounds from Soursop (Annona muricata). The research results obtained are important information as a stage for the identification and standardization of soursop leaves (Annona muricata) as a raw material for herbal medicine.
Potential and Activities of the Sunscreen Lotion Preparation of Bawang Dayak (Eleutherine americana (Aubl.) Merr. by Ethanol Extract Fraction from East Boneo Ibrahim, Arsyik; Badawi, Satriani; Rusman, Arman; Riki; Samsul, Erwin; Sulistyarini, Riski; Arifuddin, M.; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/yrb89026

Abstract

Has conducted research Potential and Activities of the Sunscreen Lotion of Bawang Dayak (Eleutherine americana (Aubl.) Merr. by ethanol extract fraction from East Borneo. The purpose of the study was to determine the potency ann activity of the sunscreen ethanol extracts fraction of Bawang Dayak in the preparation of a lotion with the parameter measuring the percent transmission erythema (% Te) and pigmentation (% Tp) in vitro in the room temperature 27oC storage and accelerated temperature 40oC. Lotion dosage formulations using ethanol extracts fraction bawang Dayak with a concentration of 0.1% and 0.2%, and positive control is a trademark preparation Bless Sunscreen Lotion SPF 15®. Stages of research include the formulation and measurement of absorbance and value %Te) and %Tp at various storage temperatures with UV-Vis spectrophotometry at λ 292.5 to 372.5 nm. The analysis of research data using a program SPSS. The results showed that ethanol extract fraction concentration in lotion preparations of bawang Dayak 0.1% and 0.2% active as a sunscreen included in the category of sunblock. The extract fraction is active as a sunscreen and in the Sunbloc category, with the best concentration as a sunscreen being 0.2%, with its sunscreen potential not being significantly different from the control Sunscreen SPF 15® at the 5% level.
Activity antibacterial from honey kelulut (Trigona sp.) against bacteria Staphylococcus epidermidis Sita, Annisa Aulia; Rijai, Laode; Rija'i, Hifdzur Rashif
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/0a3qnh10

Abstract

Honey kelulut is derived from the kelulut bee (Trigona sp.), which is native to Kalimantan and belongs to the Trigona genus of stingless bees. The honey produced by the Trigona genus has a well-documented antibacterial property. Study objective accomplished. This text discusses the potent antibacterial action of kelulut honey. The antibacterial testing method employed is the well diffusion method, utilizing the bacterium Staphylococcus epidermidis as the test organism. An antibacterial test was conducted by measuring the diameter of the zone of inhibition against bacteria. The results were obtained from concentrations of 40%, 60%, 80%, and 100%. Then the resistance diameter was measured for each concentration. The most optimal outcomes were achieved in the antibacterial test using honey kelulut. The honey kelulut with an 80% concentration exhibited a medium resistance level of 10.2 mm, while the 100% concentration demonstrated a strong resistance level of 13.7 mm.
The potency of bioactive constituents in Piper betle L. for Alzheimer Targeting on Caspase-3 - in silico studies Putri, Anindya Calista Nabila; Ashriany, Raissa Rerey; Salsabila, Sitti Kesya; Rahmaharva, Naila Dwi; Muljono, Fajar Oktavian; Fardhan, Firghi Muhammad; Novitasari, Dhania
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/rw708r52

Abstract

Alzheimer’s disease (AD) is a neurodegenerative condition that can disrupt memory, cognition, and neurological functions, Recent studies highlight caspase-3 as a potential target, with several lines of evidence pointing to the enzyme's possible role in the onset of AD. Several findings revealed that betel leaf was also examined to treat AD by targeting acetylcholinesterase in vitro and in silico, yet no evaluation had not been done in caspase-3 activity. Using molecular docking, Lipinski's and PreADMET prediction, an in-silico analysis of compounds found in betel leaf (Piper betle L.) was conducted in order to determine whether these compounds could be applied as therapeutic candidates in the treatment of Alzheimer's. To ascertain the drug similarity and ADMET profile of the evaluated ligands, the Mcule and PreADMET sites were used in the studies, which were followed by the molecular docking simulation software AutoDock. The findings demonstrated that all the tested compounds passed the physicochemical features based on Lipinski rule. Further analysis then showed that arecoline bound to the critical amino acid that involved in caspase-3 inhibition. Further evaluation needs to be done to confirm the molecular mechanism of P. betle leaves to AD.
Formulation of Air Freshener Gel Combination of Mint Leaf Essential Oil (Mentha piperita L.) and Lemon (Citrus limon (L) Burm F.) Hafidzah, Nurul; Putri, Novita Eka Kartab; Almeida, Maria; Rusman, Arman; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/qds89550

Abstract

Air freshener gel is a semi-solid fragrance product that uses carrageenan and pectin as gel-forming components to overcome unpleasant odors when in a room with high temperatures. The purpose of this study was to determine the composition of carrageenan and pectin as gel-forming materials for air fresheners and the composition of the aroma comparison of mint oil (Mentha piperita L.) and lemon (Citrus limon (L) Burm F). The gel base was made with a ratio of carrageenan: pectin concentration of 1: 2; 1.8: 1.2; 2.5: 0.5 then the base was evaluated including organoleptic examination, stability test and gel hardness. The best base was then added with mint oil and lemon with a ratio of 1: 1.5; 1.25: 1.25; 1.5: 1 and the gel preparation was evaluated with organoleptic parameters, gel stability, gel hardness, liquid evaporation, fragrance resistance and hedonic test. The results of the study showed that the best base preparation after the evaluation of the base was a ratio of carrageenan: pectin concentration of 25: 0.5. Evaluation of the preparation with the addition of mint leaf oil (Mentha piperita L.) and lemon (Citrus limon (L) Burm F) to the base showed a value that was not too significant in the evaluation results. In the hedonic test, the formula with the addition of 2.5%: 2.5% mint leaf oil (Mentha piperita L.) and lemon (Citrus limon (L) Burm F) was the formula preferred by the panelists. So it can be concluded that the carrageenan and pectin combination room freshener gel with a concentration ratio of 2.5: 0.5% can be formulated as a base for room freshener gel preparations, namely producing a chewy and elastic gel base. The formulation of the most preferred combination of mint leaf essential oil and lemon oil as a gel fragrance is with a concentration of 2.5: 2.5%, because it produces a refreshing aroma
Evaluation of the use of Antihypertensive Drugs in Outpatient Hypertension Patients at the Lasinrang Regional General Hospital, Pinrang Regency in 2023 Yuliana, Dewi; Agus, Asfira; Azizah, Rizqi
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/fyke8936

Abstract

Hypertension is a complex condition in which blood pressure is permanently above normal. Hypertension is an increase in systolic blood pressure of more than equal to 140 mmHg and diastolic more than equal to 90 mmHg. This study aims to identify how antihypertensive drugs are used in hypertensive patients at the Lasinrang Regional General Hospital, Pinrang Regency. This study is a non-experimental research with a descriptive design taken retrospectively. The sample in this study is all outpatients with a diagnosis of hypertension at the Lasinrang Regional General Hospital in 2023. The sampling technique used is purposive sampling. The sample of this study is medical record data on hypertension patients in 2023 which is adjusted to the inclusion criteria. The results of the study showed that from 83 samples consisting of 50 women and 33 men, all of which met the inclusion and exclusion criteria, and showed a prevalence of age that dominated around 58-65 years (49,40%). In the evaluation of drug use, outpatient hypertension patients at the Lasinrang Regional General Hospital, Pinrang Regency had an indication accuracy of 100%, 100% drug accuracy, and 100% dose accuracy. 

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