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Journal of Pharmaceuticals and Natural Sciences
Published by CV. Borneo Citra Kreatama
ISSN : -     EISSN : 30475457     DOI : https://doi.org/10.70392/jpns
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
The Journal of Pharmaceuticals and Natural Sciences (JPNS; ISSN 3047-5457) is a scientific, open-access, peer-reviewed journal published by B-CRETA Publisher (CV. Borneo Citra Kreatama). The journal publishes three issues per year) and is available only in the online format. JPNS publishes full-length original articles and reviews. The scope of the journal is pharmaceuticals and Natural Sciences, including its research and application. Therefore, all published articles will have a unique Digital Object Identifier (DOI) number to guarantee authors regarding long-term archiving. With the DOI, all articles in JPNS will not be affected by changes to the URL currently used.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 25 Documents
 1   2   3 
Evaluation of the Use of Anti-Diabetic Drugs in Outpatient Type 2 Diabetes Mellitus Patients at Lasinrang Regional General Hospital, Pinrang Regency in 2023 Nur Azizah, Rizqi; Damayanti, Alfina; Yuliana, Dewi
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 3 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v1i3.94101

Abstract

Diabetes Mellitus (DM), including a disease in the form of metabolic disorders characterized by impaired insulin secretion, impaired insulin production and insulin sensitivity, causing an increase in blood sugar levels (hyperglycemia). This study aims to determine the use of antidiabetic drugs which include the right drug, the right dose, the right indication and the right frequency of administration in outpatient type II diabetes mellitus patients at Lasinrang Regional General Hospital, Pinrang District in 2023. This study is a non-experimental research with a descriptive design retrospectively. The sample in this study is all outpatients with a diagnosis of type II diabetes mellitus at the Lasinrang Regional General Hospital, Pinrang District in 2023. The sampling technique used is purposive sampling. The sample of this study is medical record data of patients with type II diabetes mellitus in 2023, which is adjusted to the inclusion criteria. The results of the study showed that of 87 samples consisting of 55 women and 32 men, all of which met the inclusion and exclusion criteria, and showed that the prevalence of age was more susceptible to be affected at the age of 46-55 years as many as 40 patients (45.98%). In the analysis of the accuracy of drug use, outpatient type II diabetes mellitus patients at the Lasinrang Regional General Hospital, Pinrang regency in 2023 have an indication accuracy of 100%, 100% drug accuracy, 100% dose accuracy, and 100% accuracy frequency of drug administration.
Evaluation of Drug Related Problems of Antihypertensive Drugs in Inpatient Hypertensive Patients at the Latemmamala Regional General Hospital, Soppeng Regency for the January-March 2023 Period Yuliana, Dewi; Salam, Rika Amalia; Arifin, Sukmawati
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 3 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v1i3.8493

Abstract

Hypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg in two measurements taken five minutes apart at rest. Problems caused by drug abuse are called DRPs (Drug Related Problems). The occurrence of DRPs is known to have a detrimental effect on patient quality of life, increased mortality and high medical costs. This study aims to determine the incidence of DRPs and the types of DRPs that occur in hypertensive patients at Latemmamala Hospital, Soppeng Regency. This study is a type of non-experimental descriptive research conducted retrospectively using secondary data in medical records where samples were selected using purposive sampling technique. The results showed that of the 78 samples consisting of 42 women (53.85%) and 36 men (46.15%), all of which met the inclusion and exclusion criteria, showed that the age prevalence was more prone to hypertension at the age of 56-75 years as many as 47 patients (60.26%). There were 46 cases out of 43 patients who had the potential to experience DRPs. The most DRPs that occurred were in the case of C1.4 as many as 26 cases (56.52%), then C1.1 as many as 20 cases (43.48%).
Effect of Drying Temperature and Storage Temperature Simplisia on Antioxidant Activity of Herbal Tea Sungkai Leaf (Peronema canescens Jack) Alfiyah, Dima; Riski Sulistiarini; Supriatno Salam
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 3 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v1i3.102107

Abstract

Sungkai leaves are plants used by the community as an alternative medicine in treating diseases such as malaria, fever, poisoning, and child spasms, as well as postnatal treatment where sungkai leaves are processed into herbal brew. This study aims to determine the best drying and storage temperatures based on the antioxidant activity of sungkai leaf herbal brew. The research method is drying with wind dry temperature, Oven (40oC), and Roast (80oC). Afterward, wind-dry drying was stored for 1 week at room temperature in, an incubator (35oC), and refrigerator (4oC). Then it was made into a brew and tested for antioxidant activity by the DPPH method. The results showed that the best drying temperature antioxidant activity was obtained using oven temperature with an IC50 value of 16.76 ppm. At the same time, the best storage temperature was obtained in incubator storage with IC50 of 36.76 ppm.
Activity Test of The Combination Papaya Leaf Extract (Carica papaya L.) and Soursop Leaf Extract (Annona muricata L.) on Decreasing Blood Glucose Levels in Rats (Rattus norvegicus) Arfiani, Putri Yuni; Almeida, Maria; Arifian, Hanggara; Arief, Maryam Jamila; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 3 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v1i3.101117

Abstract

Diabetes mellitus (DM) is one of the most common health disorders and its prevalence rate is increasing every year. Natural compounds can be an alternative treatment for DM. Previous re-search reports for papaya leaves (Carica papaya L.) and soursop leaves (Annona muricata L.) showed activity in lowering blood glucose levels when used alone. Therefore, in this study, the two samples were combined to lower blood glucose levels. Both leaves were extracted using the decoction method. This study aims to identify secondary metabolite compounds in papaya leaf extract (Carica papaya L.) and soursop leaf extract (Annona muricata L.), then continued with determining the activity and effectiveness of lowering blood glucose levels. The results of the identification of secondary metabolite compounds showed several groups of compounds such as flavonoids, saponins and tannins. The combination of papaya leaf extract and soursop leaf extract showed a decrease in blood glucose levels. In more detail, EDPS 1:2 and EDPS 2:1 were statistically significant against negative controls. EDPS 1:2 showed the most effective percentage reduction in blood glucose levels at 22.72%  
Synthesis and Characterization of Cellulose Nata de Coco Inserted Nanoparticles Zn-Moringa Leaf Extract (Moringa oleifera) as Biodegradable plastic Banan Fruit Packaging Ramadan; Ramadhan, La Ode Ahmad Nur; Zainal Syam Arifin
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 3 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v1i3.118135

Abstract

Synthesis and characterization of cellulose nata de coco inserted nanoparticles of zinc-moringa leaf extract as biodegradable plastic for banana fruit packaging has been carried out. This study aims to determine the characteristics, biodegradability and preservation activity of biodegradable plastic cellulose nata de coco inserted zinc nanoparticles-moringa leaf extract. The research process was carried out through the nata de coco synthesis stage, zinc nanoparticle synthesis-moringa leaf extract and the manufacture of biodegradable plastics. The success of this synthesis is evidenced by being characterized using a UV-Vis spectrophotometer, FTIR spectrophotometer and digital optical microscope. The results of UV-Vis spectrophotometer analysis showed that the zinc nanoparticles formed had an estimated particle size of 85.72-92.92 nm and were stable. The results of FTIR analysis on Moringa leaf extract showed the presence of -OH, C-H, C=O, C=C and C-O groups. In the biodegradable plastic film nata de coco-NPZn-moringa leaf extract, there was a peak shift in several functional groups marked at the peaks of wavenumbers 555.50 and 432.05 cm-1 which are ZnZP groups. Characterization using a digital optical microscope showed that zinc nanoparticlesThe synthesis is spherical, non-uniform, and has been well distributed on the cellulose surface of nata de coco. Biodegradation test on nata de coco-NPZn-Moringa leaf extract biodegradable plastic film using activated sludge system, test results show biodegradable plastic can be degraded 100% for 15 days. Preservation activities show that packaged bananas are still able to survive up to 8 days of post-harvest storage period. These results show the effectiveness of biodegradable plastic preservation of nata de coco-NPZn-moringa leaf extract biodegradable plastic which is quite good.
Effect of Over-The-Counter (OTC) Drug Use Education on Community Knowledge Level in Karampuang Village, Panakkukang District, Makassar City through The Mother Active Learning Method Nur Azizah, Rizqi; Rahmawati, Rahmawati; Wati, Aulia; Hardiyanti, Purnamasari; Rian Iryansyah, Rian Iryansyah
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 1 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i1.1518

Abstract

Mother Active Learning (MAL) is an educational model of community empowerment to be more skilled in choosing drugs so that self-medication becomes more effective, safe, and cost-effective. This study aims to analyze the effect of over-the-counter (OTC) drug education on the public knowledge level in Panakukkang district through the MAL method. The research design used quasy-experimental, which is non-equivalent control group design. Sample was divided into control and treatment group consisting of 20 and 30 people. The data were analyzed descriptively by evaluating worksheets that were completed by participants. The analysis results found that the mean posttest value for the control group was 42.00 (SD=10.56), while the mean posttest value of treatment group was 84.67 (SD=10.74). Statistical tests found that there were significant differences between the mean values of both groups (p<0.01). Providing education to the community through the MAL method effectively increases knowledge related to the use of OTC drugs.
Toxicity Analysis: A Collection of Case Studies and Drug Management Strategies Samsul, Erwin; Khotimah, Ika; Harludi, Theodora Jane; Purba, Gmelina Adelia Putri; Wahyuda, Aji Arda Nur; Sudarma, Mahatma Setya; Rajo, Nur Wulan Mas; Rahma, Saina Cintami Abdila; Ardhito, Willy
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 1 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i1.0114

Abstract

Narcotics, Psychotropics, and Addictive Substances (NAPZA), are any compound or drug that can alter the central nervous system and behavioural patterns, that can also cause an addiction. Narcotics and psychotropics in itself can be categorized into 3 categories of narcotics, and 4 categories of psychotropics, based on their use as a medication and the possibility of an addiction. Since NAPZA can alter the central nervous system, the possibility of their toxicity needs more attention. This study is done to review the handling and the mechanism of toxicity of NAPZA. We used the narrative review method to gather information from various sources, including 3 websites, 1 book, 7 national articles, and 22 international articles that were published in the time span of 2014 to 2024. From the 11 cases of NAPZA toxicity, 4 were caused by narcotics, 4 by psychotropics, and 3 by addictive substances, with most cases were of drug misuse by the productive population. The main handling of narcotics toxicity were to secure the breathing function, oxygen supplementation, and the use of Naloxone as an antidote. While psychotropics and addictive substances poisoning were handled with the use of benzodiazepines, hemodialysis, or to increase the rate of drug elimination in the plasma.
Hedonic Test of Garcinia dulcis (Roxb.) Kurz Extract Peel-Off Gel Mask and Gel Serum Ambarwati, Neneng Siti Silfi; Irtawidjajanti, Sri; Armandari, Mari Okatini; Ana, Elsa Fitri; Triyani, Yulia
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 1 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i1.1927

Abstract

 The cosmetics industry is experiencing rapid growth as consumer awareness of the importance of safe and effective skincare products increases. This creates an excellent opportunity for natural ingredient cosmetics. Garcinia dulcis (Roxb.) Kurz has been proven to have bioactive activities, such as antioxidants and anti-elastase, which can potentially be used for skin care, such as preventing premature aging and maintaining skin elasticity. This study evaluates consumer preference levels for peel-off masks and Garcinia dulcis extract serums. The method used was a hedonic test with parameters of aroma, skin feel, texture, color, absorption, viscosity, and drying time on a scale of 1-5. Data were analyzed using the Mann-Whitney U test. The results were that 33.85% of the panelists were neutral towards the serum’s aroma, and 40% did not like the mask’s aroma. A total of 41.54% of the panelists liked the serum’s texture, and 33.85% of the panelists were neutral about liking the mask’s texture. The skin taste parameter showed that 58.46% of the panelists liked the serum, and 36.92% were neutral to liking the mask. The gel serum and peel-off gel mask colors were liked by 46.15% and 44.62% of the panelists, respectively. The gel serum’s absorption rate and the peel-off gel mask’s drying time were liked by 36.92% and 33.85% of the panelists, respectively. 33.85% of the panelists liked the gel serum’s viscosity. The statistical test showed significant differences in aroma, taste, and absorption (p < 0.05). In conclusion, the peel-off gel mask and serum of Garcinia dulcis (Roxb.) Kurz extract has good potential as a skincare product, although further development is needed to improve the aroma, taste, and drying time.
Review of the Effects of the Abuse of Narcotics, Psychotropics, and Other Addictive Substances Samsul, Erwin; Amiruddin, Widya Salsabila Putri; Hasanah, Fitri; Wulandari, Tiara Sahfitri; Basongan, Oktariani; Syam, Mawar Inrian; Yusuf, Muhammad; Gala, Kretentia Aprilia; Rachmawati, Nova Sri
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 1 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i1.2836

Abstract

The purpose of this study was to identify the forms of drug abuse and evaluate the impact of drug abuse in the community. This research uses a qualitative approach and is a descriptive study. This research uses the narrative literature method. This review process used the narrative review method by collecting literature from various sources, including scientific journals, government reports, and relevant conference articles, with the inclusion criteria being articles published within the last 10 years, in Indonesian or English, and discussing topics related to the impact or intervention of drug abuse. In the initial stage of searching journal articles, 17,083 articles from 2019-2024 with identified keywords such as "Drug Abuse", "Substance Abuse Cases", and "Psychotropic Abuse" were found. Of the collected articles, 25 journal articles met the criteria. The analysis was done descriptively to synthesize information based on certain categories, such as health impact and policy effectiveness. Based on the literature, the most common drug abuse included mephedrone, trihexyphenidil, LSD, and amphetamine. The results of this study indicate that the effects of drug use include agitation (30%), addiction (20%), hallucinations (60%), aggression (50%), euphoria (70%), and disorientation (50%). It is recommended to avoid using drugs because it can harm the body's condition.
Optimizing Sand-Based Biofilm Biosorption for Copper (Cu) Mitigation: Mechanisms, Optimal Conditions, and Environmental Implications Rosna; Zaeni, Ahmad; Kadidae, Laode; Zainal Syam Arifin
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 1 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i1.3746

Abstract

Copper (Cu) pollution from industrial wastewater has emerged as a critical environmental issue due to its toxicity, bioaccumulation, and persistence in aquatic ecosystems. Conventional methods for heavy metal remediation often fail to address the dual challenge of high costs and environmental sustainability, necessitating alternative approaches. This study explores the use of sand-based biofilms for the biosorption of Cu ions, leveraging the natural ability of biofilms to adsorb and immobilize heavy metals. The research focuses on optimizing biosorption conditions, including contact time, initial Cu concentration, and pH, while evaluating the broader impacts on water quality parameters such as Chemical Oxygen Demand (COD), Biochemical Oxygen Demand (BOD), and Total Dissolved Solids (TDS). The experimental results demonstrated that biosorption efficiency peaked at a contact time of 1 day, an initial Cu concentration of 100 mg/L, and a pH of 8. At these optimal conditions, the biofilm achieved a biosorption capacity of 39.7 mg/L for Cu ions. Moreover, the treatment significantly improved water quality, reducing COD by 77.06%, BOD by 78.92%, and TDS by 30%. The mechanism of biosorption was influenced by the availability of functional groups within the extracellular polymeric substance (EPS) of the biofilm, which provided binding sites for Cu ions. The influence of pH was particularly notable, as it regulated the ionic interactions between Cu2+ and the biofilm matrix. This study not only confirms the effectiveness of biofilm-based biosorption for heavy metal mitigation but also highlights its dual role in reducing organic and inorganic pollutants in wastewater. The use of sand as a substrate for biofilm growth adds an element of scalability and economic feasibility, making it an attractive solution for industrial applications. The findings underscore the potential of this eco-friendly approach to contribute to sustainable wastewater management, addressing both environmental and public health concerns associated with heavy metal contamination. Future research could explore the application of this method for other heavy metals and its integration into existing wastewater treatment systems.

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