cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Islamudin Ahmad
Contact Email
islamudinahmad@b-creta.com
Phone
+6281342205060
Journal Mail Official
islamudinahmad@b-creta.com
Editorial Address
Jalan Sentosa Dalam No. 90, Kel. Sungai Pinang Dalam, Kec. Sungai Pinang
Location
Kota samarinda,
Kalimantan timur
INDONESIA
Journal of Pharmaceuticals and Natural Sciences
Published by CV. Borneo Citra Kreatama
ISSN : -     EISSN : 30475457     DOI : https://doi.org/10.70392/jpns
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
The Journal of Pharmaceuticals and Natural Sciences (JPNS; ISSN 3047-5457) is a scientific, open-access, peer-reviewed journal published by B-CRETA Publisher (CV. Borneo Citra Kreatama). The journal publishes three issues per year) and is available only in the online format. JPNS publishes full-length original articles and reviews. The scope of the journal is pharmaceuticals and Natural Sciences, including its research and application. Therefore, all published articles will have a unique Digital Object Identifier (DOI) number to guarantee authors regarding long-term archiving. With the DOI, all articles in JPNS will not be affected by changes to the URL currently used.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 40 Documents
 1   2   3   4 
Profile of the Use of Oral Antidiabetic Drugs in Outpatinets at the Lonrong Health Center, Ponre District, Bone Regency in 2023 Sukmawati Sukmawati; Maulya Faradina; Ira Asmaliani
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.33

Abstract

Diabetes mellitus is a degenerative chronic disease characterized by impaired insulin secretion, impaired insulin production and impaired insulin sensitivity. The use of diabetes mellitus drugs can cause problems if the therapeutic goals are not appropriate, one of which is due to the improper selection of drugs so that the therapeutic goals are not effective. This study aims to analyze the profile of the use of antidiabetic drugs in outpatients at Lonrong Health Center in 2023 based on the parameters of the right drug, the right dose, the right indication, and the right time of administration. This study is non-experimental research with a retrospective descriptive design. The sampling technique used is purposive sampling. The sample in this study is medical record data of diabetic mellitus patients in 2023 who meet the inclusion and exclusion criteria. The results showed that of the 50 samples consisting of 41 women (82%) and 9 men (18%), the prevalence of age was dominated around > 60 years (38%). In the rational analysis of drug use, it was found that the indication accuracy was 100%, drug accuracy was 82%, correct dosage was 100% and punctuality of administration was 100%.
Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes M. Arifuddin; Rezti Amanda; Arfiani Arifin; Arfina Sukmawati Arifin; Iswahyudi Iswahyudi; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Arsyik Ibrahim; Laode Rijai
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Assessment of Sub-Chronic Toxicity of a Polyherbal Infusion of Peperomia pellucida, Moringa oleifera, and Biancaea sappan in Male Mice (Mus musculus) Heldi Fadillah Akbar; Febrina Mahmudah; Islamudin Ahmad
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.46

Abstract

This study evaluated the sub-chronic toxicity of a polyherbal infusion composed of Peperomia pellucida, Moringa oleifera, and Biancaea sappan in male mice. Thirty healthy male mice aged 6–8 weeks, weighing 20–30 g, were orally administered doses of 560, 650, and 1300 mg/kg body weight daily for 28 days, with satellite groups observed for up to 42 days. Clinical monitoring and body weight measurements revealed no signs of toxicity or growth impairment. However, organ index analysis demonstrated dose-dependent increases in liver and kidney weights, and histopathological examination confirmed hepatocellular degeneration and tubular damage at the highest dose. These findings indicate that the infusion is generally safe at low to moderate doses, but prolonged high-dose consumption may compromise hepatic and renal integrity. The study provides important toxicological evidence supporting the establishment of safe dosage ranges for polyherbal formulations and contributes to the scientific validation of traditional medicine practices.
Toxicity of Extracts and Fractions of Bangkal Leaves (Nauclea subdita (Korth.) Steud.) and Genjer (Limnocharis flava (L.) Buch) on the Bioindicator Artemia salina Leach Arsyik Ibrahim; Sealti Puji Salea; Sri Windarti; M. Rahmad Ramadhan; Hidfdzur Rashif Rija'i; M. Arifuddin; Laode Rijai
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.47

Abstract

A study was conducted on the secondary metabolite content and toxicity testing of Artemia salina leach larvae using extracts from Bangkal leaves (Nauclea subdita (Korth.) Steud.) and Genjer plants (Limnocharis flava (L.) Buch). The objective of this study is twofold: firstly, to ascertain the compounds present in Bangkal leaf extract and Genjer plant extract, and secondly, to assess the toxicity levels of the extracts and fractions from Bangkal leaves and Genjer plants on Artemia salina Leach larvae. In this study, the extraction method employed was maceration with 96% ethanol as the solvent. The crude 96% ethanol extract was fractionated in stages using n-hexane, ethyl acetate, and n-butanol solvents based on polarity levels. The toxicity testing was conducted using the Brine Shrimp Lethality Test (BSLT) method, with Artemia salina Leach larvae serving as the bioindicator. A range of test concentrations were utilised, with each concentration having three replicates. The mortality of Artemia salina was observed after a 24-hour period and was analysed using the Reed and Muench method to determine the LC50 value. The results of the study demonstrated that the secondary metabolites present in the 96% ethanol extract of bangkal leaves com-prised the following groups of compounds: steroids, and triterpenoids, phenols, quinones, and saponins. The toxicity test results of the bangkal leaf extract and fractions yielded LC50 values of 418.79 ppm for the 96% ethanol extract; 716.14 ppm for the n-hexane fraction; 263.03 ppm for the ethyl acetate fraction; and 70,79 ppm for the extract n-buthanol fraction. Meanwhile, the toxicity test results of the genjer plant extract and fractions obtained an LC50 value of 490.23 ppm for the 96% ethanol extract; n-hexane fraction 551.31 ppm; ethyl acetate fraction 425.01 ppm; and n-butanol fraction extract 46.02 ppm. These results indicate that the n-butanol fraction of bangkal leaves and genjer plants have stronger cytotoxic activity than other fraction extracts.
In Silico Study of Phytochemical Compound from Daun Kluwih  (Artocarpus camansi) as an Antidiabetic Targeting Aldose Reductase Dinar Umaimah Radani; Ignasia Anindya Pintagratia; Anindya Nursanti Syaiful; Fahri Renaldi; Fachrizal Dwi Kautsar; Dhania Novitasari
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.49

Abstract

Diabetes Mellitus (DM) is a disease characterized by increased blood glucose levels. The most common type of diabetes is type 2 diabetes mellitus. Aldose Reductase is an enzyme that works in the polyol pathway. The polyol pathway is the pathway where glucose is metabolized by aldose reductase into sorbitol. The end result of this polyol pathway will accumulate in the tissue so that there is a disruption of the osmolarity of the basal membrane which can cause complications of diabetes mellitus. Therefore, the activity of the aldose reductase enzyme must be inhibited, one of which is using chemical compounds so that complications such as cataracts do not occur. Tests conducted in this study include Lipinski's RO5, ADMETox, pharmacophore screening, and molecular docking. From the test results, it was found that the most potential compound in treating Diabetes Mellitus is Cycloartenol Acetate.
Analysis of Rhodamine B in Lipsticks Marketed in Wonosobo, Indonesia, Using Rapid Test Kits and UV–Visible Spectrophotometry Nova Andina; Dharmastuti Cahya Fatmarahmi
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 2 (2026): J Pharm Nat Sci
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i2.50

Abstract

Rhodamine B is a synthetic dye that is commonly used as a colorant in the paper and textile industries. Rhodamine B is a hazardous dye that is frequently used as a colorant in cosmetics due to its relatively low cost and ability to produce more attractive colors. The use of Rhodamine B in cosmetics can be hazardous to health as it can cause cancer, respiratory tract irritation, eye irritation, skin irritation, and digestive disorders. The objective of this study is to determine the presence of Rhodamine B in lipsticks available on the market in the Wonosobo region. This study employed both qualitative and quantitative methods. The qualitative analysis in this study utilized a rapid test kit to quickly detect the presence of Rhodamine B in lipstick samples based on color changes resulting from the addition of reagents. Samples suspected of containing Rhodamine B were analyzed quantitatively using UV-Vis Spectrophotometry to determine the concentration of Rhodamine B contained in the samples. The results of the qualitative analysis using the rapid test kit showed that, out of 17 lipstick samples tested, 5 samples were suspected of containing Rhodamine B, namely samples 4, 5, 11, 13, and 15. Quantitative analysis using UV–Vis spectrophotometry revealed that the Rhodamine B concentrations were 0.1213 mg/g in sample 4, 0.0861 mg/g in sample 5, 0.0584 mg/g in sample 11, 0.0961 mg/g in sample 13, and 0.1082 mg/g in sample 15. Based on these findings, it can be concluded that several lipsticks suspected of containing hazardous dyes, such as Rhodamine B, are still found in the market and it urges the stakeholder to be more concerned about the dangerous ingredients in cosmetics.
Review: Drug Interactions Between Depression and Epilepsy Therapy Erwin Samsul; Sandrina Nur Yulianda; Rahmawati Eka Sari; Dina Nurfauziah Rahmi; Rahma Nur Afifah; Risma Nur Ramadhani; Annisa Azhalia Syakina; Selvina Nirmaya Saputri; Listra Febrina Taruk
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 2 (2026): J Pharm Nat Sci
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i2.48

Abstract

Background: Managing comorbid depression and epilepsy is challenging due to complex drug-drug interactions (DDIs). Objective: This systematic review evaluates clinically significant pharmacokinetic and pharmacodynamic interactions between antidepressants and antiepileptic drugs (AEDs). Methods: A systematic search was conducted across PubMed, ScienceDirect, and Google Scholar (2010–2025) following PRISMA guidelines. Results: Of 377 identified records, 24 studies met the inclusion criteria. Pharmacokinetic interactions (n=18; 75%) primarily involve the CYP450 enzyme system, notably CYP2D6 inhibition by fluoxetine and induction by carbamazepine. Significant pharmacodynamic risks include serotonin syndrome (n=3) and lowered seizure thresholds. Conclusion: While modern therapies offer better safety profiles, specific combinations like valproate-lamotrigine or SSRI-tramadol require rigorous monitoring. Clinical Implications: Pharmacists must prioritize screening for enzyme-inducing AEDs to prevent therapeutic failure or toxicity in neuropsychiatric care.
Formulation and Physicochemical Evaluation of a Sodium DNA-Based Moisturizer for Cosmetic Applications Neneng Siti Silfi Ambarwati; Risky Mezi Muria; Jafar Sodik; Ratu Mayra Hakim
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 2 (2026): J Pharm Nat Sci
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i2.51

Abstract

Skin hydration plays a critical role in maintaining skin health and preserving skin barrier integrity, while impairment of the barrier may increase transepidermal water loss and lead to dry, sensitive, and irritated skin. The growing interest in biomolecule-based cosmetic ingredients has encouraged the development of innovative moisturizers containing Salmon DNA (Sodium DNA), a purified nucleic acid fragment with potential hydrating properties. This study aimed to formulate and characterize Selvique DNA Salmon Hydra Moist, a moisturizer incorporating Sodium DNA together with humectants, emollients, and skin-conditioning agents to support skin hydration and barrier function. The formulation was prepared using Sodium DNA, glycerin, butylene glycol, saccharide isomerate, allantoin, caprylic or capric triglyceride, cyclopentasiloxane, and complementary excipients, followed by physicochemical and microbiological evaluations. The resulting product exhibited desirable characteristics, including a white cream appearance, odorless profile, pH of 5.27, viscosity of 110,000 cPs, and specific gravity of 1.0092 g/mL. Microbiological analysis demonstrated compliance with cosmetic quality requirements, with total plate count and yeast-mold count of 0 cfu/mL and negative results for Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. The formulation was also classified as non-hazardous according to the ASEAN Cosmetic Directive and remained stable under normal storage conditions. These findings indicate that the developed Salmon DNA-based moisturizer possesses acceptable physicochemical stability and microbiological quality, supporting its potential use as a biomolecule-based cosmetic formulation designed to maintain skin hydration and promote skin barrier function.
In Silico Molecular Docking of Murraya koenigii (L.) Spreng. Metabolites against the Androgen Receptor Nayla Shaffa Mardhiya; Muhammad Nahrawi Udharaja; Viviana Idris; Iswahyudi Iswahyudi
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 2 (2026): J Pharm Nat Sci
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i2.53

Abstract

Prostate cancer is strongly driven by androgen receptor (AR) signaling, making the AR ligand-binding domain an important therapeutic target. Murraya koenigii (L.) Spreng. contains diverse secondary metabolites with reported pharmacological activities, but their interaction with AR remains insufficiently characterized. This study evaluated 20 secondary metabolites of M. koenigii using molecular docking with AutoDock4, using SARM C-23 as the reference ligand. The docking protocol was validated by redocking the native ligand, yielding an RMSD of 0.77 Å. Nine metabolites showed more favorable predicted binding energies and lower inhibition constants than SARM C-23: mahanine, mahanimbine, isomahanine, pyrayafoline D, murrayazoline, O-methylmurrayamine, mahanimbinine, murrayacinine, and mahanimboline. Their predicted binding energies ranged from −10.03 to −11.48 kcal/mol, with Ki values of 3.84–44.60 nM. Interaction analysis indicated that these compounds occupied the AR binding site through predominantly hydrophobic and hydrogen-bond interactions. SwissADME analysis identified O-methylmurrayamine as having the most favorable overall predicted oral drug-likeness profile, although several high-affinity compounds showed excessive lipophilicity and/or poor predicted solubility. These findings identify promising AR-binding candidates from M. koenigii, particularly O-methylmurrayamine, which warrants further biochemical, cellular, pharmacokinetic, and in vivo validation.
Evaluation of the Analgesic Potential of Bangle Rhizome (Zingiber cassumunar Roxb.) Extract in Mice (Mus musculus) Yunanda Pratiwi Sakkung; Erwin Samsul; Maria Almeida; Lizma Febrina; Junaidin Junaidin; Herman Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 2 (2026): J Pharm Nat Sci
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i2.55

Abstract

Bangle (Zingiber cassumunar Roxb.) is a medicinal plant traditionally used by local communities for various health conditions, including fever, stomach discomfort, constipation, and common cold symptoms. This study was conducted to evaluate the analgesic activity of bangle rhizome extract in mice, determine the most effective dose for producing an analgesic response, and compare its analgesic efficacy with aspirin. The experimental animals were randomly allocated into six groups consisting of a normal control group, a negative control group receiving 0.5% NaCMC, a positive control group administered aspirin, and three treatment groups receiving bangle rhizome extract at doses of 150, 200, and 300 mg/kg body weight, respectively. Analgesic activity was assessed using a chemical pain induction model in which 1% acetic acid was administered intraperitoneally 30 minutes after oral administration of the respective treatments. The number of writhing responses was recorded at 10-minute intervals over a 60-minute observation period. The findings demonstrated that the bangle rhizome extract exhibited analgesic activity by reducing the frequency of writhing responses in mice. Among the tested doses, 200 mg/kg body weight produced the most favorable analgesic effect. Furthermore, the analgesic activity observed at this dose was comparable to that produced by aspirin, suggesting that bangle rhizome extract has promising potential as a natural analgesic agent.

Page 4 of 4 | Total Record : 40

 1   2   3   4 

Filter by Year

2024 2026


Reset
Filter By Issues
All Issue Vol. 3 No. 2 (2026): J Pharm Nat Sci Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci. Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci. Vol. 2 No. 2 (2025): J. Pharm. Nat. Sci. Vol. 2 No. 1 (2025): J. Pharm. Nat. Sci. Vol. 1 No. 3 (2024): J. Pharm. Nat. Sci. Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci. Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.