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Journal of Pharmaceuticals and Natural Sciences
Published by CV. Borneo Citra Kreatama
ISSN : -     EISSN : 30475457     DOI : https://doi.org/10.70392/jpns
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
The Journal of Pharmaceuticals and Natural Sciences (JPNS; ISSN 3047-5457) is a scientific, open-access, peer-reviewed journal published by B-CRETA Publisher (CV. Borneo Citra Kreatama). The journal publishes three issues per year) and is available only in the online format. JPNS publishes full-length original articles and reviews. The scope of the journal is pharmaceuticals and Natural Sciences, including its research and application. Therefore, all published articles will have a unique Digital Object Identifier (DOI) number to guarantee authors regarding long-term archiving. With the DOI, all articles in JPNS will not be affected by changes to the URL currently used.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 35 Documents
 1   2   3   4 
Profile of the Use of Oral Antidiabetic Drugs in Outpatinets at the Lonrong Health Center, Ponre District, Bone Regency in 2023 Sukmawati; Faradina, Maulya; Ira Asmaliani
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.33

Abstract

Diabetes mellitus is a degenerative chronic disease characterized by impaired insulin secretion, impaired insulin production and impaired insulin sensitivity. The use of diabetes mellitus drugs can cause problems if the therapeutic goals are not appropriate, one of which is due to the improper selection of drugs so that the therapeutic goals are not effective. This study aims to analyze the profile of the use of antidiabetic drugs in outpatients at Lonrong Health Center in 2023 based on the parameters of the right drug, the right dose, the right indication, and the right time of administration. This study is non-experimental research with a retrospective descriptive design. The sampling technique used is purposive sampling. The sample in this study is medical record data of diabetic mellitus patients in 2023 who meet the inclusion and exclusion criteria. The results showed that of the 50 samples consisting of 41 women (82%) and 9 men (18%), the prevalence of age was dominated around > 60 years (38%). In the rational analysis of drug use, it was found that the indication accuracy was 100%, drug accuracy was 82%, correct dosage was 100% and punctuality of administration was 100%.
Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes Arifuddin, M.; Amanda, Rezti; Arifin, Arfiani; Arifin, Arfina Sukmawati; Iswahyudi, Iswahyudi; Samsul, Erwin; Riki, Riki; Rija'i, Hifdzur Rashif; Hikmawan, Baso Didik; Ibrahim, Arsyik; Rijai, Laode
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Assessment of Sub-Chronic Toxicity of a Polyherbal Infusion of Peperomia pellucida, Moringa oleifera, and Biancaea sappan in Male Mice (Mus musculus) Akbar, Heldi Fadillah; Mahmudah, Febrina; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.46

Abstract

This study evaluated the sub-chronic toxicity of a polyherbal infusion composed of Peperomia pellucida, Moringa oleifera, and Biancaea sappan in male mice. Thirty healthy male mice aged 6–8 weeks, weighing 20–30 g, were orally administered doses of 560, 650, and 1300 mg/kg body weight daily for 28 days, with satellite groups observed for up to 42 days. Clinical monitoring and body weight measurements revealed no signs of toxicity or growth impairment. However, organ index analysis demonstrated dose-dependent increases in liver and kidney weights, and histopathological examination confirmed hepatocellular degeneration and tubular damage at the highest dose. These findings indicate that the infusion is generally safe at low to moderate doses, but prolonged high-dose consumption may compromise hepatic and renal integrity. The study provides important toxicological evidence supporting the establishment of safe dosage ranges for polyherbal formulations and contributes to the scientific validation of traditional medicine practices.
Toxicity of Extracts and Fractions of Bangkal Leaves (Nauclea subdita (Korth.) Steud.) and Genjer (Limnocharis flava (L.) Buch) on the Bioindicator Artemia salina Leach Ibrahim, Arsyik; Salea, Sealti Puji; Windarti, Sri; Ramadhan, M. Rahmad; Rija'i, Hidfdzur Rashif; Arifuddin, M.; Rijai, Laode
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.47

Abstract

A study was conducted on the secondary metabolite content and toxicity testing of Artemia salina leach larvae using extracts from Bangkal leaves (Nauclea subdita (Korth.) Steud.) and Genjer plants (Limnocharis flava (L.) Buch). The objective of this study is twofold: firstly, to ascertain the compounds present in Bangkal leaf extract and Genjer plant extract, and secondly, to assess the toxicity levels of the extracts and fractions from Bangkal leaves and Genjer plants on Artemia salina Leach larvae. In this study, the extraction method employed was maceration with 96% ethanol as the solvent. The crude 96% ethanol extract was fractionated in stages using n-hexane, ethyl acetate, and n-butanol solvents based on polarity levels. The toxicity testing was conducted using the Brine Shrimp Lethality Test (BSLT) method, with Artemia salina Leach larvae serving as the bioindicator. A range of test concentrations were utilised, with each concentration having three replicates. The mortality of Artemia salina was observed after a 24-hour period and was analysed using the Reed and Muench method to determine the LC50 value. The results of the study demonstrated that the secondary metabolites present in the 96% ethanol extract of bangkal leaves com-prised the following groups of compounds: steroids, and triterpenoids, phenols, quinones, and saponins. The toxicity test results of the bangkal leaf extract and fractions yielded LC50 values of 418.79 ppm for the 96% ethanol extract; 716.14 ppm for the n-hexane fraction; 263.03 ppm for the ethyl acetate fraction; and 70,79 ppm for the extract n-buthanol fraction. Meanwhile, the toxicity test results of the genjer plant extract and fractions obtained an LC50 value of 490.23 ppm for the 96% ethanol extract; n-hexane fraction 551.31 ppm; ethyl acetate fraction 425.01 ppm; and n-butanol fraction extract 46.02 ppm. These results indicate that the n-butanol fraction of bangkal leaves and genjer plants have stronger cytotoxic activity than other fraction extracts.
In Silico Study of Phytochemical Compound from Daun Kluwih  (Artocarpus camansi) as an Antidiabetic Targeting Aldose Reductase Radani, Dinar Umaimah; Pintagratia, Ignasia Anindya; Syaiful, Anindya Nursanti; Renaldi, Fahri; Kautsar, Fachrizal Dwi; Novitasari, Dhania
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.49

Abstract

Diabetes Mellitus (DM) is a disease characterized by increased blood glucose levels. The most common type of diabetes is type 2 diabetes mellitus. Aldose Reductase is an enzyme that works in the polyol pathway. The polyol pathway is the pathway where glucose is metabolized by aldose reductase into sorbitol. The end result of this polyol pathway will accumulate in the tissue so that there is a disruption of the osmolarity of the basal membrane which can cause complications of diabetes mellitus. Therefore, the activity of the aldose reductase enzyme must be inhibited, one of which is using chemical compounds so that complications such as cataracts do not occur. Tests conducted in this study include Lipinski's RO5, ADMETox, pharmacophore screening, and molecular docking. From the test results, it was found that the most potential compound in treating Diabetes Mellitus is Cycloartenol Acetate.

Page 4 of 4 | Total Record : 35

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