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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 42 Documents
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Search results for , issue "Vol 8 No 3 (2023)" : 42 Documents clear
DETERMINATION OF THE MINIMUM INHIBITORY CONCENTRATION OF THE ETHANOLIC EXTRACT OF KIPAHIT LEAVES ON THE GROWTH OF Propionibacterium acnes Joko Priyanto Wibowo; Noor Aida; Islan Nor; Irfan Zamzani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.844

Abstract

Acne is a skin disorder characterized by inflammation in the form of comedones, papules, pustules, and nodules. The disease is caused by the gram-positive bacterium,  Propionibacterium acnes. Treatment of the disease using antibiotic agents such as erythromycin and clindamycin has been reported to cause some side effects. Therefore, alternative antibacterial agents derived from natural products are required to reduce the occurrence of side effects. Kipahit (Tithonia diversifolia A. Gray) is one of the plants with pharmacological activities, such as antibacterial and antiprotozoal activities. The aim of this study was to determine the minimum inhibitory concentration (MIC) of a 96% ethanolic extract of kipahit leaves on the growth of P. acnes. Kipahit leaves were extracted through the ultrasound-assisted extraction (UAE) method. Minimum inhibitory concentration (MIC) was determined using the liquid dilution method. A serial dilution was performed to prepare a series of extract concentrations: 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, and 0.39%. Whereas, clindamycin and DMSO 1% were used as positive and negative controls, respectively. Phytochemical  screening showed  that  the 96% ethanolic extract of kipahit leaves contains flavonoids, alkaloids, saponins, steroids/triterpenoids, tannins, and phenolic compounds. In addition, the extract showed   inhibitory activity against P. acnes at concentrations ranging from 25% to 1,56%. In contrast, the extract showed  no inhibitory activity at concentrations of 0.78% and 0.39%. Further experiments confirmed that kipahit leaf extract acted as a bacteriostatic agent (inhibiting bacterial growth) at a minimum concentration of 1.56%.  Keywords: Acne, Propionibacterium acnes, Kipahit, MIC
REVIEW: TONIC POTENCY OF ZINGIBERACEAE FAMILY HERBAL PLANTS IN IMPROVING BODY WELLNESS Nabilah Azka Nihlah; Imam Adi Wicaksono; Keri Lestari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.846

Abstract

Body wellness is closely related to health; it is the ability of a person to perform activities without fatigue. Herbal plants can be used to help improve body health and endurance. The Zingiberaceae family is widely found and used by the Indonesian people. This family is widely used as an ingredient in herbal medicines and seasonings. Herbal plants with the potential to improve body wellness can be seen in their tonic effects. Testing the tonic effect can use several methods, namely, the natatory exhaustion test, hanging test, sleep induction test, and rotarod test in mice. Among these, the natatory exhaustion method is the simplest and can be performed quickly. The method used in preparing this article is to collect and understand the primary literature from online databases, such as Google Scholar. This review article aims to provide scientific information to the public regarding herbal plants from the Zingiberaceae family, which have the potential to help maintain a healthy body. Plants that can be used as health enhancers include Red Ginger, Gajah Ginger, Temu Kunci, Temu Giring, Lempuyang Gajah, and Cardamom. Keywords: Herbal Plant, Zingiberaceae, Tonicum, Health 
REVIEW: MEDICINAL PLANTS WITH PHARMACOLOGICAL ACTIVITY AS ANTIPYRETIC Nurdiani Adiningsih; Dika Pramita Destiani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.847

Abstract

Fever is a medical condition characterized by an increased body temperature beyond the normal range of 36 – 37°C. If not managed appropriately, fever may lead to complications in therapy. The conventional treatment for fever involves using antipyretics such as paracetamol/acetaminophen, and ibuprofen. However, prolonged use of these synthetic medications may have adverse side effects. Consequently, more patients are turning to herbal medicine to manage fever. This review aims to identify medicinal plants with pharmacological activity as antipyretics. We conducted a systematic literature review using Google Scholar as the search engine database. Our search keywords were “tanaman herbal”, “antipiretik", “penurun demam", and "uji aktivitas antipiretik". In this review, a total of 18 articles were meticulously analyzed. The collective findings from these studies demonstrated that all tested medicinal plants exhibited antipyretic activity. Flavonoids, tannins, and terpenoids were the primary constituents responsible for the observed antipyretic activity. Medicinal plants with alkaloids and steroid content were also believed to exhibit antipyretic activity. Keywords: fever, antipyretics, medicinal plants
ANTIMICROBIAL ACTIVITY TEST OF 96% ETHANOL EXTRACT OF FLOWERS, LEAVES, AND STEM BARK OF TIGARUN (Crateva magna DC.) AGAINST Staphylococcus aureus and Malassezia furfur Najwi Hasani; Rika Hartati; Elin Julianti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.848

Abstract

Staphylococcus aureus and Malassezia furfur One of the microbes that can cause folliculitis is the inflammation of the skin in the hair follicles. The use of natural ingredients as antimicrobials must be developed as an alternative to overcome the resistance and side effects of chemical drugs. Tigarun (Crataeva magna DC.) is a typical plant in South Kalimantan that can be developed as a natural antimicrobial agent for the treatment of skin infections. Previous studies have reported that tigarun has antimicrobial activity, but no studies have reported its potential antimicrobial activity against folliculitis-causing microbes. Therefore, this study aimed to determine the antimicrobial activity of 96% ethanol extracts of the flowers, leaves, and stem bark of tigarun (Crataeva magna DC.) against microbes that cause folliculitis, including Staphylococcus aureus and Malassezia furfur. Extraction was performed by the maceration method using 96% ethanol. The antimicrobial activities of the extracts were tested using the agar diffusion method. Based on the results of the antimicrobial activity test using the agar diffusion method, the tigarun flower extract showed better antimicrobial activity than the leaf and tigarun bark extracts. Flower extract activity at 200 mg/mL concentrations against Staphylococcus aureus (10.65 ± 0.25) and the fungus Malassezia furfur (7.40 ± 0.40) with moderate inhibition zone ketogenic  Keywords: Folliculitis, tigarun, antimicrobial, agar diffusion
THE RELATIONSHIP BETWEEN KNOWLEDGE LEVEL AND RATIONAL HEADACHE PAIN SELF-MEDICATION BEHAVIOUR ON FIKES STUDENTS AT LAMONGAN MUHAMMADIYAH UNIVERSITY Siti Rahmatul Azizah; Irma Susanti; Devi Ristian Octavia
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.851

Abstract

The prevalence of self-medication in Indonesia is 84.23%, a figure that has been increasing over the past three years. The increase in self-medication in Indonesia, the availability of drugs that can be taken alone without a doctor's prescription, the perception of mild illness, and the relatively low price of drugs. The potential risks of self-medication are incorrect diagnosis of disease, delay in seeking necessary treatment, disease becoming more severe, wrong method administration, and wrong dose. Knowledge of rational use of drug self-medication still lacks students at 55.5%. It is important to know that student self-medication, in which students can overcome minor complaints of their own illness, does not have an impact on health and academic achievement. The incidence of headaches in students is 11-40% and mild headache levels interfere with academic performance. This study measures level knowledge behavior  to determine the relationship between level knowledge and rational headache self-medication behavior  by students at Muhammadiyah Lamongan University. The research design was cross-sectional descriptive analytics. Data were collected using online questionnaires. The sample included 166 Fike students using a purposive sampling technique. The results indicated level of knowledge: students classified sufficient (59.0%) and rational head pain self-medication behavior  classified as good (57.8%). The results of the Spearman Rho test analysis showed a p-value of <0.001 and correlation coefficient of 0.256. This study concluded that there is a relationship between level of knowledge and rational headache self-medication behavior  with low correlation strength.
INFLUENCE OF Momordica charantia (L.) ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF GLICLAZIDE IN ALLOXAN-INDUCED DIABETIC RATS Tubagus Akmal; Lucy Sasongko
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.854

Abstract

Diabetes mellitus is a metabolic disorder present in the top ten diseases that cause death. Diabetes treatment usually uses conventional drugs, such as gliclazide, which is the first choice in patients with type 2 diabetes mellitus who are intolerant to metformin. In addition to conventional medicine, herbal medicines are in great demand and have become a focus of research to obtain an alternative treatment for type 2 diabetes mellitus. One herb that has been widely used and studied is the bitter melon. This study aimed to determine the effects of bitter melon extract (BME) on the pharmacokinetics and pharmacodynamics of gliclazide when used simultaneously. The study was conducted on three groups of rats with alloxan-induced diabetes. Group 1 received a single dose of gliclazide (33 mg/kg BW, n = 3), group 2 received aqueous extracts of bitter melon fruit (341 mg/kg BW, n = 4), and group 3 received a combination of gliclazide and an aqueous extract of bitter melon (n = 4). The pharmacokinetic profile of gliclazide is affected by BME, where interactions occur during the absorption phase. The blood glucose levels were measured using a glucometer. Decreased blood glucose levels following administration of gliclazide, extract of bitter melon, and a combination of gliclazide and extract of bitter melon 6 hours after dosing were 74.73%, 82.977%, and 86.457%, respectively. This study demonstrated the interactions between gliclazide and BME in the absorption phase of gliclazide and its effect on blood glucose levels.
REVIEW: PHYSICAL CHARACTERISTICS, ANTIOXIDANT, ANTIBACTERIAL AND WOUND HEALING EFFECTS OF BASIL LEAVES IN SEVERAL TYPES OF PHARMACEUTICAL BASES Rodhia Ulfa; Wildan Khairi Muhtadi; Nesa Agistia; Haiyul Fadhli
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.855

Abstract

Topical preparations are dosage forms applied to the skin for local therapy. These topical preparations contain several types of bases that are used for drug formulations. This review aimed to determine the type of base that is effective and widely used in basil leaf preparations that function as antioxidants, antibacterial agents, and in wound healing. The research method is comparative, namely, reviewing research articles on formulations of basil leaf products with various concentrations of base types, hydrogels, emulgels, lotions, hydrocarbons, water solubility, absorption, water washing, M/A-type creams, and pastes. The recommended formulation is a gel base type that has physical characteristics, non-irritating properties, antioxidant activity, antibacterial activity, and wound healing. This review contained articles published in the last 10 years.  Keywords: basil leaves, base type, physical characteristics, basil leaves, pharmacological activity
QUALITATIVE ANALYSIS OF DRUG SUBSTANCES IN RHEUMATIC JAMU SAMPLES USING THIN LAYER CHROMATOGRAPHY Resma Dwi Putri Fitrianasari; Perdana Priya Haresmita; Herma Fanani Agusta
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.862

Abstract

Since ancient times, jamu have been used to treat various diseases. Recently, the number of jamu has increasing and this has led several manufacturers to commit fraud. They added drug substances (DS) into jamu for gaining the effect of jamu so that can raise the sales of jamu in market . The addition of DS into herbal medicine is a violation of the regulation issued by The Ministry of Health. Such practices can cause side effects that are very dangerous for health. The purpose of this research is to analyze the presence of DS in jamu samples that are frequently consumed and circulated in Kranggan, Temanggung and Magelang city. Thin-Layer Chromatography (TLC) was employed to detect the presence of prednisone, paracetamol, and mefenamic acid. The working principle of the separation of compounds with TLC is to separate samples based on the partition difference between samples and the solvent used. In this case, the stationary phase used is the silica gel plate GF254 with the mobile phase for prednisone using ethyl acetate:chloroform (4:1), mefenamic acid using chloroform:methanol (9:1),and paracetamol using chloroform:ethanol (8:1). As a result of qualitative analysis, jamu samples in those areas do not contain any drug substances that were suspected to be present. Keywords: jamu, prednisone, paracetamol, mefenamic acid
REVIEW: APPLICATION OF THE ATC/DDD METHOD FOR ANTIBIOTIC EVALUATION IN INDONESIA Yusna Fadliyyah Apriyanti; Saepudin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.888

Abstract

The global consumption of antibiotics has increased rapidly by 65% in units of daily doses over the last 15 years. Researchers predict that there will be a 200% increase in global antibiotic consumption by 2030, if there is no change in policy implementation. This article aims to provide knowledge regarding the use of the anatomical therapeutic chemical/defined daily doses (ATC/DDD) method to evaluate antibiotics in Indonesia, which is expected to provide additional knowledge for the quantitative evaluation of antibiotics. The literature data sources used were PubMed and Google Scholar online databases, using the Mendeley® tool for manager reference. There were 71 articles that met the criteria and were discussed systematically. Most of the ATC/DDD methods were used to evaluate antibiotics in 90.1% of inpatients and 9.9% of outpatients. In the application of this method, 94.4% of the data collection was carried out retrospectively, with most study designs using a cross-sectional 76%. The selected research period varied from 1 month to 5 years, with 59.1% of the study locations being carried out at the tertiary service level. The ATC/DDD method can also be used in a quasi-experimental design that examines comparisons before and after the intervention. The use of this method as an evaluation of the use of antibiotics in the specified study population resulted in the highest DDD/100 days of ceftriaxone hospitalization in 27 articles. Amoxicillin had the highest DDD/1000 patient-days in of 6/7 articles in the outpatient population...
THE EFFECT OF MACERATION METHOD AND SOXHLETATION METHOD ON TOTAL PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITY OF KIRINYUH (Chromolaena odorata (L.) R.M.King & H.Rob) LEAF Renatha Audya Larasati; Nastiti Utami; Novena Yety Lindawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.889

Abstract

This study evaluated kirinyuh leaf extract as a natural antioxidant using Soxhlet extraction and maceration extraction methods. Dried leaves of kirinyuh were extracted with 96% ethanol. The total phenolic content was measured spectrophotometrically according to the Folin Ciocalteu method, calculated as gallic acid equivalent (GAE), while the antioxidant activity was measured using ABTS. The results of the phytochemical test of kirinyuh leaf extract using maceration (EKM) and Soxhletation (EKS) methods revealed alkaloids, flavonoids, saponins, steroids, and tannins. The total phenolic content of EKM was 39.85 ± 0.20 mgGAE/gram and EKS was 46.95 ± 0.15 mgGAE/gram extract. Antioxidant activity in the form of IC50 EKM was 46.10 ± 0.09 mg/L and EKS was 45.27 ± 0.07 mg/L, both of them have a very strong category. There were significant differences in the total phenolic content and antioxidant activity of the ethanol extract of the Kirinyuh leaf using maceration and soxhletation methods based on the results of the T-test. Keywords: Kirinyuh, Eupatorium odoratum, ABTS, phenolics, antioxidant.

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