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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 39 Documents
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Search results for , issue "Vol 9 No 1 (2024)" : 39 Documents clear
DETERMINATION ANTIOXIDANT ACTIVITY, TOTAL PHENOLICS, FLAVONOIDS CONTENT, OF JUNGRAHAB LEAVES (Baeckea frutescens L.) Wahyu Priyo Legowo; Irma Erika Herawati; Lisna Dewi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1082

Abstract

Medicinal plants are widely used to treat various diseases, and one of the reasons for this is the safety of medicinal plants. The active compounds in medicinal plants include phenolics and flavonoids, which are known to have antioxidant activity. Antioxidants play an essential role in the body's defense against various diseases because they prevent the negative effects of free radicals. Jungrahab (Baeckea frutescens L.) is a medicinal plant containing phenolics and flavonoids. This study aimed to determine the antioxidant activity of jungrahab leaf extracts using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. The results showed the antioxidant activity of the extract, water fraction, ethyl acetate, and n-hexane of jungrahab leaves with IC50 values of 12.62, 61.74, 60.66, and 63.99 ppm, respectively. Meanwhile, jungrahab extract has a total phenolic content of 52.40 mg GAE (Gallic Acid Equivalent)/g and a flavonoid content of 56.72 mg QE (Quercetin Equivalent)/g. Jungrahab extract showed strongest antioxidant category compared to its fractions. Keywords: phenolics content, flavonoids content, antioxidant activity, DPPH, jungrahab
REVIEW: REVIEW ARTICLE LIPID-BASED NANOTECHNOLOGY Garnadi Jafar; R. Awaludin Nazal N; Entris Sutrisno
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1084

Abstract

Nanotechnology is defined as engineering the creation of materials, functions, and devices on the nanometer scale. Nanoscience is increasingly developing and becoming a part of various fields, such as electronics, materials, and biology. Lipid nanoparticles are a major application in nanotechnology. In formulas II and III, smaller results were obtained compared with the other formulas. Based on the results of this study, it can be concluded that the nanostructured lipid carrier system with solid lipid poloxamer and stearic acid with liquid soybean oil lipids obtained good characteristics, and each test met the range. From the explanation above, it can be concluded that lipid-based nanotechnology has great potential in various fields such as medicine, cosmetics, and agriculture. Its use can provide great benefits such as increasing the effectiveness of drug administration, increasing the absorption of nutrients in food, and developing cosmetic products. which one is safer and more effective. To compare several types of nanoparticle methods, such as Liposomes, Neosomes, Etosomes, SLN, and NLC for selection of the lipid base, namely NLC. It is important to ensure that the use and development of this technology are safe and beneficial for humans and the environment. Keywords : Nanotechnology, Nanoparticles, Lipid-Based Nanoparticles
MINI REVIEW: BLACK RICE (Oryza sativa L. Indica) AS POTENTIAL FOOD FOR ANTIHYPERGLYCAEMIC Arifah Sri Wahyuni; Diski Wahyu Wijayanto
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1094

Abstract

In Indonesia, rice (Oryza sativa L.) has different colors and shapes, visible from the plants and rice. There are several types of rice, one of which is black rice (Oryza sativa L. indica). Researchers are motivated to explore the benefits of black rice in Indonesia. This interest stems from the potential health benefits of black rice, such as its benefits in treating diabetes mellitus. The effectiveness of reducing blood sugar levels is crucial in the context of the increasing prevalence of diabetes in Indonesia, as projected by the International Diabetes Federation for 2045. The author made observations on the phytochemical and pharmacological activities of black rice, aiming to lay the foundation for further study and development. By searching online journals in the Scopus and PubMed databases using the keywords (“Black Rice”) AND (antidiabetic) OR (diabetes) OR (“glucose lowering”) for the last 10 years, the filtering process produced 3 articles on Scopus and 5 articles on PubMed, providing accurate data for review. Results show that black rice contains bioactive compounds such as flavonoids, phytic acid, polyphenolic compounds, and oryzanol, which provide significant health benefits. Anthocyanins, the main compounds responsible for the color of rice, contribute to antihyperglycemic properties and have various pharmacological activities, one of which is anti-diabetic benefits. In addition, the high content of anthocyanins, fiber, and other nutrients in black rice makes it effective in managing the glycemic index, and blood glucose levels, and improving overall health ...
REVIEW: THE USE OF TOFU RESIDUE IN THE PHARMACEUTICS Ine Suharyani; Iin Indawati; Encu Asep Setiadi; Maisya Mauliana Insani; Ibnu Mas'ud
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1096

Abstract

Tofu is a processed soy product consisting of soft solids made by clumping soy protein extracts. The residual result of tofu processing is called the tofu dredging waste. In Indonesia, tofu waste remains an unsolved problem. Many people argue that the waste from tofu processing (tofu residue waste) does not have high economic value and is only used as feed for livestock and is even thrown carelessly into the river, which causes damage to the ecosystem. Tofu pulp has high nutritional content, such as protein (26.6%), fat (18.3%), carbohydrates (41.3%), phosphorus (0.29%), calcium (0.19%), iron (0.04%), and water (0.09%). The purpose of this journal review is to determine the use of tofu residue waste and solve the problem of tofu residue waste in the community. The method used was collecting various research journals through the Google Scholar website with keywords for the use of tofu residue in the pharmaceutical field. Based on the 7 journals reviewed, tofu pulp can be used as an anti-aging, adsorbent, anti-diabetes, anti-inflammatory, bioethanol, and excipient in tablet production. Keywords: Tofu, tofu residue, pharmaceutical
ANTIDIABETIC EFFECT OF ETHANOLIC EXTRACT OF KEDONGDONG PAGAR LEAVES (Lannea coromandelica (Houtt.) Merr.) ON MALE MICE Safriana Safriana; Melati Yulia Kusumastuti; Andilala Andilala
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1097

Abstract

Diabetes mellitus is a metabolic condition defined as an increase in blood glucose levels (hyperglycemia) caused by impaired insulin production or insulin action. One of the treatments for diabetes mellitus is the use of medicinal plants because they contain bioactive phytochemicals. Kedongdong pagar leaves (Lannea coromandelica (Houtt.) Merr.) is an empirical medication used to reduce the blood glucose levels in Aceh, Indonesia.  The leaves contain flavonoids, which have antioxidant effects that can reduce damage to the pancreatic beta cells. The goal of this study was to examine the antidiabetic impact of an ethanol extract of kedongdong pagar leaves in male mice induced with alloxan to increase blood glucose levels. The test procedure involved splitting 25 mice into five treatment groups, Na-CMC suspension 0.5% w/v, Kedongdong pagar extract with dose 10 mg/kg BW, 20 mg/kg BW, 40 mg/kg BW, and glibenclamide suspension with dose 0.65 mg/kg BW as positive control. The results showed that all ethanolic extracts of Lannea coromandelica had the same potency to lower blood glucose levels in mice, implying that the ethanol extract of Lannea coromandelica leaves had antidiabetic activity due to the presence of antidiabetic compounds such as flavonoids and glycosides. Keywords: Antidiabetic, Diabetic, Kedongdong Pagar Leaves, Lannea coromandelica.
SERUM OF EXTRACT Onchidium Typhae USES HYDROXYETHYL CELLULOSE AND CARBOXYMETHYL CELLULOSE NATRIUM BASE AS ANTIOXIDANT Bambang Wijianto; Liza Pratiwi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1113

Abstract

Antioxidants can prevent premature aging (anti-aging) and various types of cancer and increase body immunity. Empirically, Onchidiid slugs have been used as natural antioxidants. This study aimed to determine the antioxidant potency of the serum of Onchidiid slug ethanolic extract. The Onchidiid slug extract was obtained by maceration and was prepared to create two effective serum formulations. Formula A involved hydroxyethyl cellulose (HEC), while Formula B employed sodium carboxymethyl cellulose (Na-CMC) as gelling agent. The second serum formula was rigorously evaluated and subjected to antioxidant activity testing by the diphenyl-2-picrylhydrazyl (DPPH) method. The serum preparation with the best physical properties and antioxidant activity was serum A at a concentration of 1%. Physical test results showed that serum A had a yellow color with a distinctive smell and was homogeneous with a soft texture. The test results for the spreadability and stickiness properties of serum A were 6 cm2 and 1'55'' second. The serum A antioxidant activity test results showed moderate free-radical scavenging activity, with an IC50 value of 277 ppm. Keywords: Anti-aging, 2,2-diphenyl-1-pikrilhidrazyl, Onchidium typhae, Antioxidant
CYTOTOXICITY TEST OF N-HEXANE, ETHYL ACETATE, AND WATER FRACTIONS FROM THE ETHANOL EXTRACT OF SENDUDUK LEAVES (Melastoma malabathricum L.) ON MCF-7 CELLS USING THE MTT ASSAY METHOD Tri Oktarina; Peni Indrayudha; Rima Munawaroh
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1119

Abstract

The world's richest flora may be found in Indonesia, where a variety of plants, such as the sesame plant (Melastoma malabathricum L) or MM, may be used to treat cancer. According to earlier studies, the methanol extract of the leaves had a substantial anticancer effect on the MCF-7 cell line, with an IC50 of 7.14 µg/mL. The purpose of this study was to evaluate the cytotoxic potential of the water, ethyl acetate, and n-hexane fractions of senduduk leaf ethanol extracts. Maceration was the extraction technique, partitioning (liquid-liquid extraction) was the fractionation technique, and the MTT method was employed to assess cytotoxic activity. The n-hexane, ethyl acetate, and water fractions showed cytotoxic effects with IC50 values of 137.200 µg/mL, 17.108 µg/mL, and 610.863 µg/mL, respectively. The water and n-hexane fractions were classified as fragile, based on the results of the cytotoxicity test. The ethyl acetate fraction, on the other hand, was added to the active category for suppressing MCF-7 cells.  Keywords: Melastoma malabathricum L, Cytotoxic, Cells, MCF-7, MTT assay
TESTING THE ACTIVITY AND FORMULATION OF NATURAL HAND SOAP BASED ON NATURAL SURFACTANTS OF LERAK FRUIT (Sapindus rarak DC.) AGAINST Staphylococcus aureus Rose Intan Perma Sari; Natasha Ardinata; Oky Hermansyah; Suci Rahmawati; Camelia Dwi Putri Masrijal
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1151

Abstract

Lerak (Sapindus rarak DC.) is a fruit belonging to the Sapindaceae family that usually grows in tropical forests. Lerak fruit flesh contains the main active compound, saponin. Saponin is a natural surfactant with foaming and emulsifying properties. The use of synthetic surfactants in the manufacture of hand soap sold on the market can have negative impacts, such as irritation and denaturation of proteins in the outer epidermis layer in humans if exposed too often. This study aimed to determine whether lerak can be formulated into natural hand soap as a natural surfactant and determine its antibacterial activity against Staphylococcus aureus bacteria. Lerak fruit solutions were prepared using a maceration method. The resulting solution was then formulated into hand soap at concentrations of 10%, 30%, and 50%. The evaluation of the natural hand soap preparation from the lerak fruit included organoleptic evaluation, homogeneity, pH, viscosity, foam height, and antibacterial activity against Staphylococcus aureus bacteria using the disc diffusion method. Based on the research results, Lerak Fruit (Sapindus rarak DC.) can be formulated as a natural surfactant in hand soap at concentrations of 0%, 10%, 30%, and 50%. Based on the evaluation of the physical properties in the foam height test, F1, F2, and F3 met the requirements, whereas F0 did not meet the requirements in the foam stability test because it did not contain lerak fruit extract, so no foam formed ...
FORMULATION AND TESTING OF ANTIOXIDANT ACTIVITY COMBINATION OF CALENDULA OIL AND SWEET ORANGE OIL WITH DPPH METHOD Deni Firmansyah; Sulistiorini Indriaty; Nina Karlina; Eka Mardiyani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1171

Abstract

Indonesia has many natural ingredients that can be used as primary ingredients for medicines with antioxidant effects. Calendula oil and sweet orange oil have the potential to be antioxidants. This study aimed to determine the stability of cream preparations based on stability test parameters and to determine antioxidant activity using the DPPH method. This study was conducted because the combination of calendula oil and sweet orange oil was tested for antioxidant activity and then formulated in cream dosage forms with ratio of 1:1, 1:2, and 2:1. Antioxidant activity tests were carried out using a combination of calendula oil and sweet orange oil and a cream preparation of a combination of calendula oil and sweet orange oil, which was tested for stability using the cycling test method. Based on the results of the study, the combination of calendula oil and sweet orange oil in a ratio of 1:1 and 1:2 had weak antioxidant activity, as can be seen from the IC50 value of 170.02 ppm, 150.43 ppm, whereas in a 2:1 ratio, it had moderate antioxidant activity because the IC50 value was 143.89 ppm. In the combination cream preparations of calendula oil and sweet orange oil, ratios of 1:1, 1:2, and 2:1 had weak antioxidant activity. It can be seen from the IC50 value of each preparation, which was 188.85 ppm, 170.01 ppm, and 189.61 ppm. Keywords: Calendula Oil, Sweet Orange Oil, Antioxidant, Cream, DPPH

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