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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Search results for , issue "Vol 9 No 2 (2024)" : 26 Documents clear
FORMULATION AND EFFICACY TESTING OF SPF (Sun Protecting Factor) SUNSCREEN GEL EXTRACT OF RAMBUSA LEAVES (Passiflora Foetida L) Fauziyyah Al Hasanah; Muthi’ah Rabbaniyyah; Eni Kurniati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1236

Abstract

The rambusa plant contains flavonoid compounds found in rambusa leaves which are good antioxidants because they have hydroxyl groups attached to aromatic carbon rings. This makes rambusa leaves able to ward off free radicals. The choice of gel composition is based on practical considerations because gel not only provides effective protection against sunlight but also has non-sticky properties, provides a soft feel and forms a film that adheres well to the skin. This research aims to determine the flavonoid content in rambusa leaves, which are antioxidants that can be formulated into sunscreen gel preparations to help protect the skin from sunlight. Determination of antioxidant levels in sunscreen gel preparations made from rambusa leaf extract was carried out by measuring the SPF (Sun Protection Factor) value at three different concentrations, namely 2%, 4%, and 6% using UV-Vis spectroscopy. The research results showed that all formulas had good physical quality values of the gel preparations. All formulas have varying SPF values, where the 2% concentration has maximum protection with an SPF value of 11.7 and the 4% and 6% concentrations have ultra protection with SPF values of 18.8 and 33.9. The conclusion of this research is that rambusa leaf extract has the potential to be an effective natural ingredient in sunscreen preparations and shows the ability to protect the skin from sunlight, where formulation 3 only has the highest SPF number, namely 33.90 (super protection).  Keywords: Rambusa leaves, Protection, Sunscreen, SPF
REVIEW: THE ROLE OF HERBAL AS A THERAPY FOR ENDOTHELIAL DYSFUNCTION IN CARDIOVASCULAR DISEASES: NARRATIVE REVIEW Febriana Astuti; Akrom; Rafiastiana Capritasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1238

Abstract

Atherosclerosis, diabetes mellitus, hypertension, and aging are examples of cardiovascular illnesses, the pathogenesis of which is affected by endothelial dysfunction. Many patients with cardiovascular disease already use herbs or combine herbs with medications prescribed by doctors. Herbs have emerged as alternative treatments for health maintenance. Herbs are in increasing demand by patients and health professionals. An overview of the role of herbal plants, their active substances, and their mechanisms of action as therapies for endothelial dysfunction to prevent the worsening of cardiovascular disease is presented in this review. The research was carried out by reviewing published scientific papers using online sources, such as PubMed and Google Scholar. Herbs can be used as a therapy for endothelial dysfunction to prevent the worsening of cardiovascular disease through various mechanisms, including inhibition of oxidative stress through the COX-2 and NOX2 pathways, inhibition of NADPH oxidase, inhibition of ROS formation through Src/EGFR/Akt, and increasing nitric oxide (NO) production by activating eNOS. The benefits and potential of herbal plants in dysfunction therapy to prevent cardiovascular disease need to be further developed for plants that grow widely in Indonesia. Furthermore, it is necessary to develop mechanisms for other targets, such as immunomodulatory therapy, to prevent cardiovascular disease from worsening. Keywords: Herbals, Endothelial Dysfunction, Cardiovascular Disease
ANALYSIS OF NaOCl CONTENT OF HAND & BODY LOTION AND FACE WASH CREAM BY IODOMETRIC TITRATION METHOD Jeli Marlita; Yuyun Febriani; Risma Hayatun Nufus; Muhlisun Azim; Baiq Maylinda Gemantari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1242

Abstract

Cosmetics are needed by the public, such as hand and body lotions and face brightening creams, and there are many misuses of hazardous chemicals in cosmetics, including lotions and face brightening creams. Sodium hypochlorite, a  hazardous chemical, can cause skin damage, such as irritation, rash, hypersensitivity, and burns. The purpose of this study was to determine the presence of sodium hypochlorite compounds and sodium hypochlorite in hand and body lotion cosmetics and face brightening cream. The method used in this research was qualitative analysis with color reaction and quantitative analysis with iodometric titration. The results qualitatively showed that color changes occurred in all samples. NaOCl concentration in hand and body lotion at 0.2% concentration showed an average NaOCl concentration of 3.263 % ± 0.25 and face brightening cream concentration at an average concentration of 10 mg showed NaOCl levels of 88.933 % ± 7.57. Based on this, it was concluded that in the samples of hand and body lotion and face brightening cream, sodium hypochlorite compounds with different levels. Therefore, these samples could have side effects and toxicity in their usefulness as cosmetics. Keywords: Hand & body lotion, face brightening cream, sodium hypochlorite (NaOCl), iodometric titration
DETECTION OF WHITE RICE ADULTERANTS IN LAMPUNG ROBUSTA COFFEE EXTRACT USING FT-IR METHOD BY FINGERPRINT ANALYSIS AND PRINCIPAL COMPONENT ANALYSIS Ivan Andriansyah; Liling Dwi Ambaga; Reza Pratama; Fauzan Zein Muttaqin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1254

Abstract

Lampung Province has 3 areas that produce coffee: West Lampung, Tanggamus, and Waykanan, which can produce 51,484 tons of coffee annually. The high demand for coffee and limited harvest are some factors that cause the addition of adulterants to coffee products such as corn, soybeans, rye, coffee beans, and rice. This study aims to detect rice adulterants in Lampung robusta coffee using the FTIR spectrophotometric method combined with chemometric analysis using the PCA (Principal Component Analysis) method. FTIR spectrophotometric method combined with chemometric analysis using PCA (Principal Component Analysis) method. The PCA method was validated using the cross-validation method. Samples were taken from 3 Lampung coffees on the market. The extraction process was carried out on Lampung coffee and Lampung rice from 3 regions using 96% ethanol. After concentrating, the coffee and rice extracts were measured using FTIR and read in the 4000-650 cm-1 wave number range. Different wave number curves were obtained between coffee and rice. A pre-processing chemometric analysis was performed, which resulted in the classification of Robusta coffee and rice using PC1 and PC2 (50% and 24%). The results of PCA analysis showed that PC1 and PC2 in the three Lampung coffee samples, samples A and C, did not contain adulterants, while sample B was suspected of containing white rice.  Keywords: Alduteran, FTIR, Chemometrics, PCA, Lampung Robusta Coffee.
ANTIBACTERIAL ACTIVITY TEST OF TEA TREE AND LEMON OIL COMBINATION AND ITS FORMULATION IN CREAM PREPARATION Sulistiorini Indriaty; Rima Yulia Senja; Deni Firmansyah; Nur Rahmi Hidayati; Nina Karlina; Muhammad Yani Zam Zam; Dhea Aulia Ramadhani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1278

Abstract

Tea tree oil contains hydrocarbon compounds, namely terpenes, especially monoterpenes, sesquiterpenes, and alcohols. Terpinen-4-ol is the main component of tea tree oil, which has antimicrobial activity. Lemon oil is useful as an antibacterial because it contains flavonoids that prevent attacks from pathogenic bacteria. This study aims to determine whether tea tree and lemon oil have antibacterial activity against Propionibacterium acnes bacteria and can be formulated into cream preparations. The antibacterial activity test of the combination of tea tree oil and lemon oil in the 1: 1, 1: 2, and 2: 1 ratio was carried out in vitro against Propionibacterium acnes bacteria by disc diffusion method and using virile gel as a positive control. The cream stability test is replicated using the cycling test method with organoleptic test parameters, homogeneity, pH, dispersion, cream type testing, viscosity, and flow properties. The stability test results with the cycling test method showed good stability results, including organoleptic tests, homogeneity, spreadability, pH, emulsion type, viscosity, and flow properties. The combination of tea tree and lemon essential oils in a 1:1, 1:2, 2:1 ratio has antibacterial activity against Propionibacterium acnes bacteria with inhibition zones diameter ±1,23 cm, ±1,12 cm, and ±1,12 cm and control has ±1,53 cm. Combining tea tree and lemon essential oil in a 1:1, 1:2, and 2:1 ratio has antibacterial activity against Propionibacterium acnes bacteria and can be formulated into cream preparations. Keywords: tea tree oil, lemon oil, antibacterial, Propionibacterium acnes, cream.
EFFECT OF COCAMIDOPROPYL BETAINE (CAPB) CONCENTRATION ON PHYSICAL CHARACTERISTIC OF BASIL LEAVES (Ocimum basilicum L.) ESSENTIAL OIL FACIAL WASH Putri, Vania Santika; Hadi, Verawati; Nuryani, Anita Dwi; Ambarwati, Ayu
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1115

Abstract

Atopic dermatitis or often called eczema is a chronic inflammatory skin disorder that often occurs around the face, legs and arms. Decreased skin barrier function can increase the spread of bacteria on the skin surface, especially Staphylococcus aureus. This study aimed to formulate facial wash preparations of basil leaf essential oil using varying concentrations of cocamydopropyl betaine (CAPB) as a surfactant and foam booster. The basil leaf essential oil facial wash was formulated into three formulas with varying concentrations of cocamydopropyl betaine (CAPB), namely F1 (8%), F2 (9%), and F3 (10%). Physical evaluation included organoleptic observations, homogeneity, pH, foam height, and viscosity. Based on the results of organoleptic and homogeneity evaluations, the three facial wash formulas are homogeneous, white in color, and have a distinctive basil smell, with an increasingly watery consistency from F1 to F3, while the pH in the range 4.97 - 5.26, the height foam test of the three formulas was 37–42 mm, and the viscosity was in the range of 2647,1 - 3516,5 cPs. Variations in the CAPB concentration used in the facial wash formulas have a significant effect on the resulting pH and viscosity values, where the higher the CAPB concentration used, the lower pH and viscosity values of the facial wash. However, an increase in CAPB concentration in the facial wash formula (8 %, 9 %, and 10 %) did not have a significant effect on the foam height of the basil leaf essential oil facial wash.

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