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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 523 Documents
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HEALTH-RELATED QUALITY OF LIFE IN POSTMENOPAUSAL WOMEN WITH ADVANCED BREAST CANCER RECEIVING ADJUVANT HORMONE THERAPY (RIBOCICLIB AND LETROZOLE) Syahru Rohman; Wawang Anwarudin; Nur Azizah; Mochammad Nur Isnaeni Mauludin; Anna Khalida Sya’bany
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1092

Abstract

Breast cancer is a type of cancer that affects many women in Indonesia. Adjuvant hormone therapies, such as letrozole and ribociclib, have succeeded in improving the patient's quality of life. This study aimed to assess the quality of life of postmenopausal women with advanced breast cancer who received adjuvant hormone therapy with ribociclib and letrozole. A cross-sectional study was conducted using retrospective data from postmenopausal female breast cancer patients at Dharmais Cancer Hospital between 2020 and 2023 who met the inclusion criteria. To determine the impact of sociodemographics on patient quality of life, data were examined using the quality of life score (EQ5D5L) and Spearman test. There were 29 patients, with a mean age of 54.9 years (SD = 8.65); the highest education level was high school (34.5%); The majority of occupations are housewives (69%), and the majority are stage IV (34.5%). The mean utility and VAS values of Ribociclib were 0.885 and 81.66, respectively, whereas those for letrozole were 0.725 and 78.46, respectively. Analysis of the relationship between quality of life and patient characteristics showed that the quality of life of patients with breast cancer treated with adjuvant ribociclib and letrozole therapy was influenced by the stage of breast cancer (p = 0.008). These findings indicate that patients receiving ribociclib and letrozole therapy have a good quality of life, which quality of life quality of life is influenced by the stage of malignancy.  Keywords: breast cancer, quality of life, letrozole, ribociclib, post menopause
MINI REVIEW: BLACK RICE (Oryza sativa L. Indica) AS POTENTIAL FOOD FOR ANTIHYPERGLYCAEMIC Arifah Sri Wahyuni; Diski Wahyu Wijayanto
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1094

Abstract

In Indonesia, rice (Oryza sativa L.) has different colors and shapes, visible from the plants and rice. There are several types of rice, one of which is black rice (Oryza sativa L. indica). Researchers are motivated to explore the benefits of black rice in Indonesia. This interest stems from the potential health benefits of black rice, such as its benefits in treating diabetes mellitus. The effectiveness of reducing blood sugar levels is crucial in the context of the increasing prevalence of diabetes in Indonesia, as projected by the International Diabetes Federation for 2045. The author made observations on the phytochemical and pharmacological activities of black rice, aiming to lay the foundation for further study and development. By searching online journals in the Scopus and PubMed databases using the keywords (“Black Rice”) AND (antidiabetic) OR (diabetes) OR (“glucose lowering”) for the last 10 years, the filtering process produced 3 articles on Scopus and 5 articles on PubMed, providing accurate data for review. Results show that black rice contains bioactive compounds such as flavonoids, phytic acid, polyphenolic compounds, and oryzanol, which provide significant health benefits. Anthocyanins, the main compounds responsible for the color of rice, contribute to antihyperglycemic properties and have various pharmacological activities, one of which is anti-diabetic benefits. In addition, the high content of anthocyanins, fiber, and other nutrients in black rice makes it effective in managing the glycemic index, and blood glucose levels, and improving overall health ...
REVIEW: THE USE OF TOFU RESIDUE IN THE PHARMACEUTICS Ine Suharyani; Iin Indawati; Encu Asep Setiadi; Maisya Mauliana Insani; Ibnu Mas'ud
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1096

Abstract

Tofu is a processed soy product consisting of soft solids made by clumping soy protein extracts. The residual result of tofu processing is called the tofu dredging waste. In Indonesia, tofu waste remains an unsolved problem. Many people argue that the waste from tofu processing (tofu residue waste) does not have high economic value and is only used as feed for livestock and is even thrown carelessly into the river, which causes damage to the ecosystem. Tofu pulp has high nutritional content, such as protein (26.6%), fat (18.3%), carbohydrates (41.3%), phosphorus (0.29%), calcium (0.19%), iron (0.04%), and water (0.09%). The purpose of this journal review is to determine the use of tofu residue waste and solve the problem of tofu residue waste in the community. The method used was collecting various research journals through the Google Scholar website with keywords for the use of tofu residue in the pharmaceutical field. Based on the 7 journals reviewed, tofu pulp can be used as an anti-aging, adsorbent, anti-diabetes, anti-inflammatory, bioethanol, and excipient in tablet production. Keywords: Tofu, tofu residue, pharmaceutical
ANTIDIABETIC EFFECT OF ETHANOLIC EXTRACT OF KEDONGDONG PAGAR LEAVES (Lannea coromandelica (Houtt.) Merr.) ON MALE MICE Safriana Safriana; Melati Yulia Kusumastuti; Andilala Andilala
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1097

Abstract

Diabetes mellitus is a metabolic condition defined as an increase in blood glucose levels (hyperglycemia) caused by impaired insulin production or insulin action. One of the treatments for diabetes mellitus is the use of medicinal plants because they contain bioactive phytochemicals. Kedongdong pagar leaves (Lannea coromandelica (Houtt.) Merr.) is an empirical medication used to reduce the blood glucose levels in Aceh, Indonesia.  The leaves contain flavonoids, which have antioxidant effects that can reduce damage to the pancreatic beta cells. The goal of this study was to examine the antidiabetic impact of an ethanol extract of kedongdong pagar leaves in male mice induced with alloxan to increase blood glucose levels. The test procedure involved splitting 25 mice into five treatment groups, Na-CMC suspension 0.5% w/v, Kedongdong pagar extract with dose 10 mg/kg BW, 20 mg/kg BW, 40 mg/kg BW, and glibenclamide suspension with dose 0.65 mg/kg BW as positive control. The results showed that all ethanolic extracts of Lannea coromandelica had the same potency to lower blood glucose levels in mice, implying that the ethanol extract of Lannea coromandelica leaves had antidiabetic activity due to the presence of antidiabetic compounds such as flavonoids and glycosides. Keywords: Antidiabetic, Diabetic, Kedongdong Pagar Leaves, Lannea coromandelica.
ADAPTATION AND VALIDATION OF THE INDONESIAN VERSION OF THE HEALTH BELIEF MODEL INSTRUMENT FOR PARENTS Eka Wuri Handayani; Fredrick Dermawan Purba; Dyah Aryani Perwitasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1101

Abstract

Children are a crucial population requiring COVID-19 vaccination. With the global rollout of COVID-19 vaccines, the increasing number of unvaccinated children and adolescents has raised concerns. To was translated, adapted, and validate the Health Belief Model instrument for parents of children aged 6–11 years regarding COVID-19 vaccination in the Indonesian language. Cross-cultural translation and adaptation were conducted according to international standards. The instrument testing process, according to Beaton et al., (2020), involves five stages: forward translation, synthesis of the translation results, back translation, review of the back translation, and readability testing. Respondents were purposively selected from the parents of children aged 6–11 years. Face and content validity were achieved for the Indonesian version of Health Belief Model for parents of children aged 6–11 years. The validity of each statement item was assessed using Pearson Correlation with a significance level of 0.05 and 193 respondents, resulting in an r table value of 0.1406. The constructs within the Health Belief Model were deemed valid based on the Pearson Correlation values, as the coefficient values were greater than the r-table value (r > 0.1406; p < 0.05). The constructs in the Health Belief Model were also reliable, with a Cronbach’s alpha value of 0.657. The culturally adapted Indonesian version of the Health Belief Model instrument for parents of children aged 6–11 years regarding COVID-19 vaccination is considered valid and reliable for use in research among the parent population of children aged 6–11 years in the context of COVID-19 vaccination.
SERUM OF EXTRACT Onchidium Typhae USES HYDROXYETHYL CELLULOSE AND CARBOXYMETHYL CELLULOSE NATRIUM BASE AS ANTIOXIDANT Bambang Wijianto; Liza Pratiwi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1113

Abstract

Antioxidants can prevent premature aging (anti-aging) and various types of cancer and increase body immunity. Empirically, Onchidiid slugs have been used as natural antioxidants. This study aimed to determine the antioxidant potency of the serum of Onchidiid slug ethanolic extract. The Onchidiid slug extract was obtained by maceration and was prepared to create two effective serum formulations. Formula A involved hydroxyethyl cellulose (HEC), while Formula B employed sodium carboxymethyl cellulose (Na-CMC) as gelling agent. The second serum formula was rigorously evaluated and subjected to antioxidant activity testing by the diphenyl-2-picrylhydrazyl (DPPH) method. The serum preparation with the best physical properties and antioxidant activity was serum A at a concentration of 1%. Physical test results showed that serum A had a yellow color with a distinctive smell and was homogeneous with a soft texture. The test results for the spreadability and stickiness properties of serum A were 6 cm2 and 1'55'' second. The serum A antioxidant activity test results showed moderate free-radical scavenging activity, with an IC50 value of 277 ppm. Keywords: Anti-aging, 2,2-diphenyl-1-pikrilhidrazyl, Onchidium typhae, Antioxidant
EFFECT OF COCAMIDOPROPYL BETAINE (CAPB) CONCENTRATION ON PHYSICAL CHARACTERISTIC OF BASIL LEAVES (Ocimum basilicum L.) ESSENTIAL OIL FACIAL Vania Santika Putri; Verawati Hadi; Anita Dwi Nuryani; Ayu Ambarwati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1115

Abstract

Atopic dermatitis or often called eczema is a chronic inflammatory skin disorder that often occurs around the face, legs and arms. Decreased skin barrier function can increase the spread of bacteria on the skin surface, especially Staphylococcus aureus. This study aimed to formulate facial wash preparations of basil leaf essential oil using varying concentrations of cocamydopropyl betaine (CAPB) as a surfactant and foam booster. The basil leaf essential oil facial wash was formulated into three formulas with varying concentrations of cocamydopropyl betaine (CAPB), namely F1 (8%), F2 (9%), and F3 (10%). Physical evaluation included organoleptic observations, homogeneity, pH, foam height, and viscosity. Based on the results of organoleptic and homogeneity evaluations, the three facial wash formulas are homogeneous, white in color, and have a distinctive basil smell, with an increasingly watery consistency from F1 to F3, while the pH in the range 4.97 - 5.26, the height foam test of the three formulas was 37–42 mm, and the viscosity was in the range of 2647,1 - 3516,5 cPs. Variations in the CAPB concentration used in the facial wash formulas have a significant effect on the resulting pH and viscosity values, where the higher the CAPB concentration used, the lower pH and viscosity values of the facial wash. However, an increase in CAPB concentration in the facial wash formula (8 %, 9 %, and 10 %) did not have a significant effect on the foam height of the basil leaf essential oil facial wash.
ANALYSIS OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY ETANOL EXTRACT OF BUTTERFLY PEA FLOWER (Clitoria ternatea) IN YOGYAKARTA Kusuma, Nyoman Rudi; Sulistyani, Nanik; Sugihartini, Nining
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1118

Abstract

Butterfly Pea Flower is one of the plants that has antioxidant activity. However, based on previous studies, the antioxidant content is highly dependent on the location and place of the BPF itself. Therefore, this study aims to measure the concentration of total flavonoids, phenolics, antioxidant and antibacterial activity in BPF so that this research can be further developed into certain products. Extraction using maceration method with 96% ethanol solvent (1:10). DPPH method for measuring antioxidant activity and the disc paper diffusion method for testing antibacterial activity. BPF contain flavonoids and total phenolics of 19.44 ± 0.060 mg Quercetin Equivalent (QE)/g and 36.37 ± 0.47 mg Gallic Acid Equivalent (GAE)/g, respectively. BPF also contains antioxidants with an IC50 index of 49.47 µg/mL and BPF extract has no antibacterial activity using the paper disc diffusion method. This antioxidant-rich BPF extract has a lot of promise for development into a cosmetic preparation with more research.  Keywords: Butterfly Pea Flower, Antioxidant, Antibacterial, Flavonoid, Phenolic.
CYTOTOXICITY TEST OF N-HEXANE, ETHYL ACETATE, AND WATER FRACTIONS FROM THE ETHANOL EXTRACT OF SENDUDUK LEAVES (Melastoma malabathricum L.) ON MCF-7 CELLS USING THE MTT ASSAY METHOD Tri Oktarina; Peni Indrayudha; Rima Munawaroh
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1119

Abstract

The world's richest flora may be found in Indonesia, where a variety of plants, such as the sesame plant (Melastoma malabathricum L) or MM, may be used to treat cancer. According to earlier studies, the methanol extract of the leaves had a substantial anticancer effect on the MCF-7 cell line, with an IC50 of 7.14 µg/mL. The purpose of this study was to evaluate the cytotoxic potential of the water, ethyl acetate, and n-hexane fractions of senduduk leaf ethanol extracts. Maceration was the extraction technique, partitioning (liquid-liquid extraction) was the fractionation technique, and the MTT method was employed to assess cytotoxic activity. The n-hexane, ethyl acetate, and water fractions showed cytotoxic effects with IC50 values of 137.200 µg/mL, 17.108 µg/mL, and 610.863 µg/mL, respectively. The water and n-hexane fractions were classified as fragile, based on the results of the cytotoxicity test. The ethyl acetate fraction, on the other hand, was added to the active category for suppressing MCF-7 cells.  Keywords: Melastoma malabathricum L, Cytotoxic, Cells, MCF-7, MTT assay
IDENTIFICATION OF MEDICINAL COMPOUND IN URIC ACID JAMU BY THIN LAYER CHROMATOGRAPHY METHOD Muhammad Yani Zamzam; Iin Indawati; Nina Karlina; Elsa Tiakomala; Windah Widia Ningrum; Aulia Nurkahfi; Andriana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1120

Abstract

Jamu is one of the traditional medicines derived from natural ingredients distributing in Indonesia. In accordance with Permenkes No. 007 of 2012, Medicinal Compound (MC) are prohibited from being added to jamu products. Previous research has found that some of the products in public contain MC. The aim of this study is to determine the presence or absence of allopurinol, piroxicam, and dexamethasone in uric acid jamu.  This research used 5 (five) samples of uric acid jamu, both those with and without distribution permits from The Indonesian Food and Drug Authority, randomly selected in Kedawung District, Cirebon Regency, West java, Indonesia. The identification method used in this study is Thin Layer Chromatography (TLC) with the stationary phase being silica gel GF 254. For the identification of allopurinol, the mobile phase is n-butanol: ammonium hydroxide: ethanol; for piroxicam identification, it is ethyl acetate-methanol-ammonia (6:3:1); and for dexamethasone identification, it is chloroform: acetone (1:4). Spot detection is done using ultraviolet (UV) light at 254 nm. The applied solutions are the test solution (A), the test solution with added allopurinol, piroxicam, or dexamethasone (B), and the reference standard solution (C). The research results from the 5 (five) samples of uric acid jamu identified one positive samples containing allopurinol, and all positive samples contained piroxicam and dexamethasone. Keywords: Jamu,  thin-layer chromatography, allopurinol, piroxicam, dexamethasone

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