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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 523 Documents
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DEVELOPMENT OF KNOWLEDGE, PERCEPTIONS, AND PUBLIC ATTITUDES QUESTIONNAIRE FACING THE ERA OF COMPULSORY HALAL MEDICINE CERTIFICATION Ahmad Azrul Zuniarto; Nurkhasanah Mahfudh; Dyah Aryani Perwitasari; Siti Pandanwangi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1002

Abstract

A questionnaire is an instrument used to collect data from several people or respondents through a set of questions to be answered. The validity and reliability of the questionnaire describe how well the preparation of the questionnaire was related to the measurement scale. Reliability indicates that the questionnaire is consistent when repeatedly used. This study aimed to obtain a valid and reliable questionnaire on community knowledge, perceptions, and attitudes toward halal drugs.  The reliability of the knowledge questionnaire, perceptions, and attitudes was defined using  Cronbach's alpha. This cross-sectional study was conducted online from January to February 2023, with 600 respondents in six provinces on Java Island. The knowledge questionnaire validation test used Point Biserial, perception, and attitude of using the Pearson Product Moment. The majority of respondents were aged <25 years (73%), the dominant last level of education was the secondary level (66.5%), and most of the jobs were students (38.7%). The r value of the knowledge domain obtained is (0.209-0.662) which was greater than the r table (0.080) and met the validity criteria, the perception domain (0.471-0.764), and the attitude domain (0.250-0.757) which is greater than the r table and satisfies the validity criteria. The Cronbach’s alpha value of the knowledge domain obtained was 0.730, that of the perception domain was 0.756, and that of the attitude domain was 0.723, which was > 0.6 and meets the reliability criteria...
CORRELATION OF MEDICATION ADHERENCE WITH THE CHARACTERISTICS AND QUALITY OF LIFE OF TUBERCULOSIS PATIENTS IN DR. DRADJAT PRAWIRANEGARA HOSPITAL Yusransyah Yusransyah; Rozwaliza Annintan; Farahdina Chairani; Baha Udin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1005

Abstract

Tuberculosis remains a health threat in Indonesia because its prevalence is relatively high; therefore, special tuberculosis control is needed. One way to control tuberculosis is to increase compliance with treatment, which can affect quality of life. The main objective of this study was to determine the relationship between the level of treatment compliance and the characteristics and quality of life of patients at dr. Dradjat Prawiranegara Serang Hospital. This study used a cross-sectional, observational research method. Data were collected by distributing questionnaires filled out through direct interviews with the patients. The questionnaires used were the MARS and EQ-5D-5L questionnaires were used. The subjects in this study were outpatients with tuberculosis who were undergoing treatment at our hospital. The Drajat Prawiranegara Serang Hospital met the inclusion and exclusion criteria. Sequential sampling was used as a sampling technique in this study. Statistical data analysis was performed using the chi-square test and correlation. The number of respondents in this study who met the inclusion criteria was 30. As many as 80.0% of tuberculosis patients adhere to taking medication, and 83.3% of tuberculosis patients have a good quality of life. The results of statistical tests show that there is a relationship between the level of compliance of tuberculosis patients and the level of knowledge, income, attitude of health workers, and family support. In contrast, the variables of the level of education, employment, motivation, distance to health facilities, and quality of life did not have a significant relationship with the level of tuberculosis patient compliance...
FORMULATION OF PEEL-OFF GEL MASK OF COCOA SKIN EXTRACT (Theobroma cacao L) WITH VARIED CONCENTRATION GELLING AGENT Yunita Dian Permata Sari; Diyan Sakti Purwanto; Umi Nafisah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1006

Abstract

Cocoa shells are waste from the plantation industry, with a fairly good potential source of energy and protein. The ethanol extract of cocoa shells contains alkaloids, flavonoids, phenols, and tannins. Cocoa shell extract has strong antioxidant activity with an IC50 value of 17.21 ppm and has sunscreen activity. This study aimed to determine the formulation and physical test of a peel-off gel mask with cocoa shell extract (Theobroma cacao L) and to determine its effect. The research method used was an experimental method with variations in the concentration of a combination of HPMC and PVA of 2%:10%, 3%:9%, 4%:8%, 5%:7%, and 0%:12%. The physical tests used on the peel-off gel mask with cocoa shell extract (Theobroma cacao L) included organoleptic, homogeneity, pH, spreadability, drying time, adhesiveness, viscosity, and cycling tests. Based on the results of the research carried out, peel-off gel mask has the characteristics of a brown color, a distinctive extract smell and a thick texture, homogeneous for F1 and F5, and not homogeneous for F2, F3, and F4, sticking force 4.53±0.24 seconds; 5.45±0.36 seconds; 8.94±0.64 seconds; 11.23±0.72 seconds; 3.87±0.70 seconds; spreadability 3.99 ± 0.18 cm; 3.33±0.31 cm; 3.47±0.78 cm; 3.32±0.50 cm; 3.05±0.42 cm; pH 6.17 ± 0.10; 6.16±0.03; 6.15±0.10; 6.11±0.05; 6.42±0.03; viscosity 19481.10±201.10; 20165.50±1.05; 20165.73±2.02; 20182.53±9.47; 14618.40±158.48. The physical stability of the gel mask preparations after treatment showed that the results of the peel-off gel mask preparations, F1 and F5, were stable. Keywords: peel-off gel mask, cocoa shell, extract, gelling agent
ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum Ruiz & Pav) AS AN ACTIVE INGREDIENT IN SUNSCREEN PREPARATIONS Siti Hindun; Nopi Rantika; Aji Najihudin; Nurul Auliasari; Winna Khoerunisa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1007

Abstract

Skin that is continuously exposed to sunlight can cause a reduction in the structure and elasticity of the skin and other bad effects, so it is necessary to have a skin protective agent, one of which is using sunscreen preparations. In the cosmetics sector, making products from natural ingredients is more profitable. They have a good tolerance for the skin because they do not cause severe irritation to sensitive skin. This research aims to determine the activity of red betel leaf ethanol extract as a sunscreen by looking at the SPF (Sun Protection Factor) value. The determination of the SPF value of red betel leaf ethanol extract was carried out in vitro using UV-Vis spectrophotometers at a wavelength range of 290 – 320 nm. Phytochemical testing is carried out to determine the content of chemical compounds that play a role in sunscreen activity. The research results show that the SPF values obtained from concentrations of 100, 200, 300, 400, 500, and 600 ppm, respectively, are 8.486 (extra-protection), 10,849 (maximum protection), 13,709 (maximum protection), 17.1 (ultra protection), 22 (ultra protection) and 25 (ultra protection). Based on the results of phytochemical tests, the ethanol extract of red betel leaves positively contains phenolics, flavonoids, alkaloids, tannins, saponins, steroids, and/or terpenoids. Keywords: Red betel leaves (Piper crocatum Ruiz &Pav), Sunscreen, SPF, In-Vitro, Ultra-protection
ACTIVITY OF ZEBRINA PENDULA SCHNIZL. EXTRACT AGAINST STAPHYLOCOCCUS AUREUS, CANDIDA ALBICANS, AND BACILLUS SUBTILIS Ririn Puspadewi; Mira Andam Dewi; Anggi Gumilar; Luki Yogaswara Yusuf; Estefania Amaris Ivana; Tiara Parmayani; Alpina Rismayati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1008

Abstract

Zebrina pendula Schnizl., known for its medicinal properties against dysentery, contains chemical compounds like polyphenols, flavonoids, quinones, and terpenoids. Despite its potential, research on Zebrina pendula Schnizl. remains limited. This study aimed to assess the antimicrobial activity of Zebrina pendula Schnizl. extract against Staphylococcus aureus, Candida albicans, and Bacillus subtilis, using the microdilution method. The stages of the study include determination, phytochemical screening of Zebrina pendula Schnizl., standardization, multilevel extraction using n-hexane, ethyl acetate, and 96% ethanol, and antimicrobial activity testing via microdilution method to determine Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC).
FORMULATION, AND CHARACTERIZATION OF NANOSTRUCTURED LIPID CARRIER (NLC) CONTAINING QUERCETIN Asti Rahayu; Astrid Kusuma Putri; Nadya Ambarwati; Fithri Farchah Frischah Sari; Rizky Anugrah Dirgantara Putra
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1009

Abstract

Quercetin, like triterpenoids, decreases blood glucose levels. Quercetin has several limitations including low solubility, low percutaneous permeability, and low bioavailability. The formulation of quercetin preparations in a Nanostructured Lipid Carrier (NLC) system is one solution to increase its solubility. The quercetin NLC system was successfully formulated by the high shear homogenization method at a speed of 6000 rpm. The solid lipid glyceryl monostearate and  sunflower oil play important roles in the formation of NLC. The physicochemical characteristics examined in this study included the particle size, dispersion, viscosity, pH, and entrapment efficiency. The particle size of NLC quercetin ranges from 22.98 ± 0.008 nm to 41.04 ± 0.082 nm, with p-values < 0.05. The dispersion power of quercetin NLC ranges from 5.12 ± 0.11 cm to 7.01 ± 0.28 cm, p values < 0.05. The resulting pH range is 7.3 ± 0.01 to 7.4 ± 0.01, and the resulting viscosity is 223.7 ± 9.8 cps to 492.0 ± 0.0 cps. Entrapment efficiency range of (62.20 ± 0.245)% to (86.17 ± 0.287)% ( p < 0.05). The ratio of solid lipid concentration to liquid lipid concentration in NLC quercetin has a significant effect on particle size, dispersion, and entrapment efficiency.  Keywords: Nanostructured Lipid Carrier, Quercetin, Lipid, Glyceryl Monosterate, Sunflower Oil
REVIEW: A STUDY ON THE USE OF GOTU KOLA EXTRACT (Centella asiatica (L.) Urb.) AS A TREATMENT FOR ACNE Endang Diyah Ikasari; Tris Harni Pebriani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1010

Abstract

Acne is an inflammatory skin condition caused by sebaceous follicles and characterized by skin inflammation in the form of a buildup of bacteria and oil that clogs pores and causes acne. Centella asiatica (L.) Urb., often known as gotu kola, has antibacterial properties that inhibit Propionibacterium acnes, thereby reducing papules, pustules, and nodules. Antioxidants, asiatic acid, and madecassic acid found in gotu kola (Centella asiatica (L.) Urb.) can treat wounds. Skin damaged by acne can be repaired and rejuvenated with gotu kola antioxidants, which also help collagen formation more quickly in the skin. This research aims to examine the ability of gotu kola (Centella asiatica (L.) Urb.) extract to inhibit acne-causing bacteria (Propionibacterium acnes) resulting from a literature review. This research method is a literature review or literature review. Research journals that met the inclusion criteria (activity test results suppressing bacterial growth activity) were collected, and a journal summary was made. A summary of the research journals is included in the table sorted by the year of publication of the journal. Based on the results of a literature review carried out by researchers, Gotu kola can be extracted using the maceration method by soaking the plant material in an extraction solvent such as ethanol or water for a specified time. This process was used to remove the active components from the plant material. The inhibition zone formed was evaluated to determine the effectiveness of the extracts or preparations containing gotu kola extract in preventing bacterial growth ...
THE EFFECT OF HOME PHARMACY CARE EDUCATION ON BLOOD PRESSURE CONTROL AND KNOWLEDGE LEVEL OF HYPERTENSIVE PATIENTS AT KENDALSARI PUBLIC HELATH CENTRE MALANG Nanang Ardianto; Allis Soraya Setyokanti Winarning; Rudy Mardianto; Ayesi Dewi Safitri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1041

Abstract

Hypertension is one of the ten most common degenerative diseases and has a high mortality rate. In 2020, the prevalence of hypertension in Malang City reached 35,641 cases. The role of pharmacists as caregivers in home pharmacy care can help to control hypertension and reduce morbidity. The main objective of this study was to determine the effect of home pharmacy care on hypertension patients’ knowledge and blood pressure management. This study used a quantitative experimental design with a Randomized Control Trial method, with a total of 34 respondents divided into 2 groups: the control group and the test group of 17 respondents each. Using an accidental sampling technique. The research location was Kendalsari Public Health Centre Malang in August 2023. Blood pressure data were measured using a tensimeter, and knowledge level data were obtained using a knowledge questionnaire. Data analysis was performed using paired and pooled t-tests. The results of the analysis of the effect of home pharmacy care on the level of patient knowledge about hypertension with a significance value (2tailed) p = 0.000, and analysis of the effect of home pharmacy care on systolic and diastolic blood pressure with a significance value (2tailed) p = 0.030. The results of this study concluded that home pharmacy care for hypertensive patients had a positive effect on blood pressure control and increased knowledge at the Kendalsari Public Health Center, Malang. Keywords: Home pharmacy care, hypertension, blood pressure control, knowledge level.
EVALUATION OF ANTIBIOTIC USE USING THE ATC/DD AND DU 90% METHODS IN OUTPATIENT PATIENTS IN PUSKESMAS RI TENAYAN RAYA Novia Sinata; Delvi Regika; Mira Febrina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1047

Abstract

Infectious diseases are one of the health problem that threaten developing countries, including Indonesia. Riau as one of the provinces with its coastal coverage is not spared from this problem. Inaccurate use of antibiotics is found in the wider community, which can be a cause of negative risks such as antibiotic resistance. Antibiotics are drugs that are used to treat diseases caused by microbes. The improper use of antibiotics can lead to a risk of resistance. Resistance can be avoided using antibiotics. This study aimed to classify antibiotic use using ATC codes and determine the quantity of antibiotic use in outpatients by calculating the DDD. This research method was observational, with a descriptive design and retrospective data collection using secondary data by searching medical records. The sample in this study consisted of outpatients at the Tenayan Raya Inpatient Health Center Outpatient Installation between January and December 2022 who received antibiotic therapy with an ATC code and DDD value in accordance with the provisions of the WHO Collaborating Center, using a total sampling technique.The results of the study showed that based on the ATC/DDD and DU 90% methods, there were 3 antibiotics with the highest quantity of use, namely amoxicillin at 165,92 DDD/1000 KPRJ with a percentage of 67,02%, ciprofloxacin at 41,07 DDD/1000 KPRJ with a percentage of 16,59 %, and cefixime as much as 14,69 DDD/1000 KPRJ with a percentage of 5,93%.  Keywords: antibiotics, ATC/DD, DU 90%, resistance
FORMULATION AND EVALUATION OF EFFERVESCENT GRANULE OF WHITE TEMU RHIZOME EXTRACT (Curcuma zedoaria (Christm.) Roscoe.) AS ANTIOXIDANT Reza Pratama; Deny Puriyani Azhary; Soni Muhsinin; Adinda Khumairani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1050

Abstract

More than 9,606 plant species have medicinal properties, but only around 3-4% of these have been cultivated commercially and used in traditional medicine in Indonesia. One of the natural ingredients believed to have properties is the white temu rhizome. White Curcuma rhizomes are usually processed into food and drinks. White ginger rhizome has antioxidant activity. Antioxidants are secondary metabolites found in herbal plants and have pharmacological activities that can minimize free radicals. Several studies have shown that white ginger rhizomes have antioxidant activities that can remove free radicals. This research aims to formulate an effervescent granule preparation. for white temu rhizome extract (Curcuma zedoaria (Christm.) Roscoe) using the wet granulation method, which meets the requirements for the physical properties of granules and has antioxidant activity. Several formulae were selected from various combinations. Next, an evaluation was performed to determine the physical properties and activities of the formulated granules. The evaluation results showed that all formulations met the requirements of the physical properties of the granules. Qualitative antioxidant activity testing using TLC plates showed positive antioxidant results in the extract and effervescent granule preparation of white curcuma rhizome extract and in quantitative testing it was found that the IC50 value of white curcuma rhizome extract was in the strong category and in the effervescent granule preparation of white curcuma rhizome extract, the granules were found to be in the strong category. Keywords: Effervescent Granule, Extracts, White Temu Rhizome (Curcuma zedoaria (Christm.) Roscoe), Antioxidants

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