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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 523 Documents
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REAL WORLD DATA : ANTIVIRUS SELECTION IN COVID-19 PATIENTS AT PKU MUHAMMADIYAH GAMPING HOSPITAL Damayanti, Hazena Misgi; Perwitasari, Dyah Aryani; Risdiana, Irma; Kuluq, Muhammad Husnul
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1125

Abstract

COVID-19 is a disease that requires antivirals, such as favipiravir and remdesivir, which have been recommended in Indonesia. Choosing the right antiviral agent can affect the length and total cost of hospitalization. The impact of COVID-19 can cause a decline in health and the economy, if not treated effectively. This study aimed to determine the average length of hospitalization and total cost of hospitalization for COVID-19 patients based on the selection of favipiravir and remdesivir antivirals at the PKU Muhammadiyah Gamping Hospital from August 2022-August to 2023 based on real world data. The research method was Observational research with a descriptive research design and retrospective data collection was used. During this period, 306 patients were diagnosed with COVID-19. A total of 171 patients met the inclusion criteria, including 130 patients using favipiravir antivirus and 41 patients using remdesivir antivirus. The results of this study are the average length of hospitalization of the patient group with antiviral favipiravir was 4.1 days and the patient group with antiviral remdesivir was 5 days and the average total cost of hospitalization of the patient group with antiviral favipiravir was IDR 12,377,415 and the average total cost of the patient group with antiviral remdesivir was IDR 14,428,132. The conclusion of this study is that the use of favipiravir antiviral therapy is more effective when viewed from the perspective of length of hospitalization and total cost of hospitalization; therefore, these results can be applied under the same conditions in the treatment of COVID-19.
REVIEW: HERBAL POTENTIAL IN THE USE OF SPF 30 AND 50 SUNSCREENS Siti Fatimah Sultan; Nina Salamah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1139

Abstract

Sunscreen is a substance that can reflect or absorb light, protecting the skin from damage caused by exposure to UV radiation. Soursop juice extract (Annona muricata L.), lime peel extract (Citrus aurantifolia), shallot skin extract (Allium cepa L.), celery leaf extract (Apium graveolens L.), and ethanol extract of kersen leaves (Muntingia calabura) are some plants that can be used as natural sunscreens. According to the SPF value and the protective power category, the soursop juice extract has an SPF value of 5.188, 12.242, and 17.247. Lime peel extract has SPF values of 28.6, 42.2, and 81.8 (max-ultra). Onion peel extract has SPF values of 11.4, 20.12, 31.8, and 34.83 (max-ultra). Celery leaf extract had SPF values of 1.7873, 4.5553, 7.3183, and 8.1573 (max-ultra). Kersen leaf ethanol extract had concentrations of 1.528, 3.890, 3.971, 4.585, and 5.252 (max-ultra). Phenolic components, polyphenols, flavonoids, tannins, and vitamin C are known as bioactive compounds in the five plant extracts that function as sunscreens. The polarity of the solvent influenced the SPF rating and protective power category. It is concluded that the SPF value and protective power of the plant extracts have SPF values and protective power categories with extracts in ultra categories. The bioactive compounds contained in the five plant extracts that act as sunscreens are phenolic compounds, polyphenols, flavonoids, tannins, and vitamin C ...
ANTIOXIDANT ACTIVITY TEST OF GUAVA LEAVES ETHANOL EXTRACT (Syzygium aqueum Burm F) WITH DPPH METHOD (1,1-Diphenyl-2-picrylhydrazil) Fina Fitriani; Siti Nur Hikmah; Fawwaz Muhammad Fauzi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1148

Abstract

Free radicals are compounds that can cause damage to human body cells, which can be prevented with antioxidants. Antioxidants can be found in several natural ingredients, such as water guava leaves. This study aims to determine the antioxidant activity of an ethanol extract from water guava leaves (Syzygium aqueum Burm F). The water guava leaves used came from the Kempek Palimanan Cirebon area. Extraction was carried out using the maceration method using a 96% ethanol solvent until a concentrated extract was obtained. The extract was identified for secondary metabolite content using a reagent test. An antioxidant activity test was carried out using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. Analysis of the strength of antioxidant activity is carried out by calculating the IC50 value, which is based on the percent inhibition of free radicals by the test sample by comparing Vitamin C. Identification of active compounds in the concentrated ethanol extract of water guava leaves indicated the presence of flavonoids, alkaloids, saponins, and tannins. The antioxidant activity of an ethanolic 96% extract of water guava leaves (Syzygium aquarium) in this study had an IC50 value of 6.89 ppm, which shows very strong antioxidant activity in warding off free radicals. Keywords: antioxidants, water guava leaves, DPPH
TESTING THE ACTIVITY AND FORMULATION OF NATURAL HAND SOAP BASED ON NATURAL SURFACTANTS OF LERAK FRUIT (Sapindus rarak DC.) AGAINST Staphylococcus aureus Rose Intan Perma Sari; Natasha Ardinata; Oky Hermansyah; Suci Rahmawati; Camelia Dwi Putri Masrijal
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1151

Abstract

Lerak (Sapindus rarak DC.) is a fruit belonging to the Sapindaceae family that usually grows in tropical forests. Lerak fruit flesh contains the main active compound, saponin. Saponin is a natural surfactant with foaming and emulsifying properties. The use of synthetic surfactants in the manufacture of hand soap sold on the market can have negative impacts, such as irritation and denaturation of proteins in the outer epidermis layer in humans if exposed too often. This study aimed to determine whether lerak can be formulated into natural hand soap as a natural surfactant and determine its antibacterial activity against Staphylococcus aureus bacteria. Lerak fruit solutions were prepared using a maceration method. The resulting solution was then formulated into hand soap at concentrations of 10%, 30%, and 50%. The evaluation of the natural hand soap preparation from the lerak fruit included organoleptic evaluation, homogeneity, pH, viscosity, foam height, and antibacterial activity against Staphylococcus aureus bacteria using the disc diffusion method. Based on the research results, Lerak Fruit (Sapindus rarak DC.) can be formulated as a natural surfactant in hand soap at concentrations of 0%, 10%, 30%, and 50%. Based on the evaluation of the physical properties in the foam height test, F1, F2, and F3 met the requirements, whereas F0 did not meet the requirements in the foam stability test because it did not contain lerak fruit extract, so no foam formed ...
THE POTENCY OF BAJAKAH TAMPALA (Spatholobus littoralis Hassk) AN INDIGENOUS INDONESIAN HERBAL MEDICINE : A BIBLIOMETRIC APPROACH Davit Nugraha; Nurkhasanah; Sapto Yuliani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1169

Abstract

Bajakah tampala (Spatholobus littoralis Hassk) has significant potential in the pharmaceutical field and could become a source for drug discovery and development in the future. This bibliometric analysis aimed to map existing research to identify novelties and gaps for future studies. The research method involved a literature review using bibliometric analysis, using the keyword "bajakah tampala" in Publish or Perish 8, followed by metadata organization using Mendeley and VOSviewer to map research trends. The research findings indicate that Bajakah tampala exhibits variability and gaps in its antioxidant and anti-inflammatory properties, and there is still limited research on this topic. Further research is needed to establish a link between antioxidant and anti-inflammatory effects. Keywords: Bibliometrics, Bajakah tampala, antioxidants, anti-inflammatory, Publish or Perish (POP), VOSviewer
FORMULATION AND TESTING OF ANTIOXIDANT ACTIVITY COMBINATION OF CALENDULA OIL AND SWEET ORANGE OIL WITH DPPH METHOD Deni Firmansyah; Sulistiorini Indriaty; Nina Karlina; Eka Mardiyani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1171

Abstract

Indonesia has many natural ingredients that can be used as primary ingredients for medicines with antioxidant effects. Calendula oil and sweet orange oil have the potential to be antioxidants. This study aimed to determine the stability of cream preparations based on stability test parameters and to determine antioxidant activity using the DPPH method. This study was conducted because the combination of calendula oil and sweet orange oil was tested for antioxidant activity and then formulated in cream dosage forms with ratio of 1:1, 1:2, and 2:1. Antioxidant activity tests were carried out using a combination of calendula oil and sweet orange oil and a cream preparation of a combination of calendula oil and sweet orange oil, which was tested for stability using the cycling test method. Based on the results of the study, the combination of calendula oil and sweet orange oil in a ratio of 1:1 and 1:2 had weak antioxidant activity, as can be seen from the IC50 value of 170.02 ppm, 150.43 ppm, whereas in a 2:1 ratio, it had moderate antioxidant activity because the IC50 value was 143.89 ppm. In the combination cream preparations of calendula oil and sweet orange oil, ratios of 1:1, 1:2, and 2:1 had weak antioxidant activity. It can be seen from the IC50 value of each preparation, which was 188.85 ppm, 170.01 ppm, and 189.61 ppm. Keywords: Calendula Oil, Sweet Orange Oil, Antioxidant, Cream, DPPH
REVIEW: ACTIVITY OF DIOSGENIN COMPOUND AS ATHEROSCLEROSIS THERAPY Rusi Rismawanti; Siti Saidah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1173

Abstract

Atherosclerosis is a disease that causes inhibition of the stability of the cardiovascular system in the body. Cardiovascular disease remains at the top of the list of diseases that cause death. Therefore, cardiovascular disease therapy, including atherosclerosis, still needs to be developed to reduce the mortality rate associated with this disease. Several studies have shown that diosgenin compounds can be used as a therapy for atherosclerosis. The purpose of this study was to determine whether diosgenin compounds and their derivatives can be used for atherosclerosis therapy with various mechanisms of action related to the development of atherosclerosis. This article review was conducted using the article search method on Google Scholar, Pubmed, and Science Direct with various keywords. The results obtained are diosgenin and several diosgenin-derived compounds that can be used as therapies for atherosclerosis with several responses obtained from experiments using rats.  Keywords: diosgenin; atherosclerosis; diosgenin derivatives
REVIEW: POTENTIAL OF NANOEMULGEL FORMULATIONS FOR TOPICAL DRUG DELIVERY Santi Hasanah; Jessie Sofia Pamudji
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1182

Abstract

Nanoemulgel is a combination of two different formulation systems, known as nanoemulsion preparation with gel matrix. In recent years, there has been an increase in the use of topical nanoemulgel preparations because they are easy to apply and can avoid damage to various drugs in the body. Although topical nanoemulgel preparations have some limitations, they are capable of delivering lipophilic drugs topically. The purpose of this review is to summarize the potential of nanoemulgel formulations for topical drug delivery against various physiological challenges and limitations of the formula. Through the publication search, as many as 124 articles were obtained based on the screening results of 29 articles that met the inclusion criteria and were used as a review. The analysis of data for this article was conducted through a narrative review. This preparation may improve the permeability of the drug into the skin by penetrating the stratum corneum through intercellular and intracellular pathways, depending on the components used: oil phase, surfactants, co-surfactants, and gelling agents. Surfactants are responsible for damaging the structure of the skin layer by lowering the surface tension, and gelling agents are responsible for increasing the viscosity and adhesiveness of the skin. Nanoemulgel formulations for topical drug delivery can be used to treat several diseases, such as inflammation, arthritis, wounds, fungal infections, bacterial infections, and psoriasis. The nanoemulgel formulation may provide promising potential in delivering lipophilic drugs topically in the future Keywords: Nanoemulgel, nanoemulsion, gel, topical drug delivery
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF RAMBUTAN HONEY TOOTHPASTE AGAINST Streptococcus mutans Euis Reni Yuslianti; Titta Hartyana Sutarna; Frita Ferlita Shafri Djohan; Amalia Hasna
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1187

Abstract

Dental caries and periodontal diseases are the most common diseases affecting the oral cavity. This can be prevented by maintaining oral hygiene. Toothpaste plays an important role in the reduction of plaque bacteria and inflammatory conditions. Rambutan honey has potential as a natural ingredient to make toothpaste with antibacterial and antioxidant properties owing to the presence of hydrogen peroxide and catalase enzymes, pH, osmolarity, and flavonoid content. The purpose of this study was to obtain a rambutan honey toothpaste formulation that effectively inhibits Streptococcus mutans growth. The laboratory experimental research method was used to combine CaCO3, glycerin, Na CMC, SLS, sodium benzoate, saccharin, menthol, and aquadest as the toothpaste base, which served as the control group. Subsequently, natural ingredients of rambutan honey at concentrations of 20%, 40%, and 60% were added to the toothpaste base to create rambutan honey toothpaste. The formulation of the rambutan honey toothpaste was followed by an antibacterial activity test using the Kirby Bauer method of disc diffusion, where the inhibition zones formed on Mueller Hinton Agar (MHA) medium were calculated. Data were analyzed using one-way and post hoc Tukey’s tests (p<0.05). The results showed that the formulation of rambutan honey toothpaste with a concentration of 60% had the greatest inhibition with 13.88±0.13 mm with a significant difference in each group (p = 0.000), so it can be concluded that rambutan honey toothpaste can inhibit the formation of Streptococcus mutans.  Keywords: antibacterial, formulation, rambutan honey, toothpaste, Streptococcus mutans
REVIEW: ANTIBACTERIAL, ANTIFUNGAL AND WOUND HEALING ACTIVITY OF NANOEMULGEL FORMULATIONS AND PHYSICAL CHARACTERISTICS Rodhia Ulfa; Wildan Khairi Muhtadi; Urva Fresiva; Amraini Amelia
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1193

Abstract

Nanoemulgel is an emulsion preparation with a droplet size of 1–100 nm suspended in a hydrogel. This review delves into the research on the impact of incorporating excipient components in nanoemulgel formulations to create products with specific physical attributes for different active ingredients with antifungal, antibacterial, and wound-healing properties. The research approach involves comparing articles on nanoemulgel preparation formulations with different combinations of active ingredients and excipients, as well as their pharmacological effects. Enhancing the level of active ingredients and altering the excipients can boost the effectiveness of nanoemulgel formulations in combating fungi, bacteria, and promoting wound healing. The review includes articles published within the past decade. Keywords: Nanoemulgel, Pharmacological activity, Physical characteristics, Review

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